Title CRYSTAL STRUCTURE OF THE LAC REPRESSOR DIMER BOUND TO OPERATOR AND THE ANTI-INDUCER ONPF 1efa_500
3D View: Jmol
Citation Bell, C.E. and Lewis, M. (1996), Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. Science 271:1247-1254
[Abstract] [PubMed]
History Deposition: 2000-02-07
Experimental Method X-RAY DIFFRACTION , Resolution: 2.6 Å
Classification TRANSCRIPTION/DNA
SCOP
Classification
Interface to Domain Species Protein Family Superfamily Fold Class
DNA d1efaa1 Escherichia coli [TaxId: 562] Lac repressor (LacR), N-terminal domain GalR/LacI-like bacterial regulator lambda repressor-like DNA-binding domains lambda repressor-like DNA-binding domains All alpha proteins
DNA d1efaa2 Escherichia coli [TaxId: 562] Lac-repressor (lacR) core (C-terminal domain) L-arabinose binding protein-like Periplasmic binding protein-like I Periplasmic binding protein-like I Alpha and beta proteins (a/b)
DNA d1efab1 Escherichia coli [TaxId: 562] Lac repressor (LacR), N-terminal domain GalR/LacI-like bacterial regulator lambda repressor-like DNA-binding domains lambda repressor-like DNA-binding domains All alpha proteins
DNA d1efab2 Escherichia coli [TaxId: 562] Lac-repressor (lacR) core (C-terminal domain) L-arabinose binding protein-like Periplasmic binding protein-like I Periplasmic binding protein-like I Alpha and beta proteins (a/b)
N/A d1efac1 Escherichia coli [TaxId: 562] Lac repressor (LacR), N-terminal domain GalR/LacI-like bacterial regulator lambda repressor-like DNA-binding domains lambda repressor-like DNA-binding domains All alpha proteins
N/A d1efac2 Escherichia coli [TaxId: 562] Lac-repressor (lacR) core (C-terminal domain) L-arabinose binding protein-like Periplasmic binding protein-like I Periplasmic binding protein-like I Alpha and beta proteins (a/b)
Structural and Functional Restraints Polymer Sequence & Restraints
A
         10        20        30        40        50        60        70        80        90        100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320      
KPVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAMAELNYIPNRVAQQLAGKQSLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVERSGVEACKTAVHNLLAQRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQTPINSIIFSHEDGTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTAMLVANDQMALGAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSVDRLLQLSQGQAVKGNQLLPVSLVKRKTT
B
         10        20        30        40        50        60        70        80        90        100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330
KPVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAMAELNYIPNRVAQQLAGKQSLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVERSGVEACKTAVHNLLAQRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQTPINSIIFSHEDGTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTAMLVANDQMALGAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSVDRLLQLSQGQAVKGNQLLPVSLVKRKTTLA
C
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NYIPNRVAQQLAGKQSLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVERSGVEACKTAVHNLLAQRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVSDQTPINSIIFSHEDGTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGWHKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTAMLVANDQMALGAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSVDRLLQLSQGQAVKGNQLLPVSLVKRKTTLA
Key for HTML output
alpha helix red x
beta sheet blue x
positive phi italic x
solvent accessible upper case x
solvent inaccessible lower case x
disulfide bond cedilla ç
hydrogen bond to DNA orange background & bold x
water-mediated hydrogen bond to DNA orange background & overline x
van der Waals contact to DNA orange background & underline x
hydrogen bond to RNA cyan background & bold x
water-mediated hydrogen bond to RNA cyan background & overline x
van der Waals contact to RNA cyan background & underline x
binding to both DNA and RNA green background & bold x
N/A
1efa_500
1EFA