14-3-3

14-3-3-like protein c

Reviewed UniProt entries for 14-3-3 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q96452 1433C_SOYBN 14-3-3-like protein C (SGF14C) GF14C Glycine max (Soybean) (Glycine hispida) 258
P93343 1433C_TOBAC 14-3-3-like protein C (14-3-3-like protein B) Nicotiana tabacum (Common tobacco) 260

Small molecules tested in 14-3-3 binding assays:

3 datapoints for 3 distinct small molecules


Name Fusicoccin
Affinity None
Assay description None
-- Direct single protein target assigned: 1433C_TOBAC (Expert curation) --
DOI http://dx.doi.org/10.1016/j.molcel.2006.12.017
Doc title Structure of a 14-3-3 Coordinated Hexamer of the Plant Plasma Membrane H+-ATPase by Combining X-Ray Crystallography and Electron Cryomicroscopy
PDB 2O98 - (FSC)

Name Pyrrolidone
Affinity None
Assay description None
-- Direct single protein target assigned: 1433C_TOBAC (Expert curation) --
DOI http://dx.doi.org/10.1002/anie.200907203
Doc title Identification and Structure of Small Molecule Stabilizers of 14-3-3 Protein-Protein Interactions
PDB 3M51 - (YR1)

Name Epibestatin
Affinity None
Assay description None
-- Direct single protein target assigned: 1433C_TOBAC (Expert curation) --
DOI http://dx.doi.org/10.1002/anie.200907203
Doc title Identification and Structure of Small Molecule Stabilizers of 14-3-3 Protein-Protein Interactions
PDB 3M50 - (EBT)

8 PDB entries for 14-3-3 and its protein partners


1O9C
Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex

Entity type Code Description
polypeptide(L) P93343 14-3-3-LIKE PROTEIN C
Ligand FLC CITRATE ANION

1O9D
Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex

Entity type Code Description
polypeptide(L) P93343 14-3-3-LIKE PROTEIN C
polypeptide(L) Q40409 PLASMA MEMBRANE H+ ATPASE

1O9E
Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex

Entity type Code Description
polypeptide(L) P93343 14-3-3-LIKE PROTEIN C
Ligand FLC CITRATE ANION
Ligand FSC FUSICOCCIN

1O9F
Structural View of a Fungal Toxin Acting on a 14-3-3 Regulatory Complex

Entity type Code Description
polypeptide(L) P93343 14-3-3-LIKE PROTEIN C
polypeptide(L) Q40409 PLASMA MEMBRANE H+ ATPASE
Ligand FSC FUSICOCCIN

2O98
Structure of a 14-3-3 coordinated hexamer of the plant plasma membrane H+ -ATPase by combining X-ray crystallography and electron cryomicroscopy

Entity type Code Description
polypeptide(L) P93343 14-3-3-like protein C
polypeptide(L) Q40409 Plasma membrane H+ ATPase
Ligand FSC FUSICOCCIN

3E6Y
A structural rationale for selective stabilization of anti-tumor interactions of 14-3-3 proteins by cotylenin A

Entity type Code Description
polypeptide(L) P93343 14-3-3-like protein C
polypeptide(L) 3E6Y H+-ATPase phosphopeptide QSYpTV
Ligand CW1 COTYLENIN A

3M50
Identification and Structure of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions

Entity type Code Description
polypeptide(L) P93343 14-3-3-like protein C
polypeptide(L) Q42932 N.plumbaginifolia H+-translocating ATPase mRNA
Ligand EBT N-[(2R,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTANOYL]-L-LEUCINE

3M51
Identification and Structure of Small-Molecule Stabilizers of 14-3-3 Protein-Protein Interactions

Entity type Code Description
polypeptide(L) P93343 14-3-3-like protein C
polypeptide(L) Q42932 N.plumbaginifolia H+-translocating ATPase mRNA
Ligand YR1 2-HYDROXY-5-[(5S)-3-HYDROXY-5-(4-NITROPHENYL)-2-OXO-4-(PHENYLCARBONYL)-2,5-DIHYDRO-1H-PYRROL-1-YL]BENZOIC ACID