Adenylyl Cyclase

Adenylyl cyclase

Reviewed UniProt entries for Adenylyl Cyclase and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
P30803 ADCY5_CANFA Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) (Ca(2+)-inhibitable adenylyl cyclase) ADCY5 Canis familiaris (Dog) (Canis lupus familiaris) 1265
O95622 ADCY5_HUMAN Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) ADCY5 Homo sapiens (Human) 1261
P84309 ADCY5_MOUSE Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) Adcy5 Mus musculus (Mouse) 1262
P40144 ADCY5_RABIT Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) ADCY5 Oryctolagus cuniculus (Rabbit) 1264
Q04400 ADCY5_RAT Adenylate cyclase type 5 (EC 4.6.1.1) (ATP pyrophosphate-lyase 5) (Adenylate cyclase type V) (Adenylyl cyclase 5) Adcy5 Rattus norvegicus (Rat) 1262
Q08462 ADCY2_HUMAN Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) ADCY2 KIAA1060 Homo sapiens (Human) 1091
Q80TL1 ADCY2_MOUSE Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) Adcy2 Kiaa1060 Mus musculus (Mouse) 1090
P26769 ADCY2_RAT Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2) Adcy2 Rattus norvegicus (Rat) 1090

Small molecules tested in Adenylyl Cyclase binding assays:

7 datapoints for 3 distinct small molecules


Name Forskolin
Affinity None
Assay description None
-- Direct single protein target assigned: ADCY5_CANFA (Expert curation) --
DOI http://dx.doi.org/10.1126/science.285.5428.756
Doc title Two-metal-Ion catalysis in adenylyl cyclase
PDB 1CJU - (FOK)

Name Forskolin
Affinity None
Assay description None
-- Direct single protein target assigned: ADCY2_RAT (Expert curation) --
DOI http://dx.doi.org/10.1038/386247a0
Doc title Structure of the adenylyl cyclase catalytic core
PDB 1AB8 - (FOK)

Name CHEMBL387152
Affinity Not Active
Assay description Inhibition of forskolin-stimulated adenylyl cyclase 5 activity expressed in HEK293 cells at 100 uM
-- Homologous single protein target assigned: ADCY5_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18630896
Doc title Structure-based development of novel adenylyl cyclase inhibitors.
PDB None

Name CHEMBL387152
Affinity Not Active
Assay description Inhibition of basal activity of adenylyl cyclase 2 expressed in HEK293 cells at 100 uM
-- Homologous single protein target assigned: ADCY2_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18630896
Doc title Structure-based development of novel adenylyl cyclase inhibitors.
PDB None

Name CHEMBL401844
Affinity Active
Assay description Inhibition of basal activity of adenylyl cyclase 2 expressed in HEK293 cells at 100 uM
-- Homologous single protein target assigned: ADCY2_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18630896
Doc title Structure-based development of novel adenylyl cyclase inhibitors.
PDB None

Name CHEMBL401844
Affinity Active
Assay description Inhibition of forskolin-stimulated adenylyl cyclase 5 activity expressed in HEK293 cells at 100 uM
-- Homologous single protein target assigned: ADCY5_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18630896
Doc title Structure-based development of novel adenylyl cyclase inhibitors.
PDB None

Name CHEMBL401844
Affinity Active
Assay description Stimulation of basal activity of adenylyl cyclase 2 expressed in HEK293 cells at 100 uM in presence of forskolin
-- Homologous single protein target assigned: ADCY2_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18630896
Doc title Structure-based development of novel adenylyl cyclase inhibitors.
PDB None

17 PDB entries for Adenylyl Cyclase and its protein partners


1AB8
Structure of the adenylyl cyclase catalytic core.

Entity type Code Description
polypeptide(L) P26769 ADENYLYL CYCLASE
Ligand FOK FORSKOLIN

1AZS
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.

Entity type Code Description
polypeptide(L) P30803 VC1
polypeptide(L) P26769 IIC2
polypeptide(L) P04896 GS-ALPHA
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Ligand FKP METHYLPIPERAZINOFORSKOLIN

1CJK
Two-metal-Ion catalysis in adenylyl cyclase.

Entity type Code Description
polypeptide(L) P30803 ADENYLATE CYCLASE, TYPE V
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
polypeptide(L) P26769 ADENYLATE CYCLASE, TYPE II
polypeptide(L) P04896 GUANINE NUCLEOTIDE-BINDING PROTEIN G(S)
Ligand FOK FORSKOLIN
Ligand TAT ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE
Ligand MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID

1CJT
Two-metal-Ion catalysis in adenylyl cyclase.

Entity type Code Description
polypeptide(L) P30803 ADENYLATE CYCLASE, TYPE V
Ligand MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
polypeptide(L) P26769 ADENYLATE CYCLASE, TYPE II
polypeptide(L) P04896 GUANINE NUCLEOTIDE-BINDING PROTEIN G(S)
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Ligand FOK FORSKOLIN
Ligand DAD 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE

1CJU
Two-metal-Ion catalysis in adenylyl cyclase.

Entity type Code Description
polypeptide(L) P30803 ADENYLATE CYCLASE, TYPE V
polypeptide(L) P26769 ADENYLATE CYCLASE, TYPE II
polypeptide(L) P04896 GUANINE NUCLEOTIDE-BINDING PROTEIN G(S)
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Ligand FOK FORSKOLIN
Ligand DAD 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE

1CJV
Two-metal-Ion catalysis in adenylyl cyclase.

Entity type Code Description
polypeptide(L) P30803 ADENYLATE CYCLASE, TYPE V
Ligand MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
polypeptide(L) P26769 ADENYLATE CYCLASE, TYPE II
polypeptide(L) P04896 GUANINE NUCLEOTIDE-BINDING PROTEIN G(S)
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Ligand FOK FORSKOLIN
Ligand DAD 2',3'-DIDEOXYADENOSINE-5'-TRIPHOSPHATE

1CS4
Molecular basis for P-site inhibition of adenylyl cyclase.

Entity type Code Description
polypeptide(L) P30803 TYPE V ADENYLATE CYCLASE
Ligand POP PYROPHOSPHATE 2-
polypeptide(L) P26769 TYPE II ADENYLATE CYCLASE
polypeptide(L) P04896 GUANINE NUCLEOTIDE-BINDING PROTEIN G(S)
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Ligand 101 2'-DEOXY-ADENOSINE 3'-MONOPHOSPHATE
Ligand FOK FORSKOLIN
Ligand MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID

1CUL
Molecular basis for P-site inhibition of adenylyl cyclase.

Entity type Code Description
polypeptide(L) P30803 TYPE V ADENYLYL CYCLASE
Ligand MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
polypeptide(L) P26769 TYPE II ADENYLYL CYCLASE
polypeptide(L) P04896 GUANINE NUCLEOTIDE-BINDING PROTEIN G(S)
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Ligand FOK FORSKOLIN
Ligand 103 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
Ligand 3PO TRIPHOSPHATE

1TL7
Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate.

Entity type Code Description
polypeptide(L) P30803 Adenylate cyclase, type V
polypeptide(L) P26769 Adenylate cyclase, type II
polypeptide(L) P04896 Guanine nucleotide-binding protein G(s), alpha subunit
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Ligand FOK FORSKOLIN
Ligand ONM 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE

1U0H
Structural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate.

Entity type Code Description
polypeptide(L) P30803 Adenylate cyclase, type V
polypeptide(L) P26769 Adenylate cyclase, type II
polypeptide(L) P04896 Guanine nucleotide-binding protein G(s), alpha subunit
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Ligand FOK FORSKOLIN
Ligand ONM 3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE

2GVD
Broad specificity of Mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors.

Entity type Code Description
polypeptide(L) P30803 Adenylate cyclase type 5
polypeptide(L) P26769 Adenylate cyclase type 2
polypeptide(L) P04896 Guanine nucleotide-binding protein G(s), alpha subunit
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Ligand FKP METHYLPIPERAZINOFORSKOLIN
Ligand 128 SPIRO(2,4,6-TRINITROBENZENE[1,2A]-2O',3O'-METHYLENE-ADENINE-TRIPHOSPHATE

2GVZ
Broad specificity of Mammalian adenylyl cyclase for interaction with 2',3'-substituted purine- and pyrimidine nucleotide inhibitors.

Entity type Code Description
polypeptide(L) P30803 Adenylate cyclase type 5
polypeptide(L) P26769 Adenylate cyclase type 2
polypeptide(L) P04896 Guanine nucleotide-binding protein G(s), alpha subunit
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Ligand FKP METHYLPIPERAZINOFORSKOLIN
Ligand ONA 3'-O-[2-(METHYLAMINO)BENZOYL]ADENOSINE 5'-(TETRAHYDROGEN TRIPHOSPHATE)

3C14
Structural basis for inhibition of mammalian adenylyl cyclase by calcium.

Entity type Code Description
polypeptide(L) P30803 Adenylate cyclase type 5
polypeptide(L) P26769 Adenylate cyclase type 2
polypeptide(L) P04896 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Ligand FOK FORSKOLIN
Ligand POP PYROPHOSPHATE 2-
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

3C15
Structural basis for inhibition of mammalian adenylyl cyclase by calcium.

Entity type Code Description
polypeptide(L) P30803 Adenylate cyclase type 5
polypeptide(L) P26769 Adenylate cyclase type 2
polypeptide(L) P04896 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Ligand FOK FORSKOLIN
Ligand POP PYROPHOSPHATE 2-

3C16
Structural basis for inhibition of mammalian adenylyl cyclase by calcium.

Entity type Code Description
polypeptide(L) P30803 Adenylate cyclase type 5
polypeptide(L) P26769 Adenylate cyclase type 2
polypeptide(L) P04896 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Ligand FOK FORSKOLIN
Ligand ATP ADENOSINE-5'-TRIPHOSPHATE

3G82
2',3'-(O)-(N-Methyl)anthraniloyl-inosine 5'-triphosphate is the Most Potent Adenylyl Cyclase 1 and 5 Inhibitor Known so far and Effectively Promotes Catalytic Subunit Assembly in the Absence of Forskolin

Entity type Code Description
polypeptide(L) P30803 Adenylate cyclase type 5
polypeptide(L) P26769 Adenylate cyclase type 2
polypeptide(L) P04896 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Ligand FOK FORSKOLIN
Ligand MI3 3'-O-{[2-(METHYLAMINO)PHENYL]CARBONYL}INOSINE 5'-(TETRAHYDROGEN TRIPHOSPHATE)
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

3MAA
Structural basis for inhibition of mammalian adenylyl cyclase by calcium.

Entity type Code Description
polypeptide(L) P30803 Adenylate cyclase type 5
polypeptide(L) P26769 Adenylate cyclase type 2
polypeptide(L) P04896 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Ligand FKP METHYLPIPERAZINOFORSKOLIN
Ligand TAT ADENOSINE-5'-RP-ALPHA-THIO-TRIPHOSPHATE
Ligand GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE