Annexin A2

Annexin a2

Reviewed UniProt entries for Annexin A2 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
P27006 ANX2A_XENLA Annexin A2-A (Annexin II type I) (Annexin-2-A) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Lipocortin II) anxa2-a Xenopus laevis (African clawed frog) 340
P24801 ANX2B_XENLA Annexin A2-B (Annexin II type II) (Annexin-2-B) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Lipocortin II) anxa2-b Xenopus laevis (African clawed frog) 340
P04272 ANXA2_BOVIN Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) ANXA2 ANX2 Bos taurus (Bovine) 339
Q6TEQ7 ANXA2_CANFA Annexin A2 (Annexin-2) ANXA2 ANX2 Canis familiaris (Dog) (Canis lupus familiaris) 339
Q2Q1M6 ANXA2_CEREL Annexin A2 (Annexin-2) ANXA2 ANX2 Cervus elaphus (Red deer) 339
P17785 ANXA2_CHICK Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) ANXA2 ANX2 Gallus gallus (Chicken) 339
P07356 ANXA2_MOUSE Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) Anxa2 Anx2 Cal1h Mus musculus (Mouse) 339
P19620 ANXA2_PIG Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) ANXA2 ANX2 Sus scrofa (Pig) 339
Q5R5A0 ANXA2_PONAB Annexin A2 (Annexin-2) ANXA2 ANX2 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 339
Q07936 ANXA2_RAT Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) Anxa2 Anx2 Rattus norvegicus (Rat) 339
A2SW69 ANXA2_SHEEP Annexin A2 (Annexin-2) ANXA2 ANX2 Ovis aries (Sheep) 339
P60902 S10AA_BOVIN Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11) S100A10 CAL1L CLP11 Bos taurus (Bovine) 97
P27003 S10AA_CHICK Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11) S100A10 Gallus gallus (Chicken) 97
P60903 S10AA_HUMAN Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11) S100A10 ANX2LG CAL1L CLP11 Homo sapiens (Human) 97
P62504 S10AA_MACMU Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (S100 calcium-binding protein A10) S100A10 CAL1L Macaca mulatta (Rhesus macaque) 97
P08207 S10AA_MOUSE Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11) S100a10 Cal1l Mus musculus (Mouse) 97
P04163 S10AA_PIG Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11) S100A10 Sus scrofa (Pig) 96
Q6SQH4 S10AA_RABIT Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (S100 calcium-binding protein A10) (p10 protein) S100a10 Oryctolagus cuniculus (Rabbit) 97
P05943 S10AA_RAT Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (Nerve growth factor-induced protein 42C) (S100 calcium-binding protein A10) (p10 protein) (p11) S100a10 Rattus norvegicus (Rat) 95
P27004 S10AA_XENLA Protein S100-A10 (Calpactin I light chain) (Calpactin-1 light chain) (Cellular ligand of annexin II) (S100 calcium-binding protein A10) (p10 protein) (p11) s100a10 Xenopus laevis (African clawed frog) 96
P07355 ANXA2_HUMAN Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) ANXA2 ANX2 ANX2L4 CAL1H LPC2D Homo sapiens (Human) 339

Small molecules tested in Annexin A2 binding assays:

164 datapoints for 54 distinct small molecules


Name CHEMBL1346735
Affinity IC50 = 275uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1346735
Affinity IC50 = 275uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766583
Affinity IC50 = 14uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766583
Affinity INH = 101%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766583
Affinity Active
Assay description Inhibition of annexin A2-S100A10 interaction in human MDA-MB-231 cells at 10 to 100 uM after 10 mins by broken cell immunoprecipitation assay
-- Direct protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766583
Affinity IC50 = 14uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766583
Affinity IC50 = 14uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766583
Affinity IC50 = 14uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766583
Affinity INH = 70%
Assay description Inhibition of annexin A2-S100A10 interaction in human MDA-MB-231 cell lysates at 50 uM after 10 mins by Western blotting relative to control
-- Direct protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766583
Affinity INH = 101%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766583
Affinity Active
Assay description Inhibition of annexin A2-S100A10 interaction in human MDA-MB-231 cells at 10 to 100 uM after 10 mins by broken cell immunoprecipitation assay
-- Direct protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766583
Affinity INH = 70%
Assay description Inhibition of annexin A2-S100A10 interaction in human MDA-MB-231 cell lysates at 50 uM after 10 mins by Western blotting relative to control
-- Direct protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766584
Affinity IC50 > 100uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766584
Affinity IC50 > 100uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766585
Affinity IC50 > 100uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766585
Affinity IC50 > 100uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766586
Affinity IC50 = 100uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766586
Affinity IC50 = 100uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766587
Affinity IC50 = 8.8uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766587
Affinity IC50 = 8.8uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766588
Affinity IC50 = 15uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766588
Affinity IC50 = 15uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766589
Affinity IC50 = 20uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766589
Affinity IC50 = 20uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766590
Affinity IC50 > 100uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766590
Affinity IC50 > 100uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766591
Affinity IC50 = 2.1uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766591
Affinity IC50 = 2.1uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766592
Affinity IC50 = 1.8uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766592
Affinity IC50 = 1.8uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766593
Affinity IC50 = 18uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766593
Affinity IC50 = 18uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766594
Affinity IC50 > 100uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766594
Affinity IC50 > 100uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766595
Affinity IC50 > 100uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766595
Affinity IC50 > 100uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by FRET assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766596
Affinity IC50 > 1000uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766596
Affinity IC50 > 1000uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766597
Affinity IC50 = 128uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766597
Affinity IC50 = 128uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766598
Affinity IC50 = 251uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766598
Affinity IC50 = 251uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766599
Affinity IC50 = 11uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766599
Affinity INH = 100%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766599
Affinity IC50 = 11uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766599
Affinity INH = 100%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766600
Affinity IC50 = 85uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766600
Affinity IC50 = 85uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766601
Affinity IC50 = 16uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766601
Affinity IC50 = 16uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766602
Affinity IC50 = 18uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766602
Affinity INH = 97%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766602
Affinity INH = 97%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766602
Affinity IC50 = 18uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766603
Affinity INH = 123%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766603
Affinity IC50 = 28uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766603
Affinity IC50 = 28uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766603
Affinity INH = 123%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766604
Affinity Not Active
Assay description Inhibition of annexin A2-S100A10 interaction in human MDA-MB-231 cell lysates at 50 uM after 10 mins by Western blotting
-- Direct protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766604
Affinity IC50 > 1000uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766604
Affinity IC50 > 1000uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766604
Affinity Not Active
Assay description Inhibition of annexin A2-S100A10 interaction in human MDA-MB-231 cell lysates at 50 uM after 10 mins by Western blotting
-- Direct protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766605
Affinity IC50 = 9uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766605
Affinity IC50 = 9uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766605
Affinity INH = 110%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766605
Affinity INH = 110%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766606
Affinity INH = 102%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766606
Affinity INH = 102%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766606
Affinity IC50 = 6uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766606
Affinity IC50 = 6uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766607
Affinity INH = 110%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766607
Affinity IC50 = 8uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766607
Affinity INH = 110%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766607
Affinity IC50 = 8uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766608
Affinity INH = 102%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766608
Affinity IC50 = 8uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766608
Affinity INH = 102%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766608
Affinity IC50 = 8uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766609
Affinity INH = 70%
Assay description Inhibition of annexin A2-S100A10 interaction in human MDA-MB-231 cell lysates at 50 uM after 10 mins by Western blotting relative to control
-- Direct protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766609
Affinity Active
Assay description Inhibition of annexin A2-S100A10 interaction in human MDA-MB-231 cells at 10 to 100 uM after 10 mins by broken cell immunoprecipitation assay
-- Direct protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766609
Affinity INH = 70%
Assay description Inhibition of annexin A2-S100A10 interaction in human MDA-MB-231 cell lysates at 50 uM after 10 mins by Western blotting relative to control
-- Direct protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766609
Affinity IC50 = 4uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766609
Affinity Active
Assay description Inhibition of annexin A2-S100A10 interaction in human MDA-MB-231 cells at 10 to 100 uM after 10 mins by broken cell immunoprecipitation assay
-- Direct protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766609
Affinity IC50 = 4uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766609
Affinity INH = 109%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766609
Affinity INH = 109%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766610
Affinity IC50 = 117uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766610
Affinity IC50 = 117uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766611
Affinity IC50 = 105uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766611
Affinity IC50 = 105uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766713
Affinity IC50 = 7uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766713
Affinity INH = 119%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766713
Affinity INH = 119%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766713
Affinity IC50 = 7uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766714
Affinity IC50 = 8uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766714
Affinity INH = 121%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766714
Affinity IC50 = 8uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766714
Affinity INH = 121%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766715
Affinity IC50 > 1000uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766715
Affinity IC50 > 1000uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766716
Affinity IC50 = 12uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766716
Affinity INH = 101%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766716
Affinity IC50 = 12uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766716
Affinity INH = 101%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766717
Affinity IC50 = 8uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766717
Affinity INH = 120%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766717
Affinity INH = 120%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766717
Affinity IC50 = 8uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766718
Affinity INH = 111%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766718
Affinity IC50 = 3uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766718
Affinity INH = 111%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766718
Affinity IC50 = 3uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766719
Affinity IC50 = 6uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766719
Affinity INH = 105%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766719
Affinity IC50 = 6uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766719
Affinity INH = 105%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766720
Affinity IC50 = 14uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766720
Affinity IC50 = 14uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766721
Affinity IC50 = 79uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766721
Affinity IC50 = 79uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766722
Affinity IC50 = 616uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766722
Affinity IC50 = 616uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766723
Affinity INH = 110%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766723
Affinity INH = 110%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766723
Affinity IC50 = 7uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766723
Affinity IC50 = 7uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766724
Affinity INH = 112%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766724
Affinity IC50 = 7uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766724
Affinity INH = 112%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766724
Affinity IC50 = 7uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766725
Affinity IC50 = 794uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766725
Affinity IC50 = 794uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766726
Affinity IC50 = 56uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766726
Affinity IC50 = 56uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766727
Affinity INH = 126%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766727
Affinity INH = 126%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766727
Affinity IC50 = 3uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766727
Affinity IC50 = 3uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766728
Affinity IC50 > 1000uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766728
Affinity IC50 > 1000uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766729
Affinity IC50 = 28uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766729
Affinity INH = 102%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766729
Affinity INH = 102%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766729
Affinity IC50 = 28uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766730
Affinity INH = 120%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766730
Affinity IC50 = 6uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766730
Affinity INH = 120%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766730
Affinity IC50 = 6uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766731
Affinity IC50 > 1000uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766731
Affinity IC50 > 1000uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766732
Affinity IC50 = 269uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766732
Affinity IC50 = 269uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766733
Affinity IC50 = 182uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766733
Affinity IC50 = 182uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766734
Affinity IC50 = 186uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766734
Affinity IC50 = 186uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766735
Affinity IC50 = 11uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766735
Affinity INH = 117%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766735
Affinity IC50 = 11uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766735
Affinity INH = 117%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766736
Affinity IC50 = 5uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766736
Affinity IC50 = 5uM
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction after 5 mins by counterscreen assay
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766736
Affinity INH = 127%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: S10AA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

Name CHEMBL1766736
Affinity INH = 127%
Assay description Inhibition of Cy3-labeled annexin A2(1-14)-Cy5- labeled S100A10 interaction at 50 uM after 5 mins by counterscreen assay relative to control
-- Homologous protein complex subunits assigned: ANXA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21375334
Doc title Design, synthesis, and structure-activity relationship exploration of 1-substituted 4-aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-one analogues as inhibitors of the annexin A2-S100A10 protein interaction.
PDB None

12 PDB entries for Annexin A2 and its protein partners


1A4P
The crystal structure of a complex of p11 with the annexin II N-terminal peptide.

Entity type Code Description
polypeptide(L) P60903 S100A10

1BT6
The crystal structure of a complex of p11 with the annexin II N-terminal peptide.

Entity type Code Description
polypeptide(L) P60903 S100A10
polypeptide(L) P17785 ANNEXIN II

1W7B
Annexin A2: Does It Induce Membrane Aggregation by a New Multimeric State of the Protein

Entity type Code Description
polypeptide(L) P07355 ANNEXIN A2

1XJL
Annexin A2: Does it induce membrane aggregation by a new multimeric state of the protein?

Entity type Code Description
polypeptide(L) P07355 Annexin A2

2HYU
Crystallographic Analysis of Calcium-dependent Heparin Binding to Annexin A2.

Entity type Code Description
polypeptide(L) P07355 Annexin A2
Ligand None SUGAR (4-MER)

2HYV
Crystallographic analysis of calcium-dependent heparin binding to annexin A2.

Entity type Code Description
polypeptide(L) P07355 Annexin A2
Ligand None SUGAR (5-MER)

2HYW
Crystallographic Analysis of Calcium-dependent Heparin Binding to Annexin A2.

Entity type Code Description
polypeptide(L) P07355 Annexin A2

4DRW
Structure of an asymmetric ternary protein complex provides insight for membrane interaction.

Entity type Code Description
polypeptide(L) P60903 Protein S100-A10/Annexin A2 chimeric protein
polypeptide(L) P07355 Protein S100-A10/Annexin A2 chimeric protein
polypeptide(L) Q09666 Neuroblast differentiation-associated protein AHNAK

4FTG
Structure of a C-terminal AHNAK peptide in a 1:2:2 complex with S100A10 and an acetylated N-terminal peptide of annexin A2.

Entity type Code Description
polypeptide(L) P60903 Protein S100-A10
polypeptide(L) P07355 Annexin A2
polypeptide(L) Q09666 Neuroblast differentiation-associated protein AHNAK

4HRE
SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action.

Entity type Code Description
polypeptide(L) P07356 Annexin A2
polypeptide(L) P60903 Protein S100-A10
polypeptide(L) Q14527 Helicase-like transcription factor

4HRG
SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action.

Entity type Code Description
polypeptide(L) P60903 Protein S100-A10
polypeptide(L) Q09666 Neuroblast differentiation-associated protein AHNAK

4HRH
SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action.

Entity type Code Description
polypeptide(L) P60903 Protein S100-A10, Annexin A2
polypeptide(L) P07355 Protein S100-A10, Annexin A2
polypeptide(L) Q14527 Helicase-like transcription factor