BIII

Voltage-dependent n-type calcium channel subunit alpha-1b

Reviewed UniProt entries for BIII and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
O73706 CAC1B_CHICK Voltage-dependent N-type calcium channel subunit alpha-1B (CHCACHA1B) (Voltage-gated calcium channel subunit alpha Cav2.2) (Fragment) CACNA1B Gallus gallus (Chicken) 159
Q00975 CAC1B_HUMAN Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel; L type; alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) CACNA1B CACH5 CACNL1A5 Homo sapiens (Human) 2339
O55017 CAC1B_MOUSE Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel; L type; alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) Cacna1b Cach5 Cacnl1a5 Cchn1a Mus musculus (Mouse) 2327
Q05152 CAC1B_RABIT Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel; L type; alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) CACNA1B CACH5 CACNL1A5 Oryctolagus cuniculus (Rabbit) 2339
Q02294 CAC1B_RAT Voltage-dependent N-type calcium channel subunit alpha-1B (Brain calcium channel III) (BIII) (Calcium channel; L type; alpha-1 polypeptide isoform 5) (Voltage-gated calcium channel subunit alpha Cav2.2) Cacna1b Cach5 Cacnl1a5 Rattus norvegicus (Rat) 2336
Q02410 APBA1_HUMAN Amyloid beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) APBA1 MINT1 X11 Homo sapiens (Human) 837
B2RUJ5 APBA1_MOUSE Amyloid beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) Apba1 Mint1 X11 Mus musculus (Mouse) 842
O35430 APBA1_RAT Amyloid beta A4 precursor protein-binding family A member 1 (Adapter protein X11alpha) (Neuron-specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint-1) Apba1 Mint1 X11 Rattus norvegicus (Rat) 839

Our searches have not found small molecules for this target yet


13 PDB entries for BIII and its protein partners


1AQC
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.

Entity type Code Description
polypeptide(L) Q02410 X11
polypeptide(L) 1AQC PEPTIDE

1U37
Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem

Entity type Code Description
polypeptide(L) Q02410 amyloid beta A4 precursor protein-binding, family A, member 1

1U38
Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem

Entity type Code Description
polypeptide(L) Q02410 amyloid beta A4 precursor protein-binding, family A, member 1
polypeptide(L) 22035548 PVYI

1U39
Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem

Entity type Code Description
polypeptide(L) Q02410 amyloid beta A4 precursor protein-binding, family A, member 1

1U3B
Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem

Entity type Code Description
polypeptide(L) Q02410 amyloid beta A4 precursor protein-binding, family A, member 1

1X11
Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain.

Entity type Code Description
polypeptide(L) Q02410 X11
polypeptide(L) P05067 13-MER PEPTIDE

1X45
Solution structure of the first PDZ domain of amyloid beta A4 precursor protein-binding family A, member 1

Entity type Code Description
polypeptide(L) Q02410 amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)

1Y7N
Solution structure of the second PDZ domain of the neuronal adaptor X11alpha and its interaction with the C-terminal peptide of the human copper chaperone for superoxide dismutase

Entity type Code Description
polypeptide(L) Q02410 Amyloid beta A4 precursor protein-binding family A member 1

2LCM
structure of S4-3 voltage sensor peptide

Entity type Code Description
polypeptide(L) Q00975 Voltage-dependent N-type calcium channel subunit alpha-1B

3DVE
Structures of Ca(V)2 Ca(2+)/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation.

Entity type Code Description
polypeptide(L) P62158 Calmodulin
polypeptide(L) Q05152 Voltage-dependent N-type calcium channel subunit alpha-1B
Ligand NI NICKEL (II) ION

3DVJ
Structures of Ca(V)2 Ca(2+)/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation.

Entity type Code Description
polypeptide(L) P62158 Calmodulin
polypeptide(L) Q05152 Voltage-dependent N-type calcium channel subunit alpha-1B

4DBB
Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing.

Entity type Code Description
polypeptide(L) O35430 Amyloid beta A4 precursor protein-binding family A member 1
polypeptide(L) O35430 Amyloid beta A4 precursor protein-binding family A member 1
Ligand ACY ACETIC ACID

4DEX
The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis.

Entity type Code Description
polypeptide(L) P54288 Voltage-dependent L-type calcium channel subunit beta-2
polypeptide(L) P54288 Voltage-dependent L-type calcium channel subunit beta-2
polypeptide(L) Q02294 Voltage-dependent N-type calcium channel subunit alpha-1B