Bcl-XL and Bcl-2

Apoptosis regulators bcl-xl and bcl-2

Reviewed UniProt entries for Bcl-XL and Bcl-2 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
O02718 BCL2_BOVIN Apoptosis regulator Bcl-2 BCL2 Bos taurus (Bovine) 229
Q6R755 BCL2_CANFA Apoptosis regulator Bcl-2 BCL2 Canis familiaris (Dog) (Canis lupus familiaris) 236
Q00709 BCL2_CHICK Apoptosis regulator Bcl-2 BCL2 BCL-2 Gallus gallus (Chicken) 233
Q9JJV8 BCL2_CRIGR Apoptosis regulator Bcl-2 BCL2 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 236
P10417 BCL2_MOUSE Apoptosis regulator Bcl-2 Bcl2 Bcl-2 Mus musculus (Mouse) 236
P49950 BCL2_RAT Apoptosis regulator Bcl-2 Bcl2 Bcl-2 Rattus norvegicus (Rat) 236
Q92934 BAD_HUMAN Bcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-XL/Bcl-2-associated death promoter) BAD BBC6 BCL2L8 Homo sapiens (Human) 168
O35147 BAD_RAT Bcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-xL/Bcl-2-associated death promoter) Bad Rattus norvegicus (Rat) 205
O02703 BAX_BOVIN Apoptosis regulator BAX BAX Bos taurus (Bovine) 192
Q07812 BAX_HUMAN Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4) BAX BCL2L4 Homo sapiens (Human) 192
Q07813 BAX_MOUSE Apoptosis regulator BAX Bax Mus musculus (Mouse) 192
Q63690 BAX_RAT Apoptosis regulator BAX Bax Rattus norvegicus (Rat) 192
Q16611 BAK_HUMAN Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) (Bcl-2-like protein 7) (Bcl2-L-7) BAK1 BAK BCL2L7 CDN1 Homo sapiens (Human) 211
O08734 BAK_MOUSE Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK) Bak1 Bak Mus musculus (Mouse) 208
Q8JGM8 BID_CHICK BH3-interacting domain death agonist BID RCJMB04_7d15 Gallus gallus (Chicken) 193
P55957 BID_HUMAN BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] BID Homo sapiens (Human) 195
P70444 BID_MOUSE BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] Bid Mus musculus (Mouse) 195
Q4JHS0 BID_PIG BH3-interacting domain death agonist BID Sus scrofa (Pig) 192
Q9JLT6 BID_RAT BH3-interacting domain death agonist (p22 BID) (BID) [Cleaved into: BH3-interacting domain death agonist p15 (p15 BID); BH3-interacting domain death agonist p13 (p13 BID); BH3-interacting domain death agonist p11 (p11 BID)] Bid Rattus norvegicus (Rat) 196
Q07816 B2CL1_CHICK Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) BCL2L1 BCL-X BCLX Gallus gallus (Chicken) 229
Q07817 B2CL1_HUMAN Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) BCL2L1 BCL2L BCLX Homo sapiens (Human) 233
Q64373 B2CL1_MOUSE Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) Bcl2l1 Bcl2l Bclx Mus musculus (Mouse) 233
O77737 B2CL1_PIG Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) BCL2L1 BCLX BLC2L Sus scrofa (Pig) 233
P53563 B2CL1_RAT Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X) Bcl2l1 Bclx Blc2l Rattus norvegicus (Rat) 233
P10415 BCL2_HUMAN Apoptosis regulator Bcl-2 BCL2 Homo sapiens (Human) 239
Q61337 BAD_MOUSE Bcl2 antagonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-xL/Bcl-2-associated death promoter) Bad Bbc6 Mus musculus (Mouse) 204

Small molecules tested in Bcl-XL and Bcl-2 binding assays:

1398 datapoints for 720 distinct small molecules


Name Nature435_frag1
Affinity None
Assay description None
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1038/nature03579
Doc title An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
PDB 1YSG - (4FC)

Name Nature435_frag2
Affinity None
Assay description None
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1038/nature03579
Doc title An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
PDB 1YSG - (TN1)

Name Nature435_comp1
Affinity None
Assay description None
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1038/nature03579
Doc title An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
PDB 1YSI - (N3B)

Name Nature435_comp2
Affinity None
Assay description None
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1038/nature03579
Doc title An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
PDB 1YSN - (43B)

Name Nature435_comp2
Affinity None
Assay description None
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm061152t
Doc title Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
PDB 2O21 - (43B)

Name Nature435_comp2
Affinity None
Assay description None
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1038/nature03579
Doc title An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
PDB 1YSW - (43B)

Name Nature435_comp2
Affinity None
Assay description None
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm061152t
Doc title Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
PDB 2O1Y - (43B)

Name JMC50_1b
Affinity None
Assay description None
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm061152t
Doc title Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
PDB 2O22 - (LIU)

Name JMC50_43a
Affinity None
Assay description None
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm061152t
Doc title Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
PDB 2O2M - (LI0)

Name JMC50_43a
Affinity None
Assay description None
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm061152t
Doc title Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
PDB 2O2F - (LI0)

Name Gossypol
Affinity Ki binding 300nM
Assay description Binding assay
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.biomedcentral.com/content/pdf/cd-747202.pdf
Doc title Small-molecule inhibitors of Bcl-2.
PDB None

Name Obatoclax
Affinity Kd binding 500nM
Assay description Radioligand binding assay
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.biomedcentral.com/content/pdf/cd-747202.pdf
Doc title Small-molecule inhibitors of Bcl-2.
PDB None

Name JMC44_6
Affinity IC50 FPA 10uM
Assay description We have used a sensitive and quantitative in vitro fluorescence polarization (FP) based binding assay.15 The basic principle behind this assay is competition: a fluorescent peptide tracer (Flu-Bak-BH3) and a nonfluorescent smallmolecule inhibitor compete for binding to the target protein (Bcl-2).
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm010016f
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name JMC44_7
Affinity IC50 FPA 2uM
Assay description We have used a sensitive and quantitative in vitro fluorescence polarization (FP) based binding assay.15 The basic principle behind this assay is competition: a fluorescent peptide tracer (Flu-Bak-BH3) and a nonfluorescent smallmolecule inhibitor compete for binding to the target protein (Bcl-2).
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm010016f
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name JMC44_8
Affinity IC50 FPA 10uM
Assay description We have used a sensitive and quantitative in vitro fluorescence polarization (FP) based binding assay.15 The basic principle behind this assay is competition: a fluorescent peptide tracer (Flu-Bak-BH3) and a nonfluorescent smallmolecule inhibitor compete for binding to the target protein (Bcl-2).
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm010016f
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name JMC44_10
Affinity IC50 FPA 12uM
Assay description We have used a sensitive and quantitative in vitro fluorescence polarization (FP) based binding assay.15 The basic principle behind this assay is competition: a fluorescent peptide tracer (Flu-Bak-BH3) and a nonfluorescent smallmolecule inhibitor compete for binding to the target protein (Bcl-2).
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm010016f
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name JMC44_11
Affinity IC50 FPA 6uM
Assay description We have used a sensitive and quantitative in vitro fluorescence polarization (FP) based binding assay.15 The basic principle behind this assay is competition: a fluorescent peptide tracer (Flu-Bak-BH3) and a nonfluorescent smallmolecule inhibitor compete for binding to the target protein (Bcl-2).
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm010016f
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name YC137
Affinity Ki (FPA) 1.3uM
Assay description Bid fluoro labelled
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://cancerres.aacrjournals.org/cgi/reprint/64/21/7947.pdf
Doc title Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2.
PDB None

Name HA14-1
Affinity IC50 FPA 9uM
Assay description Competitive Bcl-2 with Flu-Bak-BH3 pep
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1073/pnas.97.13.7124
Doc title Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells.
PDB None

Name JMC44_p2
Affinity Ki FPA 3uM
Assay description Competitive Bcl-2 with Flu-Bak-BH3 pep
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.nature.com/ncb/journal/v3/n2/pdf/ncb0201_173.pdf
Doc title Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL.
PDB None

Name JMC44_p3
Affinity Ki FPA 3uM
Assay description Competitive Bcl-2 with Flu-Bak-BH3 pep
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.nature.com/ncb/journal/v3/n2/pdf/ncb0201_173.pdf
Doc title Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL.
PDB None

Name TW-37
Affinity Ki FPA 300nM
Assay description also active with Bcl-XL and Mcl-1
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm060460o
Doc title Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.
PDB None

Name JMC50_43b
Affinity None
Assay description None
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm061152t
Doc title Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
PDB 2O2N - (LIW)

Name ABT-737
Affinity Ki FPA 1nM
Assay description Fluorencence Polorisation assay; BAK or BAD peptide fluorescent label
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1038/nature03579
Doc title An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
PDB 2YXJ - (N3C)

Name Antimycin_A3
Affinity IC50 FPA 2uM
Assay description with Bcl-2
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.nature.com/ncb/journal/v3/n2/full/ncb0201_183.html
Doc title Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.
PDB None

Name JMC50_7
Affinity Ki FPA 110nM
Assay description also active with Bcl-XL and Mcl-1
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm061400l
Doc title Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins.
PDB None

Name CHEMBL106708
Affinity Kd = 400uM
Assay description Binding affinity to BH3 binding groove of BclXL
-- Homologous single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18457385
Doc title Recent developments in fragment-based drug discovery.
PDB None

Name CHEMBL106708
Affinity Kd = 430uM
Assay description Binding affinity to Bcl-2 by NMR titration assay in presence of 500 uM 1,1-bis(4-chlorophenyl)-3-(dimethylamino)propan-1-ol
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL106708
Affinity Kd = 300uM
Assay description Binding affinity to Bcl-xL by 2D- NOESY analysis
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB 1YSG - (4FC)

Name CHEMBL106708
Affinity IC50 = 300uM
Assay description Binding affinity to Bcl2 by fluorescent polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21413808
Doc title Synopsis of some recent tactical application of bioisosteres in drug design.
PDB None

Name CHEMBL106708
Affinity Kd = 400uM
Assay description Binding affinity to Bcl-2 by NMR titration assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL108829
Affinity Kd = 2.7mM
Assay description Binding affinity to 6xHis-tagged human Bcl-xL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20192224
Doc title Fragment-based deconstruction of Bcl-xL inhibitors.
PDB None

Name CHEMBL1094130
Affinity IC50 = 40.4uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1094172
Affinity IC50 = 10.3uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1094250
Affinity IC50 = 0.32uM
Assay description Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443627
Doc title BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1094250
Affinity IC50 = 0.68uM
Assay description Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443627
Doc title BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1094250
Affinity IC50 = 1.14uM
Assay description Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443627
Doc title BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1094250
Affinity Kd = 2.4uM
Assay description Binding affinity to Bcl-XL by isothermal titration calorimetric assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443627
Doc title BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1094250
Affinity Kd = 0.1uM
Assay description Binding affinity to Bcl-XL by isothermal titration calorimetric assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443627
Doc title BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1094250
Affinity IC50 = 0.31uM
Assay description Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443627
Doc title BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1094366
Affinity Kd = 0.4uM
Assay description Binding affinity to Bcl-XL by isothermal titration calorimetric assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443627
Doc title BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1094366
Affinity IC50 = 0.43uM
Assay description Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443627
Doc title BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1094366
Affinity IC50 = 0.44uM
Assay description Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443627
Doc title BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1094366
Affinity IC50 = 0.43uM
Assay description Displacement of FITC-labeled Bak BH3 peptide from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443627
Doc title BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1094366
Affinity Kd = 2uM
Assay description Binding affinity to Bcl-XL by isothermal titration calorimetric assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443627
Doc title BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1094366
Affinity IC50 = 0.65uM
Assay description Displacement of FITC-labeled Bak BH3 peptide from Bcl-XL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443627
Doc title BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1094443
Affinity IC50 > 100uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1094444
Affinity IC50 = 72uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1094643
Affinity IC50 > 100uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1094644
Affinity IC50 > 100uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1094645
Affinity IC50 > 100uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1094809
Affinity IC50 = 36uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095146
Affinity IC50 = 5.4uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095147
Affinity IC50 = 19.7uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095307
Affinity IC50 = 1.9uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095308
Affinity IC50 = 13.4uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095309
Affinity IC50 = 7.3uM
Assay description Displacement of FITC-labeled BH3 peptide from human Bcl-XL after 1 hr by fluorescence polarization assay
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095309
Affinity IC50 = 6.9uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095309
Affinity Kd = 38.5uM
Assay description Binding affinity to human Bcl-XL by surface plasma resonance based biosensor system
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095309
Affinity IC50 = 11.1uM
Assay description Displacement of FITC labeled BH3 peptide from His-tagged human BCL2 after 1 hr by fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095310
Affinity IC50 = 17.4uM
Assay description Displacement of FITC-labeled BH3 peptide from human Bcl-XL after 1 hr by fluorescence polarization assay
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095310
Affinity IC50 = 7.3uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095310
Affinity IC50 = 19.4uM
Assay description Displacement of FITC labeled BH3 peptide from His-tagged human BCL2 after 1 hr by fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095311
Affinity IC50 > 100uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095312
Affinity IC50 > 100uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095757
Affinity IC50 = 5.2uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095758
Affinity IC50 = 35.9uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095759
Affinity IC50 = 6.2uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1095770
Affinity IC50 = 12.7uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1096087
Affinity IC50 = 12.6uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1096755
Affinity IC50 = 6.9uM
Assay description Displacement of FITC-labeled BH3 peptide from human Bcl-XL after 1 hr by fluorescence polarization assay
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1096755
Affinity IC50 = 8uM
Assay description Displacement of FITC labeled BH3 peptide from His-tagged human BCL2 after 1 hr by fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1096755
Affinity IC50 = 3uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1097075
Affinity IC50 = 3.1uM
Assay description Displacement of FITC labeled BH3 peptide from His-tagged human BCL2 after 1 hr by fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1097075
Affinity Kd = 9.5uM
Assay description Binding affinity to human Bcl-XL by surface plasma resonance based biosensor system
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1097075
Affinity IC50 = 3.4uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1097075
Affinity IC50 = 3.4uM
Assay description Displacement of FITC-labeled BH3 peptide from human Bcl-XL after 1 hr by fluorescence polarization assay
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1097427
Affinity IC50 = 100uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1097428
Affinity IC50 = 12.1uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1098322
Affinity IC50 = 26.7uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1098323
Affinity IC50 = 5.3uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1098324
Affinity IC50 = 17.4uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1098324
Affinity IC50 = 3uM
Assay description Displacement of FITC-labeled BH3 peptide from human Bcl-XL after 1 hr by fluorescence polarization assay
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1098324
Affinity IC50 = 3.2uM
Assay description Displacement of FITC labeled BH3 peptide from His-tagged human BCL2 after 1 hr by fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1098324
Affinity Kd = 96.3uM
Assay description Binding affinity to human Bcl-XL by surface plasma resonance based biosensor system
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1098754
Affinity IC50 = 12.6uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1098755
Affinity IC50 = 6.2uM
Assay description Inhibition of human Bcl-XL
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405848
Doc title Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors.
PDB None

Name CHEMBL1163268
Affinity Not Active
Assay description Displacement of fluorescently-tagged BH3 peptide from Bcl-XL by fluorimetric assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20481544
Doc title Rearranged diterpenoids from the biotransformation of ent-trachyloban-18-oic acid by Rhizopus arrhizus.
PDB None

Name CHEMBL1164030
Affinity Not Active
Assay description Displacement of fluorescently-tagged BH3 peptide from Bcl-XL by fluorimetric assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20481544
Doc title Rearranged diterpenoids from the biotransformation of ent-trachyloban-18-oic acid by Rhizopus arrhizus.
PDB None

Name CHEMBL1164031
Affinity Not Active
Assay description Displacement of fluorescently-tagged BH3 peptide from Bcl-XL by fluorimetric assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20481544
Doc title Rearranged diterpenoids from the biotransformation of ent-trachyloban-18-oic acid by Rhizopus arrhizus.
PDB None

Name CHEMBL1164319
Affinity Not Active
Assay description Displacement of fluorescently-tagged BH3 peptide from Bcl-XL by fluorimetric assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20481544
Doc title Rearranged diterpenoids from the biotransformation of ent-trachyloban-18-oic acid by Rhizopus arrhizus.
PDB None

Name CHEMBL1164460
Affinity IC50 = 400uM
Assay description Displacement of fluorescently-tagged BH3 peptide from Bcl-XL by fluorimetric assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20481544
Doc title Rearranged diterpenoids from the biotransformation of ent-trachyloban-18-oic acid by Rhizopus arrhizus.
PDB None

Name CHEMBL1165054
Affinity IC50 = 380uM
Assay description Displacement of fluorescently-tagged BH3 peptide from Bcl-XL by fluorimetric assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20481544
Doc title Rearranged diterpenoids from the biotransformation of ent-trachyloban-18-oic acid by Rhizopus arrhizus.
PDB None

Name CHEMBL1165508
Affinity IC50 = 220uM
Assay description Displacement of fluorescently-tagged BH3 peptide from Bcl-XL by fluorimetric assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20481544
Doc title Rearranged diterpenoids from the biotransformation of ent-trachyloban-18-oic acid by Rhizopus arrhizus.
PDB None

Name CHEMBL1215012
Affinity IC50 = 1.76uM
Assay description Displacement of FITC-labeled Bak-BH3 peptide from Bcl-XL after 1 hr by fluorescence polarization assay
-- Homologous single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20684596
Doc title A novel water-soluble gossypol derivative increases chemotherapeutic sensitivity and promotes growth inhibition in colon cancer.
PDB None

Name CHEMBL1269012
Affinity Ki = 0.16uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269012
Affinity IC50 = 0.24uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269012
Affinity Ki = 0.14uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269012
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269012
Affinity IC50 = 0.21uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269070
Affinity IC50 = 0.32uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269070
Affinity Ki = 0.21uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269070
Affinity Ki = 0.15uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269070
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269070
Affinity IC50 = 0.23uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269071
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269072
Affinity IC50 = 0.34uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269072
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269072
Affinity Ki = 0.15uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269072
Affinity IC50 = 0.22uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269072
Affinity Ki = 0.24uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269073
Affinity IC50 = 2.27uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269073
Affinity Ki = 1.53uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269073
Affinity Ki = 2uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269073
Affinity IC50 = 2.99uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269073
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269074
Affinity Ki = 8.4uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269074
Affinity IC50 = 12.65uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269074
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269074
Affinity Ki = 4.47uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269074
Affinity IC50 = 6.73uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269075
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269075
Affinity IC50 = 1.79uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269075
Affinity Ki = 1.73uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269075
Affinity IC50 = 2.57uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269075
Affinity Ki = 1.2uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269076
Affinity IC50 = 3.12uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269076
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269076
Affinity Ki = 2.08uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269076
Affinity Ki = 2.07uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269076
Affinity Kd = 2.5uM
Assay description Binding affinity Bcl-xL by isothermal titration calorimetry assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269076
Affinity IC50 = 3.1uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269077
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269077
Affinity Ki = 1.45uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269077
Affinity Ki = 0.96uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269077
Affinity IC50 = 2.17uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269077
Affinity IC50 = 1.44uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269078
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269107
Affinity IC50 = 0.34uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269107
Affinity Kd = 0.45uM
Assay description Binding affinity Bcl-xL by isothermal titration calorimetry assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269107
Affinity Ki = 0.23uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269107
Affinity IC50 = 0.29uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269107
Affinity Ki = 0.19uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269107
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269108
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269109
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269110
Affinity Ki = 0.23uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269110
Affinity Ki = 0.11uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269110
Affinity IC50 = 0.34uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269110
Affinity IC50 = 0.15uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269110
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269111
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1269479
Affinity Kd = 200uM
Assay description Binding affinity to Bcl-2 by NMR titration assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1269479
Affinity Kd = 5000uM
Assay description Binding affinity to Bcl-XL by NMR titration assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1269480
Affinity Kd = 250uM
Assay description Binding affinity to Bcl-2 by NMR titration assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1269503
Affinity Kd = 100uM
Assay description Binding affinity to Bcl-2 by NMR titration assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1269503
Affinity Kd = 20uM
Assay description Binding affinity to Bcl-2 by NMR titration assay in presence of 500 uM 1,1-bis(4-chlorophenyl)-3-(dimethylamino)propan-1-ol
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1269504
Affinity Ki = 0.22uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1269505
Affinity Ki = 0.2uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1269506
Affinity Ki = 0.11uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1269507
Affinity Ki = 0.04uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1270616
Affinity Kd = 20uM
Assay description Binding affinity to Bcl-2 by NMR titration assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1270616
Affinity Kd = 450uM
Assay description Binding affinity to Bcl-XL by NMR titration assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1270617
Affinity Kd = 80uM
Assay description Binding affinity to Bcl-2 by NMR titration assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1270617
Affinity Kd = 500uM
Assay description Binding affinity to Bcl-XL by NMR titration assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1270714
Affinity Ki = 5uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1270819
Affinity Ki = 20uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1270820
Affinity Ki = 5.2uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1270922
Affinity Ki = 4.6uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1271021
Affinity Ki = 3.4uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1271126
Affinity Ki > 1uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1271230
Affinity Ki = 5.8uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1271231
Affinity Ki = 8uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1271331
Affinity Ki = 83uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1271332
Affinity Ki = 12uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1271439
Affinity Ki > 1uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1271440
Affinity Ki = 0.46uM
Assay description Inhibition of Bcl-2 by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20870405
Doc title Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR.
PDB None

Name CHEMBL1272170
Affinity Kd = 2.8uM
Assay description Binding affinity Bcl-xL by isothermal titration calorimetry assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1272170
Affinity Ki = 0.25uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1272170
Affinity IC50 = 0.37uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1272170
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1272170
Affinity IC50 = 0.63uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1272170
Affinity Ki = 0.42uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1272224
Affinity Ki = 0.37uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1272224
Affinity IC50 = 0.55uM
Assay description Displacement of F-BakBH3 from Bcl-xL after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1272224
Affinity Ki = 0.17uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1272224
Affinity IC50 = 0.25uM
Assay description Displacement of F-BakBH3 from Bcl-2 after 30 mins by fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1272224
Affinity Active
Assay description Binding affinity Bcl-xL at 200 uM by one-dimensional 1H nuclear magnetic resonance spectroscopy
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL1272224
Affinity Kd = 1.5uM
Assay description Binding affinity Bcl-xL by isothermal titration calorimetry assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21033669
Doc title Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
PDB None

Name CHEMBL133255
Affinity IC50 > 100uM
Assay description Inhibitory concentration against Bcl-xl
-- Direct protein complex subunits assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/13678404
Doc title Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.
PDB None

Name CHEMBL134871
Affinity IC50 > 100uM
Assay description Inhibitory concentration against Bcl-xl
-- Direct protein complex subunits assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/13678404
Doc title Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.
PDB None

Name CHEMBL135315
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL135650
Affinity IC50 = 73uM
Assay description Inhibitory concentration against Bcl-xl
-- Direct protein complex subunits assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/13678404
Doc title Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.
PDB None

Name CHEMBL135934
Affinity IC50 = 7.7uM
Assay description In vitro inhibitory activity against Bak-Bh3 peptide binding to the Bcl-2
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL136016
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL136866
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL136987
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL137135
Affinity IC50 = 9uM
Assay description Inhibitory activity against Bcl-2
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL137177
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL137215
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL137246
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL137267
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL137306
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL137369
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL137528
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL137543
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL137740
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL137744
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL137796
Affinity Not Active
Assay description In vitro inhibition of Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60; Inactive
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL137800
Affinity IC50 = 10.4uM
Assay description In vitro inhibitory activity against Bak-Bh3 peptide binding to the Bcl-2 using human myeloid leukemia cell line HL-60
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11728179
Doc title Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening.
PDB None

Name CHEMBL165
Affinity IC50 = 190uM
Assay description Displacement of FITC-conjugated BH3-Bak peptide from human recombinant Bcl-XL expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20441222
Doc title Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention.
PDB None

Name CHEMBL1672068
Affinity Ki = 0.445uM
Assay description Displacement of FAM-Bid peptide from human recombinant Bcl2 after 30 mins by by competitive fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21684048
Doc title Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design.
PDB None

Name CHEMBL1672069
Affinity Ki = 0.278uM
Assay description Displacement of FAM-Bid peptide from human recombinant Bcl2 after 30 mins by by competitive fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21684048
Doc title Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design.
PDB None

Name CHEMBL1672070
Affinity Ki = 0.304uM
Assay description Displacement of FAM-Bid peptide from human recombinant Bcl2 after 30 mins by by competitive fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21684048
Doc title Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design.
PDB None

Name CHEMBL1672071
Affinity Ki = 0.252uM
Assay description Displacement of FAM-Bid peptide from human recombinant Bcl2 after 30 mins by by competitive fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21684048
Doc title Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design.
PDB None

Name CHEMBL1672080
Affinity IC50 = 0.342uM
Assay description Displacement of FAM-Bid from human recombinant Bcl-2 after 30 mins by ELISA
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21235240
Doc title 3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) based molecules as potent, dual inhibitors of B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1): structure-based design and structure-activity relationship studies.
PDB None

Name CHEMBL1672081
Affinity Ki = 382nM
Assay description Displacement of FAM-Bid from human Bcl-2 after 30 mins by fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21235240
Doc title 3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) based molecules as potent, dual inhibitors of B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1): structure-based design and structure-activity relationship studies.
PDB None

Name CHEMBL1672082
Affinity IC50 = 0.302uM
Assay description Displacement of FAM-Bid from human recombinant Bcl-2 after 30 mins by ELISA
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21235240
Doc title 3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) based molecules as potent, dual inhibitors of B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1): structure-based design and structure-activity relationship studies.
PDB None

Name CHEMBL1683276
Affinity Ki = 0.52uM
Assay description Binding affinity to Bcl-xL after 2 hrs by fluorescein-labeled Bak-BH3 peptide competition binding assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21300543
Doc title Anti-tumor pyrimidinylpiperazines bind to the prosurvival Bcl-2 protein family member Bcl-XL.
PDB None

Name CHEMBL1683280
Affinity Ki = 0.127uM
Assay description Binding affinity to Bcl-xL after 2 hrs by fluorescein-labeled Bak-BH3 peptide competition binding assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21300543
Doc title Anti-tumor pyrimidinylpiperazines bind to the prosurvival Bcl-2 protein family member Bcl-XL.
PDB None

Name CHEMBL1683285
Affinity Ki = 0.17uM
Assay description Binding affinity to Bcl-xL after 2 hrs by fluorescein-labeled Bak-BH3 peptide competition binding assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21300543
Doc title Anti-tumor pyrimidinylpiperazines bind to the prosurvival Bcl-2 protein family member Bcl-XL.
PDB None

Name CHEMBL1689139
Affinity IC50 = 7nM
Assay description Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaScreen competitive assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB 3QKD - (HI0)

Name CHEMBL1689139
Affinity Ka = 1.910'5/M/s
Assay description Binding affinity to Bcl-Xl assessed as association rate constant by surface plasmon resonance assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB 3QKD - (HI0)

Name CHEMBL1689139
Affinity Kd = 4.2nM
Assay description Binding affinity to Bcl-Xl
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB 3QKD - (HI0)

Name CHEMBL1689139
Affinity IC50 = 8.7nM
Assay description Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689140
Affinity IC50 = 21nM
Assay description Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689140
Affinity IC50 = 34nM
Assay description Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaScreen competitive assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689141
Affinity IC50 = 6nM
Assay description Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaScreen competitive assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689141
Affinity IC50 = 13nM
Assay description Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689142
Affinity IC50 = 16nM
Assay description Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaScreen competitive assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689142
Affinity IC50 = 81nM
Assay description Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689143
Affinity IC50 = 12nM
Assay description Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689143
Affinity IC50 = 3nM
Assay description Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaScreen competitive assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689144
Affinity IC50 = 20nM
Assay description Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaScreen competitive assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689144
Affinity IC50 = 21nM
Assay description Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689145
Affinity IC50 = 3nM
Assay description Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaScreen competitive assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689145
Affinity IC50 = 5nM
Assay description Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689146
Affinity IC50 = 29nM
Assay description Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaScreen competitive assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689146
Affinity IC50 = 84nM
Assay description Displacement of wild type mBimBH3 from human Bcl-2 by solution competition assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1689147
Affinity IC50 = 3uM
Assay description Displacement of biotinylated Bim-BH3 from GST-tagged Bcl-Xl by AlphaScreen competitive assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21366295
Doc title Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
PDB None

Name CHEMBL1760195
Affinity Not Active
Assay description Induction of Bcl-xL-mediated apoptosis in doxycyclin-stimulated human HeLa cells overexpressing Noxa at 10 uM after 12 hrs by Hoechst staining
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22386982
Doc title Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study.
PDB None

Name CHEMBL1802135
Affinity Active
Assay description Induction of Bcl-2 phosphorylation at Ser70 in human Hep3B cells at 160 uM after 18 hrs by Western blotting analysis
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22595423
Doc title Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells.
PDB None

Name CHEMBL1824186
Affinity Ki = 6.031uM
Assay description Displacement of FAM-Bid peptide from human recombinant Bcl2 after 30 mins by by competitive fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21684048
Doc title Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design.
PDB None

Name CHEMBL1824187
Affinity Ki = 1.43uM
Assay description Displacement of FAM-Bid peptide from human recombinant Bcl2 after 30 mins by by competitive fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21684048
Doc title Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design.
PDB None

Name CHEMBL1824188
Affinity Ki = 0.886uM
Assay description Displacement of FAM-Bid peptide from human recombinant Bcl2 after 30 mins by by competitive fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21684048
Doc title Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design.
PDB None

Name CHEMBL1824189
Affinity Ki = 16.6uM
Assay description Displacement of FAM-Bid peptide from human recombinant Bcl2 after 30 mins by by competitive fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21684048
Doc title Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design.
PDB None

Name CHEMBL1824190
Affinity Ki = 0.158uM
Assay description Displacement of FAM-Bid peptide from human recombinant Bcl2 after 30 mins by by competitive fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21684048
Doc title Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design.
PDB None

Name CHEMBL1824799
Affinity Kd = 378.4uM
Assay description Binding affinity to Bcl-xL by 2D- NOESY analysis
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824800
Affinity IC50 = 16.77uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824801
Affinity IC50 = 15.08uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824802
Affinity IC50 = 42.72uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824803
Affinity IC50 = 9.37uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824804
Affinity IC50 = 3.79uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824805
Affinity IC50 = 4.14uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824806
Affinity IC50 = 28.03uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824807
Affinity IC50 = 33.52uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824808
Affinity IC50 = 49.51uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824809
Affinity IC50 = 3.19uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824810
Affinity IC50 = 161.3uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824811
Affinity IC50 = 6.2uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824812
Affinity IC50 = 0.31uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824813
Affinity IC50 = 0.18uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824814
Affinity IC50 = 9.98uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824815
Affinity IC50 = 7.15uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824816
Affinity IC50 = 28.52uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824817
Affinity IC50 = 2.53uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824818
Affinity IC50 = 2.31uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824819
Affinity IC50 = 4.08uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824820
Affinity IC50 = 1.94uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824821
Affinity IC50 = 1.97uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824822
Affinity IC50 > 1000uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824823
Affinity IC50 = 10.87uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824824
Affinity IC50 = 12.11uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824825
Affinity IC50 = 2.96uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824826
Affinity IC50 = 0.16uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824827
Affinity IC50 = 3.76uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824828
Affinity IC50 = 2.7uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824829
Affinity IC50 = 2uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824830
Affinity IC50 = 2.94uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824831
Affinity IC50 = 2.87uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1824832
Affinity IC50 = 0.086uM
Assay description Displacement of FITC labeled Bak BH3 peptide from Bcl-xL after 10 mins by Fluorescence Polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1914471
Affinity EC50 = 0.76uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915438
Affinity EC50 = 0.03uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915442
Affinity EC50 = 0.14uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915445
Affinity EC50 = 0.09uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915448
Affinity EC50 = 0.05uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915449
Affinity EC50 = 0.03uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915633
Affinity EC50 = 1.58uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915636
Affinity EC50 = 0.53uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915641
Affinity EC50 = 0.04uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915644
Affinity EC50 = 1.02uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915645
Affinity EC50 = 0.1uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915646
Affinity EC50 = 0.21uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915647
Affinity EC50 = 0.89uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915648
Affinity EC50 = 0.98uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915650
Affinity EC50 = 0.2uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1915651
Affinity EC50 = 0.1uM
Assay description Inhibition of BAD phosphorylation at Ser112 in human MV-4-11 cells assessed as phospho-BAD level after 4 hrs by ELISA
-- Direct single protein target assigned: BAD_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21982499
Doc title 7-(4H-1,2,4-Triazol-3-yl)benzo[c][2,6]naphthyridines: a novel class of Pim kinase inhibitors with potent cell antiproliferative activity.
PDB None

Name CHEMBL1916190
Affinity Ki < 1nM
Assay description Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Wild type Bcl-2-like protein 1 expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21807512
Doc title Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.
PDB None

Name CHEMBL1916191
Affinity Ki = 1nM
Assay description Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Wild type Bcl-2-like protein 1 expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21807512
Doc title Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.
PDB None

Name CHEMBL1916192
Affinity Ki = 68nM
Assay description Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Wild type Bcl-2-like protein 1 expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21807512
Doc title Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.
PDB None

Name CHEMBL1916193
Affinity Ki = 3.3nM
Assay description Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Wild type Bcl-2-like protein 1 expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21807512
Doc title Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.
PDB None

Name CHEMBL1916194
Affinity Ki = 2.6nM
Assay description Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Wild type Bcl-2-like protein 1 expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21807512
Doc title Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.
PDB None

Name CHEMBL192032
Affinity Ki = 0.583uM
Assay description Binding affinity to Bcl-2 after 30 mins by florescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23167494
Doc title An anthraquinone scaffold for putative, two-face Bim BH3 alpha-helix mimic.
PDB None

Name CHEMBL192571
Affinity Ki = 0.36uM
Assay description Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assay
-- Direct protein complex subunits assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL192571
Affinity Ki = 0.8nM
Assay description Displacement of Bad-derived peptide from Bcl-xL by fluorescence polarization assay
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17256834
Doc title Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
PDB None

Name CHEMBL192571
Affinity Ki = 67nM
Assay description Displacement of Bax-derived peptide from Bcl2 by fluorescence polarization assay
-- Direct single protein target assigned: BCL2_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17256834
Doc title Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
PDB None

Name CHEMBL192571
Affinity IC50 = 360nM
Assay description Displacement of Bad-derived peptide from Bcl-xL by FPA in presence of 10% human serum
-- Direct single protein target assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17256834
Doc title Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.
PDB None

Name CHEMBL192571
Affinity Ki = 0.8nM
Assay description Binding affinity to Bcl-xl
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20925433
Doc title Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.
PDB None

Name CHEMBL192571
Affinity Ki = 6.3nM
Assay description Displacement of BODIPY-Bak conjugated peptide from GST-tagged human Wild type Bcl-2-like protein 1 expressed in Escherichia coli BL21 cells at 10 uM after 3 hrs by fluorescence polarization competition assay
-- Direct single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21807512
Doc title Biochemical and pharmacological profiling of the pro-survival protein Bcl-xL.
PDB None

Name CHEMBL192571
Affinity Ki = 62nM
Assay description Binding affinity to BCl2
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20925433
Doc title Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.
PDB None

Name CHEMBL192571
Affinity Ki = 0.0008uM
Assay description Binding affinity to Bcl-XL by fluorescence polarization assay
-- Direct protein complex subunits assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL192571
Affinity Ki = 0.067uM
Assay description Binding affinity to Bcl2 by fluorescence polarization assay
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL194009
Affinity Kd = 691.8uM
Assay description Binding affinity to Bcl-xL by 2D- NOESY analysis
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21797225
Doc title SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.
PDB None

Name CHEMBL1940662
Affinity Ki = 5.82uM
Assay description Binding affinity to Bcl-xL by competitive fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940662
Affinity Ki = 3.78uM
Assay description Binding affinity to Bcl-2 by competitive fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940663
Affinity Ki = 4.84uM
Assay description Binding affinity to Bcl-xL by competitive fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940663
Affinity Ki = 3.38uM
Assay description Binding affinity to Bcl-2 by competitive fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940664
Affinity Ki = 3.52uM
Assay description Binding affinity to Bcl-2 by competitive fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940664
Affinity Ki = 3.91uM
Assay description Binding affinity to Bcl-xL by competitive fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940665
Affinity Ki = 3.42uM
Assay description Binding affinity to Bcl-xL by competitive fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940665
Affinity Ki = 3.39uM
Assay description Binding affinity to Bcl-2 by competitive fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940666
Affinity Ki = 0.83uM
Assay description Binding affinity to Bcl-2 by competitive fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940666
Affinity Ki = 6.45uM
Assay description Binding affinity to Bcl-xL by competitive fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940667
Affinity Ki = 9.49uM
Assay description Binding affinity to Bcl-2 by competitive fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940667
Affinity Ki = 16.44uM
Assay description Binding affinity to Bcl-xL by competitive fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940668
Affinity Ki = 2.51uM
Assay description Binding affinity to Bcl-xL by competitive fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940668
Affinity Ki = 1.67uM
Assay description Binding affinity to Bcl-2 by competitive fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940669
Affinity Ki = 1.09uM
Assay description Binding affinity to Bcl-2 by competitive fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940669
Affinity Ki = 1.71uM
Assay description Binding affinity to Bcl-xL by competitive fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940670
Affinity Ki = 2.08uM
Assay description Binding affinity to Bcl-xL by competitive fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940670
Affinity Ki = 1.4uM
Assay description Binding affinity to Bcl-2 by competitive fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940671
Affinity Ki = 0.93uM
Assay description Binding affinity to Bcl-2 by competitive fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940671
Affinity Ki = 1.94uM
Assay description Binding affinity to Bcl-xL by competitive fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940678
Affinity Ki = 1.5uM
Assay description Binding affinity to Bcl-xL by competitive fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940678
Affinity Ki = 0.76uM
Assay description Binding affinity to Bcl-2 by competitive fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940679
Affinity Ki = 0.8uM
Assay description Binding affinity to Bcl-2 by competitive fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940679
Affinity Ki = 1.27uM
Assay description Binding affinity to Bcl-xL by competitive fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940680
Affinity Ki = 2.29uM
Assay description Binding affinity to Bcl-xL by competitive fluorescence polarization assay
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL1940680
Affinity Ki = 15.19uM
Assay description Binding affinity to Bcl-2 by competitive fluorescence polarization assay
-- Homologous single protein target assigned: BCL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22172701
Doc title Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.
PDB None

Name CHEMBL198903
Affinity Ki = 0.0011uM
Assay description Binding affinity to Bcl-XL by fluorescence polarization assay
-- Direct protein complex subunits assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL198903
Affinity Ki > 10uM
Assay description Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assay
-- Direct protein complex subunits assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL198903
Affinity Ki = 0.055uM
Assay description Binding affinity to Bcl2 by fluorescence polarization assay
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL2011504
Affinity Kd = 930nM
Assay description Displacement of BakBH3 from Bcl-xL by DEL method
-- Homologous single protein target assigned: B2CL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22230199
Doc title Unbiased binding assays for discovering small-molecule probes and drugs.
PDB None

Name CHEMBL201669
Affinity Ki = 1uM
Assay description Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assay
-- Direct protein complex subunits assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL201669
Affinity Ki = 4.57uM
Assay description Binding affinity to Bcl2 by fluorescence polarization assay
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL201669
Affinity Ki = 0.426uM
Assay description Binding affinity to Bcl-XL by fluorescence polarization assay
-- Direct protein complex subunits assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL201670
Affinity Ki = 0.79uM
Assay description Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assay
-- Direct protein complex subunits assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL201670
Affinity Ki = 0.0579uM
Assay description Binding affinity to Bcl-XL by fluorescence polarization assay
-- Direct protein complex subunits assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL201670
Affinity Ki = 0.366uM
Assay description Binding affinity to Bcl2 by fluorescence polarization assay
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL201947
Affinity Ki = 0.215uM
Assay description Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assay
-- Direct protein complex subunits assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL201947
Affinity Ki < 0.0005uM
Assay description Binding affinity to Bcl-XL by fluorescence polarization assay
-- Direct protein complex subunits assigned: B2CL1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL201947
Affinity Ki = 0.0588uM
Assay description Binding affinity to Bcl2 by fluorescence polarization assay
-- Direct protein complex subunits assigned: BCL2_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451081
Doc title Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo.
PDB None

Name CHEMBL202314
Affinity