CD154

Cd40 ligand (cd40-l) (tumor necrosis factor ligand superfamily member 5) (cd antigen cd154)

Reviewed UniProt entries for CD154 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q9BDM3 CD40L_AOTTR CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form] CD40LG CD40L TNFSF5 Aotus trivirgatus (Night monkey) (Douroucouli) 261
P51749 CD40L_BOVIN CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form] CD40LG CD40L TNFSF5 Bos taurus (Bovine) 261
Q9BDN3 CD40L_CALJA CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form] CD40LG CD40L TNFSF5 Callithrix jacchus (White-tufted-ear marmoset) 261
O97626 CD40L_CANFA CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form] CD40LG CD40L TNFSF5 Canis familiaris (Dog) (Canis lupus familiaris) 260
P63305 CD40L_CERAT CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form] CD40LG CD40L TNFSF5 Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) 261
Q9I8D8 CD40L_CHICK CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form] CD40LG CD40L TNFSF5 Gallus gallus (Chicken) 272
O97605 CD40L_FELCA CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form] CD40LG CD40L TNFSF5 Felis catus (Cat) (Felis silvestris catus) 260
P29965 CD40L_HUMAN CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form] CD40LG CD40L TNFSF5 TRAP Homo sapiens (Human) 261
P63304 CD40L_MACMU CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form] CD40LG CD40L TNFSF5 Macaca mulatta (Rhesus macaque) 261
Q9BDM7 CD40L_MACNE CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form] CD40LG CD40L TNFSF5 Macaca nemestrina (Pig-tailed macaque) 240
P27548 CD40L_MOUSE CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form] Cd40lg Cd40l Tnfsf5 Mus musculus (Mouse) 260
Q95MQ5 CD40L_PIG CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form] CD40LG CD40L TNFSF5 Sus scrofa (Pig) 261
Q9Z2V2 CD40L_RAT CD40 ligand (CD40-L) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand; membrane form; CD40 ligand; soluble form] Cd40lg Cd40l Tnfsf5 Rattus norvegicus (Rat) 260
Q28203 TNR5_BOVIN Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (CD40L receptor) (CD antigen CD40) CD40 TNFRSF5 Bos taurus (Bovine) 280
Q3LRP1 TNR5_CALJA Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (CD40L receptor) (CD antigen CD40) CD40 TNFRSF5 Callithrix jacchus (White-tufted-ear marmoset) 274
Q7YRL5 TNR5_CANFA Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (CD40L receptor) (CD antigen CD40) CD40 TNFRSF5 Canis familiaris (Dog) (Canis lupus familiaris) 274
Q3ZTK5 TNR5_HORSE Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (CD40L receptor) (CD antigen CD40) CD40 TNFRSF5 Equus caballus (Horse) 280
P27512 TNR5_MOUSE Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CD antigen CD40) Cd40 Tnfrsf5 Mus musculus (Mouse) 289
Q8SQ34 TNR5_PIG Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (CD40L receptor) (CD antigen CD40) CD40 TNFRSF5 Sus scrofa (Pig) 278
P25942 TNR5_HUMAN Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40) CD40 TNFRSF5 Homo sapiens (Human) 277

Small molecules tested in CD154 binding assays:

1 datapoints for 1 distinct small molecules


Name CHEMBL1241021
Affinity Not Active
Assay description Inhibition of recombinant human CD40L:mouse CD8 tail binding to human CD40 by surface plasmon resonance method
-- Homologous single protein target assigned: TNR5_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16370373
Doc title C3-symmetric peptide scaffolds are functional mimetics of trimeric CD40L.
PDB None

8 PDB entries for CD154 and its protein partners


1ALY
2 A crystal structure of an extracellular fragment of human CD40 ligand.

Entity type Code Description
polypeptide(L) P29965 CD40 LIGAND

1CZZ
The structural basis for the recognition of diverse receptor sequences by TRAF2.

Entity type Code Description
polypeptide(L) Q12933 TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN 2
polypeptide(L) P25942 CD 40 PEPTIDE

1D00
The structural basis for the recognition of diverse receptor sequences by TRAF2.

Entity type Code Description
polypeptide(L) 1363002 TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN 2
polypeptide(L) P25942 B-CELL SURFACE ANTIGEN CD40

1FLL
Molecular basis for CD40 signaling mediated by TRAF3.

Entity type Code Description
polypeptide(L) Q13114 TNF RECEPTOR ASSOCIATED FACTOR 3
polypeptide(L) P25942 B-CELL SURFACE ANTIGEN CD40

1I9R
Structure of CD40 ligand in complex with the Fab fragment of a neutralizing humanized antibody.

Entity type Code Description
polypeptide(L) P29965 CD40 LIGAND
polypeptide(L) 1I9R IMMUNOGLOBULIN H
polypeptide(L) 1I9R IMMUNOGLOBULIN L

1LB6
Distinct molecular mechanism for initiating TRAF6 signalling.

Entity type Code Description
polypeptide(L) Q9Y4K3 TNF receptor-associated factor 6
polypeptide(L) P25942 CD40 antigen

3LKJ
Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism.

Entity type Code Description
polypeptide(L) P29965 CD40 ligand
Ligand NAG SUGAR (N-ACETYL-D-GLUCOSAMINE)
Ligand LKJ (2R)-{[(2'-[(BIPHENYL-3-YLMETHYL)CARBAMOYL]-6'-{[(2R)-2-(PYRROLIDIN-1-YLMETHYL)PYRROLIDIN-1-YL]CARBONYL}-6-{[(2R)-2-(1H-PYRROL-1-YLMETHYL)PYRROLIDIN-1-YL]CARBONYL}-4,4'-BIPYRIDIN-2-YL)CARBONYL]AMINO}(CYCLOHEXYL)ETHANOIC ACID

3QD6
Crystallographic and mutational analysis of the CD40-CD154 complex and its implications for receptor activation

Entity type Code Description
polypeptide(L) P29965 CD40 ligand
polypeptide(L) P25942 Tumor necrosis factor receptor superfamily member 5
Ligand NAG SUGAR (N-ACETYL-D-GLUCOSAMINE)