CD74

Antigen cd74

Reviewed UniProt entries for CD74 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
P04233 HG2A_HUMAN HLA class II histocompatibility antigen gamma chain (HLA-DR antigens-associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD antigen CD74) CD74 DHLAG Homo sapiens (Human) 296
P04441 HG2A_MOUSE H-2 class II histocompatibility antigen gamma chain (Ia antigen-associated invariant chain) (Ii) (MHC class II-associated invariant chain) (CD antigen CD74) Cd74 Ii Mus musculus (Mouse) 279
P10247 HG2A_RAT H-2 class II histocompatibility antigen gamma chain (Ia antigen-associated invariant chain) (Ii) (MHC class II-associated invariant chain) (CD antigen CD74) Cd74 Rattus norvegicus (Rat) 280
P80177 MIF_BOVIN Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) (p12A) MIF Bos taurus (Bovine) 115
Q02960 MIF_CHICK Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) MIF Gallus gallus (Chicken) 115
Q4R549 MIF_MACFA Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) MIF QccE-19130 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 115
Q6DN04 MIF_MACMU Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) MIF Macaca mulatta (Rhesus macaque) 115
O55052 MIF_MERUN Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) MIF Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) 115
P34884 MIF_MOUSE Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Delayed early response protein 6) (DER6) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) Mif Mus musculus (Mouse) 115
P80928 MIF_PIG Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) MIF Sus scrofa (Pig) 115
P30904 MIF_RAT Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glutathione-binding 13 kDa protein) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) Mif Rattus norvegicus (Rat) 115
Q1ZZU7 MIF_SHEEP Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) MIF Ovis aries (Sheep) 115
Q76BK2 MIF_XENLA Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) mif Xenopus laevis (African clawed frog) 115
A9JSE7 MIF_XENTR Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) mif Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 115
P14174 MIF_HUMAN Macrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase) MIF GLIF MMIF Homo sapiens (Human) 115

Our searches have not found small molecules for this target yet


56 PDB entries for CD74 and its protein partners


1A6A
The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.

Entity type Code Description
polypeptide(L) P01903 HLA class II histocompatibility antigen, DR alpha chain
polypeptide(L) P01912 HLA class II histocompatibility antigen, DR-1 beta chain
polypeptide(L) P04233 HLA class II histocompatibility antigen, gamma chain
Ligand NAG SUGAR (N-ACETYL-D-GLUCOSAMINE)

1CA7
Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.

Entity type Code Description
polypeptide(L) P14174 PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)
Ligand ENO 3-(4-HYDROXY-PHENYL)PYRUVIC ACID

1CGQ
Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.

Entity type Code Description
polypeptide(L) P14174 PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)

1FIM
Crystal structure of the macrophage migration inhibitory factor from rat liver.

Entity type Code Description
polypeptide(L) P30904 MACROPHAGE MIGRATION INHIBITORY FACTOR

1GCZ
Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography.

Entity type Code Description
polypeptide(L) P14174 MACROPHAGE MIGRATION INHIBITORY FACTOR
Ligand CIT CITRIC ACID
Ligand YZ9 7-HYDROXY-2-OXO-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER

1GD0
Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography.

Entity type Code Description
polypeptide(L) P14174 MACROPHAGE MIGRATION INHIBITORY FACTOR
Ligand CIT CITRIC ACID

1GIF
The crystal structure of human glycosylation-inhibiting factor is a trimeric barrel with three 6-stranded beta-sheets.

Entity type Code Description
polypeptide(L) P14174 GLYCOSYLATION-INHIBITING FACTOR

1ICF
Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.

Entity type Code Description
polypeptide(L) P07711 PROTEIN (CATHEPSIN L: HEAVY CHAIN)
polypeptide(L) P07711 PROTEIN (CATHEPSIN L: LIGHT CHAIN)
polypeptide(L) P04233 PROTEIN (INVARIANT CHAIN)
Ligand NAG SUGAR (N-ACETYL-D-GLUCOSAMINE)

1IIE
Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii.

Entity type Code Description
polypeptide(L) P04233 PROTEIN (HLA-DR ANTIGENS ASSOCIATED INVARIANT CHAIN)

1L3H
Synthesis and NMR structure of P41ICF, a potent inhibitor of human cathepsin L

Entity type Code Description
polypeptide(L) P04233 MHC CLASS II-ASSOCIATED P41 INVARIANT CHAIN FRAGMENT (P41icf)

1LJT
The Tautomerase Active Site of Macrophage Migration Inhibitory factor is a Potential Target for Discovery of Novel Anti-inflammatory Agents

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand HDI 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER

1MFF
Mechanism of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor: properties of the P1G, P1A, Y95F, and N97A mutants.

Entity type Code Description
polypeptide(L) P34884 MACROPHAGE MIGRATION INHIBITORY FACTOR

1MFI
Crystal structure of macrophage migration inhibitory factor complexed with (E)-2-fluoro-p-hydroxycinnamate at 1.8 A resolution: implications for enzymatic catalysis and inhibition.

Entity type Code Description
polypeptide(L) P34884 PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)
Ligand FHC 2-FLUORO-3-(4-HYDROXYPHENYL)-2E-PROPENEOATE

1MIF
Crystal structure at 2.6-A resolution of human macrophage migration inhibitory factor.

Entity type Code Description
polypeptide(L) P14174 MACROPHAGE MIGRATION INHIBITORY FACTOR

1P1G
Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.

Entity type Code Description
polypeptide(L) P14174 PROTEIN (MACROPHAGE MIGRATION INHIBITORY FACTOR)

2GDG
Inactivation of the phenylpyruvate tautomerase activity of macrophage migration inhibitory factor by 2-oxo-4-phenyl-3-butynoate.

Entity type Code Description
polypeptide(L) P34884 Macrophage migration inhibitory factor

2OOH
Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand OX3 4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME

2OOW
Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand OX4 3-FLUORO-4-HYDROXYBENZALDEHYDE O-(CYCLOHEXYLCARBONYL)OXIME

2OOZ
Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand OX5 4-HYDROXYBENZALDEHYDE O-(3,3-DIMETHYLBUTANOYL)OXIME

3B9S
A novel, macrophage migration inhibitory factor suicide substrate inhibits motility and growth of lung cancer cells.

Entity type Code Description
polypeptide(L) P14174 Macrophage Migration Inhibitory Factor
Ligand RW1 4-PHENYLPYRIMIDINE

3CE4
Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand PMS PHENYLMETHANESULFONIC ACID

3DJH
Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor

3DJI
Structural and kinetic analyses of macrophage migration inhibitory factor active site interactions.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand TYL N-(4-HYDROXYPHENYL)ACETAMIDE (TYLENOL)

3HOF
Structure of macrophage migration inhibitory factor (MIF) with caffeic acid at 1.9A resolution

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand DHC CAFFEIC ACID

3IJG
Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand AVR (2R)-2-AMINO-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]PROPAN-1-ONE

3IJJ
Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand EN1 (2E)-2-HYDROXY-3-(4-HYDROXYPHENYL)PROP-2-ENOIC ACID
Ligand ENO 3-(4-HYDROXY-PHENYL)PYRUVIC ACID
Ligand AVR (2R)-2-AMINO-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]PROPAN-1-ONE

3JSF
Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand XV1 7-(2-FLUOROBENZYL)QUINOLIN-8-OL

3JSG
Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand 0IN 7-(PYRIDIN-3-YLMETHYL)QUINOLIN-8-OL

3JTU
Discovery of covalent inhibitors for MIF tautomerase via cocrystal structures with phantom hits from virtual screening.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand ZIN 7-(PYRIDIN-2-YLMETHYL)QUINOLIN-8-OL

3L5P
Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand 428 2-(1-METHYLETHYL)IMIDAZO[1,2-B]PYRIDAZIN-6-OL

3L5R
Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand 47X 3-(3,4-DIHYDROXYPHENYL)-7-HYDROXY-4H-CHROMEN-4-ONE

3L5S
Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand 88X 5-ETHYL-2-(PHENYLCARBONYL)IMIDAZO[1,2-A]PYRIMIDIN-7(1H)-ONE

3L5T
Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand 956 1-METHYL-2-OXO-4-[4-(THIOPHEN-2-YLCARBONYL)PIPERAZIN-1-YL]-1,2-DIHYDROQUINOLINE-3-CARBONITRILE

3L5U
Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand ZEC 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE

3L5V
Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor

3PDO
Bidirectional binding of invariant chain peptides to an MHC class II molecule.

Entity type Code Description
polypeptide(L) P01903 HLA class II histocompatibility antigen, DR alpha chain
polypeptide(L) P04229 HLA class II histocompatibility antigen, DRB1-1 beta chain
polypeptide(L) P04233 HLA class II histocompatibility antigen gamma chain

3PGC
Bidirectional binding of invariant chain peptides to an MHC class II molecule.

Entity type Code Description
polypeptide(L) P01903 HLA class II histocompatibility antigen, DR alpha chain
polypeptide(L) P04229 HLA class II histocompatibility antigen, DRB1-1 beta chain
polypeptide(L) P04233 HLA class II histocompatibility antigen gamma chain
Ligand PEG DI(HYDROXYETHYL)ETHER

3PGD
Bidirectional binding of invariant chain peptides to an MHC class II molecule.

Entity type Code Description
polypeptide(L) P01903 HLA class II histocompatibility antigen, DR alpha chain
polypeptide(L) P04229 HLA class II histocompatibility antigen, DRB1-1 beta chain
polypeptide(L) P04233 HLA class II histocompatibility antigen gamma chain

3QXA
Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange.

Entity type Code Description
polypeptide(L) P01903 HLA class II histocompatibility antigen, DR alpha chain
polypeptide(L) P04229 HLA class II histocompatibility antigen, DRB1-1 beta chain
polypeptide(L) P04233 HLA class II histocompatibility antigen gamma chain peptide

3QXD
Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange.

Entity type Code Description
polypeptide(L) P01903 HLA class II histocompatibility antigen, DR alpha chain
polypeptide(L) P04229 HLA class II histocompatibility antigen, DRB1-1 beta chain
polypeptide(L) P04233 HLA class II histocompatibility antigen gamma chain peptide

3SMB
Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand LE2 N-(2-PHENYLETHYL)THIOFORMAMIDE

3SMC
Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand LE3 N-{4-[(R)-METHYLSULFINYL]BUTYL}THIOFORMAMIDE

3U18
A Novel Allosteric Inhibitor of Macrophage Migration Inhibitory Factor (MIF).

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand Y0X 6,6'-[(3,3'-DIMETHOXYBIPHENYL-4,4'-DIYL)DI(E)DIAZENE-2,1-DIYL]BIS(4-AMINO-5-HYDROXYNAPHTHALENE-1,3-DISULFONIC ACID)

4AEN
Peptide Linkage to the Alpha-Subunit of Mhcii Creates a Stably Inverted Antigen Presentation Complex.

Entity type Code Description
polypeptide(L) P01903 HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN
polypeptide(L) P04229 HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DRB1-1 BETA CHAIN
polypeptide(L) P04233 HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN

4AH2
Peptide Linkage to the Alpha-Subunit of Mhcii Creates a Stably Inverted Antigen Presentation Complex.

Entity type Code Description
polypeptide(L) P01903 HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN
polypeptide(L) P04233 HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN,DRB1-1 BETA CHAIN
polypeptide(L) P04229 HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN,DRB1-1 BETA CHAIN

4ETG
Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor

4EUI
Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor

4EVG
Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket.

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor

4F2K
Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand LE2 N-(2-PHENYLETHYL)THIOFORMAMIDE

4GRN
crystallographic and biological chacerterization of N- and C-terminus of MIF

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor

4GRO
crystallographic and biological characterization of N- and C- terminus mutants of human MIF

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor

4GRP
Crystallographic and biological characterization of N- and C- terminus mutants of human MIF

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor

4GRQ
Characterization of N- and C- terminus mutants of human MIF

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand AVL 2-METHYL-1-[2-(PROPAN-2-YL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]PROPAN-1-ONE

4GRR
Characterization of N- and C- terminus mutants of human MIF

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand AVR (2R)-2-AMINO-1-[2-(1-METHYLETHYL)PYRAZOLO[1,5-A]PYRIDIN-3-YL]PROPAN-1-ONE

4GRU
crystallographic and biological characterization of N- and C- terminus mutants of human MIF

Entity type Code Description
polypeptide(L) P14174 Macrophage migration inhibitory factor
Ligand DIO 1,4-DIETHYLENE DIOXIDE

4GUM
MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations.

Entity type Code Description
polypeptide(L) Q6DN04 Macrophage migration inhibitory factor