CRM1

Exportin-1 (chromosome region maintenance 1 protein)

Reviewed UniProt entries for CRM1 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q54EV7 XPO1_DICDI Exportin-1 (Exp1) xpo1 crm1 DDB_G0291306 Dictyostelium discoideum (Slime mold) 1057
O14980 XPO1_HUMAN Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) XPO1 CRM1 Homo sapiens (Human) 1071
Q6P5F9 XPO1_MOUSE Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) Xpo1 Crm1 Mus musculus (Mouse) 1071
Q80U96 XPO1_RAT Exportin-1 (Exp1) (Chromosome region maintenance 1 protein homolog) Xpo1 Crm1 Rattus norvegicus (Rat) 1071
P14068 XPO1_SCHPO Exportin-1 (Caffeine resistance protein 2) (Chromosome region maintenance protein 1) xpo1 caf2 crm1 SPAC1805.17 SPAC1B2.01 Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 1078
P30822 XPO1_YEAST Exportin-1 (Chromosome region maintenance protein 1) (Karyopherin-124) CRM1 KAP124 XPO1 YGR218W G8514 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) 1084

Small molecules tested in CRM1 binding assays:

182 datapoints for 59 distinct small molecules


Name PKF050-638
Affinity IC50 (inh Rev-mediated expression) 40nM
Assay description cell based luciferase reporter assay. Inhibitors of the Rev function cause a dose-dependent inhibition of Rev-dependent luciferase expression
-- Direct single protein target assigned: XPO1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1073/pnas.212285299
Doc title A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export.
PDB None

Name PKF050-637 (IA)
Affinity None
Assay description cell based luciferase reporter assay. Inhibitors of the Rev function cause a dose-dependent inhibition of Rev-dependent luciferase expression
-- Direct single protein target assigned: XPO1_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1073/pnas.212285299
Doc title A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export.
PDB None

Name CHEMBL1084286
Affinity IC50 = 6.4uM
Assay description Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by indirect fluorescent antibody technique
-- Direct single protein target assigned: XPO1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20493693
Doc title Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.
PDB None

Name CHEMBL1084300
Affinity IC50 > 25uM
Assay description Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by indirect fluorescent antibody technique
-- Direct single protein target assigned: XPO1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20493693
Doc title Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.
PDB None

Name CHEMBL1084300
Affinity INH = 2.6%
Assay description Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization at 25 uM after 12 hrs by indirect fluorescent antibody technique
-- Direct single protein target assigned: XPO1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20493693
Doc title Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.
PDB None

Name CHEMBL1095652
Affinity Not Active
Assay description Inhibition of CRM1-mediated nuclear export of Rio2 in human HeLa cells at 2 uM
-- Direct single protein target assigned: XPO1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20381347
Doc title The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transport.
PDB None

Name CHEMBL1095653
Affinity Not Active
Assay description Inhibition of CRM1-mediated nuclear export of Rio2 in human HeLa cells at 2 uM
-- Direct single protein target assigned: XPO1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20381347
Doc title The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transport.
PDB None

Name CHEMBL1095975
Affinity Not Active
Assay description Inhibition of CRM1-mediated nuclear export of Rio2 in human HeLa cells at 2 uM
-- Direct single protein target assigned: XPO1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20381347
Doc title The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transport.
PDB None

Name CHEMBL1097020
Affinity Not Active
Assay description Inhibition of CRM1-mediated nuclear export of Rio2 in human HeLa cells at 2 uM
-- Direct single protein target assigned: XPO1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20381347
Doc title The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transport.
PDB None

Name CHEMBL2094003
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL2094003
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL2094003
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL2094003
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL39261
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL39261
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL39261
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL39261
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL443864
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL443864
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL443864
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL443864
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL444950
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL444950
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL446805
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL446805
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of HIV1 RevM5 mutant in human HeLa cells assessed as HIV1 RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL446805
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL446805
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL446805
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL447008
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL447008
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL447008
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL448378
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL448378
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL448378
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL448378
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL449211
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL449211
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL449211
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL449211
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL449442
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL449442
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL449442
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL449442
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL449776
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL449776
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL449776
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL450306
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL450306
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL450306
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL450306
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL450860
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL450860
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL450860
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL450860
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL451378
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL451378
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL451378
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL451378
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL464443
Affinity Active
Assay description Inhibition of CRM1-mediated nuclear export of Rio2 in human HeLa cells at 1 uM
-- Direct single protein target assigned: XPO1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20381347
Doc title The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transport.
PDB None

Name CHEMBL472479
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL472479
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL472479
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL472479
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486003
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486003
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486003
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486003
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486122
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486122
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486122
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486132
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486132
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486132
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486132
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486133
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of HIV1 RevM5 mutant in human HeLa cells assessed as HIV1 RevM5-GFP nuclear localization at 25 nM after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486134
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486134
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486134
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486329
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486329
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486329
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486329
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486952
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486952
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL486952
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487151
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487151
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487151
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487151
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487373
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487373
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487373
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487373
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487374
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487374
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487374
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487375
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487375
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487375
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487375
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487758
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487758
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487758
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487758
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487775
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487775
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487775
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487968
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487968
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL487968
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488386
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488386
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488386
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488586
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488586
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488586
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488587
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488587
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488587
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488587
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488588
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488588
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488588
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488593
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488593
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488593
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488593
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488597
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488597
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488597
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488597
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488598
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488598
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488598
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488598
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488599
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488599
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488599
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL488599
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL49732
Affinity IC50 > 25uM
Assay description Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by indirect fluorescent antibody technique
-- Direct single protein target assigned: XPO1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20493693
Doc title Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.
PDB None

Name CHEMBL501019
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL501019
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL501019
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL501850
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL501850
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL501850
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL501850
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL503422
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL503422
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL503422
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL503422
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL506262
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL506262
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL506262
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL506262
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL510951
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL510951
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL510951
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL512653
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL512653
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL512653
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL520230
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL520230
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL520230
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL520230
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL520231
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL520231
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL520231
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of HIV1 RevM5 mutant in human HeLa cells assessed as HIV1 RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL520231
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL520709
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL520709
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL520709
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL520709
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL52229
Affinity IC50 = 1.6uM
Assay description Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by indirect fluorescent antibody technique
-- Direct single protein target assigned: XPO1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20493693
Doc title Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.
PDB None

Name CHEMBL52229
Affinity Active
Assay description Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nuclear localization at 5 uM after 12 hrs by indirect fluorescent antibody technique
-- Direct single protein target assigned: XPO1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20493693
Doc title Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.
PDB None

Name CHEMBL527426
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL527426
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL527426
Affinity Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL527649
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL527649
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL527649
Affinity Not Active
Assay description Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy
-- Homologous single protein target assigned: XPO1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18835718
Doc title Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action.
PDB None

Name CHEMBL6466
Affinity IC50 > 25uM
Assay description Inhibition of CRM1-mediated hemagglutininin-tagged HIV1 Rev protein nuclear export in human HeLa cells assessed as nucleus localization after 12 hrs by indirect fluorescent antibody technique
-- Direct single protein target assigned: XPO1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20493693
Doc title Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.
PDB None

25 PDB entries for CRM1 and its protein partners


1W9C
Architecture of Crm1-Exportin 1 Suggests How Cooperativity is Achieved During Formation of a Nuclear Export Complex

Entity type Code Description
polypeptide(L) O14980 CRM1 PROTEIN

2L1L
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

Entity type Code Description
polypeptide(L) P61925 cAMP-dependent protein kinase inhibitor alpha
polypeptide(L) O14980 Exportin-1

3GB8
Structural basis for leucine-rich nuclear export signal recognition by CRM1.

Entity type Code Description
polypeptide(L) O14980 Exportin-1
polypeptide(L) O95149 Snurportin-1

3GJX
Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP.

Entity type Code Description
polypeptide(L) O95149 Snurportin-1
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) Q6P5F9 Exportin-1
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE

3M1I
An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1

Entity type Code Description
polypeptide(L) P32835 GTP-binding nuclear protein GSP1/CNR1
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
polypeptide(L) P30822 Exportin-1
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE

3NBY
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

Entity type Code Description
polypeptide(L) O95149 Snurportin-1
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) Q6P5F9 Exportin-1
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE

3NBZ
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

Entity type Code Description
polypeptide(L) Q6P5F9 Exportin-1
polypeptide(L) O95149 Snurportin-1
polypeptide(L) P62826 GTP-binding nuclear protein Ran
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE

3NC0
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

Entity type Code Description
polypeptide(L) Q6P5F9 Exportin-1
polypeptide(L) O95149 Snurportin-1
polypeptide(L) P62826 GTP-binding nuclear protein Ran
Ligand PEG DI(HYDROXYETHYL)ETHER
Ligand IPH PHENOL
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE

3NC1
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.

Entity type Code Description
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) Q6P5F9 Exportin-1
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE

3VYC
A 2.1- angstrom -resolution crystal structure of unliganded CRM1 reveals the mechanism of autoinhibition

Entity type Code Description
polypeptide(L) P30822 Exportin-1

4BSM
Structure of a Truncation Mutant of the Nuclear Export Factor Crm1 Provides Insights Into the Auto-Inhibitory Role of its C-Terminal Helix.

Entity type Code Description
polypeptide(L) O14980 EXPORTIN-1

4BSN
Structure of a Truncation Mutant of the Nuclear Export Factor Crm1 Provides Insights Into the Auto-Inhibitory Role of its C-Terminal Helix.

Entity type Code Description
polypeptide(L) O14980 EXPORTIN-1

4GMX
Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.

Entity type Code Description
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
polypeptide(L) P30822 Exportin-1
Ligand GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Ligand K85 PROPAN-2-YL 3-{3-[3-METHOXY-5-(TRIFLUOROMETHYL)PHENYL]-1H-1,2,4-TRIAZOL-1-YL}PROPANOATE

4GPT
Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells.

Entity type Code Description
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
polypeptide(L) P30822 Exportin-1
Ligand GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Ligand 51K 2-(2-{3-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]-1H-1,2,4-TRIAZOL-1-YL}ETHYL)-1,3,4-OXADIAZOLE

4HAT
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.

Entity type Code Description
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
polypeptide(L) P30822 Exportin-1
polypeptide(L) P30822 Exportin-1
Ligand GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Ligand LMB LEPTOMYCIN B, BOUND FORM

4HAU
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.

Entity type Code Description
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
polypeptide(L) P30822 Exportin-1
polypeptide(L) P30822 Exportin-1
Ligand GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Ligand RJA RATJADONE A, BOUND FORM

4HAV
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.

Entity type Code Description
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
polypeptide(L) P30822 Exportin-1
polypeptide(L) P30822 Exportin-1
Ligand GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Ligand AA8 ANGUINOMYCIN A, BOUND FORM

4HAW
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.

Entity type Code Description
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
polypeptide(L) P30822 Exportin-1
polypeptide(L) P30822 Exportin-1
Ligand GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Ligand LMB LEPTOMYCIN B, BOUND FORM

4HAX
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.

Entity type Code Description
polypeptide(L) P30822 Exportin-1
polypeptide(L) P30822 Exportin-1
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
Ligand RJA RATJADONE A, BOUND FORM
Ligand GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER

4HAY
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.

Entity type Code Description
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
polypeptide(L) P30822 Exportin-1
polypeptide(L) P30822 Exportin-1
Ligand GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Ligand LMB LEPTOMYCIN B, BOUND FORM

4HAZ
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.

Entity type Code Description
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
polypeptide(L) P30822 Exportin-1
polypeptide(L) P30822 Exportin-1
Ligand GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Ligand LBF LEPTOMYCIN B

4HB0
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.

Entity type Code Description
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
polypeptide(L) P30822 Exportin-1
polypeptide(L) P30822 Exportin-1
Ligand GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Ligand LBF LEPTOMYCIN B

4HB2
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.

Entity type Code Description
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
polypeptide(L) P30822 Exportin-1
polypeptide(L) P30822 Exportin-1
Ligand GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER

4HB3
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.

Entity type Code Description
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
polypeptide(L) P30822 Exportin-1
polypeptide(L) P30822 Exportin-1
Ligand GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER

4HB4
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.

Entity type Code Description
polypeptide(L) P62826 GTP-binding nuclear protein Ran
polypeptide(L) P41920 Ran-specific GTPase-activating protein 1
polypeptide(L) P30822 Exportin-1
polypeptide(L) P30822 Exportin-1
Ligand GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Ligand LMB LEPTOMYCIN B, BOUND FORM