Cyclophilins

Peptidyl-prolyl cis-trans isomerase

Reviewed UniProt entries for Cyclophilins and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q6DTV9 PPIA_AOTTR Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Aotus trivirgatus (Night monkey) (Douroucouli) 164
P62935 PPIA_BOVIN Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Bos taurus (Bovine) 164
P62938 PPIA_CHLAE Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA CYPA Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) 165
P14851 PPIA_CRIGR Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 164
O53021 PPIA_DICD3 Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A) rotA ppiA Dda3937_04190 Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) 190
Q54SM3 PPIA_DICDI Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A) ppiA cyp1 DDB_G0282359 Dictyostelium discoideum (Slime mold) 179
P0AFL5 PPIA_ECO57 Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A) ppiA Z4724 ECs4214 Escherichia coli O157:H7 190
P0AFL4 PPIA_ECOL6 Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A) ppiA c4138 Escherichia coli O6 190
P0AFL3 PPIA_ECOLI Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A) ppiA rot rotA b3363 JW3326 Escherichia coli (strain K12) 190
Q8HXS3 PPIA_FELCA Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA CYPA Felis catus (Cat) (Felis silvestris catus) 164
Q0ZQL0 PPIA_GORGO Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Gorilla gorilla gorilla (Lowland gorilla) 165
P62937 PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA CYPA Homo sapiens (Human) 165
Q0ZQK8 PPIA_HYLLA Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Hylobates lar (Common gibbon) 165
Q0ZQK6 PPIA_HYLSY Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Hylobates syndactylus (Siamang) (Symphalangus syndactylus) 165
P62940 PPIA_MACMU Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA CYPA Macaca mulatta (Rhesus macaque) 165
P17742 PPIA_MOUSE Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) (SP18) Ppia Mus musculus (Mouse) 164
Q0ZQK7 PPIA_NOMLE Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) 165
Q0ZQL2 PPIA_PANPA Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Pan paniscus (Pygmy chimpanzee) (Bonobo) 165
Q0ZQL1 PPIA_PANTR Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Pan troglodytes (Chimpanzee) 165
P62941 PPIA_PAPAN Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA CYPA Papio anubis (Olive baboon) 165
P62936 PPIA_PIG Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Sus scrofa (Pig) 164
Q5R8S7 PPIA_PONPY Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Pongo pygmaeus (Bornean orangutan) 165
Q59641 PPIA_PSEAE Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A) ppiA cypH PA3227 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 187
Q9TTC6 PPIA_RABIT Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin 18) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Oryctolagus cuniculus (Rabbit) 164
Q0ZQK3 PPIA_SAGOE Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Saguinus oedipus (Cotton-top tamarin) 164
P80311 PPIB_BOVIN Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Bos taurus (Bovine) 216
P24367 PPIB_CHICK Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Gallus gallus (Chicken) 207
P24369 PPIB_MOUSE Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) Ppib Mus musculus (Mouse) 216
P24368 PPIB_RAT Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) Ppib Rattus norvegicus (Rat) 216
Q08E11 PPIC_BOVIN Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C) PPIC Bos taurus (Bovine) 212
P45877 PPIC_HUMAN Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C) PPIC CYPC Homo sapiens (Human) 212
P30412 PPIC_MOUSE Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C) Ppic Cypc Mus musculus (Mouse) 212
P30404 PPIF_BOVIN Peptidyl-prolyl cis-trans isomerase F; mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin F) (Rotamase F) PPIF CYP3 Bos taurus (Bovine) 209
P30405 PPIF_HUMAN Peptidyl-prolyl cis-trans isomerase F; mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin F) (Rotamase F) PPIF CYP3 Homo sapiens (Human) 207
Q99KR7 PPIF_MOUSE Peptidyl-prolyl cis-trans isomerase F; mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin F) (Rotamase F) Ppif Mus musculus (Mouse) 206
P29117 PPIF_RAT Peptidyl-prolyl cis-trans isomerase F; mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin F) (Rotamase F) Ppif Rattus norvegicus (Rat) 206
P10111 PPIA_RAT Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) (p1B15) (p31) Ppia Rattus norvegicus (Rat) 164
P23284 PPIB_HUMAN Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB CYPB Homo sapiens (Human) 216

Small molecules tested in Cyclophilins binding assays:

263 datapoints for 196 distinct small molecules


Name CHEMBL1272245
Affinity Not Active
Assay description Inhibition of cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20932746
Doc title Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution.
PDB None

Name CHEMBL13127
Affinity Inhibition = 8%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13128
Affinity Inhibition = 38%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13317
Affinity IC50 = 1920nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13317
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13342
Affinity IC50 = 2950nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13342
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13346
Affinity Inhibition = 7%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13347
Affinity IC50 = 4850nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13347
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13411
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13411
Affinity IC50 = 4550nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13413
Affinity IC50 = 930nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13421
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13421
Affinity IC50 = 5090nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13423
Affinity IC50 = 1180nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13436
Affinity IC50 = 1410nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13476
Affinity Inhibition = 6%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13488
Affinity Inhibition = 28%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13519
Affinity IC50 = 2120nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13526
Affinity Inhibition = 24%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13534
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13534
Affinity IC50 = 6200nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13550
Affinity IC50 = 3950nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13598
Affinity IC50 = 1120nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13602
Affinity IC50 = 870nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13604
Affinity IC50 = 1020nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13611
Affinity Inhibition = 93%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13611
Affinity IC50 = 4000nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13638
Affinity Inhibition = 22%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13640
Affinity IC50 = 8500nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13640
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13671
Affinity Inhibition = 32%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13683
Affinity Inhibition = 40%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13686
Affinity IC50 = 620nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13693
Affinity IC50 = 5900nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13709
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13709
Affinity IC50 = 4200nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13745
Affinity Inhibition = 44%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13751
Affinity Inhibition = 11%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13756
Affinity Inhibition = 23%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13768
Affinity Inhibition = 98%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13768
Affinity IC50 = 2900nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13778
Affinity IC50 = 480nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL148546
Affinity IC50 = 2600uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL148657
Affinity IC50 = 2800uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL149224
Affinity IC50 = 260uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL151381
Affinity IC50 = 280uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL151385
Affinity IC50 = 325uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL1770807
Affinity Not Active
Assay description Inhibition of PPIase activity of human recombinant cyclophilin-A using succinyl-Ala-Ala-Pro-Phe-4-nitroanilide as substrate at 100 uM pretreated for 3 hrs before substrate addition by spectrophotometry
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21963115
Doc title Oligopeptide cyclophilin inhibitors: a reassessment.
PDB None

Name CHEMBL1770807
Affinity Not Active
Assay description Inhibition of PPIase activity of human recombinant cyclophilin-A using succinyl-Ala-Ala-Pro-Phe-4-nitroanilide as substrate at 100 uM by protease coupled assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21963115
Doc title Oligopeptide cyclophilin inhibitors: a reassessment.
PDB None

Name CHEMBL1770807
Affinity Not Active
Assay description Binding affinity to human recombinant cyclophilin-A up to 25 uM by isothermal titration calorimetry assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21963115
Doc title Oligopeptide cyclophilin inhibitors: a reassessment.
PDB None

Name CHEMBL1770807
Affinity Dose-dependent effect
Assay description Inhibition of PPIase activity of Cyclophilin A by Spectrophotometry
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1770807
Affinity Kd = 3.4110'-6M
Assay description Binding affinity to Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1770807
Affinity IC50 = 33.11nM
Assay description Inhibition of PPIase activity of Cyclophilin A by Spectrophotometry
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1770808
Affinity Not Active
Assay description Inhibition of PPIase activity of Cyclophilin A by Spectrophotometry
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1770808
Affinity Not Active
Assay description Binding affinity to Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1770809
Affinity Not Active
Assay description Binding affinity to Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1770809
Affinity Not Active
Assay description Inhibition of PPIase activity of Cyclophilin A by Spectrophotometry
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1790316
Affinity Inhibition = 99%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790316
Affinity IC50 = 6uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790318
Affinity IC50 > 10000uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790319
Affinity IC50 = 280uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790319
Affinity Inhibition = 55%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790322
Affinity Inhibition = 15%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790322
Affinity IC50 = 2000uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790323
Affinity Inhibition = 20%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790323
Affinity IC50 = 2600uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790324
Affinity Inhibition = 76%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790324
Affinity IC50 = 165uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790325
Affinity Inhibition = 38%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790325
Affinity IC50 = 1500uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790326
Affinity Inhibition = 88%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790326
Affinity IC50 = 115uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790327
Affinity IC50 = 260uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790327
Affinity Inhibition = 59%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1793897
Affinity IC50 = 680uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1793898
Affinity Inhibition = 57%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1793898
Affinity IC50 = 90uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1793899
Affinity IC50 = 500uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1793899
Affinity Inhibition = 50%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL198293
Affinity IC50 = 458nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL198293
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL198402
Affinity Inhibition = 52%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL199550
Affinity Inhibition = 89%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL199550
Affinity IC50 = 528nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL199777
Affinity Inhibition = 35%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL199807
Affinity Inhibition = 5%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL199967
Affinity Inhibition = 22%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL199968
Affinity IC50 = 316nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL200133
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL200133
Affinity IC50 = 640nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201025
Affinity IC50 = 951nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201025
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201113
Affinity IC50 = 1437nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201113
Affinity Inhibition = 63%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201129
Affinity Inhibition = 34%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201164
Affinity IC50 = 5500nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201164
Affinity Inhibition = 55%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201394
Affinity IC50 = 361nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201394
Affinity Inhibition = 95%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201395
Affinity IC50 = 60nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201395
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201403
Affinity Inhibition = 25%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201450
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201450
Affinity IC50 = 592nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201452
Affinity Inhibition = 19%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201529
Affinity Inhibition = 44%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201645
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201645
Affinity IC50 = 71nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201652
Affinity Inhibition = 63%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201664
Affinity Inhibition = 98%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201664
Affinity IC50 = 140nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201705
Affinity Inhibition = 74%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201718
Affinity Inhibition = 84%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201718
Affinity IC50 = 810nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201719
Affinity Inhibition = 21%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201790
Affinity Inhibition = 29%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201894
Affinity Inhibition = 40%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL202414
Affinity IC50 = 303nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL202880
Affinity IC50 = 754nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL202880
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203086
Affinity Inhibition = 8%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203099
Affinity Inhibition = 55%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203100
Affinity Inhibition = 95%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203100
Affinity IC50 = 4100nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203142
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203142
Affinity IC50 = 880nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203155
Affinity Inhibition = 12%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203193
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203193
Affinity IC50 = 14nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203194
Affinity IC50 = 20nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203194
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203197
Affinity Inhibition = 25%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203248
Affinity Inhibition = 0%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203303
Affinity Inhibition = 5%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL2338699
Affinity Not Active
Assay description Binding affinity to cyclophilin A in human Jurkat cell lysates at 1.1 uM after 24 hrs by SDS-PAGE analysis
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23414805
Doc title Chemical tagging of a drug target using 5-sulfonyl tetrazole.
PDB None

Name CHEMBL2338702
Affinity Not Active
Assay description Binding affinity to cyclophilin A in human Jurkat cell lysates at 1.1 uM after 24 hrs by SDS-PAGE analysis
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23414805
Doc title Chemical tagging of a drug target using 5-sulfonyl tetrazole.
PDB None

Name CHEMBL2371033
Affinity IC50 = 680uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL263062
Affinity IC50 = 115uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL263578
Affinity Inhibition = 11%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL268519
Affinity IC50 = 880nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL276363
Affinity IC50 > 10000uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL276383
Affinity Inhibition = 0%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL276409
Affinity IC50 = 690nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL276458
Affinity Inhibition = 19%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL276713
Affinity IC50 = 3350nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL296587
Affinity IC50 > 10000uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL300523
Affinity IC50 = 760uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL300523
Affinity Inhibition = 45%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL313327
Affinity Kd = 0.0000047M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL314028
Affinity Kd > 0.0002M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL314456
Affinity Kd = 0.0000015M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL314660
Affinity Kd > 0.0002M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL315033
Affinity Kd = 0.000017M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL329797
Affinity Kd = 0.000124M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL356871
Affinity IC50 = 2000uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL358023
Affinity IC50 = 500uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL358925
Affinity IC50 = 90uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL371213
Affinity IC50 = 320nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL371213
Affinity Inhibition = 97%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL371728
Affinity Inhibition = 45%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL373254
Affinity Inhibition = 96%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL373254
Affinity IC50 = 60nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL378790
Affinity Inhibition = 0%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL380501
Affinity Inhibition = 12%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL382343
Affinity Inhibition = 35%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL382465
Affinity IC50 = 499nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL382465
Affinity Inhibition = 79%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL382567
Affinity Inhibition = 95%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL382567
Affinity IC50 = 748nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL382661
Affinity Inhibition = 49%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL383535
Affinity Inhibition = 10%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL406277
Affinity Kd > 0.0002M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL417253
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL417253
Affinity IC50 = 590nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL429034
Affinity IC50 = 9500nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL429034
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL432322
Affinity IC50 > 10000uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL433082
Affinity IC50 = 2800uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL433082
Affinity Inhibition = 28%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL433738
Affinity IC50 = 365uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL434694
Affinity IC50 = 165uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL441409
Affinity IC50 = 940nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL443891
Affinity IC50 = 0.16uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL443891
Affinity Kd = 51.6uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL443992
Affinity Kd = 141uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL445240
Affinity Kd = 512.8uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL445297
Affinity IC50 = 0.35uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL445297
Affinity Kd = 109.5uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL449855
Affinity Kd = 227.3uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL482839
Affinity Kd = 79.3uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL482839
Affinity IC50 = 0.81uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL482840
Affinity Kd = 200.5uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489001
Affinity Kd = 147.1uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489021
Affinity IC50 = 0.38uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489021
Affinity Kd = 128.5uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489022
Affinity IC50 = 0.33uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489022
Affinity Kd = 79.6uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489040
Affinity Kd = 60.8uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489041
Affinity IC50 = 0.13uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489041
Affinity Kd = 51uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489042
Affinity IC50 = 0.45uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489042
Affinity Kd = 76.9uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489612
Affinity Kd = 125.1uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489613
Affinity Kd = 222.2uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489614
Affinity Kd = 133.3uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489636
Affinity Kd = 118.8uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489637
Affinity Kd = 88.1uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489637
Affinity IC50 = 0.58uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489821
Affinity Kd = 171.8uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489822
Affinity IC50 = 0.46uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489822
Affinity Kd = 88.9uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL490247
Affinity Kd = 88.6uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL490247
Affinity IC50 = 0.45uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL490840
Affinity Kd = 124.4uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL490848
Affinity Kd = 140.4uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL492070
Affinity Kd = 96.6uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL492070
Affinity IC50 = 0.59uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL505691
Affinity Not Active
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL506108
Affinity Kd = 100.7uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL518980
Affinity IC50 = 0.74uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL518980
Affinity Kd = 73.3uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL521943
Affinity IC50 = 0.65uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL521943
Affinity Kd = 55.8uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL522094
Affinity Kd = 116.5uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL522094
Affinity IC50 = 0.6uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL522416
Affinity Kd = 107.3uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL522416
Affinity IC50 = 0.69uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL525897
Affinity IC50 = 263nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL540193
Affinity IC50 = 6uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL540479
Affinity IC50 = 620nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL549627
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL549755
Affinity IC50 = 136nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL550098
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL551508
Affinity IC50 = 159nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL551795
Affinity Not Active
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL551796
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL551990
Affinity Not Active
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL552181
Affinity IC50 = 370nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL552255
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL556690
Affinity Not Active
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL556893
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL557628
Affinity IC50 = 71.2nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL557910
Affinity Not Active
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL558302
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL559525
Affinity IC50 = 1.52nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL559858
Affinity IC50 = 31.6nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL560115
Affinity IC50 = 12.1nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL560173
Affinity IC50 = 103nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL560850
Affinity IC50 = 364nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL560851
Affinity IC50 = 2.59nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL564391
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL564539
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL564647
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL564826
Affinity IC50 = 1910nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL569840
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL570542
Affinity Not Active
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL594125
Affinity Not Active
Assay description Inhibition of peptidyl-prolyl cis/trans isomerase activity of cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19969456
Doc title Structure-guided design of alpha-amino acid-derived Pin1 inhibitors.
PDB None

Name CHEMBL86442
Affinity Kd > 0.0002M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL86465
Affinity Kd > 0.0002M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL88028
Affinity Kd = 0.00014M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL89881
Affinity Kd = 0.000077M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

69 PDB entries for Cyclophilins and its protein partners


1AK4
Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) P12497 HIV-1 CAPSID

1AWQ
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) 1AWQ PEPTIDE FROM THE HIV-1 CAPSID PROTEIN

1AWR
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) 1AWR PEPTIDE FROM THE HIV-1 CAPSID PROTEIN

1AWS
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) 1AWS PEPTIDE FROM THE HIV-1 CAPSID PROTEIN

1AWT
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) 1AWT PEPTIDE FROM THE HIV-1 CAPSID PROTEIN

1AWU
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) 1AWU PEPTIDE FROM THE HIV-1 CAPSID PROTEIN

1AWV
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) 1AWV PEPTIDE FROM THE HIV-1 CAPSID PROTEIN

1BCK
X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.

Entity type Code Description
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00035 CYCLOSPORIN C

1CWF
X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.

Entity type Code Description
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00036 CYCLOSPORIN D

1CWH
X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.

Entity type Code Description
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00033 CYCLOSPORIN A

1CWI
X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.

Entity type Code Description
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00036 CYCLOSPORIN D

1CWM
X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.

Entity type Code Description
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00033 CYCLOSPORIN A

1CWO
Conformational Differences of an Immunosuppressant Peptolide in a Single Crystal and in a Crystal Complex with Human Cyclophilin A.

Entity type Code Description
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00035 CYCLOSPORIN C

1CYN
X-Ray Structure of a Cyclophilin B/Cyclosporin Complex: Comparison with Cyclophilin a and Delineation of its Calcineurin-Binding Domain.

Entity type Code Description
polypeptide(L) P23284 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B
polypeptide(L) NOR00033 CYCLOSPORIN A

1FGL
Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) P05889 HIV-1 GAG PROTEIN

1M63
Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes

Entity type Code Description
polypeptide(L) Q08209 SERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT, ALPHA ISOFORM
polypeptide(L) P63098 CALCINEURIN B SUBUNIT ISOFORM 1
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00033 CYCLOSPORIN A

1M9C
Structural insights into the catalytic mechanism of cyclophilin A

Entity type Code Description
polypeptide(L) P62937 Cyclophilin A
polypeptide(L) Q72497 HIV-1 Capsid

1M9D
Structural insights into the catalytic mechanism of cyclophilin A

Entity type Code Description
polypeptide(L) P62937 Cyclophilin A
polypeptide(L) Q72497 HIV-1 Capsid

1M9E
Structural insights into the catalytic mechanism of cyclophilin A

Entity type Code Description
polypeptide(L) P62937 Cyclophilin A
polypeptide(L) Q72497 HIV-1 Capsid

1M9F
Structural insights into the catalytic mechanism of cyclophilin A

Entity type Code Description
polypeptide(L) P62937 Cyclophilin A
polypeptide(L) Q72497 HIV-1 Capsid

1M9X
Structural insights into the catalytic mechanism of cyclophilin A

Entity type Code Description
polypeptide(L) P62937 Cyclophilin A
polypeptide(L) Q72497 HIV-1 Capsid

1M9Y
Structural insights into the catalytic mechanism of cyclophilin A

Entity type Code Description
polypeptide(L) P62937 Cyclophilin A
polypeptide(L) Q72497 HIV-1 Capsid

1MF8
Crystal Structure of Human Calcineurin Complexed with Cyclosporin a and Human Cyclophilin

Entity type Code Description
polypeptide(L) Q08209 CALMODULIN-DEPENDENT CALCINEURIN A SUBUNIT, ALPHA ISOFORM
polypeptide(L) P63098 CALCINEURIN B SUBUNIT ISOFORM 1
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00033 CYCLOSPORIN A

1NMK
Sanglifehrin-Cyclophilin Interaction: Degradation Work, Synthetic Macrocyclic Analogues, X-ray Crystal Structure and Binding Data

Entity type Code Description
polypeptide(L) P62937 Peptidyl-prolyl cis-trans isomerase A
Ligand SFM (13E,15E)-(3S,6S,9R,10R,11S,12S,18S,21S)-10,12-DIHYDROXY-3-(3-HYDROXYBEN-ZYL)-18-((E)-3-HYDROXY-1-METHYLPROPENYL)-6-ISOPROPYL-11-METHYL-9-(3-OXO-BUTYL)-19-OXA-1,4,7,25-TETRAAZA-BICYCLO[19.3.1]PENTACOSA-13,15-DIENE-2,5,8,20-TETRAONE

1OCA
The NMR solution conformation of unligated human cyclophilin A.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A

1W8L
Enzymatic and Structural Characterization of Non-Peptide Ligand-Cyclophilin Complexes

Entity type Code Description
polypeptide(L) 1W8L PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
Ligand 1P3 (3R)-1-ACETYL-3-METHYLPIPERIDINE

1W8M
Enzymatic and Structural Characterization of Non-Peptide Ligand-Cyclophilin Complexes

Entity type Code Description
polypeptide(L) 1W8M PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
Ligand E1P ETHYL OXO(PIPERIDIN-1-YL)ACETATE

1W8V
Enzymatic and Structural Characterization of Non-Peptide Ligand-Cyclophilin Complexes

Entity type Code Description
polypeptide(L) 1W8V PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A

1YND
Structure of human cyclophilin A in complex with the novel immunosuppressant sanglifehrin A at 1.6 A resolution.

Entity type Code Description
polypeptide(L) P62937 Peptidyl-prolyl cis-trans isomerase A
Ligand SFA SANGLIFEHRIN A

1ZKF
Mechanistic Insights of Cyclophilin-A from X-Ray Cyrstallographic and Nuclear Magnet Resonance Investigations

Entity type Code Description
polypeptide(L) P62937 Peptidyl-prolyl cis-trans isomerase A
polypeptide(L) 1ZKF Suc-ALA-GLY-PRO-PHE-pNA

2ALF
Nuclease activity of Cyclophilin A and its structural basis

Entity type Code Description
polypeptide(L) P62937 Peptidyl-prolyl cis-trans isomerase A

2BIT
Crystal Engineering Yields Crystals of Cyclophilin D Diffracting to 1.7 A Resolution

Entity type Code Description
polypeptide(L) P30405 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE