Cyclophilins

Peptidyl-prolyl cis-trans isomerase

Reviewed UniProt entries for Cyclophilins and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q6DTV9 PPIA_AOTTR Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Aotus trivirgatus (Night monkey) (Douroucouli) 164
P62935 PPIA_BOVIN Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Bos taurus (Bovine) 164
P62938 PPIA_CHLAE Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA CYPA Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) 165
P14851 PPIA_CRIGR Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 164
O53021 PPIA_DICD3 Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A) rotA ppiA Dda3937_04190 Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) 190
Q54SM3 PPIA_DICDI Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A) ppiA cyp1 DDB_G0282359 Dictyostelium discoideum (Slime mold) 179
P0AFL5 PPIA_ECO57 Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A) ppiA Z4724 ECs4214 Escherichia coli O157:H7 190
P0AFL4 PPIA_ECOL6 Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A) ppiA c4138 Escherichia coli O6 190
P0AFL3 PPIA_ECOLI Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A) ppiA rot rotA b3363 JW3326 Escherichia coli (strain K12) 190
Q8HXS3 PPIA_FELCA Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA CYPA Felis catus (Cat) (Felis silvestris catus) 164
Q0ZQL0 PPIA_GORGO Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Gorilla gorilla gorilla (Lowland gorilla) 165
P62937 PPIA_HUMAN Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA CYPA Homo sapiens (Human) 165
Q0ZQK8 PPIA_HYLLA Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Hylobates lar (Common gibbon) 165
Q0ZQK6 PPIA_HYLSY Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Hylobates syndactylus (Siamang) (Symphalangus syndactylus) 165
P62940 PPIA_MACMU Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA CYPA Macaca mulatta (Rhesus macaque) 165
P17742 PPIA_MOUSE Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) (SP18) Ppia Mus musculus (Mouse) 164
Q0ZQK7 PPIA_NOMLE Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) 165
Q0ZQL2 PPIA_PANPA Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Pan paniscus (Pygmy chimpanzee) (Bonobo) 165
Q0ZQL1 PPIA_PANTR Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Pan troglodytes (Chimpanzee) 165
P62941 PPIA_PAPAN Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA CYPA Papio anubis (Olive baboon) 165
P62936 PPIA_PIG Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Sus scrofa (Pig) 164
Q5R8S7 PPIA_PONPY Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Pongo pygmaeus (Bornean orangutan) 165
Q59641 PPIA_PSEAE Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A) ppiA cypH PA3227 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 187
Q9TTC6 PPIA_RABIT Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin 18) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Oryctolagus cuniculus (Rabbit) 164
Q0ZQK3 PPIA_SAGOE Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) PPIA Saguinus oedipus (Cotton-top tamarin) 164
P80311 PPIB_BOVIN Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Bos taurus (Bovine) 216
P24367 PPIB_CHICK Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB Gallus gallus (Chicken) 207
P24369 PPIB_MOUSE Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) Ppib Mus musculus (Mouse) 216
P24368 PPIB_RAT Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) Ppib Rattus norvegicus (Rat) 216
Q08E11 PPIC_BOVIN Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C) PPIC Bos taurus (Bovine) 212
P45877 PPIC_HUMAN Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C) PPIC CYPC Homo sapiens (Human) 212
P30412 PPIC_MOUSE Peptidyl-prolyl cis-trans isomerase C (PPIase C) (EC 5.2.1.8) (Cyclophilin C) (Rotamase C) Ppic Cypc Mus musculus (Mouse) 212
P30404 PPIF_BOVIN Peptidyl-prolyl cis-trans isomerase F; mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin F) (Rotamase F) PPIF CYP3 Bos taurus (Bovine) 209
P30405 PPIF_HUMAN Peptidyl-prolyl cis-trans isomerase F; mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin F) (Rotamase F) PPIF CYP3 Homo sapiens (Human) 207
Q99KR7 PPIF_MOUSE Peptidyl-prolyl cis-trans isomerase F; mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin F) (Rotamase F) Ppif Mus musculus (Mouse) 206
P29117 PPIF_RAT Peptidyl-prolyl cis-trans isomerase F; mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin F) (Rotamase F) Ppif Rattus norvegicus (Rat) 206
P10111 PPIA_RAT Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Cyclosporin A-binding protein) (Rotamase A) (p1B15) (p31) Ppia Rattus norvegicus (Rat) 164
P23284 PPIB_HUMAN Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) PPIB CYPB Homo sapiens (Human) 216

Small molecules tested in Cyclophilins binding assays:

297 datapoints for 209 distinct small molecules


Name CHEMBL1213204
Affinity IC50 = 30nM
Assay description Inhibition of PPIase activity of cyclophilin 18 by protease coupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213204
Affinity IC50 = 266nM
Assay description Binding affinity to cyclophilin 18 assessed as reduction in calcineurin activity by protease coupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213204
Affinity Active
Assay description Inhibition of PPIase activity of cyclophilin 18 at 200 nM by protease coupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213205
Affinity INH = 30%
Assay description Binding affinity to streptavidin-coupled biotin-labeled cyclophilin 18 assessed as reduction in [33P]phosphatase activity of calcineurin at 10 uM by protease coupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213205
Affinity IC50 = 206nM
Assay description Inhibition of PPIase activity of cyclophilin 18 by protease coupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213205
Affinity IC50 = 487nM
Assay description Binding affinity to cyclophilin 18 assessed as reduction in calcineurin activity by protease coupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213206
Affinity Active
Assay description Inhibition of PPIase activity of cyclophilin 18 in human blood at 50 to 200 nM measured after 45 mins of irradiation with 740 nm light by protease coupled assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213206
Affinity Active
Assay description Inhibition of PPIase activity of cyclophilin 18 in human blood lysate at 50 to 200 nM measured after 3 mins of irradiation with 370 nm light by protease coupled assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213206
Affinity Active
Assay description Inhibition of PPIase activity of cyclophilin 18 in human blood at 50 to 200 nM by protease coupled assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213206
Affinity IC50 = 0.95uM
Assay description Binding affinity to cyclophilin 18 assessed as reduction in [33P]phosphatase activity of calcineurin by protease coupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213207
Affinity Active
Assay description Binding affinity to streptavidin-coupled biotin-labeled cyclophilin 18 assessed as reduction in [33P] phosphatase activity of calcineurin by protease coupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213207
Affinity Active
Assay description Inhibition of PPIase activity of cyclophilin 18 in human blood lysate at 50 to 200 nM measured after 3 mins of irradiation with 370 nm light by protease coupled assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213207
Affinity Active
Assay description Inhibition of PPIase activity of cyclophilin 18 in human blood at 50 to 200 nM by protease coupled assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213207
Affinity INH = 30%
Assay description Binding affinity to streptavidin-coupled biotin-labeled cyclophilin 18 assessed as reduction in [33P]phosphatase activity of calcineurin at 10 uM by protease coupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213207
Affinity Active
Assay description Inhibition of PPIase activity of cyclophilin 18 in human blood at 50 to 200 nM measured after 45 mins of irradiation with 740 nm light by protease coupled assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213208
Affinity IC50 = 2.79nM
Assay description Inhibition of PPIase activity of cyclophilin 18 by protease coupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213208
Affinity IC50 = 147nM
Assay description Binding affinity to cyclophilin 18 assessed as reduction in [33P]phosphatase activity of calcineurin by protease coupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213209
Affinity IC50 = 4.75nM
Assay description Inhibition of PPIase activity of cyclophilin 18 by protease coupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1213209
Affinity IC50 = 227nM
Assay description Binding affinity to streptavidin-coupled biotin-labeled cyclophilin 18 assessed as reduction in [33P] phosphatase activity of calcineurin by protease coupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19734911
Doc title
PDB None

Name CHEMBL1269580
Affinity IC50 = 26.1nM
Assay description Binding affinity to cyclophilin B by ELISA
-- Homologous single protein target assigned: PPIB_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20943390
Doc title
PDB None

Name CHEMBL1269580
Affinity IC50 = 31.2nM
Assay description Binding affinity to cyclophilin A by ELISA
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20943390
Doc title
PDB None

Name CHEMBL1269581
Affinity IC50 = 30.5nM
Assay description Binding affinity to cyclophilin B by ELISA
-- Homologous single protein target assigned: PPIB_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20943390
Doc title
PDB None

Name CHEMBL1269581
Affinity IC50 = 26.7nM
Assay description Binding affinity to cyclophilin A by ELISA
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20943390
Doc title
PDB None

Name CHEMBL1269582
Affinity IC50 = 22.8nM
Assay description Binding affinity to cyclophilin A by ELISA
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20943390
Doc title
PDB None

Name CHEMBL1269582
Affinity IC50 = 20.6nM
Assay description Binding affinity to cyclophilin B by ELISA
-- Homologous single protein target assigned: PPIB_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20943390
Doc title
PDB None

Name CHEMBL1272245
Affinity Not Active
Assay description Inhibition of cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20932746
Doc title Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution.
PDB None

Name CHEMBL13127
Affinity Inhibition = 8%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13128
Affinity Inhibition = 38%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13317
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13317
Affinity IC50 = 1920nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13342
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13342
Affinity IC50 = 2950nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13346
Affinity Inhibition = 7%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13347
Affinity IC50 = 4850nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13347
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13411
Affinity IC50 = 4550nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13411
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13413
Affinity IC50 = 930nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13421
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13421
Affinity IC50 = 5090nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13423
Affinity IC50 = 1180nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13436
Affinity IC50 = 1410nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13476
Affinity Inhibition = 6%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13488
Affinity Inhibition = 28%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13519
Affinity IC50 = 2120nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13526
Affinity Inhibition = 24%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13534
Affinity IC50 = 6200nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13534
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13550
Affinity IC50 = 3950nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13598
Affinity IC50 = 1120nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13602
Affinity IC50 = 870nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13604
Affinity IC50 = 1020nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13611
Affinity IC50 = 4000nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13611
Affinity Inhibition = 93%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13638
Affinity Inhibition = 22%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13640
Affinity IC50 = 8500nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13640
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13671
Affinity Inhibition = 32%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13683
Affinity Inhibition = 40%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13686
Affinity IC50 = 620nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13693
Affinity IC50 = 5900nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13709
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13709
Affinity IC50 = 4200nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13745
Affinity Inhibition = 44%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13751
Affinity Inhibition = 11%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13756
Affinity Inhibition = 23%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13768
Affinity Inhibition = 98%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13768
Affinity IC50 = 2900nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL13778
Affinity IC50 = 480nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL148546
Affinity IC50 = 2600uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL148657
Affinity IC50 = 2800uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL149224
Affinity IC50 = 260uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL151381
Affinity IC50 = 280uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL151385
Affinity IC50 = 325uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL1770807
Affinity Not Active
Assay description Inhibition of PPIase activity of human recombinant cyclophilin-A using succinyl-Ala-Ala-Pro-Phe-4-nitroanilide as substrate at 100 uM pretreated for 3 hrs before substrate addition by spectrophotometry
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21963115
Doc title Oligopeptide cyclophilin inhibitors: a reassessment.
PDB None

Name CHEMBL1770807
Affinity Not Active
Assay description Inhibition of PPIase activity of human recombinant cyclophilin-A using succinyl-Ala-Ala-Pro-Phe-4-nitroanilide as substrate at 100 uM by protease coupled assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21963115
Doc title Oligopeptide cyclophilin inhibitors: a reassessment.
PDB None

Name CHEMBL1770807
Affinity Dose-dependent effect
Assay description Inhibition of PPIase activity of Cyclophilin A by Spectrophotometry
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1770807
Affinity IC50 = 33.11nM
Assay description Inhibition of PPIase activity of Cyclophilin A by Spectrophotometry
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1770807
Affinity Kd = 3.4110'-6M
Assay description Binding affinity to Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1770807
Affinity Not Active
Assay description Binding affinity to human recombinant cyclophilin-A up to 25 uM by isothermal titration calorimetry assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21963115
Doc title Oligopeptide cyclophilin inhibitors: a reassessment.
PDB None

Name CHEMBL1770808
Affinity Not Active
Assay description Inhibition of PPIase activity of Cyclophilin A by Spectrophotometry
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1770808
Affinity Not Active
Assay description Binding affinity to Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1770809
Affinity Not Active
Assay description Binding affinity to Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1770809
Affinity Not Active
Assay description Inhibition of PPIase activity of Cyclophilin A by Spectrophotometry
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21396746
Doc title Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro.
PDB None

Name CHEMBL1790316
Affinity IC50 = 6uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790316
Affinity Inhibition = 99%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790318
Affinity IC50 > 10000uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790319
Affinity Inhibition = 55%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790319
Affinity IC50 = 280uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790322
Affinity Inhibition = 15%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790322
Affinity IC50 = 2000uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790323
Affinity IC50 = 2600uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790323
Affinity Inhibition = 20%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790324
Affinity IC50 = 165uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790324
Affinity Inhibition = 76%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790325
Affinity Inhibition = 38%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790325
Affinity IC50 = 1500uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790326
Affinity IC50 = 115uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790326
Affinity Inhibition = 88%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790327
Affinity IC50 = 260uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1790327
Affinity Inhibition = 59%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1793897
Affinity IC50 = 680uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1793898
Affinity IC50 = 90uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1793898
Affinity Inhibition = 57%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1793899
Affinity Inhibition = 50%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1793899
Affinity IC50 = 500uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL1911379
Affinity IC50 = 4.9nM
Assay description Inhibition of PPIase activity of human recombinant cyclophilin-A using succinyl-Ala-Ala-Pro-Phe-4-nitroanilide as substrate by protease coupled assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21963115
Doc title
PDB None

Name CHEMBL198293
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL198293
Affinity IC50 = 458nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL198402
Affinity Inhibition = 52%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL199550
Affinity IC50 = 528nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL199550
Affinity Inhibition = 89%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL199777
Affinity Inhibition = 35%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL199807
Affinity Inhibition = 5%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL199967
Affinity Inhibition = 22%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL199968
Affinity IC50 = 316nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL200133
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL200133
Affinity IC50 = 640nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201025
Affinity IC50 = 951nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201025
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201113
Affinity Inhibition = 63%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201113
Affinity IC50 = 1437nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201129
Affinity Inhibition = 34%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201164
Affinity Inhibition = 55%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201164
Affinity IC50 = 5500nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201394
Affinity Inhibition = 95%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201394
Affinity IC50 = 361nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201395
Affinity IC50 = 60nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201395
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201403
Affinity Inhibition = 25%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201450
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201450
Affinity IC50 = 592nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201452
Affinity Inhibition = 19%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201529
Affinity Inhibition = 44%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201645
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201645
Affinity IC50 = 71nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201652
Affinity Inhibition = 63%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201664
Affinity IC50 = 140nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201664
Affinity Inhibition = 98%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201705
Affinity Inhibition = 74%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201718
Affinity IC50 = 810nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201718
Affinity Inhibition = 84%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201719
Affinity Inhibition = 21%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201790
Affinity Inhibition = 29%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL201894
Affinity Inhibition = 40%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL202414
Affinity IC50 = 303nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL202880
Affinity IC50 = 754nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL202880
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203086
Affinity Inhibition = 8%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203099
Affinity Inhibition = 55%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203100
Affinity IC50 = 4100nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203100
Affinity Inhibition = 95%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203142
Affinity IC50 = 880nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203142
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203155
Affinity Inhibition = 12%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203193
Affinity IC50 = 14nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203193
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203194
Affinity Inhibition = 100%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203194
Affinity IC50 = 20nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203197
Affinity Inhibition = 25%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203248
Affinity Inhibition = 0%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL203303
Affinity Inhibition = 5%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL2338699
Affinity Not Active
Assay description Binding affinity to cyclophilin A in human Jurkat cell lysates at 1.1 uM after 24 hrs by SDS-PAGE analysis
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23414805
Doc title Chemical tagging of a drug target using 5-sulfonyl tetrazole.
PDB None

Name CHEMBL2338702
Affinity Not Active
Assay description Binding affinity to cyclophilin A in human Jurkat cell lysates at 1.1 uM after 24 hrs by SDS-PAGE analysis
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23414805
Doc title Chemical tagging of a drug target using 5-sulfonyl tetrazole.
PDB None

Name CHEMBL2371033
Affinity IC50 = 680uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL263062
Affinity IC50 = 115uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL263578
Affinity Inhibition = 11%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL268519
Affinity IC50 = 880nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL276363
Affinity IC50 > 10000uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL276383
Affinity Inhibition = 0%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL276409
Affinity IC50 = 690nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL276458
Affinity Inhibition = 19%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL276713
Affinity IC50 = 3350nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL296587
Affinity IC50 > 10000uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL300523
Affinity Inhibition = 45%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL300523
Affinity IC50 = 760uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL3085530
Affinity IC50 = 1000uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title
PDB None

Name CHEMBL3085530
Affinity IC50 = 1000uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title
PDB None

Name CHEMBL3085530
Affinity Inhibition = 13%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title
PDB None

Name CHEMBL313327
Affinity Kd = 0.0000047M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL314028
Affinity Kd > 0.0002M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL314456
Affinity Kd = 0.0000015M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL314660
Affinity Kd > 0.0002M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL315033
Affinity Kd = 0.000017M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL329797
Affinity Kd = 0.000124M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL356871
Affinity IC50 = 2000uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL358023
Affinity IC50 = 500uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL358925
Affinity IC50 = 90uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL371213
Affinity Inhibition = 97%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL371213
Affinity IC50 = 320nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL371728
Affinity Inhibition = 45%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL373254
Affinity IC50 = 60nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL373254
Affinity Inhibition = 96%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL378790
Affinity Inhibition = 0%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL380501
Affinity Inhibition = 12%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL382343
Affinity Inhibition = 35%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL382465
Affinity Inhibition = 79%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL382465
Affinity IC50 = 499nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL382567
Affinity IC50 = 748nM
Assay description Inhibition of isomerase activity of Cyclophilin A
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL382567
Affinity Inhibition = 95%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL382661
Affinity Inhibition = 49%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL383535
Affinity Inhibition = 10%
Assay description Inhibition of isomerase activity of Cyclophilin A at 10 uM
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16451056
Doc title Structure-based design, synthesis, and biological evaluation of novel inhibitors of human cyclophilin A.
PDB None

Name CHEMBL384058
Affinity Ki = 75nM
Assay description Inhibition of cyclophilin A rotamase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15357990
Doc title
PDB None

Name CHEMBL384718
Affinity Ki = 10nM
Assay description Inhibition of cyclophilin A rotamase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15357990
Doc title
PDB None

Name CHEMBL406277
Affinity Kd > 0.0002M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL407456
Affinity Ki = 24nM
Assay description Inhibition of cyclophilin A rotamase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15357990
Doc title
PDB None

Name CHEMBL409139
Affinity Ki = 100nM
Assay description Inhibition of cyclophilin A rotamase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15357990
Doc title
PDB None

Name CHEMBL413867
Affinity Ki = 18nM
Assay description Inhibition of cyclophilin A rotamase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15357990
Doc title
PDB None

Name CHEMBL417253
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL417253
Affinity IC50 = 590nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL429034
Affinity IC50 = 9500nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL429034
Affinity Inhibition = 100%
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA) 10 M
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL432322
Affinity IC50 > 10000uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL433082
Affinity IC50 = 2800uM
Assay description 50% inhibitory concentration of competitive binding against human Peptidyl-prolyl isomerase activity using uncoupled assay
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL433082
Affinity Inhibition = 28%
Assay description % inhibition of competitive binding, at 500 uM, against human Peptidyl-prolyl isomerase
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10794694
Doc title Design of a Gag pentapeptide analogue that binds human cyclophilin A more efficiently than the entire capsid protein: new insights for the development of novel anti-HIV-1 drugs.
PDB None

Name CHEMBL433738
Affinity IC50 = 365uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL434694
Affinity IC50 = 165uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL441409
Affinity IC50 = 940nM
Assay description In vitro inhibition of the rotamase activity of cyclophilin A (CyPA)
-- Homologous single protein target assigned: PPIA_RAT (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12646018
Doc title Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
PDB None

Name CHEMBL443891
Affinity Kd = 51.6uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL443891
Affinity IC50 = 0.16uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL443992
Affinity Kd = 141uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL445240
Affinity Kd = 512.8uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL445297
Affinity Kd = 109.5uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL445297
Affinity IC50 = 0.35uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL449855
Affinity Kd = 227.3uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL482839
Affinity IC50 = 0.81uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL482839
Affinity Kd = 79.3uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL482840
Affinity Kd = 200.5uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489001
Affinity Kd = 147.1uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489021
Affinity IC50 = 0.38uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489021
Affinity Kd = 128.5uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489022
Affinity Kd = 79.6uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489022
Affinity IC50 = 0.33uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489040
Affinity Kd = 60.8uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489041
Affinity IC50 = 0.13uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489041
Affinity Kd = 51uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489042
Affinity Kd = 76.9uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489042
Affinity IC50 = 0.45uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489612
Affinity Kd = 125.1uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489613
Affinity Kd = 222.2uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489614
Affinity Kd = 133.3uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489636
Affinity Kd = 118.8uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489637
Affinity Kd = 88.1uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489637
Affinity IC50 = 0.58uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489821
Affinity Kd = 171.8uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489822
Affinity IC50 = 0.46uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL489822
Affinity Kd = 88.9uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL490247
Affinity Kd = 88.6uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL490247
Affinity IC50 = 0.45uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL490840
Affinity Kd = 124.4uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL490848
Affinity Kd = 140.4uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL492070
Affinity IC50 = 0.59uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL492070
Affinity Kd = 96.6uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL505691
Affinity Not Active
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL506108
Affinity Kd = 100.7uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL518980
Affinity IC50 = 0.74uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL518980
Affinity Kd = 73.3uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL521943
Affinity IC50 = 0.65uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL521943
Affinity Kd = 55.8uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL522094
Affinity IC50 = 0.6uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL522094
Affinity Kd = 116.5uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL522416
Affinity IC50 = 0.69uM
Assay description Inhibition of human cyclophilin A at 6 degC
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL522416
Affinity Kd = 107.3uM
Assay description Binding affinity to human cyclophilin A by intrinsic tryptophan fluorescence titration assay
-- Direct single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19328002
Doc title Discovery of dual inhibitors targeting both HIV-1 capsid and human cyclophilin A to inhibit the assembly and uncoating of the viral capsid.
PDB None

Name CHEMBL525897
Affinity IC50 = 263nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL540193
Affinity IC50 = 6uM
Assay description In vitro inhibition of human Cyclophilin A/protein interaction.
-- Homologous single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12431052
Doc title Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.
PDB None

Name CHEMBL540479
Affinity IC50 = 620nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL549627
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL549755
Affinity IC50 = 136nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL550098
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL551508
Affinity IC50 = 159nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL551795
Affinity Not Active
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL551796
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL551990
Affinity Not Active
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL552181
Affinity IC50 = 370nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL552255
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL556690
Affinity Not Active
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL556893
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL557628
Affinity IC50 = 71.2nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL557910
Affinity Not Active
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL558302
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL559525
Affinity IC50 = 1.52nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL559858
Affinity IC50 = 31.6nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL560115
Affinity IC50 = 12.1nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL560173
Affinity IC50 = 103nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL560850
Affinity IC50 = 364nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL560851
Affinity IC50 = 2.59nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL564391
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL564539
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL564647
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL564826
Affinity IC50 = 1910nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL569840
Affinity IC50 > 10000nM
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL570542
Affinity Not Active
Assay description Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19691347
Doc title Discovering potent small molecule inhibitors of cyclophilin A using de novo drug design approach.
PDB None

Name CHEMBL594125
Affinity Not Active
Assay description Inhibition of peptidyl-prolyl cis/trans isomerase activity of cyclophilin A
-- Homologous single protein target assigned: PPIA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19969456
Doc title Structure-guided design of alpha-amino acid-derived Pin1 inhibitors.
PDB None

Name CHEMBL86442
Affinity Kd > 0.0002M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL86465
Affinity Kd > 0.0002M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL88028
Affinity Kd = 0.00014M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

Name CHEMBL89881
Affinity Kd = 0.000077M
Assay description Binding affinity towards cyclophilin A by fluorescence
-- Direct single protein target assigned: PPIA_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11472213
Doc title Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin.
PDB None

69 PDB entries for Cyclophilins and its protein partners


1AK4
Crystal structure of human cyclophilin A bound to the amino-terminal domain of HIV-1 capsid.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) P12497 HIV-1 CAPSID

1AWQ
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) 1AWQ PEPTIDE FROM THE HIV-1 CAPSID PROTEIN

1AWR
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) 1AWR PEPTIDE FROM THE HIV-1 CAPSID PROTEIN

1AWS
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) 1AWS PEPTIDE FROM THE HIV-1 CAPSID PROTEIN

1AWT
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) 1AWT PEPTIDE FROM THE HIV-1 CAPSID PROTEIN

1AWU
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) 1AWU PEPTIDE FROM THE HIV-1 CAPSID PROTEIN

1AWV
Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) 1AWV PEPTIDE FROM THE HIV-1 CAPSID PROTEIN

1BCK
X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.

Entity type Code Description
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00035 CYCLOSPORIN C

1CWF
X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.

Entity type Code Description
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00036 CYCLOSPORIN D

1CWH
X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.

Entity type Code Description
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00033 CYCLOSPORIN A

1CWI
X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.

Entity type Code Description
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00036 CYCLOSPORIN D

1CWM
X-Ray Structures and Analysis of 11 Cyclosporin Derivatives Complexed with Cyclophilin A.

Entity type Code Description
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00033 CYCLOSPORIN A

1CWO
Conformational Differences of an Immunosuppressant Peptolide in a Single Crystal and in a Crystal Complex with Human Cyclophilin A.

Entity type Code Description
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00035 CYCLOSPORIN C

1CYN
X-Ray Structure of a Cyclophilin B/Cyclosporin Complex: Comparison with Cyclophilin a and Delineation of its Calcineurin-Binding Domain.

Entity type Code Description
polypeptide(L) P23284 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE B
polypeptide(L) NOR00033 CYCLOSPORIN A

1FGL
Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity.

Entity type Code Description
polypeptide(L) P62937 CYCLOPHILIN A
polypeptide(L) P05889 HIV-1 GAG PROTEIN

1M63
Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes

Entity type Code Description
polypeptide(L) Q08209 SERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT, ALPHA ISOFORM
polypeptide(L) P63098 CALCINEURIN B SUBUNIT ISOFORM 1
polypeptide(L) P62937 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A
polypeptide(L) NOR00033 CYCLOSPORIN A

1M9C
Structural insights into the catalytic mechanism of cyclophilin A

Entity type Code Description
polypeptide(L) P62937 Cyclophilin A
polypeptide(L) Q72497 HIV-1 Capsid

1M9D
Structural insights into the catalytic mechanism of cyclophilin A

Entity type Code Description
polypeptide(L) P62937 Cyclophilin A
polypeptide(L) Q72497 HIV-1 Capsid

1M9E
Structural insights into the catalytic mechanism of cyclophilin A

Entity type Code Description
polypeptide(L) P62937 Cyclophilin A
polypeptide(L) Q72497 HIV-1 Capsid

1M9F
Structural insights into the catalytic mechanism of cyclophilin A

Entity type Code Description
polypeptide(L) P62937 Cyclophilin A
polypeptide(L) Q72497 HIV-1 Capsid