E2

Regulatory protein e2

Reviewed UniProt entries for E2 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
P03122 VE2_BPV1 Regulatory protein E2 E2 Bovine papillomavirus type 1 410
P11299 VE2_BPV2 Regulatory protein E2 E2 Bovine papillomavirus type 2 411
Q8BDD6 VE2_BPV3 Regulatory protein E2 E2 Bovine papillomavirus type 3 414
P08345 VE2_BPV4 Regulatory protein E2 E2 Bovine papillomavirus type 4 334
Q8BDG4 VE2_BPV5 Regulatory protein E2 E2 Bovine papillomavirus type 5 409
Q705F3 VE2_BPV6 Regulatory protein E2 E2 Bovine papillomavirus type 6 435
Q89420 VE2_COPV6 Regulatory protein E2 E2 Canine oral papillomavirus (strain Y62) (COPV) 385
P36778 VE2_HPV03 Regulatory protein E2 E2 Human papillomavirus type 3 383
Q07849 VE2_HPV04 Regulatory protein E2 E2 Human papillomavirus type 4 402
P06921 VE2_HPV05 Regulatory protein E2 E2 Human papillomavirus type 5 514
P36779 VE2_HPV07 Regulatory protein E2 E2 Human papillomavirus type 7 375
P06422 VE2_HPV08 Regulatory protein E2 E2 Human papillomavirus type 8 498
P36780 VE2_HPV09 Regulatory protein E2 E2 Human papillomavirus type 9 461
P36781 VE2_HPV10 Regulatory protein E2 E2 Human papillomavirus type 10 376
P04015 VE2_HPV11 Regulatory protein E2 E2 Human papillomavirus type 11 367
P36782 VE2_HPV12 Regulatory protein E2 E2 Human papillomavirus type 12 494
Q02263 VE2_HPV13 Regulatory protein E2 E2 Human papillomavirus type 13 377
P36783 VE2_HPV14 Regulatory protein E2 E2 Human papillomavirus type 14 483
P36784 VE2_HPV15 Regulatory protein E2 E2 Human papillomavirus type 15 382
P03120 VE2_HPV16 Regulatory protein E2 E2 Human papillomavirus type 16 365
P36785 VE2_HPV17 Regulatory protein E2 E2 Human papillomavirus type 17 452
P06790 VE2_HPV18 Regulatory protein E2 E2 Human papillomavirus type 18 365
P36786 VE2_HPV19 Regulatory protein E2 E2 Human papillomavirus type 19 493
P03118 VE2_HPV1A Regulatory protein E2 E2 Human papillomavirus type 1a 401
P50766 VE2_HPV20 Regulatory protein E2 E2 Human papillomavirus type 20 497
P50767 VE2_HPV21 Regulatory protein E2 E2 Human papillomavirus type 21 503
P50768 VE2_HPV22 Regulatory protein E2 E2 Human papillomavirus type 22 436
P50769 VE2_HPV23 Regulatory protein E2 E2 Human papillomavirus type 23 431
P50770 VE2_HPV24 Regulatory protein E2 E2 Human papillomavirus type 24 467
P36787 VE2_HPV25 Regulatory protein E2 E2 Human papillomavirus type 25 502
P36788 VE2_HPV26 Regulatory protein E2 E2 Human papillomavirus type 26 375
P36789 VE2_HPV27 Regulatory protein E2 E2 Human papillomavirus type 27 388
P50771 VE2_HPV28 Regulatory protein E2 E2 Human papillomavirus type 28 376
P50772 VE2_HPV29 Regulatory protein E2 E2 Human papillomavirus type 29 388
P25482 VE2_HPV2A Regulatory protein E2 E2 Human papillomavirus type 2a 391
P36790 VE2_HPV30 Regulatory protein E2 E2 Human papillomavirus type 30 378
P17383 VE2_HPV31 Regulatory protein E2 E2 Human papillomavirus type 31 372
P36791 VE2_HPV32 Regulatory protein E2 E2 Human papillomavirus type 32 394
P06423 VE2_HPV33 Regulatory protein E2 E2 Human papillomavirus type 33 353
P36792 VE2_HPV34 Regulatory protein E2 E2 Human papillomavirus type 34 345
P27222 VE2_HPV35 Regulatory protein E2 E2 Human papillomavirus type 35 367
P50809 VE2_HPV36 Regulatory protein E2 E2 Human papillomavirus type 36 509
Q80903 VE2_HPV37 Regulatory protein E2 E2 Human papillomavirus type 37 454
Q80910 VE2_HPV38 Regulatory protein E2 E2 Human papillomavirus type 38 441
P24830 VE2_HPV39 Regulatory protein E2 E2 Human papillomavirus type 39 370
P36793 VE2_HPV40 Regulatory protein E2 E2 Human papillomavirus type 40 370
P27552 VE2_HPV41 Regulatory protein E2 E2 Human papillomavirus type 41 387
P27223 VE2_HPV42 Regulatory protein E2 E2 Human papillomavirus type 42 398
Q80916 VE2_HPV44 Regulatory protein E2 E2 Human papillomavirus type 44 377
P36794 VE2_HPV45 Regulatory protein E2 E2 Human papillomavirus type 45 368
P22420 VE2_HPV47 Regulatory protein E2 E2 Human papillomavirus type 47 506
Q80923 VE2_HPV48 Regulatory protein E2 E2 Human papillomavirus type 48 396
P36795 VE2_HPV49 Regulatory protein E2 E2 Human papillomavirus type 49 488
Q80930 VE2_HPV50 Regulatory protein E2 E2 Human papillomavirus type 50 396
P26547 VE2_HPV51 Regulatory protein E2 E2 Human papillomavirus type 51 358
P36796 VE2_HPV52 Regulatory protein E2 E2 Human papillomavirus type 52 368
P36797 VE2_HPV53 Regulatory protein E2 E2 Human papillomavirus type 53 384
Q81021 VE2_HPV54 Regulatory protein E2 E2 Human papillomavirus type 54 367
Q80937 VE2_HPV55 Regulatory protein E2 E2 Human papillomavirus type 55 378
P36798 VE2_HPV56 Regulatory protein E2 E2 Human papillomavirus type 56 310
P22155 VE2_HPV57 Regulatory protein E2 E2 Human papillomavirus type 57 383
P26546 VE2_HPV58 Regulatory protein E2 E2 Human papillomavirus type 58 358
P26545 VE2_HPV5B Regulatory protein E2 E2 Human papillomavirus type 5b 514
Q80944 VE2_HPV60 Regulatory protein E2 E2 Human papillomavirus type 60 404
Q80951 VE2_HPV61 Regulatory protein E2 E2 Human papillomavirus type 61 382
Q07850 VE2_HPV63 Regulatory protein E2 E2 Human papillomavirus type 63 398
Q07851 VE2_HPV65 Regulatory protein E2 E2 Human papillomavirus type 65 402
Q80958 VE2_HPV66 Regulatory protein E2 E2 Human papillomavirus type 66 369
Q9JH48 VE2_HPV69 Regulatory protein E2 E2 Human papillomavirus type 69 368
Q84294 VE2_HPV6A Regulatory protein E2 E2 Human papillomavirus type 6a 368
P03119 VE2_HPV6B Regulatory protein E2 E2 Human papillomavirus type 6b 368
P50773 VE2_HPV70 Regulatory protein E2 E2 Human papillomavirus type 70 360
Q02264 VE2_PCPV1 Regulatory protein E2 E2 Pygmy chimpanzee papillomavirus type 1 (PCPV-1) 377
P22156 VE2_RHPV1 Regulatory protein E2 E2 Rhesus papillomavirus type 1 (Rhpv 1) 366
P03116 VE1_BPV1 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Bovine papillomavirus type 1 605
P11298 VE1_BPV2 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Bovine papillomavirus type 2 604
Q8BDD7 VE1_BPV3 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Bovine papillomavirus type 3 613
P08344 VE1_BPV4 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Bovine papillomavirus type 4 608
Q705G8 VE1_BPV5 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Bovine papillomavirus type 5 626
Q705F4 VE1_BPV6 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Bovine papillomavirus type 6 609
Q89536 VE1_COPV6 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Canine oral papillomavirus (strain Y62) (COPV) 597
P03112 VE1_CRPVK Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Cottontail rabbit papillomavirus (strain Kansas) (CRPV) (Papillomavirus sylvilagi) 602
P51894 VE1_CRPVW Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) (Fragments) E1 Cottontail rabbit papillomavirus (strain Washington B) (CRPV) (Papillomavirus sylvilagi) 178
P06455 VE1_FPVL Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) (Fragment) E1 Avian papillomavirus fpv-l 152
P36719 VE1_HPV03 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 3 659
Q07846 VE1_HPV04 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 4 599
P06920 VE1_HPV05 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 5 606
Q05133 VE1_HPV07 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 7 646
P06420 VE1_HPV08 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 8 603
Q05111 VE1_HPV09 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 9 605
P36720 VE1_HPV10 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 10 681
Q05134 VE1_HPV12 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 12 604
Q02261 VE1_HPV13 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 13 646
P36721 VE1_HPV14 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 14 605
Q05135 VE1_HPV15 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 15 602
P03114 VE1_HPV16 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 16 649
Q02512 VE1_HPV17 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 17 609
P06789 VE1_HPV18 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 18 657
Q02048 VE1_HPV19 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 19 604
P03111 VE1_HPV1A Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 1a 612
P50758 VE1_HPV20 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 20 605
P50759 VE1_HPV21 Replication protein E1 (EC 3.6.4.12) E1 Human papillomavirus type 21 603
P50760 VE1_HPV22 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 22 608
P50761 VE1_HPV23 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 23 607
P50762 VE1_HPV24 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 24 607
Q02049 VE1_HPV25 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 25 604
P36722 VE1_HPV26 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 26 638
P36723 VE1_HPV27 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 27 643
P50763 VE1_HPV28 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 28 662
P50764 VE1_HPV29 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 29 660
P25481 VE1_HPV2A Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 2a 643
Q05112 VE1_HPV30 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 30 631
P17382 VE1_HPV31 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 31 629
P36724 VE1_HPV32 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 32 642
P06421 VE1_HPV33 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 33 644
P36725 VE1_HPV34 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 34 647
P27220 VE1_HPV35 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 35 637
P50808 VE1_HPV36 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 36 604
Q80902 VE1_HPV37 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 37 609
Q80909 VE1_HPV38 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 38 604
P24829 VE1_HPV39 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 39 647
P36727 VE1_HPV40 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 40 647
P27551 VE1_HPV41 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 41 614
P27221 VE1_HPV42 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 42 643
Q80915 VE1_HPV44 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 44 643
P36728 VE1_HPV45 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 45 643
P22419 VE1_HPV47 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 47 605
Q80922 VE1_HPV48 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 48 593
P36729 VE1_HPV49 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 49 609
P26544 VE1_HPV51 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 51 634
P36730 VE1_HPV52 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 52 647
Q02513 VE1_HPV53 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) (Fragment) E1 Human papillomavirus type 53 52
Q81020 VE1_HPV54 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 54 633
P22153 VE1_HPV57 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 57 643
P26543 VE1_HPV58 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 58 644
Q81966 VE1_HPV59 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 59 644
P26542 VE1_HPV5B Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 5b 606
Q80943 VE1_HPV60 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 60 610
Q80950 VE1_HPV61 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 61 652
Q07847 VE1_HPV63 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 63 618
Q07848 VE1_HPV65 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 65 598
Q80957 VE1_HPV66 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 66 630
Q9JH49 VE1_HPV69 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 69 634
Q84293 VE1_HPV6A Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 6a 649
P03113 VE1_HPV6B Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 6b 649
P50765 VE1_HPV70 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 70 652
Q81999 VE1_HPV72 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 72 650
Q82007 VE1_HPV73 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 73 650
O40619 VE1_HPVR7 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type RTRX7 606
Q84356 VE1_MNPVA Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Mastomys natalensis papillomavirus (isolate African multimammate rat) (MnPV) 602
P03117 VE1_PAPVD Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Deer papillomavirus (DPV) (Deer fibroma virus) 613
P11328 VE1_PAPVE Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 European elk papillomavirus (EEPV) 611
Q02262 VE1_PCPV1 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Pygmy chimpanzee papillomavirus type 1 (PCPV-1) 648
P81174 VE1_PCPVC Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Pygmy chimpanzee papillomavirus type 1C (PCPV-1C) 648
P22154 VE1_RHPV1 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Rhesus papillomavirus type 1 (Rhpv 1) 625
P04014 VE1_HPV11 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1) E1 Human papillomavirus type 11 649

Small molecules tested in E2 binding assays:

50 datapoints for 44 distinct small molecules


Name JMC40_21
Affinity Kd (NMR) 60uM
Assay description Dissociation constants were derived from an analysis of the changes in amide chemical shifts as a function of added compound.
-- Direct single protein target assigned: VE2_HPV11 (Expert curation) --
DOI http://dx.doi.org/10.1021/jm9703404
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name JMC40_39
Affinity Kd (NMR) 350uM
Assay description Dissociation constants were derived from an analysis of the changes in amide chemical shifts as a function of added compound.
-- Direct single protein target assigned: VE2_HPV11 (Expert curation) --
DOI http://dx.doi.org/10.1021/jm9703404
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name BOMCL13_1
Affinity IC50 (binding) 11uM
Assay description not detail descrived; E2-dependent E1/DNA binding assay
-- Direct single protein target assigned: VE2_HPV11 (Expert curation) --
DOI http://dx.doi.org/10.1021/ac035335o
Doc title Characterization of the binding site for inhibitors of the HPV11 E1-E2 protein interaction on the E2 transactivation domain by photoaffinity labeling and mass spectrometry.
PDB None

Name BILH434
Affinity IC50 (binding) 180nM
Assay description E1-E2-ori complex formation assay.
-- Direct single protein target assigned: VE2_HPV11 (Expert curation) --
DOI http://dx.doi.org/10.1074/jbc.M311376200
Doc title Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor.
PDB 1R6N - (434)

Name CHEMBL105786
Affinity Kd = 1.6mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL105808
Affinity Kd = 6.8mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL105876
Affinity Kd = 2.7mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL106091
Affinity Kd = 1.2mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL106136
Affinity Kd = 2.1mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL106291
Affinity Kd = 1.9mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL106402
Affinity Kd = 1.6mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL106470
Affinity Kd = 0.35mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL106585
Affinity Kd = 0.85mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL106590
Affinity Kd = 0.06mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL106708
Affinity Kd = 1.5mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL106761
Affinity Kd = 4.5mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL106863
Affinity Kd = 6.6mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL106976
Affinity Kd = 3.4mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL107057
Affinity Kd = 2.5mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL107066
Affinity Kd > 10mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL107085
Affinity Kd = 3.5mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL107103
Affinity Kd = 0.6mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL107517
Affinity Kd = 1.5mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL107518
Affinity Kd = 9.1mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL107525
Affinity Kd > 10mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL108320
Affinity Kd > 10mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL108457
Affinity Kd = 1.5mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL108881
Affinity Kd = 8.8mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL109066
Affinity Kd > 10mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL110563
Affinity Kd > 10mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL178590
Affinity Ki = 2uM
Assay description Binding affinity for human papillomavirus (HPV6) E1 helicase
-- Direct protein complex subunits assigned: VE1_HPV11 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/14695816
Doc title Discovery of small-molecule inhibitors of the ATPase activity of human papillomavirus E1 helicase.
PDB None

Name CHEMBL316806
Affinity Kd > 10mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL320524
Affinity Kd > 10mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL321440
Affinity Kd = 0.32mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL321615
Affinity Kd = 1.9mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL322977
Affinity Kd > 10mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL323182
Affinity Kd > 10mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL326915
Affinity Kd = 8.9mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL423319
Affinity Kd = 2.3mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL432785
Affinity Kd = 1.7mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL44657
Affinity Kd = 210uM
Assay description Binding affinity to HPV1a recombinant E2 protein by surface plasmon resonance method
-- Direct single protein target assigned: VE2_HPV1A (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18396405
Doc title Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
PDB None

Name CHEMBL61
Affinity Kd = 70.5uM
Assay description Binding affinity to HPV16 recombinant E2 protein by surface plasmon resonance method
-- Direct single protein target assigned: VE2_HPV16 (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18396405
Doc title Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
PDB None

Name CHEMBL61
Affinity Kd = 20.1uM
Assay description Binding affinity to HPV11 recombinant E2 protein by surface plasmon resonance method
-- Direct single protein target assigned: VE2_HPV11 (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18396405
Doc title Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
PDB None

Name CHEMBL61
Affinity Kd = 24.1uM
Assay description Binding affinity to HPV1a recombinant E2 protein by surface plasmon resonance method
-- Direct single protein target assigned: VE2_HPV1A (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18396405
Doc title Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
PDB None

Name CHEMBL61
Affinity Kd > 400uM
Assay description Binding affinity to HPV1a recombinant E2 protein activator domain by surface plasmon resonance assay
-- Direct single protein target assigned: VE2_HPV1A (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18396405
Doc title Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
PDB None

Name CHEMBL61
Affinity Kd = 1.05uM
Assay description Binding affinity to HPV1a recombinant E2 protein hinge domain by surface plasmon resonance assay
-- Direct single protein target assigned: VE2_HPV1A (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18396405
Doc title Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
PDB None

Name CHEMBL61
Affinity Kd > 400uM
Assay description Binding affinity to HPV1a recombinant E2 protein DNA binding domain by surface plasmon resonance assay
-- Direct single protein target assigned: VE2_HPV1A (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18396405
Doc title Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
PDB None

Name CHEMBL61
Affinity Not Active
Assay description Inhibition of HPV1a recombinant E2 protein-DNA interaction by electron mobility shift assay
-- Direct single protein target assigned: VE2_HPV1A (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18396405
Doc title Podophyllotoxin directly binds a hinge domain in E2 of HPV and inhibits an E2/E7 interaction in vitro.
PDB None

Name CHEMBL663
Affinity Kd > 10mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

Name CHEMBL90522
Affinity Kd > 10mM
Assay description Dissociation constant after binding to human papillomavirus E2 DNA-binding domain (DBD) by observing the changes in [15N]-HSQC spectra.
-- Homologous single protein target assigned: VE2_HPV16 (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9379433
Doc title NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.
PDB None

30 PDB entries for E2 and its protein partners


1A7G
Structure of the E2 DNA-binding domain from human papillomavirus serotype 31 at 2.4 A.

Entity type Code Description
polypeptide(L) P17383 REGULATORY PROTEIN E2

1BY9
Crystal structure of the E2 DNA-binding domain from human papillomavirus type 16: implications for its DNA binding-site selection mechanism.

Entity type Code Description
polypeptide(L) P03120 REGULATORY PROTEIN E2

1DBD
Structural correlates for enhanced stability in the E2 DNA-binding domain from bovine papillomavirus.

Entity type Code Description
polypeptide(L) P03122 REGULATORY PROTEIN E2

1DHM
Solution structure of the DNA-binding domain of a human papillomavirus E2 protein: evidence for flexible DNA-binding regions.

Entity type Code Description
polypeptide(L) P17383 E2 PROTEIN

1DTO
Structure of the intact transactivation domain of the human papillomavirus E2 protein.

Entity type Code Description
polypeptide(L) P03120 REGULATORY PROTEIN E2

1F08
Crystal structure of the DNA binding domain of the replication initiation protein E1 from papillomavirus.

Entity type Code Description
polypeptide(L) P03116 REPLICATION PROTEIN E1

1F9F
The structural basis of DNA target discrimination by papillomavirus E2 proteins.

Entity type Code Description
polypeptide(L) P06790 REGULATORY PROTEIN E2
polypeptide(L) 1F9F REGULATORY PROTEIN E2

1JJ4
The structural basis of DNA target discrimination by papillomavirus E2 proteins.

Entity type Code Description
polydeoxyribonucleotide 1JJ4 E2 binding site DNA
polypeptide(L) P06790 Regulatory protein E2

1JJH
Subunit rearrangement accompanies sequence-specific DNA binding by the bovine papillomavirus-1 E2 protein.

Entity type Code Description
polypeptide(L) P03122 REGULATORY PROTEIN E2

1KSX
Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex.

Entity type Code Description
polydeoxyribonucleotide 1KSX E1 Recognition Sequence
polypeptide(L) P03116 REPLICATION PROTEIN E1

1KSY
Crystal structures of two intermediates in the assembly of the papillomavirus replication initiation complex.

Entity type Code Description
polydeoxyribonucleotide 1KSY E1 Recognition Sequence, Strand 1
polydeoxyribonucleotide 1KSY E1 Recognition Sequence, Strand 2
polypeptide(L) P03116 REPLICATION PROTEIN E1

1QQH
Crystal structure of the human papillomavirus type 18 E2 activation domain.

Entity type Code Description
polypeptide(L) P06790 PAPILLOMAVIRUS TRANSCRIPTION FACTOR E2

1R6K
Crystal Structure of the E2 Transactivation Domain of Human Papillomavirus Type 11 Bound to a Protein Interaction Inhibitor

Entity type Code Description
polypeptide(L) P04015 HPV11 REGULATORY PROTEIN E2

1R6N
Crystal Structure of the E2 Transactivation Domain of Human Papillomavirus Type 11 Bound to a Protein Interaction Inhibitor

Entity type Code Description
polypeptide(L) P04015 HPV11 REGULATORY PROTEIN E2
Ligand 434 SPIRO[3-CARBOXY-4-{(4-[1,2,3]THIADIAZOL-4-YL-PHENYL)-AMINO-CARBONYL} -5-[3,4-DICHLORO-PHENYL]-TETRAHYDROFURAN-2,2'-5-METHYL-INDAN-1,3-DIONE]

1R8H
Comparison of the structure and DNA-binding properties of the E2 proteins from an oncogenic and a non-oncogenic human papillomavirus.

Entity type Code Description
polypeptide(L) Q84294 Regulatory protein E2

1R8P
Solution structure of the HPV-16 E2 DNA binding domain, a transcriptional regulator with a dimeric beta-barrel fold

Entity type Code Description
polypeptide(L) P03120 Regulatory protein E2

1R9W
The DNA-binding domain of human papillomavirus type 18 E1. Crystal structure, dimerization, and DNA binding.

Entity type Code Description
polypeptide(L) P06789 Replication protein E1

1TUE
The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2

Entity type Code Description
polypeptide(L) P06789 Replication protein E1
polypeptide(L) Q80B71 Regulatory protein E2

1ZZF
The DNA-bound solution structure of HPV-16 E2 DNA-binding domain

Entity type Code Description
polypeptide(L) P03120 Regulatory protein E2

2AYB
The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein.

Entity type Code Description
polydeoxyribonucleotide 2AYB 5'-D(*CP*AP*AP*CP*CP*GP*AP*AP*TP*TP*CP*GP*GP*TP*TP*G)-3'
polypeptide(L) Q84294 Regulatory protein E2

2AYE
The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein.

Entity type Code Description
polypeptide(L) Q84294 Regulatory protein E2

2AYG
The recognition of local DNA conformation by the human papillomavirus type 6 E2 protein.

Entity type Code Description
polydeoxyribonucleotide 2AYG 5'-D(*GP*CP*AP*AP*CP*CP*GP*AP*AP*TP*TP*CP*GP*GP*TP*TP*GP*C)-3'
polypeptide(L) Q84294 Regulatory protein E2

2BOP
Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target.

Entity type Code Description
polydeoxyribonucleotide 2BOP DNA (5'-D(*CP*CP*GP*AP*CP*CP*GP*AP*CP*GP*TP*CP*GP*GP*TP*CP*G )-3')
polypeptide(L) P03122 PROTEIN (E2)

2GXA
Mechanism of DNA translocation in a replicative hexameric helicase.

Entity type Code Description
polydeoxyribonucleotide 2GXA 5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'
polypeptide(L) P03116 Replication protein E1
Ligand ADP ADENOSINE-5'-DIPHOSPHATE

2JEU
Transcription Activator Structure Reveals Redox Control of a Replication Initiation Reaction.

Entity type Code Description
polypeptide(L) P03122 REGULATORY PROTEIN E2

2JEX
Transcription Activator Structure Reveals Redox Control of a Replication Initiation Reaction.

Entity type Code Description
polypeptide(L) P03122 REGULATORY PROTEIN E2

2NNU
Structure of the Papillomavirus DNA-Tethering Complex E2:Brd4 and a Peptide that Ablates HPV Chromosomal Association.

Entity type Code Description
polypeptide(L) P03120 Regulatory protein E2
polypeptide(L) O60885 Bromodomain-containing protein 4

2Q79
Increased Stability and DNA Site Discrimination of ""Single Chain"" Variants of the Dimeric beta-Barrel DNA Binding Domain of the Human Papillomavirus E2 Transcriptional Regulator.

Entity type Code Description
polypeptide(L) P03120 Regulatory protein E2

2V9P
Papillomavirus E1 Helicase Assembly Maintains an Asymmetric State in the Absence of DNA and Nucleotide Cofactors.

Entity type Code Description
polypeptide(L) P03116 REPLICATION PROTEIN E1

3MI7
Design and characterization of an enhanced repressor of human papillomavirus E2 protein.

Entity type Code Description
polypeptide(L) P03120 Regulatory protein E2