IL-2

Interleukin-2 (il-2) (t-cell growth factor) (tcgf)

Reviewed UniProt entries for IL-2 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q5PXD0 IL2_AILME Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Ailuropoda melanoleuca (Giant panda) 155
Q7JFM2 IL2_AOTLE Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Aotus lemurinus (Northern gray-necked night monkey) 154
Q7JFM5 IL2_AOTNA Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Aotus nancymaae (Mas night monkey) 154
Q7JFM3 IL2_AOTNI Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Aotus nigriceps (Black-headed owl monkey) 154
Q7JFM4 IL2_AOTVO Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Aotus vociferans (Spixs owl monkey) 154
Q4U313 IL2_BOSTR Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Boselaphus tragocamelus (Nilgai) 155
P05016 IL2_BOVIN Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 IL-2 Bos taurus (Bovine) 155
Q95KP3 IL2_BUBBU Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Bubalus bubalis (Domestic water buffalo) 155
Q2PE78 IL2_BUBCA Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Bubalus carabanensis (Swamp type water buffalo) (Bubalus bubalis carabanensis) 155
Q2PE47 IL2_CAMBA Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Camelus bactrianus (Bactrian camel) 154
Q29416 IL2_CANFA Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Canis familiaris (Dog) (Canis lupus familiaris) 155
P36835 IL2_CAPHI Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Capra hircus (Goat) 155
P46649 IL2_CERAT Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) 154
P51747 IL2_CEREL Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Cervus elaphus (Red deer) 162
Q1WM29 IL2_DASNO Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Dasypus novemcinctus (Nine-banded armadillo) 155
Q9XT84 IL2_DELLE Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Delphinapterus leucas (Beluga whale) 154
Q07885 IL2_FELCA Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Felis catus (Cat) (Felis silvestris catus) 154
Q9XT83 IL2_HALGR Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Halichoerus grypus (Gray seal) 155
P37997 IL2_HORSE Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Equus caballus (Horse) 149
P60569 IL2_HYLLA Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Hylobates lar (Common gibbon) 153
Q865X2 IL2_LAMGL Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Lama glama (Llama) 154
Q29615 IL2_MACFA Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 154
P68291 IL2_MACMU Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Macaca mulatta (Rhesus macaque) 154
P68290 IL2_MACNE Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Macaca nemestrina (Pig-tailed macaque) 154
Q08081 IL2_MERUN Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) 155
O62641 IL2_MIRAN Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Mirounga angustirostris (Northern elephant seal) 154
Q5MBA8 IL2_MOSBE Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Moschus berezovskii (Chinese forest musk deer) 155
P04351 IL2_MOUSE Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) Il2 Il-2 Mus musculus (Mouse) 169
Q08867 IL2_MUSSP Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) Il2 Mus spretus (Western Mediterranean mouse) (Algerian mouse) 166
O97513 IL2_ORCOR Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Fragment) IL2 Orcinus orca (Killer whale) 152
Q865Y1 IL2_PAPAN Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 IL-2 Papio anubis (Olive baboon) 154
Q9XS38 IL2_PAPHA Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Papio hamadryas (Hamadryas baboon) 154
P26891 IL2_PIG Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Sus scrofa (Pig) 154
O77620 IL2_RABIT Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Oryctolagus cuniculus (Rabbit) 153
P17108 IL2_RAT Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) Il2 Il-2 Rattus norvegicus (Rat) 155
Q8MKH2 IL2_SAISC Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Saimiri sciureus (Common squirrel monkey) 154
P19114 IL2_SHEEP Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 Ovis aries (Sheep) 155
Q25BC3 IL2_VULVU Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) IL2 IL-2 Vulpes vulpes (Red fox) 155
P12342 IL2RA_BOVIN Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25) IL2RA Bos taurus (Bovine) 275
O62802 IL2RA_CANFA Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25) IL2RA Canis familiaris (Dog) (Canis lupus familiaris) 268
P41690 IL2RA_FELCA Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (CD antigen CD25) IL2RA Felis catus (Cat) (Felis silvestris catus) 275
P01589 IL2RA_HUMAN Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (TAC antigen) (p55) (CD antigen CD25) IL2RA Homo sapiens (Human) 272
Q5MNY4 IL2RA_MACMU Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (CD antigen CD25) IL2RA Macaca mulatta (Rhesus macaque) 272
P01590 IL2RA_MOUSE Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (p55) (CD antigen CD25) Il2ra Il2r Mus musculus (Mouse) 268
Q38IC8 IL2RA_PANTR Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (CD antigen CD25) (Fragment) IL2RA Pan troglodytes (Chimpanzee) 265
O02733 IL2RA_PIG Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (CD antigen CD25) IL2RA Sus scrofa (Pig) 270
P26897 IL2RA_RAT Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (CD antigen CD25) Il2ra Rattus norvegicus (Rat) 267
P26898 IL2RA_SHEEP Interleukin-2 receptor subunit alpha (IL-2 receptor subunit alpha) (IL-2-RA) (IL-2R subunit alpha) (IL2-RA) (CD antigen CD25) IL2RA Ovis aries (Sheep) 275
P60568 IL2_HUMAN Interleukin-2 (IL-2) (T-cell growth factor) (TCGF) (Aldesleukin) IL2 Homo sapiens (Human) 153

Small molecules tested in IL-2 binding assays:

52 datapoints for 48 distinct small molecules


Name Ro26-4550
Affinity IC50 (SPA) 3uM at pH 7.4
Assay description Scintilantion Proximity competitive BINDING Assay. Measurament of labeled 125Iode-IL2 to immobilized IL2Ra in presence of varios conc of Inh
-- Direct single protein target assigned: IL2_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/ja970702x
Doc title Identification of a Small Molecule Inhibitor of the IL-2/IL-2Ra Receptor Interaction Which Binds to IL-2
PDB 1M48 - (FRG)

Name Enantiomer Ro26-4550 (IA)
Affinity 14%Inh(@500uM) IA; 14% @ 500uM
Assay description Scintilantion Proximity competitive BINDING Assay. Measurament of labeled 125Iode-IL2 to immobilized IL2Ra in presence of varios conc of Inh
-- Direct single protein target assigned: IL2_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/ja970702x
Doc title Identification of a Small Molecule Inhibitor of the IL-2/IL-2Ra Receptor Interaction Which Binds to IL-2
PDB 1M48 - (FRG)

Name JMC47_2
Affinity IC50 SPA 2.2mM
Assay description Scintilantion Proximity competitive BINDING Assay. Measurament of labeled 125Iode-IL2 to immobilized IL2Ra in presence of varios conc of Inh
-- Direct single protein target assigned: IL2_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm049967u
Doc title Lymphocyte-transformation test in drug allergy.
PDB None

Name JMC47_3
Affinity >>10mM IA; >10mM
Assay description Scintilantion Proximity competitive BINDING Assay. Measurament of labeled 125Iode-IL2 to immobilized IL2Ra in presence of varios conc of Inh
-- Direct single protein target assigned: IL2_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm049967u
Doc title Lymphocyte-transformation test in drug allergy.
PDB None

Name JMC47_15e
Affinity IC50 SPA 10uM
Assay description Scintilantion Proximity competitive BINDING Assay. Measurament of labeled 125Iode-IL2 to immobilized IL2Ra in presence of varios conc of Inh
-- Direct single protein target assigned: IL2_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm049967u
Doc title Lymphocyte-transformation test in drug allergy.
PDB 1PW6 - (FRB)

Name JMC47_33i
Affinity IC50 SPA 60nM
Assay description Scintilantion Proximity competitive BINDING Assay. Measurament of labeled 125Iode-IL2 to immobilized IL2Ra in presence of varios conc of Inh
-- Direct single protein target assigned: IL2_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm049967u
Doc title Lymphocyte-transformation test in drug allergy.
PDB 1PY2 - (FRH)

Name SP1985
Affinity None
Assay description None
-- Direct single protein target assigned: IL2_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1073/pnas.252756299
Doc title Binding of small molecules to an adaptive protein-protein interface.
PDB 1M49 - (CMM)

Name CHEMBL104059
Affinity IC50 = 1200uM
Assay description Inhibition of mouse interleukin-2 alpha receptor by ELISA
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL104086
Affinity IC50 = 720uM
Assay description Inhibition of mouse interleukin-2 alpha receptor by ELISA
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL104564
Affinity IC50 = 900uM
Assay description Inhibition of mouse interleukin-2 alpha receptor by ELISA
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL104594
Affinity IC50 = 0.2uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL104746
Affinity IC50 = 20uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL104791
Affinity IC50 = 50uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL104914
Affinity IC50 = 40uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL105023
Affinity IC50 = 500uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL105251
Affinity IC50 = 400uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL105518
Affinity IC50 = 150uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL105741
Affinity IC50 = 2.2mM
Assay description Inhibition of mouse Interleukin-2 receptor alpha
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL105741
Affinity KdSPA ~ 1.5mM
Assay description Dissociation constant for mouse Interleukin-2 receptor alpha by SPR assay
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL105780
Affinity IC50 = 8.1uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL106187
Affinity IC50 = 10uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL106262
Affinity IC50 = 40uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL106316
Affinity IC50 = 280uM
Assay description Inhibition of mouse interleukin-2 alpha receptor by ELISA
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL106368
Affinity IC50 = 130uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL106518
Affinity IC50 = 10uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL106672
Affinity IC50 = 150uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL106698
Affinity IC50 = 120uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL106951
Affinity IC50 = 0.6uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL107011
Affinity IC50 ~ 2000uM
Assay description Inhibition of mouse interleukin-2 alpha receptor by ELISA
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL107320
Affinity IC50 = 2uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL107320
Affinity EC50 ~ 30nM
Assay description Effective concentration required against mouse Interleukin-2 alpha receptor
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL107371
Affinity IC50 = 20uM
Assay description Inhibition of mouse interleukin-2 alpha receptor by ELISA
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL107570
Affinity IC50 >> 10mM
Assay description Inhibition of mouse Interleukin-2 receptor alpha
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL107685
Affinity IC50 = 50uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL107739
Affinity IC50 = 30uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL108123
Affinity IC50 = 0.4uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL108470
Affinity IC50 = 37uM
Assay description Inhibition of mouse interleukin-2 alpha receptor by ELISA
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL1790808
Affinity IC50 = 26uM
Assay description Inhibition of mouse interleukin-2 alpha receptor by ELISA
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL265306
Affinity IC50 = 35uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL317898
Affinity IC50 = 9uM
Assay description Inhibition of mouse interleukin-2 alpha receptor by ELISA
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL318396
Affinity IC50 = 80uM
Assay description Inhibition of mouse interleukin-2 alpha receptor by ELISA
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL320692
Affinity IC50 = 1000uM
Assay description Inhibition of mouse interleukin-2 alpha receptor by ELISA
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL321540
Affinity IC50 = 110uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL419362
Affinity IC50 = 6uM
Assay description Inhibition of mouse Interleukin-2 receptor alpha
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL419362
Affinity KdSPR = 22uM
Assay description Dissociation constant for mouse Interleukin-2 receptor alpha by SPR assay
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL420283
Affinity IC50 = 130uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL420478
Affinity IC50 > 2000uM
Assay description Inhibition of mouse interleukin-2 alpha receptor by ELISA
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL421412
Affinity IC50 = 3.5uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL429852
Affinity IC50 = 0.06uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL429852
Affinity Ki = 60nM
Assay description Binding affinity to IL2 assessed as inhibition of IL2-IL2Ralpha interaction
-- Homologous single protein target assigned: IL2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18075579
Doc title Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
PDB 1PY2 - (FRH)

Name CHEMBL429868
Affinity IC50 > 2000uM
Assay description Inhibition of mouse interleukin-2 alpha receptor by ELISA
-- Direct protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

Name CHEMBL449094
Affinity IC50 = 50uM
Assay description Concentration required to inhibit mouse interleukin-2 alpha receptor was determined by SPA assay
-- Homologous protein complex subunits assigned: IL2RA_MOUSE (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15163192
Doc title Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions.
PDB None

19 PDB entries for IL-2 and its protein partners


1IRL
The solution structure of the F42A mutant of human interleukin 2.

Entity type Code Description
polypeptide(L) P60568 INTERLEUKIN-2

1M47
Binding of small molecules to an adaptive protein-protein interface

Entity type Code Description
polypeptide(L) P60568 interleukin-2

1M48
Binding of small molecules to an adaptive protein-protein interface

Entity type Code Description
polypeptide(L) P60568 interleukin-2
Ligand FRG 2-[3-METHYL-4-(N-METHYL-GUANIDINO)-BUTYRYLAMINO]-3-(4-PHENYLETHYNYL-PHENYL)-PROPIONIC ACID METHYL ESTER

1M49
Binding of small molecules to an adaptive protein-protein interface

Entity type Code Description
polypeptide(L) P60568 interleukin-2
Ligand CMM 2-[2-(1-CARBAMIMIDOYL-PIPERIDIN-3-YL)-ACETYLAMINO]-3-{4-[2-(3-OXALYL-1H-INDOL-7-YL)ETHYL]-PHENYL}-PROPIONIC ACID METHYL ESTER

1M4A
Binding of small molecules to an adaptive protein-protein interface

Entity type Code Description
polypeptide(L) P60568 interleukin-2
Ligand MPE (1H-INDOL-3-YL)-(2-MERCAPTO-ETHOXYIMINO)-ACETIC ACID

1M4B
Binding of small molecules to an adaptive protein-protein interface

Entity type Code Description
polypeptide(L) P60568 interleukin-2
Ligand NMP 2-[2-(2-CYCLOHEXYL-2-GUANIDINO-ACETYLAMINO)-ACETYLAMINO]-N-(3-MERCAPTO-PROPYL)-PROPIONAMIDE

1M4C
Binding of small molecules to an adaptive protein-protein interface

Entity type Code Description
polypeptide(L) P60568 interleukin-2

1NBP
Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2

Entity type Code Description
polypeptide(L) P60568 Interleukin-2
Ligand MHC 3-MERCAPTO-1-(1,3,4,9-TETRAHYDRO-B-CARBOLIN-2-YL)-PROPAN-1-ONE

1PW6
Potent small-molecule binding to a dynamic hot spot on IL-2.

Entity type Code Description
polypeptide(L) P60568 Interleukin-2
Ligand FRB 2-CYCLOHEXYL-N-(2-{4-[5-(2,3-DICHLORO-PHENYL)-2H-PYRAZOL-3-YL]-PIPERIDIN-1-YL}-2-OXO-ETHYL)-2-GUANIDINO-ACETAMIDE

1PY2
Potent small-molecule binding to a dynamic hot spot on IL-2.

Entity type Code Description
polypeptide(L) P60568 Interleukin-2
Ligand FRH 5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-PENTANOYLAMINO)-ACETYL]-PIPERIDIN-4-YL}-1-METHYL-1H-PYRAZOL-3-YL)-PHENOXYMETHYL]-FURAN-2-CARBOXYLIC ACID

1QVN
Hot-spot mimicry of a cytokine receptor by a small molecule.

Entity type Code Description
polypeptide(L) P60568 Interleukin-2
Ligand FRI 2-GUANIDINO-4-METHYL-PENTANOIC ACID [2-(4-{5-[4-(4-ACETYLAMINO-BENZYLOXY)-2,3-DICHLORO-PHENYL]-2-METHYL-2H-PYRAZOL-3-YL}-PIPERIDIN-1-YL)-2-OXO-ETHYL]-AMIDE

1Z92
The structure of interleukin-2 complexed with its alpha receptor.

Entity type Code Description
polypeptide(L) P60568 Interleukin-2
polypeptide(L) P01589 Interleukin-2 receptor alpha chain

2B5I
Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.

Entity type Code Description
polypeptide(L) P60568 Interleukin-2
polypeptide(L) P14784 Interleukin-2 receptor beta chain
polypeptide(L) P31785 Cytokine receptor common gamma chain
polypeptide(L) P01589 Interleukin-2 receptor alpha chain
Ligand None SUGAR (NAG-NAG)
Ligand NAG SUGAR (N-ACETYL-D-GLUCOSAMINE)

2ERJ
Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor.

Entity type Code Description
polypeptide(L) P01589 Interleukin-2 receptor alpha chain
Ligand None SUGAR (3-MER)
polypeptide(L) P14784 Interleukin-2 receptor beta chain
polypeptide(L) P31785 Cytokine receptor common gamma chain
polypeptide(L) P60568 Interleukin-2
Ligand None SUGAR (4-MER)
Ligand None SUGAR (2-MER)
Ligand None SUGAR (3-MER)
Ligand None SUGAR (2-MER)
Ligand NAG SUGAR (N-ACETYL-D-GLUCOSAMINE)

3INK
Unraveling the structure of IL-2.

Entity type Code Description
polypeptide(L) P60568 INTERLEUKIN-2

3IU3
Structural basis for the blockage of IL-2 signaling by therapeutic antibody basiliximab

Entity type Code Description
polypeptide(L) 3IU3 Heavy chain of Fab fragment of Basiliximab
polypeptide(L) 3IU3 Light chain of Fab fragment of Basiliximab
polypeptide(L) P01589 Interleukin-2 receptor alpha chain
Ligand None SUGAR (3-MER)

3NFP
Structural basis of immunosuppression by the therapeutic antibody daclizumab

Entity type Code Description
polypeptide(L) 3NFP Heavy chain of Fab fragment of daclizumab
polypeptide(L) 3NFP Light chain of Fab fragment of daclizumab
polypeptide(L) P01589 Interleukin-2 receptor subunit alpha

3QAZ
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

Entity type Code Description
polypeptide(L) P60568 Interleukin-2
polypeptide(L) P14784 Interleukin-2 receptor subunit beta
polypeptide(L) P31785 Cytokine receptor common subunit gamma
Ligand NAG SUGAR (N-ACETYL-D-GLUCOSAMINE)

3QB1
Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'

Entity type Code Description
polypeptide(L) P60568 Interleukin-2