Integrins

Integrin alpha and beta subunits

Reviewed UniProt entries for Integrins and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
O75578 ITA10_HUMAN Integrin alpha-10 ITGA10 UNQ468/PRO827 Homo sapiens (Human) 1167
Q9UKX5 ITA11_HUMAN Integrin alpha-11 ITGA11 MSTP018 Homo sapiens (Human) 1188
P61622 ITA11_MOUSE Integrin alpha-11 Itga11 Mus musculus (Mouse) 1188
Q90615 ITA1_CHICK Integrin alpha-1 (Laminin and collagen receptor) (VLA-1) (Fragment) ITGA1 Gallus gallus (Chicken) 285
P56199 ITA1_HUMAN Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) ITGA1 Homo sapiens (Human) 1179
Q3V3R4 ITA1_MOUSE Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) Itga1 Mus musculus (Mouse) 1179
P18614 ITA1_RAT Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) Itga1 Rattus norvegicus (Rat) 1180
P08514 ITA2B_HUMAN Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain; form 1; Integrin alpha-IIb light chain; form 2] ITGA2B GP2B ITGAB Homo sapiens (Human) 1039
Q9QUM0 ITA2B_MOUSE Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain] Itga2b Mus musculus (Mouse) 1033
P53711 ITA2B_PAPCY Integrin alpha-IIb (GPalpha IIb) (GPIIb) (Platelet membrane glycoprotein IIb) (CD antigen CD41) [Cleaved into: Integrin alpha-IIb heavy chain; Integrin alpha-IIb light chain] (Fragment) ITGA2B Papio cynocephalus (Yellow baboon) 604
P53710 ITA2_BOVIN Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) (Fragment) ITGA2 Bos taurus (Bovine) 1170
P17301 ITA2_HUMAN Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) ITGA2 CD49B Homo sapiens (Human) 1181
Q62469 ITA2_MOUSE Integrin alpha-2 (CD49 antigen-like family member B) (Collagen receptor) (Platelet membrane glycoprotein Ia) (GPIa) (VLA-2 subunit alpha) (CD antigen CD49b) Itga2 Mus musculus (Mouse) 1178
F1MMS9 ITA3_BOVIN Integrin alpha-3 (CD49 antigen-like family member C) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] ITGA3 Bos taurus (Bovine) 1050
P17852 ITA3_CRIGR Integrin alpha-3 (CD49 antigen-like family member C) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] ITGA3 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 1051
P26006 ITA3_HUMAN Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] ITGA3 MSK18 Homo sapiens (Human) 1051
Q62470 ITA3_MOUSE Integrin alpha-3 (CD49 antigen-like family member C) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain] Itga3 Mus musculus (Mouse) 1053
Q91687 ITA4_XENLA Integrin alpha-4 (Integrin alpha-IV) (VLA-4 subunit alpha) itga4 Xenopus laevis (African clawed frog) 1032
Q27977 ITA5_BOVIN Integrin alpha-5 (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] (Fragment) ITGA5 Bos taurus (Bovine) 385
P08648 ITA5_HUMAN Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] ITGA5 FNRA Homo sapiens (Human) 1049
P11688 ITA5_MOUSE Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] Itga5 Mus musculus (Mouse) 1053
Q06274 ITA5_XENLA Integrin alpha-5 (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] itga5 Xenopus laevis (African clawed frog) 1050
P26007 ITA6_CHICK Integrin alpha-6 (VLA-6) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain] ITGA6 Gallus gallus (Chicken) 1072
P05106 ITB3_HUMAN Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) ITGB3 GP3A Homo sapiens (Human) 788
P23229 ITA6_HUMAN Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain] ITGA6 Homo sapiens (Human) 1130
Q61739 ITA6_MOUSE Integrin alpha-6 (CD49 antigen-like family member F) (VLA-6) (CD antigen CD49f) [Cleaved into: Integrin alpha-6 heavy chain; Integrin alpha-6 light chain] Itga6 Mus musculus (Mouse) 1091
Q13683 ITA7_HUMAN Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form] ITGA7 UNQ406/PRO768 Homo sapiens (Human) 1181
Q61738 ITA7_MOUSE Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain] Itga7 Mus musculus (Mouse) 1179
Q63258 ITA7_RAT Integrin alpha-7 (H36-alpha7) [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form] Itga7 Rattus norvegicus (Rat) 1135
P26009 ITA8_CHICK Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] ITGA8 Gallus gallus (Chicken) 1044
P53708 ITA8_HUMAN Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] ITGA8 Homo sapiens (Human) 1063
A2ARA8 ITA8_MOUSE Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain] Itga8 Mus musculus (Mouse) 1062
Q13797 ITA9_HUMAN Integrin alpha-9 (Integrin alpha-RLC) ITGA9 Homo sapiens (Human) 1035
P12606 ITB1A_XENLA Integrin beta-1-A itgb1-a Xenopus laevis (African clawed frog) 798
P12607 ITB1B_XENLA Integrin beta-1-B (Integrin beta-1*) itgb1-b Xenopus laevis (African clawed frog) 798
P53712 ITB1_BOVIN Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 Bos taurus (Bovine) 798
A5Z1X6 ITB1_CAMBA Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 Camelus bactrianus (Bactrian camel) 798
P07228 ITB1_CHICK Integrin beta-1 (CSAT antigen) (JG22 antigen) (RGD-receptor) ITGB1 Gallus gallus (Chicken) 803
P53713 ITB1_FELCA Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 Felis catus (Cat) (Felis silvestris catus) 798
P05556 ITB1_HUMAN Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 FNRB MDF2 MSK12 Homo sapiens (Human) 798
P09055 ITB1_MOUSE Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29) Itgb1 Mus musculus (Mouse) 798
Q9GLP0 ITB1_PIG Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 Sus scrofa (Pig) 798
Q5RCA9 ITB1_PONAB Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 Pongo abelii (Sumatran orangutan) 798
B0FYY4 ITB1_SHEEP Integrin beta-1 (Fibronectin receptor subunit beta) (Integrin subunit beta-1) (VLA-4 subunit beta) (CD antigen CD29) ITGB1 Ovis aries (Sheep) 798
P32592 ITB2_BOVIN Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150;95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) ITGB2 CD18 Bos taurus (Bovine) 769
Q5VI41 ITB2_CAPHI Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150;95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) ITGB2 CD18 Capra hircus (Goat) 770
P05107 ITB2_HUMAN Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150;95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) ITGB2 CD18 MFI7 Homo sapiens (Human) 769
Q2VJ42 ITB2_OVICA Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150;95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) ITGB2 CD18 Ovis canadensis (Bighorn sheep) 770
P53714 ITB2_PIG Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150;95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) ITGB2 CD18 Sus scrofa (Pig) 769
Q6ECI6 ITB2_SHEEP Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150;95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) ITGB2 CD18 Ovis aries (Sheep) 770
Q09062 ITB2_XENLA Integrin beta-2 (Fragment) itgb2 Xenopus laevis (African clawed frog) 77
O54890 ITB3_MOUSE Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61) Itgb3 Mus musculus (Mouse) 787
P16144 ITB4_HUMAN Integrin beta-4 (GP150) (CD antigen CD104) ITGB4 Homo sapiens (Human) 1822
A2A863 ITB4_MOUSE Integrin beta-4 (CD antigen CD104) Itgb4 Mus musculus (Mouse) 1818
Q64632 ITB4_RAT Integrin beta-4 (GP150) (CD antigen CD104) Itgb4 Rattus norvegicus (Rat) 1807
P80747 ITB5_BOVIN Integrin beta-5 ITGB5 Bos taurus (Bovine) 800
P18084 ITB5_HUMAN Integrin beta-5 ITGB5 Homo sapiens (Human) 799
O70309 ITB5_MOUSE Integrin beta-5 Itgb5 Mus musculus (Mouse) 798
Q07441 ITB5_PAPCY Integrin beta-5 (Fragment) ITGB5 Papio cynocephalus (Yellow baboon) 655
Q8SQB8 ITB6_BOVIN Integrin beta-6 ITGB6 Bos taurus (Bovine) 788
P18563 ITB6_CAVPO Integrin beta-6 (Fragment) ITGB6 Cavia porcellus (Guinea pig) 577
P18564 ITB6_HUMAN Integrin beta-6 ITGB6 Homo sapiens (Human) 788
Q9Z0T9 ITB6_MOUSE Integrin beta-6 Itgb6 Mus musculus (Mouse) 787
Q1RPR6 ITB6_PIG Integrin beta-6 ITGB6 Sus scrofa (Pig) 788
Q6AYF4 ITB6_RAT Integrin beta-6 Itgb6 Rattus norvegicus (Rat) 787
Q863C4 ITB6_SHEEP Integrin beta-6 ITGB6 Ovis aries (Sheep) 787
P26010 ITB7_HUMAN Integrin beta-7 (Gut homing receptor beta subunit) ITGB7 Homo sapiens (Human) 798
P26011 ITB7_MOUSE Integrin beta-7 (Integrin beta-P) (M290 IEL antigen) Itgb7 Mus musculus (Mouse) 806
P26012 ITB8_HUMAN Integrin beta-8 ITGB8 Homo sapiens (Human) 769
P26013 ITB8_RABIT Integrin beta-8 ITGB8 Oryctolagus cuniculus (Rabbit) 768
P13612 ITA4_HUMAN Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d) ITGA4 CD49D Homo sapiens (Human) 1032
P49134 ITB1_RAT Integrin beta-1 (Beta oligodendroglia) (Beta OL) (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29) Itgb1 Rattus norvegicus (Rat) 799
Q00651 ITA4_MOUSE Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (Lymphocyte Peyer patch adhesion molecules subunit alpha) (LPAM subunit alpha) (VLA-4 subunit alpha) (CD antigen CD49d) Itga4 Mus musculus (Mouse) 1039
P11835 ITB2_MOUSE Integrin beta-2 (Cell surface adhesion glycoproteins LFA-1/CR3/p150;95 subunit beta) (Complement receptor C3 subunit beta) (CD antigen CD18) Itgb2 Mus musculus (Mouse) 771

Small molecules tested in Integrins binding assays:

9790 datapoints for 3708 distinct small molecules


Name CHEMBL100151
Affinity Ki = 5.1nM
Assay description Binding affinity towards vitronectin receptor (AlphaV-beta3 integrin).
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15125957
Doc title N-Aryl-gamma-lactams as integrin alphavbeta3 antagonists.
PDB None

Name CHEMBL100164
Affinity IC50 = 34.9nM
Assay description Inhibitory activity against alpha4-beta1 integrin (vascular celladhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100164
Affinity IC50 = 55.9nM
Assay description Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosaladdressin cell adhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100164
Affinity IC50 = 55.9nM
Assay description Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosaladdressin cell adhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITB7_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100164
Affinity IC50 = 34.9nM
Assay description Inhibitory activity against alpha4-beta1 integrin (vascular celladhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100242
Affinity IC50 = 103000nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100242
Affinity IC50 = 103000nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100246
Affinity IC50 > 10000nM
Assay description Displacement of a non-peptide radioligand from human recombinant alphaV-beta3 integrin
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738566
Doc title Nonpeptide alpha(v)beta(3) antagonists. Part 2: constrained glycyl amides derived from the RGD tripeptide.
PDB None

Name CHEMBL100277
Affinity IC50 = 15uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL100277
Affinity IC50 = 15uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL100339
Affinity IC50 = 3uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL100339
Affinity IC50 = 3uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL100417
Affinity Ki = 52.7nM
Assay description Binding affinity towards vitronectin receptor (AlphaV-beta3 integrin).
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15125957
Doc title N-Aryl-gamma-lactams as integrin alphavbeta3 antagonists.
PDB None

Name CHEMBL100479
Affinity IC50 = 10nM
Assay description Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosaladdressin cell adhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100479
Affinity IC50 = 25nM
Assay description Inhibitory activity against alpha4-beta1 integrin (vascular celladhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100479
Affinity IC50 = 25nM
Assay description Inhibitory activity against alpha4-beta1 integrin (vascular celladhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100479
Affinity IC50 = 10nM
Assay description Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosaladdressin cell adhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITB7_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100489
Affinity IC50 = 604nM
Assay description Inhibitory activity against alpha4-beta1 integrin (vascular celladhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100489
Affinity IC50 = 604nM
Assay description Inhibitory activity against alpha4-beta1 integrin (vascular celladhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100489
Affinity IC50 = 1320nM
Assay description Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosaladdressin cell adhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100489
Affinity IC50 = 1320nM
Assay description Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosaladdressin cell adhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITB7_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL10051
Affinity IC50 = 0.3nM
Assay description Displacement of [125I]L-775,219 from human recombinant alphaV-beta3 integrin
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15013021
Doc title Non-peptide alpha v beta 3 antagonists. Part 7: 3-Substituted tetrahydro-naphthyridine derivatives.
PDB None

Name CHEMBL100519
Affinity IC50 = 24.5nM
Assay description Inhibition of fluorescent Ramos cell adhesion to VCAM-1 by rat Very late antigen 4 (VLA-4) integrin
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100519
Affinity IC50 = 21.7nM
Assay description Inhibition of fluorescent Ramos cell adhesion to VCAM-1 by mouse Very late antigen 4 (VLA-4) integrin
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100519
Affinity IC50 = 11.7nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100519
Affinity IC50 > 100000nM
Assay description Inhibition of fluorescent Ramos cell adhesion to VCAM-1 by alpha4-beta7 integrin
-- Direct protein complex subunits assigned: ITB7_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100519
Affinity IC50 = 24.5nM
Assay description Inhibition of fluorescent Ramos cell adhesion to VCAM-1 by rat Very late antigen 4 (VLA-4) integrin
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100519
Affinity IC50 = 11.7nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100519
Affinity IC50 = 14.4nM
Assay description Inhibition of fluorescent Ramos cell adhesion to fibronectin by Very late antigen 4 (VLA-4)
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100519
Affinity IC50 = 14.4nM
Assay description Inhibition of fluorescent Ramos cell adhesion to fibronectin by Very late antigen 4 (VLA-4)
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100519
Affinity IC50 = 21.7nM
Assay description Inhibition of fluorescent Ramos cell adhesion to VCAM-1 by mouse Very late antigen 4 (VLA-4) integrin
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100519
Affinity IC50 > 100000nM
Assay description Inhibition of fluorescent Ramos cell adhesion to VCAM-1 by alpha4-beta7 integrin
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100665
Affinity IC50 = 7300nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100665
Affinity IC50 = 7300nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100767
Affinity IC50 = 11.3nM
Assay description Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosaladdressin cell adhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITB7_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100767
Affinity IC50 = 11.3nM
Assay description Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosaladdressin cell adhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100767
Affinity IC50 = 16.8nM
Assay description Inhibitory activity against alpha4-beta1 integrin (vascular celladhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100767
Affinity IC50 = 16.8nM
Assay description Inhibitory activity against alpha4-beta1 integrin (vascular celladhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100782
Affinity IC50 = 18nM
Assay description Inhibitory activity against alpha4-beta1 integrin (vascular celladhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100782
Affinity IC50 = 18nM
Assay description Inhibitory activity against alpha4-beta1 integrin (vascular celladhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100782
Affinity IC50 = 170nM
Assay description Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosaladdressin cell adhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100782
Affinity IC50 = 170nM
Assay description Inhibitory activity against alpha4-beta7/ MAdCAM integrin (mucosaladdressin cell adhesion molecule) in ELISA assay
-- Homologous protein complex subunits assigned: ITB7_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12270174
Doc title Solid-phase synthesis of dual alpha4beta1/alpha4beta7 integrin antagonists: two scaffolds with overlapping pharmacophores.
PDB None

Name CHEMBL100886
Affinity IC50 > 500000nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL100886
Affinity IC50 > 500000nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL10107
Affinity IC50 = 320nM
Assay description Inhibition of binding of Very late antigen 4/vascular cell adhesion molecule 1 in a cell based ligand binding assay (Jurkat cells)
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11909715
Doc title Squaric acid derivatives as VLA-4 integrin antagonists.
PDB None

Name CHEMBL10107
Affinity IC50 = 3.7nM
Assay description Inhibition of binding of Very late antigen 4/vascular cell adhesion molecule 1 in a protein-based ligand binding assay
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11909715
Doc title Squaric acid derivatives as VLA-4 integrin antagonists.
PDB None

Name CHEMBL10107
Affinity IC50 = 320nM
Assay description Inhibition of binding of Very late antigen 4/vascular cell adhesion molecule 1 in a cell based ligand binding assay (Jurkat cells)
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11909715
Doc title Squaric acid derivatives as VLA-4 integrin antagonists.
PDB None

Name CHEMBL10107
Affinity IC50 = 3.7nM
Assay description Inhibition of binding of Very late antigen 4/vascular cell adhesion molecule 1 in a protein-based ligand binding assay
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11909715
Doc title Squaric acid derivatives as VLA-4 integrin antagonists.
PDB None

Name CHEMBL101126
Affinity IC50 = 0.8uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL101126
Affinity IC50 = 0.8uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL101151
Affinity IC50 = 3nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL101151
Affinity IC50 = 3nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL101209
Affinity IC50 = 98nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL101209
Affinity IC50 = 98nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL101248
Affinity IC50 = 4.7uM
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 of Jurkat cells
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL101248
Affinity Inhibition = 96%
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 in Jurkat cells at 10 uM
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL101248
Affinity Inhibition = 96%
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 in Jurkat cells at 10 uM
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL101248
Affinity IC50 = 4.7uM
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 of Jurkat cells
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL101416
Affinity IC50 = 0.14uM
Assay description Ability to block the interaction between integrin LFA-1 and its adhesion partner ICAM-1 in a time-resolved fluorescent LFA-1/ICAM-1 biochemical interaction assay
-- Homologous protein complex subunits assigned: ITB2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11052808
Doc title Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead.
PDB None

Name CHEMBL101955
Affinity IC50 = 262000nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL101955
Affinity IC50 = 262000nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL102299
Affinity Inhibition = 100%
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 in Jurkat cells at 10 uM
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL102299
Affinity IC50 > 200uM
Assay description Inhibition of VCAM-1 binding to integrin alphaV-beta3 in Jurkat cells
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL102299
Affinity Inhibition = 100%
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 in Jurkat cells at 10 uM
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL102299
Affinity IC50 = 0.3uM
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 of Jurkat cells
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL102299
Affinity IC50 = 0.3uM
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 of Jurkat cells
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL102339
Affinity IC50 = 0.55uM
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 of Jurkat cells
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL102339
Affinity Inhibition = 98%
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 in Jurkat cells at 10 uM
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL102339
Affinity Inhibition = 98%
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 in Jurkat cells at 10 uM
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL102339
Affinity IC50 = 0.55uM
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 of Jurkat cells
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL102351
Affinity IC50 = 4.96uM
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 of Jurkat cells
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL102351
Affinity Inhibition = 99%
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 in Jurkat cells at 10 uM
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL102351
Affinity Inhibition = 99%
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 in Jurkat cells at 10 uM
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL102351
Affinity IC50 = 4.96uM
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 of Jurkat cells
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL103036
Affinity IC50 > 10uM
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 of Jurkat cells
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL103036
Affinity Inhibition = 25%
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 in Jurkat cells at 10 uM
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL103036
Affinity Inhibition = 25%
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 in Jurkat cells at 10 uM
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL103036
Affinity IC50 > 10uM
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 of Jurkat cells
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL103089
Affinity IC50 > 10uM
Assay description Inhibition of alpha IIb beta-3 integrin binding to fibrinogen
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10447947
Doc title N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists.
PDB None

Name CHEMBL103089
Affinity IC50 = 0.56uM
Assay description Inhibition of Vitronectin receptor (alpha V beta 3) binding to fibrinogen
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10447947
Doc title N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists.
PDB None

Name CHEMBL103089
Affinity IC50 > 10uM
Assay description Inhibition of alpha IIb beta-3 integrin binding to fibrinogen
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10447947
Doc title N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists.
PDB None

Name CHEMBL103214
Affinity IC50 = 0.00058uM
Assay description Inhibition of Vitronectin receptor (alpha V beta 3) binding to fibrinogen
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10447947
Doc title N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists.
PDB None

Name CHEMBL103214
Affinity IC50 = 0.86uM
Assay description Inhibition of alpha IIb beta-3 integrin binding to fibrinogen
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10447947
Doc title N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists.
PDB None

Name CHEMBL103214
Affinity IC50 = 0.86uM
Assay description Inhibition of alpha IIb beta-3 integrin binding to fibrinogen
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10447947
Doc title N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists.
PDB None

Name CHEMBL103301
Affinity IC50 = 11.4uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL103301
Affinity IC50 = 11.4uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL103417
Affinity IC50 = 11000nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL103417
Affinity IC50 = 11000nM
Assay description In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11677134
Doc title Design and synthesis of potent and selective inhibitors of integrin VLA-4.
PDB None

Name CHEMBL103432
Affinity IC50 = 0.0013uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL103432
Affinity IC50 = 0.0013uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL103502
Affinity IC50 = 2uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL103502
Affinity IC50 = 2uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL103513
Affinity Not Active
Assay description Displacement of vitronectin from alphaV-beta3 integrin in ELISA (Not active)
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11814816
Doc title Synthesis and SAR of N-substituted dibenzazepinone derivatives as novel potent and selective alpha(V)beta(3) antagonists.
PDB None

Name CHEMBL103539
Affinity IC50 = 2.5uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL103539
Affinity IC50 = 2.5uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL103602
Affinity IC50 = 0.067uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL103602
Affinity IC50 = 0.067uM
Assay description Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12086484
Doc title Identification of potent and novel alpha4beta1 antagonists using in silico screening.
PDB None

Name CHEMBL103992
Affinity Inhibition = 55%
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 in Jurkat cells at 10 uM
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL103992
Affinity IC50 = 7.2uM
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 of Jurkat cells
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL103992
Affinity IC50 = 7.2uM
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 of Jurkat cells
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL103992
Affinity Inhibition = 55%
Assay description Inhibition of VCAM-1 binding to integrin alpha4-beta1 in Jurkat cells at 10 uM
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11714601
Doc title Discovery and evaluation of piperidinyl carboxylic acid derivatives as potent alpha(4)beta(1) integrin antagonists.
PDB None

Name CHEMBL104518
Affinity IC50 > 10000nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL104518
Affinity IC50 > 10000nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL104534
Affinity Ki = 4.2uM
Assay description Tested for inhibition of fibrinogen binding to purified GPIIb/IIIa isolated from human platelets and reconstituted in liposomes
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8145226
Doc title Conformationally constrained peptides and semipeptides derived from RGD as potent inhibitors of the platelet fibrinogen receptor and platelet aggregation.
PDB None

Name CHEMBL104534
Affinity Ki = 4.2uM
Assay description Tested for inhibition of fibrinogen binding to purified GPIIb/IIIa isolated from human platelets and reconstituted in liposomes
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8145226
Doc title Conformationally constrained peptides and semipeptides derived from RGD as potent inhibitors of the platelet fibrinogen receptor and platelet aggregation.
PDB None

Name CHEMBL104556
Affinity Ki = 0.058uM
Assay description Inhibition of 125[I] Fibrinogen binding to isolated purified human fibrinogen receptor
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/1920361
Doc title Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro.
PDB None

Name CHEMBL104556
Affinity Ki = 0.058uM
Assay description Inhibition of 125[I] Fibrinogen binding to isolated purified human fibrinogen receptor
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/1920361
Doc title Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro.
PDB None

Name CHEMBL105553
Affinity IC50 > 10uM
Assay description Inhibition of alpha IIb beta-3 integrin binding to fibrinogen
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10447947
Doc title N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists.
PDB None

Name CHEMBL105553
Affinity IC50 > 10uM
Assay description Inhibition of alpha IIb beta-3 integrin binding to fibrinogen
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10447947
Doc title N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists.
PDB None

Name CHEMBL105553
Affinity IC50 = 0.045uM
Assay description Inhibition of Vitronectin receptor (alpha V beta 3) binding to fibrinogen
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10447947
Doc title N-Methylated cyclic RGD peptides as highly active and selective alpha(V)beta(3) integrin antagonists.
PDB None

Name CHEMBL105814
Affinity Ki = 28nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL105934
Affinity Ki = 30nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL106036
Affinity Ki = 4nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL106059
Affinity IC50 = 900nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL106059
Affinity IC50 = 900nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL106349
Affinity IC50 = 90nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL106349
Affinity IC50 = 90nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL106456
Affinity Ki = 5.5nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL106500
Affinity IC50 > 10000nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL106500
Affinity IC50 > 10000nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL10675
Affinity Ki = 210nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL106763
Affinity Ki = 5nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL106763
Affinity Ki = 2750nM
Assay description Affinity for alphaIIb-beta3 receptor
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL106763
Affinity Ki = 2750nM
Assay description Affinity for alphaIIb-beta3 receptor
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL106838
Affinity IC50 > 8000nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL106838
Affinity IC50 > 8000nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL106947
Affinity IC50 > 10000nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL106947
Affinity IC50 > 10000nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL107009
Affinity Ki = 0.78uM
Assay description Tested for inhibition of fibrinogen binding to purified GPIIb/IIIa isolated from human platelets and reconstituted in liposomes
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8145226
Doc title Conformationally constrained peptides and semipeptides derived from RGD as potent inhibitors of the platelet fibrinogen receptor and platelet aggregation.
PDB None

Name CHEMBL107009
Affinity Ki = 0.78uM
Assay description Inhibition of 125[I] Fibrinogen binding to isolated purified human fibrinogen receptor
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/1920361
Doc title Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro.
PDB None

Name CHEMBL107009
Affinity Ki = 0.78uM
Assay description Tested for inhibition of fibrinogen binding to purified GPIIb/IIIa isolated from human platelets and reconstituted in liposomes
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8145226
Doc title Conformationally constrained peptides and semipeptides derived from RGD as potent inhibitors of the platelet fibrinogen receptor and platelet aggregation.
PDB None

Name CHEMBL107009
Affinity Ki = 0.78uM
Assay description Inhibition of 125[I] Fibrinogen binding to isolated purified human fibrinogen receptor
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/1920361
Doc title Development of a small RGD peptide fibrinogen receptor antagonist with potent antiaggregatory activity in vitro.
PDB None

Name CHEMBL10708
Affinity Ki = 74nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL10709
Affinity Ki = 300nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL107130
Affinity IC50 > 10000nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL107130
Affinity IC50 > 10000nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL10718
Affinity Ki = 170nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL107279
Affinity IC50 = 51nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL107279
Affinity IC50 = 51nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL10735
Affinity Ki = 80nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL10737
Affinity Ki = 1nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL107449
Affinity IC50 > 10000nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL107449
Affinity IC50 > 10000nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL107471
Affinity IC50 = 594nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL107471
Affinity IC50 = 594nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL1077191
Affinity IC50 = 0.7nM
Assay description Inhibition of human Integrin alpha5beta3 receptors expressed in HOP cells assessed as cell attachment after 30 mins by colorimetric assay
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20172716
Doc title Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation.
PDB None

Name CHEMBL1077191
Affinity IC50 = 0.7nM
Assay description Inhibition of human Integrin alpha5beta3 receptors expressed in HOP cells assessed as cell attachment after 30 mins by colorimetric assay
-- Direct protein complex subunits assigned: ITA5_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20172716
Doc title Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation.
PDB None

Name CHEMBL1077192
Affinity IC50 = 0.3nM
Assay description Inhibition of human Integrin alpha5beta3 receptors expressed in HOP cells assessed as cell attachment after 30 mins by colorimetric assay
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20172716
Doc title Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation.
PDB None

Name CHEMBL1077192
Affinity IC50 = 0.3nM
Assay description Inhibition of human Integrin alpha5beta3 receptors expressed in HOP cells assessed as cell attachment after 30 mins by colorimetric assay
-- Direct protein complex subunits assigned: ITA5_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20172716
Doc title Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation.
PDB None

Name CHEMBL10784
Affinity Ki = 100nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL107983
Affinity Ki = 6nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL10803
Affinity Ki = 8nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL10805
Affinity Ki = 100nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL10811
Affinity Ki = 128nM
Assay description Binding affinity to GP2b3a receptor
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17910915
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides.
PDB None

Name CHEMBL10811
Affinity Ki = 2.5nM
Assay description Binding affinity to integrin alpha-v-beta-3 receptor
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17910915
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides.
PDB None

Name CHEMBL10811
Affinity Ki = 2.5nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL10811
Affinity Ki = 128nM
Assay description Binding affinity to GP2b3a receptor
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17910915
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides.
PDB None

Name CHEMBL108111
Affinity IC50 = 1.4nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL108111
Affinity IC50 = 1.4nM
Assay description Inhibition of FG binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8759635
Doc title Orally active fibrinogen receptor antagonists. 2. Amidoximes as prodrugs of amidines.
PDB None

Name CHEMBL10820
Affinity Ki = 900nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL108366
Affinity Ki = 6.5nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL1083695
Affinity IC50 = 0.19nM
Assay description Inhibition of integrin alphaVbeta3
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20218623
Doc title Emerging targets in osteoporosis disease modification.
PDB None

Name CHEMBL1083695
Affinity INH = 0.44nM
Assay description Inhibition of integrin alpha2Bbeta3
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20218623
Doc title Emerging targets in osteoporosis disease modification.
PDB None

Name CHEMBL1083695
Affinity INH = 0.44nM
Assay description Inhibition of integrin alpha2Bbeta3
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20218623
Doc title Emerging targets in osteoporosis disease modification.
PDB None

Name CHEMBL1083696
Affinity IC50 = 304nM
Assay description Inhibition of integrin alphaVbeta3
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20218623
Doc title Emerging targets in osteoporosis disease modification.
PDB None

Name CHEMBL10837
Affinity Ki = 75nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL10839
Affinity Ki = 11nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL10839
Affinity Ki = 11nM
Assay description Binding affinity to integrin alpha-v-beta-3 receptor
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17910915
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 3: Squaric acid amides.
PDB None

Name CHEMBL108490
Affinity Ki = 1.6nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL108685
Affinity Ki = 2nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL108693
Affinity Ki = 15nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL10871
Affinity Ki = 850nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL10898
Affinity Ki = 120nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL109003
Affinity Ki = 4nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL10965
Affinity Ki = 500nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL109703
Affinity IC50 = 0.3nM
Assay description Displacement of vitronectin from human integrin alphaV-beta5
-- Direct protein complex subunits assigned: ITB5_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL109703
Affinity IC50 = 1495nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL109703
Affinity IC50 = 0.3nM
Assay description Displacement of vitronectin from Human integrin alphaV-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL109703
Affinity IC50 = 1495nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL109817
Affinity IC50 = 584nM
Assay description Displacement of vitronectin from Human integrin alphaV-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL109817
Affinity IC50 = 1700nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL109817
Affinity IC50 = 22nM
Assay description Displacement of vitronectin from human integrin alphaV-beta5
-- Direct protein complex subunits assigned: ITB5_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL109817
Affinity IC50 = 1700nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL1098726
Affinity INH = 0%
Assay description Inhibition of integrin alpha-2-beta-3-mediated aggregation in collagen-stimulated platelets at 30 uM
-- Homologous protein complex subunits assigned: ITA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405922
Doc title Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-tria zaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
PDB None

Name CHEMBL1098726
Affinity INH = 0%
Assay description Inhibition of integrin alpha-2-beta-3-mediated aggregation in ADP-stimulated platelets at 30 uM
-- Homologous protein complex subunits assigned: ITA2_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405922
Doc title Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-tria zaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
PDB None

Name CHEMBL1098726
Affinity INH = 0%
Assay description Inhibition of integrin alpha-2-beta-3-mediated aggregation in ADP-stimulated platelets at 30 uM
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405922
Doc title Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-tria zaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
PDB None

Name CHEMBL1098726
Affinity INH = 0%
Assay description Inhibition of VLA4-mediated human Jurkat cell adhesion to glycoprotein CS1 at 10 uM
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405922
Doc title Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-tria zaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
PDB None

Name CHEMBL1098726
Affinity INH = 0%
Assay description Inhibition of VLA4-mediated human Jurkat cell adhesion to glycoprotein CS1 at 10 uM
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405922
Doc title Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-tria zaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
PDB None

Name CHEMBL1098726
Affinity INH = 0%
Assay description Inhibition of integrin alpha-2-beta-3-mediated aggregation in collagen-stimulated platelets at 30 uM
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20405922
Doc title Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-tria zaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
PDB None

Name CHEMBL109930
Affinity IC50 = 330nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL109930
Affinity IC50 = 0.1nM
Assay description Displacement of vitronectin from human integrin alphaV-beta5
-- Direct protein complex subunits assigned: ITB5_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL109930
Affinity IC50 = 330nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL109930
Affinity IC50 = 0.2nM
Assay description Displacement of vitronectin from Human integrin alphaV-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL110039
Affinity IC50 > 100000nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL110039
Affinity IC50 = 20nM
Assay description Displacement of vitronectin from human integrin alphaV-beta5
-- Direct protein complex subunits assigned: ITB5_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL110039
Affinity IC50 = 45nM
Assay description Displacement of vitronectin from Human integrin alphaV-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL110039
Affinity IC50 > 100000nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL11007
Affinity Ki = 4nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL110083
Affinity Ki = 1300nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL110114
Affinity Ki = 20nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL110130
Affinity Ki = 14nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL11018
Affinity Ki = 800nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL110412
Affinity Ki = 8.5nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL110413
Affinity Ki = 2.5nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL110459
Affinity Ki = 47000nM
Assay description Affinity for alphaIIb-beta3 receptor
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL110459
Affinity Ki = 2900nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL110459
Affinity Ki = 47000nM
Assay description Affinity for alphaIIb-beta3 receptor
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL110517
Affinity Ki = 2.5nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL110722
Affinity Ki = 9nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL110920
Affinity Ki = 30000nM
Assay description Affinity for alphaIIb-beta3 receptor
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL110920
Affinity Ki = 1100nM
Assay description Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptor
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL110920
Affinity Ki = 30000nM
Assay description Affinity for alphaIIb-beta3 receptor
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873696
Doc title Benzimidazole derivatives as arginine mimetics in 1,4-benzodiazepine nonpeptide vitronectin receptor (alpha v beta 3) antagonists.
PDB None

Name CHEMBL110964
Affinity IC50 = 19uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL110964
Affinity IC50 = 0.1uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL110964
Affinity IC50 = 0.1uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL110964
Affinity IC50 = 19uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL11107
Affinity Ki = 4nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL111401
Affinity IC50 = 1200nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL111401
Affinity IC50 = 2.7nM
Assay description Displacement of vitronectin from Human integrin alphaV-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL111401
Affinity IC50 = 1200nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL111401
Affinity IC50 = 0.9nM
Assay description Displacement of vitronectin from human integrin alphaV-beta5
-- Direct protein complex subunits assigned: ITB5_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL111986
Affinity IC50 = 68nM
Assay description Displacement of vitronectin from Human integrin alphaV-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL111986
Affinity IC50 = 667nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL111986
Affinity IC50 = 40nM
Assay description Displacement of vitronectin from human integrin alphaV-beta5
-- Direct protein complex subunits assigned: ITB5_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL111986
Affinity IC50 = 667nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL11207
Affinity Ki = 14nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL112252
Affinity Not Active
Assay description Displacement of [125I]echistatin from alphaIIb-beta3 integrin of human platelets at 1 mM (Inactive)
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12565923
Doc title Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors.
PDB None

Name CHEMBL112252
Affinity Not Active
Assay description Displacement of [125I]echistatin from alphaIIb-beta3 integrin of human platelets at 1 mM (Inactive)
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12565923
Doc title Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors.
PDB None

Name CHEMBL112252
Affinity Not Active
Assay description Displacement of [125I]-echistatin from alphaV-beta3 integrin of human skin fibroblasts at 1 mM (Inactive)
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12565923
Doc title Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors.
PDB None

Name CHEMBL112321
Affinity IC50 = 210uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112321
Affinity IC50 = 210uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112321
Affinity IC50 = 4.2uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112321
Affinity IC50 = 4.2uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112619
Affinity IC50 = 1.1uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112619
Affinity IC50 = 40uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112619
Affinity IC50 = 40uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112619
Affinity IC50 = 1.1uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112675
Affinity IC50 = 0.2uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112675
Affinity IC50 = 0.2uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112675
Affinity IC50 = 0.004uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112675
Affinity IC50 = 0.004uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112936
Affinity IC50 = 6uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112936
Affinity IC50 = 210uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112936
Affinity IC50 = 6uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL112936
Affinity IC50 = 210uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL113063
Affinity IC50 = 0.5nM
Assay description Displacement of vitronectin from human integrin alphaV-beta5
-- Direct protein complex subunits assigned: ITB5_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL113063
Affinity IC50 = 1020nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL113063
Affinity IC50 = 0.6nM
Assay description Displacement of vitronectin from Human integrin alphaV-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL113063
Affinity IC50 = 1020nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL113100
Affinity IC50 = 80uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL113100
Affinity IC50 = 80uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL113100
Affinity IC50 = 3.7uM
Assay description Inhibition of alpha4-beta1 binding to VCAM-1 in ELISA.
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL113100
Affinity IC50 = 3.7uM
Assay description Inhibition of alpha4-beta1 binding to VCAM-1 in ELISA.
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL113277
Affinity IC50 = 198uM
Assay description Displacement of [125I]echistatin from alphaIIb-beta3 integrin of human platelets
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12565923
Doc title Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors.
PDB None

Name CHEMBL113277
Affinity IC50 = 597uM
Assay description Displacement of [125I]echistatin from alphaV-beta3 integrin of human skin fibroblasts
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12565923
Doc title Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors.
PDB None

Name CHEMBL113277
Affinity IC50 = 198uM
Assay description Displacement of [125I]echistatin from alphaIIb-beta3 integrin of human platelets
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12565923
Doc title Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors.
PDB None

Name CHEMBL113731
Affinity IC50 = 3.6uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL113731
Affinity IC50 = 3.6uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL113731
Affinity IC50 = 0.054uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL113731
Affinity IC50 = 0.054uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL113853
Affinity IC50 = 4360nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL113853
Affinity IC50 = 4360nM
Assay description Displacement of fibrinogen from Human integrin alphaIIb-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL113853
Affinity IC50 = 0.8nM
Assay description Displacement of vitronectin from human integrin alphaV-beta5
-- Direct protein complex subunits assigned: ITB5_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL113853
Affinity IC50 = 1.9nM
Assay description Displacement of vitronectin from Human integrin alphaV-beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12392735
Doc title Substituted benzocyloheptenes as potent and selective alpha(v) integrin antagonists.
PDB None

Name CHEMBL114151
Affinity IC50 = 15uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114151
Affinity IC50 = 0.42uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114151
Affinity IC50 = 0.42uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114151
Affinity IC50 = 15uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114362
Affinity IC50 = 0.31nM
Assay description Inhibition of high affinity radioligand binding to human alphaV-beta3 integrin
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL114362
Affinity Inhibition = 28%
Assay description Inhibition of ADP-stimulated alphaIIb-beta3 integrin mediated human platelet aggregation at 10 uM
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL114362
Affinity Inhibition = 28%
Assay description Inhibition of ADP-stimulated alphaIIb-beta3 integrin mediated human platelet aggregation at 10 uM
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL114369
Affinity IC50 = 10.5uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114369
Affinity IC50 = 0.034uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114369
Affinity IC50 = 0.034uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114369
Affinity IC50 = 10.5uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114391
Affinity IC50 = 1.65uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114391
Affinity IC50 = 1.65uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114391
Affinity IC50 = 120uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114391
Affinity IC50 = 120uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114418
Affinity IC50 = 0.29nM
Assay description Inhibition of high affinity radioligand binding to human alphaV-beta3 integrin
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL114418
Affinity Inhibition = 19%
Assay description Inhibition of ADP-stimulated alphaIIb-beta3 integrin mediated human platelet aggregation at 10 uM
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL114418
Affinity Inhibition = 19%
Assay description Inhibition of ADP-stimulated alphaIIb-beta3 integrin mediated human platelet aggregation at 10 uM
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL11447
Affinity Ki > 10000nM
Assay description Binding affinity towards vitronectin receptor (alpha V-beta3) was determined
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12643914
Doc title Biphenyls as potent vitronectin receptor antagonists. Part 2: biphenylalanine ureas.
PDB None

Name CHEMBL114486
Affinity IC50 = 2.8uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114486
Affinity IC50 = 2.8uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114486
Affinity IC50 = 182uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114486
Affinity IC50 = 182uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114489
Affinity IC50 = 0.008uM
Assay description Inhibition of alpha4-beta1 binding to VCAM-1 in ELISA.
-- Direct protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114489
Affinity IC50 = 0.008uM
Assay description Inhibition of alpha4-beta1 binding to VCAM-1 in ELISA.
-- Direct protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114533
Affinity Inhibition = 29%
Assay description Inhibition of ADP-stimulated alphaIIb-beta3 integrin mediated human platelet aggregation at 10 uM
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL114533
Affinity Inhibition = 29%
Assay description Inhibition of ADP-stimulated alphaIIb-beta3 integrin mediated human platelet aggregation at 10 uM
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL114533
Affinity IC50 = 2.2nM
Assay description Inhibition of high affinity radioligand binding to human alphaV-beta3 integrin
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL114579
Affinity IC50 = 22uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114579
Affinity IC50 = 22uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114583
Affinity IC50 = 0.41uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114583
Affinity IC50 = 17uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114583
Affinity IC50 = 0.41uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114583
Affinity IC50 = 17uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114685
Affinity IC50 = 1.1nM
Assay description Inhibition of high affinity radioligand binding to human alphaV-beta3 integrin
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL114685
Affinity Inhibition = 20%
Assay description Inhibition of ADP-stimulated alphaIIb-beta3 integrin mediated human platelet aggregation at 10 uM
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL114685
Affinity Inhibition = 20%
Assay description Inhibition of ADP-stimulated alphaIIb-beta3 integrin mediated human platelet aggregation at 10 uM
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL114736
Affinity IC50 = 230nM
Assay description Inhibition of high affinity radioligand binding to human alphaV-beta3 integrin
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL114767
Affinity IC50 = 4.7uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114767
Affinity IC50 = 4.7uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114767
Affinity IC50 = 0.02uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114767
Affinity IC50 = 0.02uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114882
Affinity IC50 = 1.5uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114882
Affinity IC50 = 1.5uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114882
Affinity IC50 = 0.14uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114882
Affinity IC50 = 0.14uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114889
Affinity IC50 = 18uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114889
Affinity IC50 = 18uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL114946
Affinity Ki = 0.1nM
Assay description Dissociation constant for [3H]-DMP728 binding to alphaIIb beta III integrin
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10999999
Doc title Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents.
PDB None

Name CHEMBL114946
Affinity IC50 > 10uM
Assay description Inhibition of alphaV-beta3 interaction with vitronectin
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/8893849
Doc title Synthesis and solution conformation of cyclo[RGDRGD]: a cyclic peptide with selectivity for the alpha V beta 3 receptor.
PDB None

Name CHEMBL114946
Affinity IC50 = 2.3nM
Assay description Inhibition of fibrinogen binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10999999
Doc title Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents.
PDB None

Name CHEMBL114946
Affinity Ki = 0.1nM
Assay description Dissociation constant for [3H]-DMP728 binding to alphaIIb beta III integrin
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10999999
Doc title Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents.
PDB None

Name CHEMBL114946
Affinity IC50 = 2.3nM
Assay description Inhibition of fibrinogen binding to alpha IIb beta-3 integrin
-- Homologous protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10999999
Doc title Platelet glycoprotein IIb-IIIa antagonists as prototypical integrin blockers: novel parenteral and potential oral antithrombotic agents.
PDB None

Name CHEMBL115130
Affinity IC50 = 5.8nM
Assay description Inhibition of high affinity radioligand binding to human alphaV-beta3 integrin
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL115130
Affinity Inhibition = 3%
Assay description Inhibition of ADP-stimulated alphaIIb-beta3 integrin mediated human platelet aggregation at 10 uM
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL115130
Affinity Inhibition = 3%
Assay description Inhibition of ADP-stimulated alphaIIb-beta3 integrin mediated human platelet aggregation at 10 uM
-- Direct protein complex subunits assigned: ITA2B_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11738567
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL115322
Affinity IC50 = 0.23uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115322
Affinity IC50 = 0.23uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115443
Affinity IC50 = 14uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115443
Affinity IC50 = 0.23uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115443
Affinity IC50 = 14uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115443
Affinity IC50 = 0.23uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115504
Affinity IC50 = 0.007uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115504
Affinity IC50 = 0.6uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115504
Affinity IC50 = 0.007uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115504
Affinity IC50 = 0.6uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115564
Affinity IC50 = 1uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115564
Affinity IC50 = 0.038uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115564
Affinity IC50 = 1uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115564
Affinity IC50 = 0.038uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115597
Affinity IC50 = 1.5uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115597
Affinity IC50 = 0.031uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115597
Affinity IC50 = 0.031uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115597
Affinity IC50 = 1.5uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115605
Affinity IC50 = 0.71uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115605
Affinity IC50 = 0.71uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115715
Affinity IC50 = 80uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115715
Affinity IC50 = 1.3uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115715
Affinity IC50 = 80uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115715
Affinity IC50 = 1.3uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115848
Affinity IC50 = 10.9nM
Assay description Inhibition of binding to human integrin receptor alpha V beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12419389
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 5: identification of potent RGD mimetics incorporating 2-aryl beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL115855
Affinity IC50 = 0.74nM
Assay description Inhibition of binding to human integrin receptor alpha V beta3
-- Direct protein complex subunits assigned: ITB3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12419389
Doc title Non-peptide alpha(v)beta(3) antagonists. Part 5: identification of potent RGD mimetics incorporating 2-aryl beta-amino acids as aspartic acid replacements.
PDB None

Name CHEMBL115881
Affinity IC50 = 126uM
Assay description Inhibition of fluorescently labeled alpha4-beta1 positive Ramos cells binding to immobilized VCAM-1.
-- Homologous protein complex subunits assigned: ITA4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9341911
Doc title Potent alpha 4 beta 1 peptide antagonists as potential anti-inflammatory agents.
PDB None

Name CHEMBL115881
Affinity IC50 = 0.89uM
Assay description Inhibition of purified alpha-4 beta-1 binding to VCAM-1 was determined in an ELISA assay.