Keap1

Kelch-like ech-associated protein 1 (cytosolic inhibitor of nrf2)

Reviewed UniProt entries for Keap1 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q9Z2X8 KEAP1_MOUSE Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) Keap1 Inrf2 Kiaa0132 Mus musculus (Mouse) 624
Q684M4 KEAP1_PIG Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) KEAP1 INRF2 Sus scrofa (Pig) 624
Q5R774 KEAP1_PONAB Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) KEAP1 INRF2 Pongo abelii (Sumatran orangutan) 624
P57790 KEAP1_RAT Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) Keap1 Inrf2 Rattus norvegicus (Rat) 624
Q14145 KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2) (Kelch-like protein 19) KEAP1 INRF2 KIAA0132 KLHL19 Homo sapiens (Human) 624

Our searches have not found small molecules for this target yet


9 PDB entries for Keap1 and its protein partners


1U6D
Crystal structure of the kelch domain of human keap1

Entity type Code Description
polypeptide(L) Q14145 kelch-like ECH-associated protein 1

1X2J
Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer

Entity type Code Description
polypeptide(L) Q9Z2X8 Kelch-like ECH-associated protein 1

1X2R
Structural basis for defects of keap1 activity provoked by its point mutations in lung cancer

Entity type Code Description
polypeptide(L) Q9Z2X8 Kelch-like ECH-associated protein 1
polypeptide(L) Q60795 Nuclear factor erythroid 2 related factor 2

1ZGK
Conserved solvent and side-chain interactions in the 1.35 Angstrom structure of the Kelch domain of Keap1.

Entity type Code Description
polypeptide(L) Q14145 Kelch-like ECH-associated protein 1

2DYH
Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response

Entity type Code Description
polypeptide(L) Q9Z2X8 Kelch-like ECH-associated protein 1
polypeptide(L) Q60795 Nrf2/Neh2 peptide from Nuclear factor erythroid 2-related factor 2

2Z32
Structural analysis of the complex of Keap1 with a prothymosin alpha peptide

Entity type Code Description
polypeptide(L) Q9Z2X8 Kelch-like ECH-associated protein 1
polypeptide(L) P26350 Prothymosin alpha

3ADE
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Entity type Code Description
polypeptide(L) Q9Z2X8 Kelch-like ECH-associated protein 1
polypeptide(L) Q64337 Sequestosome-1

3VNG
Crystal Structure of Keap1 in Complex with Synthetic Small Molecular based on a co-crystallization

Entity type Code Description
polypeptide(L) Q14145 Kelch-like ECH-associated protein 1
Ligand FUU 2-(3-((3-(5-(FURAN-2-YL)-1,3,4-OXADIAZOL-2-YL)UREIDO)METHYL)PHENOXY)ACETIC ACID

3VNH
Crystal Structure of Keap1 Soaked with Synthetic Small Molecular

Entity type Code Description
polypeptide(L) Q14145 Kelch-like ECH-associated protein 1
Ligand FUU 2-(3-((3-(5-(FURAN-2-YL)-1,3,4-OXADIAZOL-2-YL)UREIDO)METHYL)PHENOXY)ACETIC ACID