MDMX

Protein mdm4 (double minute 4 protein)

Reviewed UniProt entries for MDMX and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q2HJ21 MDM4_BOVIN Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) MDM4 MDMX Bos taurus (Bovine) 491
Q7ZUW7 MDM4_DANRE Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) mdm4 mdmx Danio rerio (Zebrafish) (Brachydanio rerio) 496
O15151 MDM4_HUMAN Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) MDM4 MDMX Homo sapiens (Human) 490
O35618 MDM4_MOUSE Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) Mdm4 Mdmx Mus musculus (Mouse) 489
Q5XIN1 MDM4_RAT Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4) Mdm4 Mdmx Rattus norvegicus (Rat) 490
Q7ZYI3 MDM4_XENLA Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Mdmx protein) (p53-binding protein Mdm4) mdm4 mdmx Xenopus laevis (African clawed frog) 475

Small molecules tested in MDMX binding assays:

44 datapoints for 40 distinct small molecules


Name WK298
Affinity Ki (FP) 11000 nM
Assay description Fluorescence polorization assay
-- Direct single protein target assigned: MDM4_HUMAN (Expert curation) --
DOI http://www.landesbioscience.com/journals/cc/article/10956/
Doc title Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
PDB 3LBJ - (WW8)

Name CHEMBL1256044
Affinity IC50 = 348uM
Assay description Inhibition of GST-tagged p53 binding to MDMX by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256050
Affinity Not Active
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256051
Affinity IC50 = 463uM
Assay description Inhibition of GST-tagged p53 binding to MDMX by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256051
Affinity INH = 42%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256051
Affinity INH = 42%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256052
Affinity INH = 14%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256053
Affinity INH = 82%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256053
Affinity IC50 = 192uM
Assay description Inhibition of GST-tagged p53 binding to MDMX by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256054
Affinity INH = 13%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256057
Affinity INH = 47%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256058
Affinity INH = 35%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256060
Affinity INH = 43%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256061
Affinity INH = 37%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256062
Affinity IC50 = 307uM
Assay description Inhibition of GST-tagged p53 binding to MDMX by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256062
Affinity INH = 58%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256063
Affinity Not Active
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256064
Affinity IC50 = 339uM
Assay description Inhibition of GST-tagged p53 binding to MDMX by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256067
Affinity IC50 = 300uM
Assay description Inhibition of GST-tagged p53 binding to MDMX by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256071
Affinity INH = 29%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256078
Affinity INH = 17%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256079
Affinity INH = 6%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256080
Affinity INH = 43%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256081
Affinity INH = 42%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256082
Affinity INH = 28%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256083
Affinity INH = 10%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256084
Affinity Not Active
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256085
Affinity INH = 15%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256086
Affinity INH = 10%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256087
Affinity INH = 6%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256088
Affinity INH = 25%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256089
Affinity INH = 14%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256090
Affinity INH = 19%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256091
Affinity INH = 65%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256092
Affinity INH = 54%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256093
Affinity INH = 40%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1256094
Affinity INH = 62%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL1258838
Affinity INH = 13%
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

Name CHEMBL191334
Affinity Not Active
Assay description Inhibition of human GST-tagged MDMX expressed in Escherichia coli harboring integrated p53-Hmd2 protein assessed as blockade of enzyme-p53 interaction by ELISA assay
-- Direct single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21277201
Doc title Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition.
PDB None

Name CHEMBL2024320
Affinity IC50 = 70uM
Assay description Inhibition of p53 derived peptide binding to MDM4 using fluorescent dye Cy5 by TR-FRET assay
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22507962
Doc title The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction.
PDB None

Name CHEMBL2024321
Affinity IC50 = 18uM
Assay description Inhibition of p53 derived peptide binding to MDM4 using fluorescent dye Cy5 by TR-FRET assay
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22507962
Doc title The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction.
PDB None

Name CHEMBL2024322
Affinity IC50 = 22uM
Assay description Inhibition of p53 derived peptide binding to MDM4 using fluorescent dye Cy5 by TR-FRET assay
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22507962
Doc title The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction.
PDB None

Name CHEMBL2024323
Affinity IC50 = 19uM
Assay description Inhibition of p53 derived peptide binding to MDM4 using fluorescent dye Cy5 by TR-FRET assay
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22507962
Doc title The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction.
PDB None

Name CHEMBL32301
Affinity Not Active
Assay description Inhibition of GST-tagged p53 binding to MDMX at 320 uM by ELISA
-- Homologous single protein target assigned: MDM4_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20638853
Doc title Functional profiling of p53-binding sites in Hdm2 and Hdmx using a genetic selection system.
PDB None

15 PDB entries for MDMX and its protein partners


2CR8
Solution structure of the zf-RanBP domain of p53-binding protein Mdm4

Entity type Code Description
polypeptide(L) O15151 Mdm4 protein

2VJE
Structure of the Mdm2/Mdmx Ring Domain Heterodimer Reveals Dimerization is Required for Their Ubiquitylation in Trans.

Entity type Code Description
polypeptide(L) Q00987 E3 UBIQUITIN-PROTEIN LIGASE MDM2
polypeptide(L) O15151 MDM4 PROTEIN
Ligand FLC CITRATE ANION

2VJF
Structure of the Mdm2/Mdmx Ring Domain Heterodimer Reveals Dimerization is Required for Their Ubiquitylation in Trans.

Entity type Code Description
polypeptide(L) Q00987 E3 UBIQUITIN-PROTEIN LIGASE MDM2
polypeptide(L) O15151 MDM4 PROTEIN
Ligand FLC CITRATE ANION

2VYR
Structure of Human Mdm4 N-Terminal Domain Bound to a Single-Domain Antibody.

Entity type Code Description
polypeptide(L) O15151 MDM4 PROTEIN
polypeptide(L) 2VYR HUMAN SINGLE DOMAIN ANTIBODY

3DAB
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

Entity type Code Description
polypeptide(L) O15151 Mdm4 protein
polypeptide(L) P04637 Cellular tumor antigen p53

3DAC
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain

Entity type Code Description
polypeptide(L) Q7ZUW7 Mdm4 protein
polypeptide(L) P04637 Cellular tumor antigen p53

3EQY
Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.

Entity type Code Description
polypeptide(L) O15151 Mdm4 protein
polypeptide(L) 3EQY 12-mer peptide inhibitor
Ligand GAI GUANIDINE

3FDO
High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx

Entity type Code Description
polypeptide(L) O15151 Protein Mdm4
polypeptide(L) 3FDO Synthetic high affinity peptide

3FE7
Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes

Entity type Code Description
polypeptide(L) O15151 Mdm4 protein
polypeptide(L) 3FE7 p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-Trp-Glu-Ac3c-Leu-NH2

3FEA
Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes

Entity type Code Description
polypeptide(L) O15151 Mdm4 protein
polypeptide(L) 3FEA p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-6-Cl-Trp-Glu-Ac3c-Leu-NH2
Ligand MPD (4S)-2-METHYL-2,4-PENTANEDIOL

3JZO
Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.

Entity type Code Description
polypeptide(L) O15151 Protein Mdm4
polypeptide(L) 3JZO pDI peptide (12mer)

3JZP
Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.

Entity type Code Description
polypeptide(L) O15151 Protein Mdm4
polypeptide(L) 3JZP pDI6W peptide (12mer)

3JZQ
Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.

Entity type Code Description
polypeptide(L) O15151 Protein Mdm4
polypeptide(L) 3JZQ pDIQ peptide (12mer)

3LBJ
Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery

Entity type Code Description
polypeptide(L) O15151 Protein Mdm4
Ligand WW8 N-[(3S)-1-({6-CHLORO-3-[1-(4-CHLOROBENZYL)-4-PHENYL-1H-IMIDAZOL-5-YL]-1H-INDOL-2-YL}CARBONYL)PYRROLIDIN-3-YL]-N,N',N'-TRIMETHYLPROPANE-1,3-DIAMINE

3U15
Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization.

Entity type Code Description
polypeptide(L) O15151 Protein Mdm4
Ligand 03M (5Z)-5-[(6-CHLORO-7-METHYL-1H-INDOL-3-YL)METHYLIDENE]-3-(3,4-DIFLUOROBENZYL)IMIDAZOLIDINE-2,4-DIONE