MLL

Menin

Reviewed UniProt entries for MLL and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q0P5I0 MEN1_BOVIN Menin MEN1 Bos taurus (Bovine) 610
A2SXS5 MEN1_CANFA Menin MEN1 Canis familiaris (Dog) (Canis lupus familiaris) 615
O00255 MEN1_HUMAN Menin MEN1 SCG2 Homo sapiens (Human) 615
O88559 MEN1_MOUSE Menin Men1 Mus musculus (Mouse) 611
Q9WVR8 MEN1_RAT Menin Men1 Rattus norvegicus (Rat) 610
Q03164 MLL1_HUMAN Histone-lysine N-methyltransferase MLL (EC 2.1.1.43) (ALL-1) (CXXC-type zinc finger protein 7) (Lysine N-methyltransferase 2A) (KMT2A) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] MLL ALL1 CXXC7 HRX HTRX KMT2A MLL1 TRX1 Homo sapiens (Human) 3969

Small molecules tested in MLL binding assays:

43 datapoints for 24 distinct small molecules


Name MI-2
Affinity Kd = 158nM
Assay description None
-- Direct single protein target assigned: MEN1_HUMAN (Expert curation) --
DOI http://bloodjournal.hematologylibrary.org/content/120/23/4461.long
Doc title Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
PDB 4GQ3 - (0RO)

Name MI-2-2
Affinity Kd = 22nM
Assay description None
-- Direct single protein target assigned: MEN1_HUMAN (Expert curation) --
DOI http://bloodjournal.hematologylibrary.org/content/120/23/4461.long
Doc title Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
PDB 4GQ4 - (0RT)

Name CHEMBL2314568
Affinity IC50 = 194nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314568
Affinity Ki = 55.5nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314569
Affinity Ki = 26.7nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314569
Affinity IC50 = 102nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314570
Affinity Ki = 1660nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314570
Affinity IC50 = 6320nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314571
Affinity IC50 = 3330nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314571
Affinity Ki = 862nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314572
Affinity IC50 = 112nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314572
Affinity Ki = 30nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314573
Affinity IC50 = 159nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314573
Affinity Ki = 44.6nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314574
Affinity IC50 = 2010nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314574
Affinity Ki = 549nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314575
Affinity Ki = 332nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314575
Affinity IC50 = 1150nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314576
Affinity Ki = 725nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314576
Affinity IC50 = 2520nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314813
Affinity IC50 = 4610nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314813
Affinity Ki = 1330nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314814
Affinity Ki = 11600nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314814
Affinity IC50 = 36000nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314815
Affinity Ki = 14000nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314815
Affinity IC50 = 39400nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314816
Affinity IC50 = 25.1nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314816
Affinity Ki = 6.8nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314817
Affinity Ki = 27.5nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314817
Affinity IC50 = 102nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314818
Affinity Ki = 123nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314818
Affinity IC50 = 422nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314819
Affinity IC50 = 18.5nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314819
Affinity Ki = 4.7nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314820
Affinity Ki = 143000nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314828
Affinity Ki = 41800nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2314828
Affinity IC50 = 140000nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2315086
Affinity Ki = 1840nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2315086
Affinity IC50 = 6450nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2315087
Affinity Ki = 67nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2315087
Affinity IC50 = 226nM
Assay description Binding affinity to menin (unknown origin) after 60 mins by fluorescence polarization assay
-- Direct single protein target assigned: MEN1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23244744
Doc title Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction.
PDB None

Name CHEMBL2325183
Affinity Not Active
Assay description Inhibition of MLL1:WDR5:RbBP5:ASH2L complex (unknown origin) using histone H3 (1 to 25) as substrate after 1 hr by scintillation proximity assay in presence of [3H]-S-adenosylmethionine
-- Direct single protein target assigned: MLL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23445220
Doc title Exploiting an allosteric binding site of PRMT3 yields potent and selective inhibitors.
PDB None

Name CHEMBL2349526
Affinity Not Active
Assay description Inhibition of MLL1 (unknown origin) using [3H]SAM assessed as inhibition of biotinylated-H3 (21 to 44 amino acid residues) methylation at 0.1 to 100 uM after 1 hr by scintillation proximity assay
-- Direct single protein target assigned: MLL1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23433670
Doc title Bromo-deaza-SAH: a potent and selective DOT1L inhibitor.
PDB None

25 PDB entries for MLL and its protein partners


2AGH
Structural Basis for Cooperative Transcription Factor Binding to the CBP Coactivator

Entity type Code Description
polypeptide(L) P06876 Myb proto-oncogene protein
polypeptide(L) P45481 Crebbp protein
polypeptide(L) Q03164 Zinc finger protein HRX

2J2S
Solution Structure of the Nonmethyl-Cpg-Binding Cxxc Domain of the Leukaemia-Associated Mll Histone Methyltransferase

Entity type Code Description
polypeptide(L) Q03164 ZINC FINGER PROTEIN HRX

2JYI
Structural basis for maintenance of unmethylated CpG elements by the CXXC domain of MLL and its critical contributions to MLL-AF9 immortalization activity

Entity type Code Description
polypeptide(L) Q03164 Zinc finger protein HRX

2KKF
Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia.

Entity type Code Description
polypeptide(L) Q03164 Histone-lysine N-methyltransferase HRX
polydeoxyribonucleotide 2KKF 5'-D(*CP*CP*CP*TP*GP*CP*GP*CP*AP*GP*GP*G)-3'

2KU7
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.

Entity type Code Description
polypeptide(L) Q03164 MLL1 PHD3-Cyp33 RRM chimeric protein
polypeptide(L) Q9UNP9 MLL1 PHD3-Cyp33 RRM chimeric protein

2KYU
The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression.

Entity type Code Description
polypeptide(L) Q03164 Histone-lysine N-methyltransferase MLL

2LXS
Allosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic Core.

Entity type Code Description
polypeptide(L) Q92793 CREB-binding protein
polypeptide(L) Q03164 Histone-lysine N-methyltransferase MLL

2LXT
Allosteric Communication in the KIX Domain Proceeds through Dynamic Repacking of the Hydrophobic Core.

Entity type Code Description
polypeptide(L) Q92793 CREB-binding protein
polypeptide(L) Q03164 Histone-lysine N-methyltransferase MLL
polypeptide(L) P16220 Cyclic AMP-responsive element-binding protein 1

2W5Y
Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.

Entity type Code Description
polypeptide(L) 2W5Y HISTONE-LYSINE N-METHYLTRANSFERASE HRX
polypeptide(L) Q03164 HISTONE-LYSINE N-METHYLTRANSFERASE HRX
Ligand SAH S-ADENOSYL-L-HOMOCYSTEINE

2W5Z
Structural Basis for the Requirement of Additional Factors for Mll1 Set Domain Activity and Recognition of Epigenetic Marks.

Entity type Code Description
polypeptide(L) 2W5Z HISTONE-LYSINE N-METHYLTRANSFERASE HRX
polypeptide(L) Q03164 HISTONE-LYSINE N-METHYLTRANSFERASE HRX
polypeptide(L) 2W5Z HISTONE PEPTIDE
Ligand SAH S-ADENOSYL-L-HOMOCYSTEINE

3EG6
Structure of WDR5 bound to mixed lineage leukemia protein-1 peptide.

Entity type Code Description
polypeptide(L) P61964 WD repeat-containing protein 5
polypeptide(L) Q03164 MLL-1 peptide

3LQH
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.

Entity type Code Description
polypeptide(L) Q03164 Histone-lysine N-methyltransferase MLL
polypeptide(L) Q03164 Histone-lysine N-methyltransferase MLL

3LQI
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.

Entity type Code Description
polypeptide(L) Q03164 MLL1 PHD3-Bromo
polypeptide(L) Q03164 MLL1 PHD3-Bromo
polypeptide(L) P68431 Histone H3

3LQJ
Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression.

Entity type Code Description
polypeptide(L) Q03164 MLL1 PHD3-Bromo
polypeptide(L) Q03164 MLL1 PHD3-Bromo
polypeptide(L) P68431 Histone H3

3P4F
Structural and biochemical insights into MLL1 core complex assembly.

Entity type Code Description
polypeptide(L) P61964 WD repeat-containing protein 5
polypeptide(L) Q15291 Retinoblastoma-binding protein 5
polypeptide(L) Q03164 Histone-lysine N-methyltransferase MLL

3U84
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

Entity type Code Description
polypeptide(L) O00255 Menin
polypeptide(L) O00255 Menin

3U85
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

Entity type Code Description
polypeptide(L) O00255 Menin
polypeptide(L) O00255 Menin
polypeptide(L) Q03164 Histone-lysine N-methyltransferase MLL

3U86
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

Entity type Code Description
polypeptide(L) O00255 Menin
polypeptide(L) O00255 Menin
polypeptide(L) P17535 Transcription factor jun-D

3U88
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.

Entity type Code Description
polypeptide(L) O00255 Menin
polypeptide(L) O00255 Menin
polypeptide(L) Q03164 Histone-lysine N-methyltransferase MLL
polypeptide(L) O75475 Lens epithelium-derived growth factor
Ligand CHD CHOLIC ACID
Ligand 0BR (4BETA,8ALPHA,9R)-6'-METHOXY-10,11-DIHYDROCINCHONAN-9-OL
Ligand GGB L-CANAVANINE
Ligand GLV GLYOXYLIC ACID

4ESG
Structural basis for SET1 family Win motif recognition by WDR5

Entity type Code Description
polypeptide(L) P61964 WD repeat-containing protein 5
polypeptide(L) Q03164 Histone-lysine N-methyltransferase MLL

4GPQ
Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.

Entity type Code Description
polypeptide(L) O00255 Menin
Ligand PEG DI(HYDROXYETHYL)ETHER
Ligand PG4 TETRAETHYLENE GLYCOL
Ligand EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID

4GQ3
Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.

Entity type Code Description
polypeptide(L) O00255 Menin
Ligand 0RO 4-[4-(5,5-DIMETHYL-4,5-DIHYDRO-1,3-THIAZOL-2-YL)PIPERAZIN-1-YL]-6-PROPYLTHIENO[2,3-D]PYRIMIDINE
Ligand PEG DI(HYDROXYETHYL)ETHER
Ligand UNX UNKNOWN ATOM OR ION

4GQ4
Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.

Entity type Code Description
polypeptide(L) O00255 Menin
Ligand 0RT 4-[4-(5,5-DIMETHYL-4,5-DIHYDRO-1,3-THIAZOL-2-YL)PIPERAZIN-1-YL]-6-(2,2,2-TRIFLUOROETHYL)THIENO[2,3-D]PYRIMIDINE
Ligand UNX UNKNOWN ATOM OR ION
Ligand EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Ligand PE4 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL

4GQ6
Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.

Entity type Code Description
polypeptide(L) O00255 Menin
polypeptide(L) Q03164 Histone-lysine N-methyltransferase MLL
Ligand 1PE PENTAETHYLENE GLYCOL

4I80
Structure-Based Design of High-Affinity Macrocyclic Peptidomimetics to Block the Menin-Mixed Lineage Leukemia 1 (MLL1) Protein-Protein Interaction.

Entity type Code Description
polypeptide(L) O00255 Menin
polypeptide(L) O00255 Menin
polypeptide(L) 4I80 macrocyclic peptidomimetic