Neuropilin-1

Neuropilin-1

Reviewed UniProt entries for Neuropilin-1 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
P79795 NRP1_CHICK Neuropilin-1 (A5 protein) NRP1 NRP Gallus gallus (Chicken) 914
O14786 NRP1_HUMAN Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304) NRP1 NRP VEGF165R Homo sapiens (Human) 923
P97333 NRP1_MOUSE Neuropilin-1 (A5 protein) (CD antigen CD304) Nrp1 Nrp Mus musculus (Mouse) 923
Q9QWJ9 NRP1_RAT Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304) Nrp1 Rattus norvegicus (Rat) 922
P28824 NRP1_XENLA Neuropilin-1 (A5 antigen) (A5 protein) nrp1 Xenopus laevis (African clawed frog) 928
P15691 VEGFA_BOVIN Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) VEGFA VEGF Bos taurus (Bovine) 190
Q9MYV3 VEGFA_CANFA Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) VEGFA VEGF Canis familiaris (Dog) (Canis lupus familiaris) 214
P26617 VEGFA_CAVPO Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) VEGFA VEGF Cavia porcellus (Guinea pig) 164
P67964 VEGFA_CHICK Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) VEGFA VEGF Gallus gallus (Chicken) 216
P67965 VEGFA_COTJA Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) VEGFA VEGF Coturnix coturnix japonica (Japanese quail) (Coturnix japonica) 216
Q9GKR0 VEGFA_HORSE Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) VEGFA VEGF Equus caballus (Horse) 190
P15692 VEGFA_HUMAN Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) VEGFA VEGF Homo sapiens (Human) 232
Q99PS1 VEGFA_MESAU Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) VEGFA VEGF Mesocricetus auratus (Golden hamster) 190
Q00731 VEGFA_MOUSE Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) Vegfa Vegf Mus musculus (Mouse) 214
P49151 VEGFA_PIG Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) VEGFA VEGF Sus scrofa (Pig) 190
P16612 VEGFA_RAT Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) Vegfa Vegf Rattus norvegicus (Rat) 214
P50412 VEGFA_SHEEP Vascular endothelial growth factor A (VEGF-A) (Vascular permeability factor) (VPF) VEGFA VEGF Ovis aries (Sheep) 146
O73682 VGFAA_DANRE Vascular endothelial growth factor A-A (VEGF-A-A) vegfaa vegf vegfa Danio rerio (Zebrafish) (Brachydanio rerio) 188

Small molecules tested in Neuropilin-1 binding assays:

183 datapoints for 163 distinct small molecules


Name EG00229
Affinity IC50 = 3uM
Assay description None
-- Direct single protein target assigned: NRP1_HUMAN (Expert curation) --
DOI http://pubs.acs.org/doi/abs/10.1021/jm901755g
Doc title Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction
PDB 3I97 - (8DR)

Name CHEMBL106590
Affinity Dissociation constant > 5mM
Assay description Dissociation constant against VEGF (vascular endothelial growth factor) was determined.
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10978192
Doc title Privileged molecules for protein binding identified from NMR-based screening.
PDB None

Name CHEMBL107057
Affinity Dissociation constant > 5mM
Assay description Dissociation constant against VEGF (vascular endothelial growth factor) was determined.
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10978192
Doc title Privileged molecules for protein binding identified from NMR-based screening.
PDB None

Name CHEMBL1077919
Affinity Activity = 21%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1077920
Affinity Activity = 13%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1078797
Affinity IC50 = 9uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1078797
Affinity Activity = 100%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1078848
Affinity Activity = 70%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1078849
Affinity Activity = 28%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1078850
Affinity IC50 = 14uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1078850
Affinity Activity = 84%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1078851
Affinity Activity = 95%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1078851
Affinity IC50 = 17uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1078868
Affinity Activity = 25%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1078972
Affinity Activity = 42%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1078973
Affinity Activity = 79%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1078973
Affinity IC50 = 33uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1078974
Affinity IC50 = 3uM
Assay description Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in human DU145 cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB 3I97 - (8DR)

Name CHEMBL1078974
Affinity IC50 = 7uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in human A549 cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB 3I97 - (8DR)

Name CHEMBL1078974
Affinity IC50 = 8uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB 3I97 - (8DR)

Name CHEMBL1078974
Affinity IC50 = 23uM
Assay description Displacement of biotinylated-VEGF-A125 from human NRP1 expressed in HUVEC
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB 3I97 - (8DR)

Name CHEMBL1078974
Affinity Activity = 99%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB 3I97 - (8DR)

Name CHEMBL1078974
Affinity IC50 = 3uM
Assay description Displacement of biotinylated-VEGF-A125 from NRP1 b1 domain by cell-free assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB 3I97 - (8DR)

Name CHEMBL1079064
Affinity IC50 = 17uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1079064
Affinity Activity = 87%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1079081
Affinity Activity = 88%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1079081
Affinity IC50 = 12uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1079082
Affinity IC50 = 6uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1079082
Affinity Activity = 88%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1079083
Affinity Activity = 36%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1079279
Affinity Activity = 75%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1079279
Affinity IC50 = 52uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1079279
Affinity IC50 = 52uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1079279
Affinity Activity = 75%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1079280
Affinity Activity = 20%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1083206
Affinity Activity = 40%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1083518
Affinity Activity = 49%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1083519
Affinity Activity = 31%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1083806
Affinity Activity = 58%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1083807
Affinity Activity = 12%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1083840
Affinity Activity = 0%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1083843
Affinity Activity = 63%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1084113
Affinity Activity = 3%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1085193
Affinity Activity = 32%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1085194
Affinity Activity = 10%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1085195
Affinity IC50 = 13uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1085195
Affinity Activity = 78%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1085424
Affinity Activity = 21%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1085663
Affinity Activity = 11%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1085664
Affinity Activity = 59%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1086169
Affinity Activity = 35%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1087941
Affinity Activity = 20%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1088739
Affinity Activity = 22%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1088744
Affinity IC50 = 18uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1088744
Affinity Activity = 84%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1089055
Affinity Activity = 19%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1090056
Affinity IC50 = 30uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1090056
Affinity Activity = 83%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1090057
Affinity Activity = 51%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1090745
Affinity Activity = 36%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1091089
Affinity Activity = 96%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1091089
Affinity IC50 = 14uM
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1091824
Affinity Activity = 22%
Assay description Displacement of [125I]VEGF-A from human NRP1 expressed in pig aortic endothelial cells at 100 uM
-- Direct single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20151671
Doc title Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
PDB None

Name CHEMBL1094354
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1094355
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1094356
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1095220
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1095221
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1095853
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1097149
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1097150
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1097792
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098181
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098182
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098234
Affinity IC50 = 92uM
Assay description Displacement of biotinylated VEGF165 from recombinant NRP1 after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098234
Affinity INH = 65%
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098235
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098350
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098500
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098501
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098519
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098530
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098555
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098556
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098557
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098564
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098829
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098830
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098862
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1098866
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1099153
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1099183
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1099215
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1099216
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1099217
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1099320
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL1099321
Affinity Active
Assay description Inhibition of biotinylated VEGF165 binding to recombinant NRP1 at 100 uM after 2 hrs by competitive binding assay
-- Homologous single protein target assigned: NRP1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20363638
Doc title Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1.
PDB None

Name CHEMBL114523
Affinity Dissociation constant > 5mM
Assay description Dissociation constant against VEGF (vascular endothelial growth factor) was determined.
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10978192
Doc title Privileged molecules for protein binding identified from NMR-based screening.
PDB None

Name CHEMBL2087888
Affinity Kd = 76uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087889
Affinity Kd = 77uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087890
Affinity Kd = 109uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087891
Affinity Kd = 1700uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087892
Affinity Kd = 3000uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087893
Affinity Kd = 1200uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087894
Affinity Kd = 1000uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087895
Affinity Kd = 45.3uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087896
Affinity Kd = 280uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087897
Affinity Kd = 512uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087898
Affinity Kd = 207uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087899
Affinity Kd = 104uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087900
Affinity Kd = 545uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087901
Affinity Kd = 1100uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087902
Affinity Kd = 596uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087903
Affinity Kd = 81uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087904
Affinity Kd = 402uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087905
Affinity Kd = 76.6uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087906
Affinity Kd = 29uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087907
Affinity Kd = 91uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087908
Affinity Kd = 40uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087909
Affinity Kd = 81uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087910
Affinity Kd = 50uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087911
Affinity Kd = 630uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL2087912
Affinity Kd = 198uM
Assay description Binding affinity to VEGF by surface plasmon resonance-based solution affinity assay
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22929233
Doc title A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.
PDB None

Name CHEMBL211967
Affinity IC50 = 5uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL211986
Affinity IC50 = 13uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL212352
Affinity Not Active
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL212539
Affinity IC50 = 6uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL212560
Affinity IC50 = 79uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL212828
Affinity Not Active
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL212851
Affinity IC50 = 43uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL213245
Affinity IC50 = 3uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL213321
Affinity IC50 = 60uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL213325
Affinity IC50 = 6uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL213376
Affinity IC50 = 10uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL213414
Affinity Not Active
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL213415
Affinity Not Active
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL213855
Affinity Not Active
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL214248
Affinity IC50 = 3uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL214266
Affinity IC50 = 95uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL215471
Affinity Not Active
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL215511
Affinity Not Active
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL215514
Affinity Not Active
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL215632
Affinity IC50 = 22uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL215821
Affinity IC50 = 2uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL215831
Affinity IC50 = 2uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL215838
Affinity IC50 = 5uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL215902
Affinity IC50 = 2uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL215962
Affinity IC50 = 3uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL215998
Affinity IC50 = 9uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL2335721
Affinity Not Active
Assay description Binding affinity to recombinant VEGFA (unknown origin) measured for 60 seconds by surface plasmon resonance assay
-- Direct single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23268742
Doc title Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities.
PDB None

Name CHEMBL2335722
Affinity Kd = 16nM
Assay description Binding affinity to recombinant VEGFA (unknown origin) measured for 60 seconds by surface plasmon resonance assay
-- Direct single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23268742
Doc title Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities.
PDB None

Name CHEMBL286933
Affinity Not Active
Assay description Binding affinity to recombinant VEGFA (unknown origin) measured for 60 seconds by surface plasmon resonance assay
-- Direct single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23268742
Doc title Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities.
PDB None

Name CHEMBL331146
Affinity Dissociation constant = 0.5mM
Assay description Dissociation constant against VEGF (vascular endothelial growth factor) was determined.
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10978192
Doc title Privileged molecules for protein binding identified from NMR-based screening.
PDB None

Name CHEMBL377006
Affinity IC50 = 13uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL377214
Affinity IC50 = 3uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL377450
Affinity IC50 = 9uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL377657
Affinity IC50 = 13uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL378392
Affinity Not Active
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL378441
Affinity Not Active
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL379106
Affinity IC50 = 6uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL379360
Affinity IC50 = 19uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL379547
Affinity IC50 = 47uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL379579
Affinity IC50 = 29uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL379832
Affinity IC50 = 10uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL384737
Affinity IC50 = 4uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL384861
Affinity IC50 = 3uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL385633
Affinity Not Active
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL386361
Affinity IC50 = 2uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL386641
Affinity IC50 = 42uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL386808
Affinity IC50 = 4uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL387002
Affinity IC50 = 2uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL387255
Affinity IC50 = 2uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL411137
Affinity IC50 = 4uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL425427
Affinity IC50 = 4uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL425440
Affinity IC50 = 80uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL427044
Affinity IC50 = 14uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL436932
Affinity IC50 = 62uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL438268
Affinity IC50 = 3uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL450916
Affinity Kd = 476nM
Assay description Binding affinity to recombinant VEGFA (unknown origin) measured for 60 seconds by surface plasmon resonance assay
-- Direct single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23268742
Doc title Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities.
PDB None

Name CHEMBL499587
Affinity Kd = 48nM
Assay description Binding affinity to recombinant VEGFA (unknown origin) measured for 60 seconds by surface plasmon resonance assay
-- Direct single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23268742
Doc title Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities.
PDB None

Name CHEMBL540714
Affinity IC50 = 5uM
Assay description Inhibition of VEGF165-NRP1 interaction by ELISA
-- Direct protein complex subunits assigned: NRP1_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16765048
Doc title Discovery of protein-protein binding disruptors using multi-component condensations small molecules.
PDB None

Name CHEMBL63354
Affinity Kd = 16.5nM
Assay description Binding affinity to recombinant VEGFA (unknown origin) measured for 60 seconds by surface plasmon resonance assay
-- Direct single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23268742
Doc title Bioassay-guided isolation of proanthocyanidins with antiangiogenic activities.
PDB None

Name CHEMBL73380
Affinity Dissociation constant > 5mM
Assay description Dissociation constant against VEGF (vascular endothelial growth factor) was determined.
-- Homologous single protein target assigned: VEGFA_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/10978192
Doc title Privileged molecules for protein binding identified from NMR-based screening.
PDB None

37 PDB entries for Neuropilin-1 and its protein partners


1BJ1
VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface.

Entity type Code Description
polypeptide(L) 468243 FAB FRAGMENT
polypeptide(L) 1BJ1 FAB FRAGMENT
polypeptide(L) P15692 VASCULAR ENDOTHELIAL GROWTH FACTOR

1CZ8
Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.

Entity type Code Description
polypeptide(L) P15692 VASCULAR ENDOTHELIAL GROWTH FACTOR
polypeptide(L) 1CZ8 LIGHT CHAIN OF NEUTRALIZING ANTIBODY
polypeptide(L) 1CZ8 HEAVY CHAIN OF NEUTRALIZING ANTIBODY

1FLT
Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor.

Entity type Code Description
polypeptide(L) P15692 VASCULAR ENDOTHELIAL GROWTH FACTOR
polypeptide(L) P17948 FMS-LIKE TYROSINE KINASE 1

1KAT
Solution Structure of a Phage-derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor

Entity type Code Description
polypeptide(L) P15692 Vascular Endothelial Growth Factor
polypeptide(L) 1KAT Phage-Derived Peptide Antagonist

1KEX
Crystal Structure of the Human Neuropilin-1 b1 Domain

Entity type Code Description
polypeptide(L) O14786 Neuropilin-1

1KMX
Refinement of the Solution Structure of the Heparin-binding Domain of Vascular Endothelial Growth Factor using Residual Dipolar Couplings

Entity type Code Description
polypeptide(L) P15692 vascular endothelial growth factor

1MJV
The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor

Entity type Code Description
polypeptide(L) P15692 Vascular Endothelial Growth Factor A

1MKG
The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor

Entity type Code Description
polypeptide(L) P15692 Vascular Endothelial Growth Factor A

1MKK
The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor

Entity type Code Description
polypeptide(L) P15692 Vascular Endothelial Growth Factor A

1QTY
Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.

Entity type Code Description
polypeptide(L) P15692 VASCULAR ENDOTHELIAL GROWTH FACTOR
polypeptide(L) P17948 FMS-LIKE TYROSINE KINASE 1

1TZH
Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition

Entity type Code Description
polypeptide(L) P15692 Vascular endothelial growth factor A
polypeptide(L) 1TZH Fab YADS1 Light Chain
polypeptide(L) 1TZH Fab YADS1 Heavy Chain

1TZI
Synthetic antibodies from a four-amino-acid code: A dominant role for tyrosine in antigen recognition

Entity type Code Description
polypeptide(L) 1TZI Fab YADS2 Light Chain
polypeptide(L) 1TZI Fab YADS2 Heavy Chain
polypeptide(L) P15692 Vascular endothelial growth factor A

1VGH
Solution structure of the heparin-binding domain of vascular endothelial growth factor.

Entity type Code Description
polypeptide(L) P15692 VASCULAR ENDOTHELIAL GROWTH FACTOR-165

1VPF
Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site.

Entity type Code Description
polypeptide(L) P15692 VASCULAR ENDOTHELIAL GROWTH FACTOR

1VPP
Crystal structure of the complex between VEGF and a receptor-blocking peptide.

Entity type Code Description
polypeptide(L) P15692 PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR)
polypeptide(L) 1VPP PROTEIN (PEPTIDE V108)

2ORX
Structural basis for ligand and heparin binding to neuropilin B domains

Entity type Code Description
polypeptide(L) Q9QWJ9 Neuropilin-1

2ORZ
Structural basis for ligand and heparin binding to neuropilin B domains.

Entity type Code Description
polypeptide(L) Q9QWJ9 Neuropilin-1
polypeptide(L) 2ORZ Tuftsin

2QQI
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

Entity type Code Description
polypeptide(L) O14786 Neuropilin-1

2QQM
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

Entity type Code Description
polypeptide(L) O14786 Neuropilin-1
Ligand None SUGAR (4-MER)
Ligand None SUGAR (2-MER)

2QQN
Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding

Entity type Code Description
polypeptide(L) O14786 Neuropilin-1
polypeptide(L) 2QQN Antibody heavy chain
polypeptide(L) 2QQN Antibody light chain

2QR0
High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries

Entity type Code Description
polypeptide(L) 2QR0 Fab-Fragment Light Chain
polypeptide(L) 2QR0 Fab-Fragment Heavy Chain
polypeptide(L) P15692 Vascular endothelial growth factor A

2VGH
Solution structure of the heparin-binding domain of vascular endothelial growth factor.

Entity type Code Description
polypeptide(L) P15692 VASCULAR ENDOTHELIAL GROWTH FACTOR-165

2VPF
The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.

Entity type Code Description
polypeptide(L) P15692 VASCULAR ENDOTHELIAL GROWTH FACTOR

3BDY
Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site

Entity type Code Description
polypeptide(L) 3BDY Fab Fragment -Heavy Chain
polypeptide(L) 3BDY Fab Fragment -Light Chain
polypeptide(L) P15692 Vascular endothelial growth factor A

3I97
Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.

Entity type Code Description
polypeptide(L) O14786 Neuropilin-1
Ligand 8DR (S)-2-(3-(BENZO[C][1,2,5]THIADIAZOLE-4-SULFONAMIDO)THIOPHENE-2-CARBOXAMIDO)-5-GUANIDINOPENTANOIC ACID

3MTU
Structure of the tropomyosin overlap complex from chicken smooth muscle: insight into the diversity of N-terminal recognition .

Entity type Code Description
polypeptide(L) P04268 Tropomyosin alpha-1 chain, Microtubule-associated protein RP/EB family member 1
polypeptide(L) P15691 Tropomyosin alpha-1 chain, Microtubule-associated protein RP/EB family member 1
polypeptide(L) P13848 Head morphogenesis protein, Tropomyosin alpha-1 chain
polypeptide(L) P04268 Head morphogenesis protein, Tropomyosin alpha-1 chain

3MUD
Structure of the tropomyosin overlap complex from chicken smooth muscle: insight into the diversity of N-terminal recognition .

Entity type Code Description
polypeptide(L) Q13426 DNA repair protein XRCC4, Tropomyosin alpha-1 chain
polypeptide(L) P04268 DNA repair protein XRCC4, Tropomyosin alpha-1 chain
polypeptide(L) P04268 Tropomyosin alpha-1 chain, Microtubule-associated protein RP/EB family member 1
polypeptide(L) P15691 Tropomyosin alpha-1 chain, Microtubule-associated protein RP/EB family member 1

3P9W
Design of Synthetic Autonomous VH Domain Libraries and Structural Analysis of a VH Domain Bound to Vascular Endothelial Growth Factor.

Entity type Code Description
polypeptide(L) P15692 Vascular endothelial growth factor A
polypeptide(L) 3P9W human VEGF

3QTK
Total chemical synthesis of biologically active vascular endothelial growth factor.

Entity type Code Description
polypeptide(L) P15692 Vascular endothelial growth factor A
Ligand TFA TRIFLUOROACETIC ACID

3S1B
The development of Peptide-based tools for the analysis of angiogenesis.

Entity type Code Description
polypeptide(L) P15692 Vascular endothelial growth factor A
polypeptide(L) 3S1B mini-Z

3S1K
The development of Peptide-based tools for the analysis of angiogenesis.

Entity type Code Description
polypeptide(L) 3S1K Z-domain
polypeptide(L) P15692 Vascular endothelial growth factor A

3V2A
Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization.

Entity type Code Description
polypeptide(L) P35968 Vascular endothelial growth factor receptor 2
polypeptide(L) P15692 Vascular endothelial growth factor A

4DEQ
Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1.

Entity type Code Description
polypeptide(L) O14786 Neuropilin-1, Vascular endothelial growth factor A
polypeptide(L) P15692 Neuropilin-1, Vascular endothelial growth factor A

4GLN
Chemical Synthesis and X-Ray Structure of a Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex by Racemic Crystallography

Entity type Code Description
polypeptide(D) 4GLN D-RFX001
polypeptide(L) P15692 Vascular endothelial growth factor A

4GLS
Chemical Synthesis and X-Ray Structure of a Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex by Racemic Crystallography

Entity type Code Description
polypeptide(D) 4GLS D- Vascular endothelial growth factor-A
polypeptide(L) 4GLS L- RFX001
polypeptide(D) 4GLS D- RFX001
polypeptide(L) P15692 Vascular endothelial growth factor A
Ligand PEG DI(HYDROXYETHYL)ETHER

4GZ9
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.

Entity type Code Description
polypeptide(L) P97333 Neuropilin-1
Ligand None SUGAR (3-MER)
Ligand NAG SUGAR (N-ACETYL-D-GLUCOSAMINE)

4GZA
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.

Entity type Code Description
polypeptide(L) P70207 Plexin-A2
polypeptide(L) O08665 Semaphorin-3A
polypeptide(L) P97333 Semaphorin-3A
polypeptide(L) P97333 Semaphorin-3A
polypeptide(L) P97333 Neuropilin-1
polypeptide(L) O08665 Neuropilin-1