PPAR-gamma

Peroxisome proliferator-activated receptor gamma

Reviewed UniProt entries for PPAR-gamma and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
O18971 PPARG_BOVIN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) PPARG NR1C3 Bos taurus (Bovine) 505
Q4U3Q4 PPARG_CANFA Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) PPARG NR1C3 Canis familiaris (Dog) (Canis lupus familiaris) 505
P57797 PPARG_CRIGR Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) PPARG NR1C3 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 475
P37231 PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) PPARG NR1C3 Homo sapiens (Human) 505
O18924 PPARG_MACMU Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) PPARG NR1C3 Macaca mulatta (Rhesus macaque) 505
P37238 PPARG_MOUSE Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) Pparg Nr1c3 Mus musculus (Mouse) 505
O62807 PPARG_PIG Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) PPARG NR1C3 Sus scrofa (Pig) 504
O19052 PPARG_RABIT Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) PPARG NR1C3 Oryctolagus cuniculus (Rabbit) 475
O88275 PPARG_RAT Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) Pparg Nr1c3 Rattus norvegicus (Rat) 505
P37234 PPARG_XENLA Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3) pparg nr1c3 Xenopus laevis (African clawed frog) 477
P70365 NCOA1_MOUSE Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Nuclear receptor coactivator protein 1) (mNRC-1) (Steroid receptor coactivator 1) (SRC-1) Ncoa1 Src1 Mus musculus (Mouse) 1447
Q4PJW2 NCOA1_PIG Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Steroid receptor coactivator 1) (SRC-1) NCOA1 SRC1 Sus scrofa (Pig) 1440
Q98TW1 NCOA2_DANRE Nuclear receptor coactivator 2 (NCoA-2) (NCoA2) (Glucocorticoid receptor-interacting protein 1) (Steroid receptor coactivator 2) (Transcriptional intermediary factor 2) ncoa2 grip1 src2 tif2 Danio rerio (Zebrafish) (Brachydanio rerio) 1505
Q15596 NCOA2_HUMAN Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2) NCOA2 BHLHE75 TIF2 Homo sapiens (Human) 1464
Q61026 NCOA2_MOUSE Nuclear receptor coactivator 2 (NCoA-2) (Glucocorticoid receptor-interacting protein 1) (GRIP-1) (Transcriptional intermediary factor 2) Ncoa2 Grip1 Tif2 Mus musculus (Mouse) 1462
Q9WUI9 NCOA2_RAT Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) Ncoa2 Tif2 Rattus norvegicus (Rat) 1465
Q9W705 NCOA2_XENLA Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) (xTIF2) ncoa2 tif2 Xenopus laevis (African clawed frog) 1516
B5DE09 NCOA2_XENTR Nuclear receptor coactivator 2 (NCoA-2) (Transcriptional intermediary factor 2) ncoa2 tif2 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 1440
O09000 NCOA3_MOUSE Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (Amplified in breast cancer-1 protein homolog) (AIB-1) (CBP-interacting protein) (p/CIP) (pCIP) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (ACTR) (TRAM-1) Ncoa3 Aib1 Pcip Rac3 Tram1 Mus musculus (Mouse) 1398
Q9EPU2 NCOA3_RAT Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (Amplified in breast cancer-1 protein homolog) (AIB-1) (Fragment) Ncoa3 Aib1 Rattus norvegicus (Rat) 1082
O57539 NCOA3_XENLA Nuclear receptor coactivator 3 (EC 2.3.1.48) (Retinoid X receptor-interacting coactivator xSRC-3) ncoa3 Xenopus laevis (African clawed frog) 1391
Q15788 NCOA1_HUMAN Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1) NCOA1 BHLHE74 SRC1 Homo sapiens (Human) 1441
Q9Y6Q9 NCOA3_HUMAN Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1) NCOA3 AIB1 BHLHE42 RAC3 TRAM1 Homo sapiens (Human) 1424

Our searches have not found small molecules for this target yet


258 PDB entries for PPAR-gamma and its protein partners


1FM6
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.

Entity type Code Description
polypeptide(L) P19793 RETINOIC ACID RECEPTOR RXR-ALPHA
polypeptide(L) P37231 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
polypeptide(L) O43793 STEROID RECEPTOR COACTIVATOR
Ligand 9CR (9CIS)-RETINOIC ACID
Ligand BRL 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL)

1FM9
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.

Entity type Code Description
polypeptide(L) P19793 RETINOIC ACID RECEPTOR RXR-ALPHA
polypeptide(L) P37231 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
polypeptide(L) O43793 STEROID RECEPTOR COACTIVATOR
Ligand 9CR (9CIS)-RETINOIC ACID
Ligand 570 2-(2-BENZOYL-PHENYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID

1GWQ
Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor Alpha.

Entity type Code Description
polypeptide(L) P03372 OESTROGEN RECEPTOR
polypeptide(L) Q15596 NUCLEAR RECEPTOR COACTIVATOR 2
Ligand ZTW RALOXIFENE CORE

1GWR
Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor Alpha.

Entity type Code Description
polypeptide(L) P03372 OESTROGEN RECEPTOR
polypeptide(L) Q15596 TRANSCRIPTION INTERMEDIARY FACTOR-2
Ligand EST ESTRADIOL

1I7I
Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family.

Entity type Code Description
polypeptide(L) P37231 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
Ligand AZ2 (2S)-2-ETHOXY-3-[4-(2-{4-[(METHYLSULFONYL)OXY]PHENYL}ETHOXY)PHENYL]PROPANOIC ACID

1K74
Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.

Entity type Code Description
polypeptide(L) P19793 Retinoic acid receptor RXR-alpha
polypeptide(L) P37231 Peroxisome proliferator activated receptor gamma
polypeptide(L) O43792 steroid receptor coactivator
Ligand 9CR (9CIS)-RETINOIC ACID
Ligand 544 2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID

1KBH
Mutual synergistic folding in recruitment of CBP/p300 by p160 nuclear receptor coactivators.

Entity type Code Description
polypeptide(L) Q9Y6Q9 nuclear receptor coactivator
polypeptide(L) P45481 CREB-BINDING PROTEIN

1KNU
Novel tricyclic-alpha-alkyloxyphenylpropionic acids: dual PPARalpha/gamma agonists with hypolipidemic and antidiabetic activity

Entity type Code Description
polypeptide(L) P37231 PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA
Ligand YPA (S)-3-(4-(2-CARBAZOL-9-YL-ETHOXY)-PHENYL)-2-ETHOXY-PROPIONIC ACID

1L2I
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.

Entity type Code Description
polypeptide(L) P03372 ESTROGEN RECEPTOR
polypeptide(L) Q61026 GLUCOCORTICOID RECEPTOR-INTERACTING PROTEIN 1
Ligand ETC (R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL

1M2Z
Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition

Entity type Code Description
polypeptide(L) P04150 glucocorticoid receptor
polypeptide(L) Q15596 nuclear receptor coactivator 2
Ligand BOG SUGAR (B-OCTYLGLUCOSIDE)
Ligand DEX DEXAMETHASONE

1MV9
Molecular Recognition of Agonist Ligands by RXRs

Entity type Code Description
polypeptide(L) P19793 RXR retinoid X receptor
polypeptide(L) Q15596 Nuclear receptor coactivator 2
Ligand HXA DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID

1MVC
Molecular Recognition of Agonist Ligands by RXRs

Entity type Code Description
polypeptide(L) P19793 RXR retinoid X receptor
polypeptide(L) Q15596 Nuclear receptor coactivator 2
Ligand BM6 4-[2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-[1,3]DIOXOLAN-2-YL]-BENZOIC ACID

1MZN
Molecular Recognition of Agonist Ligands by RXRs

Entity type Code Description
polypeptide(L) P19793 RXR retinoid X receptor
polypeptide(L) Q15596 Nuclear receptor coactivator 2
Ligand BM6 4-[2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-[1,3]DIOXOLAN-2-YL]-BENZOIC ACID

1NYX
Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar

Entity type Code Description
polypeptide(L) P37231 peroxisome proliferator activated receptor gamma
Ligand DRF (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID

1OSV
Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR

Entity type Code Description
polypeptide(L) Q62735 Bile acid receptor
polypeptide(L) Q61026 Nuclear receptor coactivator 2
Ligand CHC 6-ETHYL-CHENODEOXYCHOLIC ACID

1P93
The Three-dimensional Structures of Antagonistic and Agonistic Forms of the Glucocorticoid Receptor Ligand-binding Domain: RU-486 INDUCES A TRANSCONFORMATION THAT LEADS TO ACTIVE ANTAGONISM.

Entity type Code Description
polypeptide(L) P04150 Glucocorticoid receptor
polypeptide(L) Q15596 Nuclear receptor coactivator 2
Ligand DEX DEXAMETHASONE

1PRG
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma.

Entity type Code Description
polypeptide(L) P37231 PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA)

1RDT
Structure-based design of potent retinoid X receptor alpha agonists.

Entity type Code Description
polypeptide(L) P19793 Retinoic acid receptor RXR-alpha
polypeptide(L) 1RDT LxxLL motif coactivator
polypeptide(L) P37231 Peroxisome proliferator activated receptor gamma
polypeptide(L) 1RDT LxxLL motif coactivator
Ligand L79 (S)-(2E)-3[4-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-2-NAPHTHALENYL)TETRAHYDRO-1-BENZOFURAN-2-YL]-2-PROPENOIC ACID
Ligand 570 2-(2-BENZOYL-PHENYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID

1T63
The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor.

Entity type Code Description
polypeptide(L) P10275 Androgen receptor
polypeptide(L) Q15596 Nuclear receptor coactivator 2
Ligand DHT 5-ALPHA-DIHYDROTESTOSTERONE

1T65
The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor.

Entity type Code Description
polypeptide(L) P10275 Androgen receptor
polypeptide(L) Q15596 Nuclear receptor coactivator 2
Ligand DHT 5-ALPHA-DIHYDROTESTOSTERONE

1TFC
Structural Basis for the Deactivation of the Estrogen-related Receptor {gamma} by Diethylstilbestrol or 4-Hydroxytamoxifen and Determinants of Selectivity.

Entity type Code Description
polypeptide(L) P62508 Estrogen-related receptor gamma
polypeptide(L) Q15788 steroid receptor coactivator-1

1UHL
Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation

Entity type Code Description
polypeptide(L) P28702 Retinoic acid receptor RXR-beta
polypeptide(L) Q13133 Oxysterols receptor LXR-alpha
polypeptide(L) Q15596 10-mer peptide from Nuclear receptor coactivator 2
Ligand 444 N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE
Ligand MEI (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID

1WM0
A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects

Entity type Code Description
polypeptide(L) Q96J12 Peroxisome proliferator activated receptor gamma
polypeptide(L) Q61026 14-mer from Nuclear receptor coactivator 2
Ligand PLB 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID

1XIU
Crystal Structure of a Novel Tetrameric Complex of Agonist-bound Ligand-binding Domain of Biomphalaria glabrata Retinoid X Receptor.

Entity type Code Description
polypeptide(L) 19386469 RXR-like protein
polypeptide(L) Q15788 Nuclear receptor coactivator 1
Ligand REA RETINOIC ACID

1XLS
The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization.

Entity type Code Description
polypeptide(L) P19793 Retinoic acid receptor RXR-alpha
polypeptide(L) O35627 Orphan nuclear receptor NR1I3
polypeptide(L) Q9WUI9 Nuclear receptor coactivator 2
Ligand REA RETINOIC ACID
Ligand TCD 3,5-DICHLORO-2-{4-[(3,5-DICHLOROPYRIDIN-2-YL)OXY]PHENOXY}PYRIDINE

1YOK
Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

Entity type Code Description
polypeptide(L) O00482 Orphan nuclear receptor NR5A2
polypeptide(L) Q15596 Nuclear receptor coactivator 2
Ligand P6L (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE

1ZAF
Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones

Entity type Code Description
polypeptide(L) Q92731 Estrogen receptor beta
polypeptide(L) Q15788 Nuclear receptor coactivator 1
Ligand 789 3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE

1ZDT
The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1

Entity type Code Description
polypeptide(L) Q13285 Steroidogenic factor 1
polypeptide(L) Q15596 Nuclear receptor coactivator 2
Ligand PEF DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE