RGS4

Regulator of g-protein signaling 4 (rgs4)

Reviewed UniProt entries for RGS4 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q0R4E4 RGS4_RABIT Regulator of G-protein signaling 4 (RGS4) RGS4 Oryctolagus cuniculus (Rabbit) 205
Q29RM9 RGS4_BOVIN Regulator of G-protein signaling 4 (RGS4) RGS4 Bos taurus (Bovine) 205
Q7SZC6 RGS4_CHICK Regulator of G-protein signaling 4 (RGS4) RGS4 Gallus gallus (Chicken) 208
P49798 RGS4_HUMAN Regulator of G-protein signaling 4 (RGP4) (RGS4) RGS4 Homo sapiens (Human) 205
Q4R525 RGS4_MACFA Regulator of G-protein signaling 4 (RGS4) RGS4 QflA-11075 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 205
O08899 RGS4_MOUSE Regulator of G-protein signaling 4 (RGS4) Rgs4 Mus musculus (Mouse) 205
Q5R747 RGS4_PONAB Regulator of G-protein signaling 4 (RGS4) RGS4 Pongo abelii (Sumatran orangutan) 205
P49799 RGS4_RAT Regulator of G-protein signaling 4 (RGP4) (RGS4) Rgs4 Rattus norvegicus (Rat) 205

Small molecules tested in RGS4 binding assays:

1 datapoints for 1 distinct small molecules


Name CCG-4986
Affinity Icro(FCPIA) 4.2uM
Assay description flow cytometry protein interaction assay (see paper for details)
-- Direct single protein target assigned: RGS4_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1124/mol.106.028670
Doc title Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay.
PDB None

3 PDB entries for RGS4 and its protein partners


1AGR
Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis.

Entity type Code Description
polypeptide(L) P10824 GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)
polypeptide(L) P49799 RGS4
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand CIT CITRIC ACID

1EZT
NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha.

Entity type Code Description
polypeptide(L) P49799 REGULATOR OF G-PROTEIN SIGNALING 4

1EZY
NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha.

Entity type Code Description
polypeptide(L) P49799 REGULATOR OF G-PROTEIN SIGNALING 4