RRTF1

Runt-related transcription factor 1

Reviewed UniProt entries for RRTF1 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q03347 RUNX1_MOUSE Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) Runx1 Aml1 Cbfa2 Pebp2ab Mus musculus (Mouse) 451
Q63046 RUNX1_RAT Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) Runx1 Aml1 Cbfa2 Rattus norvegicus (Rat) 450
Q6PF39 RUNX1_XENLA Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (XAML) (Core-binding factor subunit alpha-2) (CBF-alpha-2) runx1 aml cbfa2 Xenopus laevis (African clawed frog) 462
Q13951 PEBB_HUMAN Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit) CBFB Homo sapiens (Human) 182
Q08024 PEBB_MOUSE Core-binding factor subunit beta (CBF-beta) (Polyomavirus enhancer-binding protein 2 beta subunit) (PEA2-beta) (PEBP2-beta) (SL3-3 enhancer factor 1 subunit beta) (SL3/AKV core-binding factor beta subunit) Cbfb Pebp2b Pebpb2 Mus musculus (Mouse) 187
Q01196 RUNX1_HUMAN Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit) RUNX1 AML1 CBFA2 Homo sapiens (Human) 453

Our searches have not found small molecules for this target yet


15 PDB entries for RRTF1 and its protein partners


1CL3
Molecular insights into PEBP2/CBF beta-SMMHC associated acute leukemia revealed from the structure of PEBP2/CBF beta

Entity type Code Description
polypeptide(L) Q13951 POLYOMAVIRUS ENHANCER BINDING PROTEIN 2

1CMO
Immunoglobulin motif DNA recognition and heterodimerization of the PEBP2/CBF Runt domain.

Entity type Code Description
polypeptide(L) Q01196 POLYOMAVIRUS ENHANCER BINDING PROTEIN 2

1CO1
The Ig fold of the core binding factor alpha Runt domain is a member of a family of structurally and functionally related Ig-fold DNA-binding domains.

Entity type Code Description
polypeptide(L) Q01196 CORE BINDING FACTOR ALPHA

1E50
Structural Basis for the Heterodimeric Interaction between the Acute Leukaemia-Associated Transcription Factors Aml1 and Cbfbeta

Entity type Code Description
polypeptide(L) Q01196 CORE-BINDING FACTOR ALPHA SUBUNIT
polypeptide(L) Q13951 CORE-BINDING FACTOR CBF-BETA

1EAN
The Runx1 Runt Domain at 1.25 A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding

Entity type Code Description
polypeptide(L) Q03347 RUNT-RELATED TRANSCRIPTION FACTOR 1

1EAO
The Runx1 Runt Domain at 1.25A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding

Entity type Code Description
polypeptide(L) Q03347 RUNT-RELATED TRANSCRIPTION FACTOR 1

1EAQ
The Runx1 Runt Domain at 1.25 A Resolution: A Structural Switch and Specifically Bound Chloride Ions Modulate DNA Binding

Entity type Code Description
polypeptide(L) Q03347 RUNT-RELATED TRANSCRIPTION FACTOR 1

1H9D
The Leukemia-Associated Aml1 (Runx1)-Cbfbeta Complex Functions as a DNA-Induced Molecular Clamp

Entity type Code Description
polypeptide(L) Q01196 CORE-BINDING FACTOR ALPHA SUBUNIT1
polypeptide(L) Q13951 CORE-BINDING FACTOR CBF-BETA
polydeoxyribonucleotide 1H9D DNA (5'-(*GP*TP*TP*GP*CP*GP*GP*TP*TP*G)-3')
polydeoxyribonucleotide 1H9D DNA (5'-(*CP*AP*AP*CP*CP*GP*CP*AP*AP*C)-3')

1HJB
Structural Analyses of DNA Recognition by the Aml1/Runx-1 Runt Domain and its Allosteric Control by Cbfbeta

Entity type Code Description
polypeptide(L) P17676 CCAAT/ENHANCER BINDING PROTEIN BETA
polypeptide(L) Q03347 RUNT-RELATED TRANSCRIPTION FACTOR 1
polydeoxyribonucleotide 1HJB DNA (5'-(*GP*AP*AP*GP*AP*TP*TP*TP*CP*CP* AP*AP*AP*CP*TP*CP*TP*GP*TP*GP*GP*TP*TP*GP*CP*G)-3')
polydeoxyribonucleotide 1HJB DNA (5'-(*CP*CP*GP*CP*AP*AP*CP*CP*AP*CP* AP*GP*AP*GP*TP*TP*TP*GP*GP*AP*AP*AP*TP*CP*TP*T)-3')

1HJC
Structural Analyses of DNA Recognition by the Aml1/Runx-1 Runt Domain and its Allosteric Control by Cbfbeta

Entity type Code Description
polypeptide(L) Q03347 RUNT-RELATED TRANSCRIPTION FACTOR 1
polydeoxyribonucleotide 1HJC DNA (5'-(*GP*AP*AP*CP*TP*CP*TP*GP*TP*GP*GP* TP*TP*GP*CP*G)-3')
polydeoxyribonucleotide 1HJC DNA (5'-(CP*CP*GP*CP*AP*AP*CP*CP*AP*CP*AP* GP*AP*GP*TP*T)-3')

1ILF
Structure and backbone dynamics of Apo-CBFbeta in solution.

Entity type Code Description
polypeptide(L) Q08024 CORE-BINDING FACTOR

1IO4
Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta.

Entity type Code Description
polydeoxyribonucleotide 1IO4 CSF-1R PROMOTER
polydeoxyribonucleotide 1IO4 CSF-1R PROMOTER
polypeptide(L) P17676 CAAT/ENHANCER BINDING PROTEIN BETA
polypeptide(L) Q03347 RUNT-RELATED TRANSCRIPTION FACTOR 1
polypeptide(L) Q08024 CORE-BINDING FACTOR, BETA SUBUNIT
Ligand AU GOLD ION

1LJM
DNA Recognition by the RUNX1 Transcription Factor Is Mediated by an Allosteric Transition in the RUNT Domain and by DNA Bending.

Entity type Code Description
polypeptide(L) Q01196 RUNX1 transcription factor

2J6W
A Mutation in the S-Switch Region of the Runt Domain Alters the Dynamics of an Allosteric Network Responsible for Cbfbeta Regulation.

Entity type Code Description
polypeptide(L) Q03347 RUNT-RELATED TRANSCRIPTION FACTOR 1

2JHB
Solution structure of core binding factor beta and map of the CBF alpha binding site.

Entity type Code Description
polypeptide(L) Q08024 PROTEIN (CORE BINDING FACTOR BETA)