Rad51

Dna repair and recombination protein rada

Reviewed UniProt entries for Rad51 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
P0CW92 RADA_AERPE DNA repair and recombination protein RadA radA APE_0119 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 319
P0CW91 RADA_AERPX DNA repair and recombination protein RadA radA Aeropyrum pernix 319
O29269 RADA_ARCFU DNA repair and recombination protein RadA radA AF_0993 Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126) 337
O93748 RADA_CENSY DNA repair and recombination protein RadA radA CENSYa_0250 Cenarchaeum symbiosum (strain A) 398
Q9Y8J4 RADA_DESAM DNA repair and recombination protein RadA radA Desulfurococcus amylolyticus 328
B8D610 RADA_DESK1 DNA repair and recombination protein RadA radA DKAM_1215 Desulfurococcus kamchatkensis (strain 1221n / DSM 18924) 328
B0R7Y4 RADA_HALS3 DNA repair and recombination protein RadA radA OE_4466R Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) 343
Q9HMM4 RADA_HALSA DNA repair and recombination protein RadA radA radA1 VNG_2473G Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) (Halobacterium halobium) 343
Q48328 RADA_HALVD DNA repair and recombination protein RadA radA HVO_0104 Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii) 343
Q18EU1 RADA_HALWD DNA repair and recombination protein RadA radA HQ_3429A Haloquadratum walsbyi (strain DSM 16790) 343
A8AB83 RADA_IGNH4 DNA repair and recombination protein RadA radA Igni_1006 Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) 327
Q8TK71 RADA_METAC DNA repair and recombination protein RadA radA MA_3545 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 325
Q46A31 RADA_METBF DNA repair and recombination protein RadA radA Mbar_A2338 Methanosarcina barkeri (strain Fusaro / DSM 804) 325
Q12UG7 RADA_METBU DNA repair and recombination protein RadA radA Mbur_2033 Methanococcoides burtonii (strain DSM 6242) 325
Q49593 RADA_METJA DNA repair and recombination protein RadA radA MJ0869 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) 352
A2SR54 RADA_METLZ DNA repair and recombination protein RadA radA Mlab_0637 Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) 329
A4FWV5 RADA_METM5 DNA repair and recombination protein RadA radA MmarC5_0368 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 322
A9AA90 RADA_METM6 DNA repair and recombination protein RadA radA MmarC6_1450 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 322
A6VGG2 RADA_METM7 DNA repair and recombination protein RadA radA MmarC7_0469 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 322
Q8PZN5 RADA_METMA DNA repair and recombination protein RadA radA MM_0457 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) 325
P0CW58 RADA_METMI DNA repair and recombination protein RadA radA Methanococcus maripaludis (Methanococcus deltae) 322
A3CWU4 RADA_METMJ DNA repair and recombination protein RadA radA Memar_1918 Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) 324
P0CW59 RADA_METMP DNA repair and recombination protein RadA radA MMP1222 Methanococcus maripaludis (strain S2 / LL) 322
A5UMW0 RADA_METS3 DNA repair and recombination protein RadA radA Msm_1333 Methanobrevibacter smithii (strain PS / ATCC 35061 / DSM 861) 311
A4YCN4 RADA_METS5 DNA repair and recombination protein RadA radA Msed_0009 Metallosphaera sedula (strain ATCC 51363 / DSM 5348) 324
Q2NE95 RADA_METST DNA repair and recombination protein RadA radA Msp_1488 Methanosphaera stadtmanae (strain DSM 3091) 311
O27436 RADA_METTH DNA repair and recombination protein RadA radA MTH_1383 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum) 311
O73948 RADA_METVO DNA repair and recombination protein RadA radA Methanococcus voltae 322
Q74MX9 RADA_NANEQ DNA repair and recombination protein RadA radA NEQ426 Nanoarchaeum equitans (strain Kin4-M) 325
Q6L126 RADA_PICTO DNA repair and recombination protein RadA radA PTO0741 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) 323
Q9V233 RADA_PYRAB DNA repair and recombination protein RadA radA PYRAB02410 PAB0164 Pyrococcus abyssi (strain GE5 / Orsay) 353
Q8ZYR9 RADA_PYRAE DNA repair and recombination protein RadA radA PAE0654 Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827) 333
A4WN87 RADA_PYRAR DNA repair and recombination protein RadA radA Pars_2310 Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321) 333
A3MXX9 RADA_PYRCJ DNA repair and recombination protein RadA radA Pcal_2081 Pyrobaculum calidifontis (strain JCM 11548 / VA1) 332
O74036 RADA_PYRFU DNA repair and recombination protein RadA radA PF1926 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 349
O58001 RADA_PYRHO DNA repair and recombination protein RadA [Cleaved into: Pho RadA intein] radA PH0263 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 529
Q9UWR5 RADA_PYRIL DNA repair and recombination protein RadA radA Pisl_0713 Pyrobaculum islandicum (strain DSM 4184 / JCM 9189) 330
Q5JET4 RADA_PYRKO DNA repair and recombination protein RadA [Cleaved into: Pko RadA intein] radA TK1899 Pyrococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) (Thermococcus kodakaraensis (strain KOD1)) 836
B1YC14 RADA_PYRNV DNA repair and recombination protein RadA radA Tneu_1953 Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / V24Sta) (Thermoproteus neutrophilus) 330
Q4JAT5 RADA_SULAC DNA repair and recombination protein RadA radA Saci_0715 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 321
C3MZK6 RADA_SULIA DNA repair and recombination protein RadA radA M1627_1967 Sulfolobus islandicus (strain M.16.27) 324
C4KIT6 RADA_SULIK DNA repair and recombination protein RadA radA M164_1897 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 324
C3MRI1 RADA_SULIL DNA repair and recombination protein RadA radA LS215_1999 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 324
C3MY77 RADA_SULIM DNA repair and recombination protein RadA radA M1425_1890 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 324
C3NFU5 RADA_SULIN DNA repair and recombination protein RadA radA YN1551_0954 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 324
C3N7M8 RADA_SULIY DNA repair and recombination protein RadA radA YG5714_1966 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 324
Q55075 RADA_SULSO DNA repair and recombination protein RadA radA SSO0250 Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 324
Q975Y1 RADA_SULTO DNA repair and recombination protein RadA radA STK_02970 Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 324
Q9HJ68 RADA_THEAC DNA repair and recombination protein RadA radA Ta1104 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 323
Q97BJ9 RADA_THEVO DNA repair and recombination protein RadA radA TV0456 TVG0443339 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 323
P94102 RAD51_ARATH DNA repair protein RAD51 homolog 1 (Rad51-like protein 1) (AtRAD51) RAD51 At5g20850 F22D1.20 Arabidopsis thaliana (Mouse-ear cress) 342
Q2KJ94 RAD51_BOVIN DNA repair protein RAD51 homolog 1 RAD51 Bos taurus (Bovine) 339
Q8MKI8 RAD51_CANFA DNA repair protein RAD51 homolog 1 (cRad51) RAD51 Canis familiaris (Dog) (Canis lupus familiaris) 339
P37383 RAD51_CHICK DNA repair protein RAD51 homolog 1 RAD51A RAD51 Gallus gallus (Chicken) 339
P70099 RAD51_CRIGR DNA repair protein RAD51 homolog 1 RAD51 RAD51A Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 339
Q06609 RAD51_HUMAN DNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A) RAD51 RAD51A RECA Homo sapiens (Human) 339
Q08297 RAD51_MOUSE DNA repair protein RAD51 homolog 1 (RAD51 homolog A) Rad51 Rad51a Reca Mus musculus (Mouse) 339
O77507 RAD51_RABIT DNA repair protein RAD51 homolog 1 RAD51 Oryctolagus cuniculus (Rabbit) 339
Q864S8 BRCA2_FELCA Breast cancer type 2 susceptibility protein homolog (Fanconi anemia group D1 protein homolog) BRCA2 FANCD1 Felis catus (Cat) (Felis silvestris catus) 3372
P51587 BRCA2_HUMAN Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) BRCA2 FACD FANCD1 Homo sapiens (Human) 3418
P97929 BRCA2_MOUSE Breast cancer type 2 susceptibility protein homolog (Fanconi anemia group D1 protein homolog) Brca2 Fancd1 Mus musculus (Mouse) 3329
O35923 BRCA2_RAT Breast cancer type 2 susceptibility protein homolog (Fanconi anemia group D1 protein homolog) Brca2 Fancd1 Rattus norvegicus (Rat) 3343

Small molecules tested in Rad51 binding assays:

66 datapoints for 32 distinct small molecules


Name Frag_5
Affinity Kd = 1mM
Assay description ITC
-- Direct single protein target assigned: RADA_PYRFU (Expert curation) --
DOI http://dx.doi.org/10.1002/cbic.201200521
Doc title Using a Fragment-Based Approach To Target Protein-Protein Interactions
PDB 4B2I - (LZ1)

Name Frag_8
Affinity Kd = 0.57mM
Assay description ITC
-- Direct single protein target assigned: RADA_PYRFU (Expert curation) --
DOI http://dx.doi.org/10.1002/cbic.201200521
Doc title Using a Fragment-Based Approach To Target Protein–Protein Interactions
PDB 4B2L - (TR7)

Name Frag_10
Affinity Kd = 0.46mM
Assay description ITC
-- Direct single protein target assigned: RADA_PYRFU (Expert curation) --
DOI http://dx.doi.org/10.1002/cbic.201200521
Doc title Using a Fragment-Based Approach To Target Protein–Protein Interactions
PDB 4B32 - (03V)

Name Frag_9
Affinity Kd = 0.43mM
Assay description ITC
-- Direct single protein target assigned: RADA_PYRFU (Expert curation) --
DOI http://dx.doi.org/10.1002/cbic.201200521
Doc title Using a Fragment-Based Approach To Target Protein–Protein Interactions
PDB 4B33 - (1NP)

Name Frag_6
Affinity Kd = 0.73mM
Assay description ITC
-- Direct single protein target assigned: RADA_PYRFU (Expert curation) --
DOI http://dx.doi.org/10.1002/cbic.201200521
Doc title Using a Fragment-Based Approach To Target Protein–Protein Interactions
PDB 4B34 - (ABV)

Name Frag_4
Affinity Kd = 1.3mM
Assay description ITC
-- Direct single protein target assigned: RADA_PYRFU (Expert curation) --
DOI http://dx.doi.org/10.1002/cbic.201200521
Doc title Using a Fragment-Based Approach To Target Protein–Protein Interactions
PDB 4B35 - (4ME)

Name Frag_1
Affinity Kd = 2.1mM
Assay description ITC
-- Direct single protein target assigned: RADA_PYRFU (Expert curation) --
DOI http://dx.doi.org/10.1002/cbic.201200521
Doc title Using a Fragment-Based Approach To Target Protein–Protein Interactions
PDB 4B3C - (5H1)

Name Frag_2
Affinity Kd = 2.1mM
Assay description ITC
-- Direct single protein target assigned: RADA_PYRFU (Expert curation) --
DOI http://dx.doi.org/10.1002/cbic.201200521
Doc title Using a Fragment-Based Approach To Target Protein–Protein Interactions
PDB 4B3D - (5MI)

Name CHEMBL1271764
Affinity IC50 = 6.43uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL1271993
Affinity IC50 = 6.82uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL1271993
Affinity Active
Assay description Inhibition of RAD51-mediated homologous recombination in HEK293 cells at 20 uM after 24 hrs by reporter gene assay based FACS analysis
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL1271993
Affinity tde
Assay description Inhibition of human RAD51 binding to single stranded DNA at 59 uM by fluorescence polarization based assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL1271993
Affinity Active
Assay description Irreversible inhibition of human RAD51 binding to single stranded DNA at 10 uM after 30 mins by fluorescence polarization based assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL1271993
Affinity Active
Assay description Inhibition of RAD51 in HEK293 cells assessed as stimulation of single strand annealing at 20 uM after 24 hrs by reporter gene assay based FACS analysis
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL1334552
Affinity IC50 = 19.7uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL1414442
Affinity IC50 = 14.88uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL1497208
Affinity IC50 = 17.85uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Inhibition of RAD51 in HEK cells assessed as potentiation of cisplatin-induced cytotoxicity at 5 uM in presence of RAD51 siRNA transfected 40 hrs before compound and cisplatin exposure for 16 hrs by clonogenic survival assay relative to untreated control
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Inhibition of RAD51 in MEF cells assessed as potentiation of MMC-induced cytotoxicity at 5 uM incubated for 1 hr in presence of 0.01 uM PARP1 inhibitor AZD2281 by clonogenic survival assay relative to untreated control
-- Direct single protein target assigned: RAD51_MOUSE (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Inhibition of DNA binding to human RAD51 in irradiated HEK cells assessed as reduction in RAD51 foci formation at 25 uM by fluorescence microscopy relative to untreated control
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity IC50 = 35uM
Assay description Inhibition of human RAD51-mediated DNA strand exchange at using pBSK (+) gapped and linear dsDNA substrates by joint molecule formation assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity IC50 = 35uM
Assay description Inhibition of human RAD51-mediated DNA branch migration using [32P]-labeled 5'-joint molecules after 8 hrs by branch migration assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Activity = 3.2%
Assay description Inhibition of human RAD51 in HEK-GFP cells assessed as reduction in double-strand breaks-induced homologous recombination by measuring GFP fluorescence at 5 uM by chromosomally integrated DR-GFP reporter gene assay (Rvb = 3.3%)
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Inhibition of human RAD51-mediated DNA branch migration at 10 to 100 microM using [32P]-labeled 5'-joint molecules after 8 hrs by branch migration assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Inhibition of RAD51 in Tp53-/- MEF cells assessed as potentiation of 1 uM MMC-induced cytotoxicity at 5 uM incubated for 1 hr by clonogenic survival assay relative to untreated control
-- Direct single protein target assigned: RAD51_MOUSE (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Not Active
Assay description Inhibition of RAD51 in MEF cells assessed as potentiation of MMC-induced cytotoxicity at 5 uM incubated for 1 hr by clonogenic survival assay relative to untreated control
-- Direct single protein target assigned: RAD51_MOUSE (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Inhibition of RAD51 in Tp53-/- MEF cells assessed as potentiation of 32 uM cisplatin-induced cytotoxicity at 5 uM incubated for 1 hr by clonogenic survival assay relative to untreated control
-- Direct single protein target assigned: RAD51_MOUSE (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Dose-dependent effect
Assay description Inhibition of human RAD51 in HEK-GFP cells assessed as reduction in double-strand breaks-induced homologous recombination by chromosomally integrated DR-GFP reporter gene assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Inhibition of human RAD51 ATPase activity at 25 uM by ATP hydrolysis assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Binding affinity to human RAD51 at 50 microM by SPR method
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Inhibition of human RAD51-ssDNA filament formation at 20 uM added to free RAD51 prior to filament formation by D-loop formation assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Inhibition of human RAD51-mediated DNA strand exchange at 10 to 100 microM using pBSK (+) gapped and linear dsDNA substrates by joint molecule formation assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Activity = 19%
Assay description Inhibition of DNA binding to human RAD51 in irradiated HEK cells assessed as RAD51 foci formation at 50 uM by fluorescence microscopy (Rvb= 72 +/- 10%)
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Inhibition of RAD51 in HEK cells assessed as potentiation of cisplatin-induced cytotoxicity at 5 uM in presence of RAD51 siRNA transfected 40 hrs before compound and cisplatin exposure for 10 to 12 hrs by clonogenic survival assay relative to untreated control
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Inhibition of RAD51 in HEK cells assessed as potentiation of cisplatin-induced cytotoxicity at 5 uM in presence of RAD51 siRNA transfected 40 hrs before compound and cisplatin addition by clonogenic survival assay relative to untreated control
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Kd = 5.6uM
Assay description Binding affinity to human RAD51 in absence of ATP by SPR method
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Inhibition of ssDNA binding to human RAD51 assessed as reduction in RAD51-90-mer ssDNA complex formation at 25 uM by EMSA method
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Active
Assay description Inhibition of dsDNA binding to human RAD51-ssDNA filament assessed as reduction in coaggregation formation at 20 uM in presence of 50 mM NaCl by dsDNA coaggregation assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Activity = 0.4%
Assay description Inhibition of human RAD51 in HEK-GFP cells assessed as reduction in double-strand breaks-induced homologous recombination by measuring GFP fluorescence at 20 uM by chromosomally integrated DR-GFP reporter gene assay (Rvb = 3.3%)
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Activity = 1.7%
Assay description Inhibition of human RAD51 in HEK-GFP cells assessed as reduction in double-strand breaks-induced homologous recombination by measuring GFP fluorescence at 10 uM by chromosomally integrated DR-GFP reporter gene assay (Rvb = 3.3%)
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL1567670
Affinity Not Active
Assay description Inhibition of human RAD51 oligomerization at 200 uM by gel filtration method
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL2036037
Affinity Not Active
Assay description Inhibition of human RAD51 in HEK-GFP cells assessed as reduction in double-strand breaks-induced homologous recombination at 5 to 20 uM by chromosomally integrated DR-GFP reporter gene assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL2036037
Affinity Not Active
Assay description Inhibition of human RAD51-mediated DNA strand exchange at 5 to 20 uM using pBSK (+) gapped and linear dsDNA substrates by joint molecule formation assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22380680
Doc title Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.
PDB None

Name CHEMBL2316719
Affinity IC50 = 15.62uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316720
Affinity IC50 = 2.14uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316721
Affinity IC50 = 1.4uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316722
Affinity IC50 = 0.93uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316723
Affinity IC50 = 0.81uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316724
Affinity IC50 = 0.37uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316725
Affinity IC50 = 0.25uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316726
Affinity Not Active
Assay description Irreversible inhibition of human RAD51 binding to single stranded DNA at 240 uM after 30 mins by fluorescence polarization based assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316726
Affinity Dose-dependent effect
Assay description Competitive inhibition of human RAD51 binding to single stranded DNA after 30 mins by fluorescence polarization based assay in the presence of 3-chloro-1-(3,4-dichlorophenyl)-4-morpholino-1H-pyrrole-2,5-dione
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316726
Affinity IC50 = 44.17uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316726
Affinity Active
Assay description Inhibition of RAD51 in HEK293 cells assessed as stimulation of single strand annealing at 60 uM after 24 hrs by reporter gene assay based FACS analysis
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316726
Affinity Active
Assay description Reversible inhibition of human RAD51 binding to single stranded DNA at 240 uM after 30 mins by fluorescence polarization based assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316726
Affinity Not Active
Assay description Time dependent inhibition of human RAD51 binding to single stranded DNA at 59 uM by fluorescence polarization based assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316726
Affinity Active
Assay description Inhibition of RAD51-mediated homologous recombination in HEK293 cells at 60 uM after 24 hrs by reporter gene assay based FACS analysis
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316728
Affinity IC50 > 50uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316730
Affinity IC50 > 50uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316733
Affinity IC50 = 38.17uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316734
Affinity IC50 = 13.16uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316735
Affinity IC50 = 8.32uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316736
Affinity IC50 = 7.91uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316737
Affinity IC50 = 9.94uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316738
Affinity IC50 = 3.1uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

Name CHEMBL2316739
Affinity IC50 = 5.29uM
Assay description Inhibition of human RAD51 binding to single stranded DNA by fluorescence polarization assay
-- Direct single protein target assigned: RAD51_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23231413
Doc title An optimized RAD51 inhibitor that disrupts homologous recombination without requiring Michael acceptor reactivity.
PDB None

43 PDB entries for Rad51 and its protein partners


1B22
The N-terminal domain of the human Rad51 protein binds DNA: structure and a DNA binding surface as revealed by NMR.

Entity type Code Description
polypeptide(L) Q06609 DNA REPAIR PROTEIN RAD51

1IYJ
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.

Entity type Code Description
polypeptide(L) P60896 Deleted in split hand/split foot protein 1
polypeptide(L) O35923 breast cancer susceptibility

1MIU
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

Entity type Code Description
polypeptide(L) P60896 Deleted in split hand/split foot protein 1
polypeptide(L) P97929 Breast Cancer type 2 susceptibility protein

1N0W
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

Entity type Code Description
polypeptide(L) Q06609 DNA repair protein RAD51 homolog 1
polypeptide(L) P51587 Breast cancer type 2 susceptibility protein
polypeptide(L) 1N0W peptide linker
polypeptide(L) 1N0W ARTIFICIAL GLY-SER-MSE-GLY PEPTIDE

1PZN
Full-length archaeal Rad51 structure and mutants: Mechanisms for RAD51 assembly and control by BRCA2

Entity type Code Description
polypeptide(L) O74036 DNA repair and recombination protein rad51
Ligand IMD IMIDAZOLE
Ligand MPD (4S)-2-METHYL-2,4-PENTANEDIOL

1T4G
Crystal Structure of Archaeal Recombinase RadA; A Snapshot of Its Extended Conformation.

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

1XU4
Crystal structure of an ATPase-active form of Rad51 homolog from Methanococcus voltae. Insights into potassium dependence

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

2B21
Crystal Structure of Methanococcus Voltae Rada at an Acidic pH

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

2BKE
Conformational Flexibility Revealed by the Crystal Structure of a Crenarchaeal Rada

Entity type Code Description
polypeptide(L) Q55075 DNA REPAIR AND RECOMBINATION PROTEIN RADA

2DFL
Crystal structure of the left-handed archaeal RadA helical filament: identification of a functional motif for controlling quaternary structures and enzymatic functions of RecA family proteins

Entity type Code Description
polypeptide(L) Q55075 DNA repair and recombination protein radA

2F1H
Asp302 determines potassium dependence of a RadA recombinase from Methanococcus voltae.

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

2F1I
Asp302 determines potassium dependence of a RadA recombinase from Methanococcus voltae.

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

2F1J
Asp302 determines potassium dependence of a RadA recombinase from Methanococcus voltae.

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA
Ligand ADP ADENOSINE-5'-DIPHOSPHATE

2FPK
Crystal Structure of Methanococcus Voltae Rada in Complex with Adp: hydrolysis-induced conformational change

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA
Ligand ADP ADENOSINE-5'-DIPHOSPHATE

2FPL
Crystal Structure of Methanococcus Voltae Rada in Complex with Adp: hydrolysis-induced conformational change

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

2FPM
Crystal Structure of Methanoccocus Voltae Rada in Complex with Adp: hydrolysis-induced conformational change

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

2GDJ
The Rad51/RadA N-Terminal Domain Activates Nucleoprotein Filament ATPase Activity.

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

2I1Q
Calcium Stiffens Archaeal Rad51 Recombinase from Methanococcus voltae for Homologous Recombination.

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

2LQM
NMR and Crystal Structures of the Pyrococcus horikoshii RadA Intein Guide a Strategy for Engineering a Highly Efficient and Promiscuous Intein.

Entity type Code Description
polypeptide(L) O58001 Pho radA intein

2Z43
Structural and functional analyses of five conserved positively charged residues in the L1 and N-terminal DNA binding motifs of archaeal RADA protein

Entity type Code Description
polypeptide(L) Q55075 DNA repair and recombination protein radA

2ZUB
Three new structures of left-handed RADA helical filaments: structural flexibility of N-terminal domain is critical for recombinase activity

Entity type Code Description
polypeptide(L) Q55075 DNA repair and recombination protein radA

2ZUC
Three new structures of left-handed RADA helical filaments: structural flexibility of N-terminal domain is critical for recombinase activity

Entity type Code Description
polypeptide(L) Q55075 DNA repair and recombination protein radA

2ZUD
Three new structures of left-handed RADA helical filaments: structural flexibility of N-terminal domain is critical for recombinase activity

Entity type Code Description
polypeptide(L) Q55075 DNA repair and recombination protein radA

3EU7
Structural basis for recruitment of BRCA2 by PALB2

Entity type Code Description
polypeptide(L) Q86YC2 Partner and localizer of BRCA2
polypeptide(L) P51587 19meric peptide from Breast cancer type 2 susceptibility protein

3FYH
Crystal structure of an archaeal Rad51 homologue in complex with a metatungstate inhibitor.

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA
Ligand ADP ADENOSINE-5'-DIPHOSPHATE
Ligand W TUNGSTEN ION

3NTU
RAD51 protein ATP cap regulates nucleoprotein filament stability.

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

4A6P
Pyrococcus Furiosus Rada ATP-Half Site Binds Nucleotides

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA

4A6X
Pyrococcus Furiosus Rada ATP-Half Site Binds Nucleotides

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA
Ligand ATP ADENOSINE-5'-TRIPHOSPHATE

4A74
Pyrococcus Furiosus Rada ATP-Half Site Binds Nucleotides

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

4A7O
Pyrococcus Furiosus Rada ATP-Half Site Binds Nucleotides

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA
Ligand ADP ADENOSINE-5'-DIPHOSPHATE

4B2I
Using a Fragment-Based Approach to Target Protein-Protein Interactions.

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA
Ligand LZ1 1H-INDAZOLE

4B2L
Using a Fragment-Based Approach to Target Protein-Protein Interactions.

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA
Ligand TR7 METHYL L-TRYPTOPHANATE

4B2P
Pyrococcus Furiosus Rada ATP-Half Site Binds Nucleotides

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE

4B32
Using a Fragment-Based Approach to Target Protein-Protein Interactions.

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA
Ligand 03V NAPHTHALEN-2-OL

4B33
Using a Fragment-Based Approach to Target Protein-Protein Interactions.

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA
Ligand 1NP 1-NAPHTHOL

4B34
Using a Fragment-Based Approach to Target Protein-Protein Interactions.

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA
Ligand ABV 1,3-BENZOTHIAZOL-2-AMINE

4B35
Using a Fragment-Based Approach to Target Protein-Protein Interactions.

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA
Ligand 4ME METHYL 1H-INDOLE-4-CARBOXYLATE

4B3B
Using a Fragment-Based Approach to Target Protein-Protein Interactions.

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA
polypeptide(L) 4B3B FHTA TETRAPEPTIDE

4B3C
Using a Fragment-Based Approach to Target Protein-Protein Interactions.

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA
Ligand 5H1 1H-INDOL-5-OL

4B3D
Using a Fragment-Based Approach to Target Protein-Protein Interactions.

Entity type Code Description
polypeptide(L) O74036 DNA REPAIR AND RECOMBINATION PROTEIN RADA
Ligand 5MI 5-METHYL INDOLE

4DC9
Structure of a hexameric form of RadA recombinase from Methanococcus voltae.

Entity type Code Description
polypeptide(L) O73948 DNA repair and recombination protein radA

4E2T
NMR and Crystal Structures of the Pyrococcus horikoshii RadA Intein Guide a Strategy for Engineering a Highly Efficient and Promiscuous Intein.

Entity type Code Description
polypeptide(L) O58001 Pho radA intein
Ligand EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID

4E2U
NMR and Crystal Structures of the Pyrococcus horikoshii RadA Intein Guide a Strategy for Engineering a Highly Efficient and Promiscuous Intein.

Entity type Code Description
polypeptide(L) O58001 Pho radA intein