STAT5

Signal transducer and activator of transcription 5a

Reviewed UniProt entries for STAT5 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q95115 STA5A_BOVIN Signal transducer and activator of transcription 5A (Mammary gland factor) STAT5A MGF Bos taurus (Bovine) 794
P42229 STA5A_HUMAN Signal transducer and activator of transcription 5A STAT5A STAT5 Homo sapiens (Human) 794
P42230 STA5A_MOUSE Signal transducer and activator of transcription 5A (Mammary gland factor) Stat5a Mgf Mpf Mus musculus (Mouse) 793
Q9TUZ1 STA5A_PIG Signal transducer and activator of transcription 5A STAT5A Sus scrofa (Pig) 799
Q62771 STA5A_RAT Signal transducer and activator of transcription 5A (Mammary gland factor) Stat5a Mgf Rattus norvegicus (Rat) 793
P42231 STA5A_SHEEP Signal transducer and activator of transcription 5A (Mammary gland factor) STAT5A MGF STAT5 Ovis aries (Sheep) 794

Small molecules tested in STAT5 binding assays:

19 datapoints for 5 distinct small molecules


Name CHEMBL1829862
Affinity Active
Assay description Inhibition of STAT5-mediated cyclin D2 expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL1829862
Affinity Active
Assay description Inhibition of STAT5-mediated cyclin D1 expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL1829862
Affinity Active
Assay description Inhibition of STAT5-mediated C-MYC expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL1829862
Affinity Active
Assay description Inhibition of STAT5 binding to cyclin D1 promoter region human K562 cells at 40 uM after 6 hrs by chromatin immunoprecipitation assay
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL1829862
Affinity Active
Assay description Inhibition of STAT5-mediated MCL-1 expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL1829862
Affinity Active
Assay description Inhibition of STAT5 binding to C-MYC promoter region human K562 cells at 40 uM after 6 hrs by chromatin immunoprecipitation assay
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL1829874
Affinity Active
Assay description Inhibition of STAT5-mediated cyclin D2 expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL1829874
Affinity Active
Assay description Inhibition of STAT5-mediated cyclin D1 expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL1829874
Affinity Active
Assay description Inhibition of STAT5-mediated MCL-1 expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL1829874
Affinity Active
Assay description Inhibition of STAT5-mediated C-MYC expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL1934094
Affinity Active
Assay description Inhibition of STAT5 protein expression in p53-deficient human HL60 cells at 20 to 50 uM after 6 hrs by western blot analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22123322
Doc title Acyl derivatives of boswellic acids as inhibitors of NF-kappaB and STATs.
PDB None

Name CHEMBL2023985
Affinity Active
Assay description Inhibition of STAT5-mediated cyclin D1 expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL2023985
Affinity Active
Assay description Inhibition of STAT5-mediated MCL-1 expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL2023985
Affinity Active
Assay description Inhibition of STAT5-mediated C-MYC expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL2023985
Affinity Active
Assay description Inhibition of STAT5-mediated cyclin D2 expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL2023989
Affinity Active
Assay description Inhibition of STAT5-mediated MCL-1 expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL2023989
Affinity Active
Assay description Inhibition of STAT5-mediated cyclin D2 expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL2023989
Affinity Active
Assay description Inhibition of STAT5-mediated cyclin D1 expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

Name CHEMBL2023989
Affinity Active
Assay description Inhibition of STAT5-mediated C-MYC expression in human K562 cells at 40 uM after 6 hrs by RT-PCR analysis
-- Direct single protein target assigned: STA5A_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148584
Doc title Small molecule STAT5-SH2 domain inhibitors exhibit potent antileukemia activity.
PDB None

1 PDB entries for STAT5 and its protein partners


1Y1U
Structure of the unphosphorylated STAT5a dimer

Entity type Code Description
polypeptide(L) P42230 Signal transducer and activator of transcription 5A