Sur-2

Mediator of rna polymerase ii transcription subunit 23

Reviewed UniProt entries for Sur-2 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q16HH9 MED23_AEDAE Mediator of RNA polymerase II transcription subunit 23 (Mediator complex subunit 23) MED23 AAEL014021 Aedes aegypti (Yellowfever mosquito) (Culex aegypti) 1409
Q5RIW8 MED23_DANRE Mediator of RNA polymerase II transcription subunit 23 (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) med23 crsp3 si:ch211-272f15.2 zgc:91979 Danio rerio (Zebrafish) (Brachydanio rerio) 1376
Q55BN0 MED23_DICDI Putative mediator of RNA polymerase II transcription subunit 23 (Putative mediator complex subunit 23) med23 DDB_G0270434 Dictyostelium discoideum (Slime mold) 1662
Q9W1X7 MED23_DROME Mediator of RNA polymerase II transcription subunit 23 (Mediator complex subunit 23) (dSUR2) (dTRAP150) MED23 Trap150 CG3695 Drosophila melanogaster (Fruit fly) 1439
Q80YQ2 MED23_MOUSE Mediator of RNA polymerase II transcription subunit 23 (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (mSur-2) Med23 Crsp3 Kiaa1216 Sur2 Mus musculus (Mouse) 1367
Q5EB59 MED23_RAT Mediator of RNA polymerase II transcription subunit 23 (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) Med23 Crsp3 Rattus norvegicus (Rat) 1367
Q6P423 MED23_XENLA Mediator of RNA polymerase II transcription subunit 23 (Mediator complex subunit 23) med23 Xenopus laevis (African clawed frog) 1369
Q3UPW2 ELF3_MOUSE ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) Elf3 Ert Esx Jen Mus musculus (Mouse) 391
Q4V7E1 ELF3_RAT ETS-related transcription factor Elf-3 (E74-like factor 3) Elf3 Rattus norvegicus (Rat) 395
P78545 ELF3_HUMAN ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1) ELF3 ERT ESX JEN Homo sapiens (Human) 371
Q9ULK4 MED23_HUMAN Mediator of RNA polymerase II transcription subunit 23 (Activator-recruited cofactor 130 kDa component) (ARC130) (Cofactor required for Sp1 transcriptional activation subunit 3) (CRSP complex subunit 3) (Mediator complex subunit 23) (Protein sur-2 homolog) (hSur-2) (Transcriptional coactivator CRSP130) (Vitamin D3 receptor-interacting protein complex 130 kDa component) (DRIP130) MED23 ARC130 CRSP3 DRIP130 KIAA1216 SUR2 Homo sapiens (Human) 1368

Small molecules tested in Sur-2 binding assays:

30 datapoints for 10 distinct small molecules


Name Adamanolol
Affinity IC50 (binding) 8uM
Assay description competitive Sur-2 with fluorecent labelled ESX
-- Direct single protein target assigned: MED23_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/ja0292703
Doc title A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction.
PDB None

Name CHEMBL1077445
Affinity Kd = 0.59uM
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression by western blotting
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1077445
Affinity Kd = 0.59uM
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression by western blotting
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1077454
Affinity Kd = 1uM
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression by western blotting
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1077454
Affinity Kd = 1uM
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression by western blotting
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1077474
Affinity Kd = 0.62uM
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression by western blotting
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1077474
Affinity Kd = 0.62uM
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression by western blotting
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1077475
Affinity Kd = 5.9uM
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression by western blotting
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1077475
Affinity Kd = 5.9uM
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression by western blotting
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078663
Affinity Dose-dependent effect
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression after 24 hrs by western blotting
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078663
Affinity Not Active
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression up to 50 uM by western blotting
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078663
Affinity Not Active
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression up to 50 uM by western blotting
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078663
Affinity Dose-dependent effect
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression after 24 hrs by western blotting
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078684
Affinity Not Active
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression up to 50 uM by western blotting
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078684
Affinity Dose-dependent effect
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression after 24 hrs by western blotting
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078684
Affinity Dose-dependent effect
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression after 24 hrs by western blotting
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078684
Affinity Not Active
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression up to 50 uM by western blotting
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078864
Affinity Active
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as reduction in ErbB2 mRNA level after 6 hrs by qPCR relative to control
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078864
Affinity Dose-dependent effect
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression after 24 hrs by western blotting
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078864
Affinity Active
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as reduction in ErbB2 mRNA level after 6 hrs by qPCR relative to control
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078864
Affinity Not Active
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression up to 50 uM by western blotting
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078864
Affinity Active
Assay description Inhibition of ESX-Med23 interaction in human SK-BR-3 cells assessed as down regulation of ErbB2 expression by western blotting
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078864
Affinity Dose-dependent effect
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression after 24 hrs by western blotting
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078864
Affinity Not Active
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression up to 50 uM by western blotting
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078864
Affinity Active
Assay description Inhibition of ESX-Med23 interaction in human SK-BR-3 cells assessed as down regulation of ErbB2 expression by western blotting
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078865
Affinity Not Active
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression up to 50 uM by western blotting
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078865
Affinity Not Active
Assay description Inhibition of ESX-Med23 interaction in human BT474 cells assessed as down regulation of ErbB2 expression up to 50 uM by western blotting
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078865
Affinity Active
Assay description Inhibition of ESX-Med23 interaction in human SK-BR-3 cells assessed as down regulation of ErbB2 expression at 25 uM by western blotting
-- Direct protein complex subunits assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL1078865
Affinity Active
Assay description Inhibition of ESX-Med23 interaction in human SK-BR-3 cells assessed as down regulation of ErbB2 expression at 25 uM by western blotting
-- Direct protein complex subunits assigned: ELF3_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19782563
Doc title Inhibition of ErbB2(Her2) expression with small molecule transcription factor mimics.
PDB None

Name CHEMBL2170196
Affinity Kd = 1.8uM
Assay description Binding affinity to Sur2
-- Homologous single protein target assigned: MED23_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21354674
Doc title The many faces of the adamantyl group in drug design.
PDB None

1 PDB entries for Sur-2 and its protein partners


3JTG
Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA.

Entity type Code Description
polypeptide(L) Q3UPW2 ETS-related transcription factor Elf-3
polydeoxyribonucleotide 3JTG DNA (5'-D(*GP*AP*GP*GP*AP*GP*TP*TP*TP*CP*CP*TP*GP*TP*TP*T)-3')
polydeoxyribonucleotide 3JTG DNA (5'-D(*CP*AP*AP*AP*CP*AP*GP*GP*AP*AP*AP*CP*TP*CP*CP*T)-3')