Tak1

Tgf-beta-activated kinase 1

Reviewed UniProt entries for Tak1 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q15750 TAB1_HUMAN TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) TAB1 MAP3K7IP1 Homo sapiens (Human) 504
Q8CF89 TAB1_MOUSE TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) Tab1 Map3k7ip1 Mus musculus (Mouse) 502

Small molecules tested in Tak1 binding assays:

86 datapoints for 86 distinct small molecules


Name CHEMBL162
Affinity IC50 = 0.035uM
Assay description Inhibition of TAB1
-- Homologous single protein target assigned: TAB1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19397322
Doc title Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells.
PDB None

Name CHEMBL2402081
Affinity INH = 5%
Assay description Inhibition of TAK1/TAB1 (unknown origin) at 10 uM relative to control
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23522834
Doc title Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
PDB None

Name CHEMBL2407098
Affinity IC50 = 2.4uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407752
Affinity IC50 = 3.5uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407753
Affinity IC50 = 2.5uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407754
Affinity IC50 > 30uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407755
Affinity IC50 = 2.8uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407756
Affinity IC50 = 1.5uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407757
Affinity IC50 = 0.023uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407758
Affinity IC50 = 0.013uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407759
Affinity IC50 = 0.004uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407760
Affinity IC50 = 0.03uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407761
Affinity IC50 = 0.018uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407762
Affinity IC50 = 1uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407763
Affinity IC50 = 0.34uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407764
Affinity IC50 = 1.4uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407765
Affinity IC50 = 2.7uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407766
Affinity IC50 = 1.2uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407767
Affinity IC50 = 0.25uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407768
Affinity IC50 = 2.8uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407769
Affinity IC50 = 2.8uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407770
Affinity IC50 = 0.53uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407771
Affinity IC50 = 0.79uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407772
Affinity IC50 = 0.85uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407773
Affinity IC50 = 17.5uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407774
Affinity IC50 = 25.7uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407775
Affinity IC50 = 1.8uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407776
Affinity IC50 = 4.9uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407777
Affinity IC50 = 0.27uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407778
Affinity IC50 = 0.88uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407779
Affinity IC50 = 0.43uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407780
Affinity IC50 > 30uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407781
Affinity IC50 = 0.56uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407782
Affinity IC50 > 30uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407783
Affinity IC50 = 5.4uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407784
Affinity IC50 = 6uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407785
Affinity IC50 = 0.75uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407786
Affinity IC50 = 1.4uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407787
Affinity IC50 = 0.25uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407788
Affinity IC50 = 4.3uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407789
Affinity IC50 = 4.9uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407790
Affinity IC50 = 1.8uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407791
Affinity IC50 = 1.4uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407792
Affinity IC50 = 0.089uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407793
Affinity IC50 = 0.77uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407794
Affinity IC50 = 3.2uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407795
Affinity IC50 = 0.061uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407796
Affinity IC50 = 1.8uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407956
Affinity IC50 = 3.2uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407957
Affinity IC50 = 3.5uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407958
Affinity IC50 = 1.1uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407959
Affinity IC50 = 0.71uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407960
Affinity IC50 = 0.8uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407961
Affinity IC50 = 0.46uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407962
Affinity IC50 = 0.65uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407963
Affinity IC50 = 1.2uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407964
Affinity IC50 = 2.1uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407965
Affinity IC50 = 0.48uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407966
Affinity IC50 = 0.13uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407967
Affinity IC50 = 1.6uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2407968
Affinity IC50 = 1.2uM
Assay description Inhibition of truncated TAK1-TAB1(unknown origin) using MKK7 as substrate by ALPHAScreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23850198
Doc title Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.
PDB None

Name CHEMBL2408610
Affinity IC50 = 0.009uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408611
Affinity IC50 = 0.028uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408612
Affinity IC50 = 0.16uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408613
Affinity IC50 = 0.11uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408614
Affinity IC50 = 0.031uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408615
Affinity IC50 = 0.017uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408616
Affinity IC50 = 0.014uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408617
Affinity IC50 = 0.15uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408618
Affinity IC50 = 4.9uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408619
Affinity IC50 = 12.7uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408721
Affinity IC50 = 0.56uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408722
Affinity IC50 = 2.1uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408723
Affinity IC50 = 2.2uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408724
Affinity IC50 = 4.6uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408725
Affinity IC50 = 1.4uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408726
Affinity IC50 = 0.23uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408727
Affinity IC50 = 3.2uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408728
Affinity IC50 = 3.8uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408729
Affinity IC50 = 23.6uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408730
Affinity IC50 = 2.9uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408731
Affinity IC50 = 3.5uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408732
Affinity IC50 = 4.1uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408733
Affinity IC50 = 23.9uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408734
Affinity IC50 = 0.6uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

Name CHEMBL2408735
Affinity IC50 = 22.8uM
Assay description Inhibition of TAK1-TAB1 (unknown origin) by alphascreen assay in presence of ATP
-- Direct protein complex subunits assigned: TAB1_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23856049
Doc title Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: optimization of kinase selectivity and pharmacokinetics.
PDB None

14 PDB entries for Tak1 and its protein partners


2J4O
Tak1-Binding Protein 1 is a Pseudophosphatase.

Entity type Code Description
polypeptide(L) Q15750 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 1

2POM
XIAP Induces NF-kappaB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization.

Entity type Code Description
polypeptide(L) Q15750 Mitogen-activated protein kinase kinase kinase 7-interacting protein 1

2POP
XIAP Induces NF-kappaB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization.

Entity type Code Description
polypeptide(L) Q15750 Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
polypeptide(L) Q15750 Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
polypeptide(L) P98170 Baculoviral IAP repeat-containing protein 4

2YDS
Synergy of Peptide and Sugar in O-Glcnacase Substrate Recognition.

Entity type Code Description
polypeptide(L) Q0TR53 O-GLCNACASE NAGJ
polypeptide(L) Q15750 TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
Ligand NAG SUGAR (N-ACETYL-D-GLUCOSAMINE)

2YIY
The Discovery and Synthesis of Selective Dfg-Out Tak-1 Inhibitors

Entity type Code Description
polypeptide(L) O43318 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7, TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
polypeptide(L) Q15750 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7, TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
Ligand YIY (1E)-1-[5-TERT-BUTYL-2-(3-FLUOROPHENYL)-1H-PYRAZOL-3-YLIDENE]-3-(4-PYRIDIN-3-YLOXYPHENYL)UREA

4AY6
O-Glcnac Transferase Invokes Nucleotide Sugar Pyrophosphate Participation in Catalysis

Entity type Code Description
polypeptide(L) O15294 UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANS FERASE 110 KDA SUBUNIT
polypeptide(L) Q15750 TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
Ligand 12V (2S,3R,4R,5S,6R)-3-(ACETYLAMINO)-4,5-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-THIOPYRAN-2-YL [(2R,3S,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE

4GS6
Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)-7-Oxozeaenol.

Entity type Code Description
polypeptide(L) O43318 Tak1-Tab1 fusion protein
polypeptide(L) Q15750 Tak1-Tab1 fusion protein
Ligand 1FM (3S,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE

4KA3
Crystal structure of the p38alpha MAP kinase in complex with a docking peptide from TAB1

Entity type Code Description
polypeptide(L) P47811 Mitogen-activated protein kinase 14
polypeptide(L) Q15750 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

4L3P
Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.

Entity type Code Description
polypeptide(L) O43318 Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera
polypeptide(L) Q15750 Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera
Ligand 1UH 2-(1-BENZOTHIOPHEN-7-YL)-4-[1-(PIPERIDIN-4-YL)-1H-PYRAZOL-4-YL]FURO[2,3-C]PYRIDIN-7-AMINE

4L52
Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1.

Entity type Code Description
polypeptide(L) O43318 Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera
polypeptide(L) Q15750 Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera
Ligand 1UL 1-(4-{4-[7-AMINO-2-(1,2,3-BENZOTHIADIAZOL-7-YL)FURO[2,3-C]PYRIDIN-4-YL]-1H-PYRAZOL-1-YL}PIPERIDIN-1-YL)ETHANONE

4L53
Discovery of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1: Optimization of kinase selectivity and pharmacokinetics.

Entity type Code Description
polypeptide(L) O43318 Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera
polypeptide(L) Q15750 Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera
Ligand 1UO TRANS-4-{4-[7-AMINO-2-(1,2,3-BENZOTHIADIAZOL-7-YL)-3-CHLOROFURO[2,3-C]PYRIDIN-4-YL]-1H-PYRAZOL-1-YL}CYCLOHEXANOL

4LOO
Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1.

Entity type Code Description
polypeptide(L) P47811 Mitogen-activated protein kinase 14
polypeptide(L) Q8CF89 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Ligand SB4 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE

4LOP
Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1.

Entity type Code Description
polypeptide(L) P47811 Mitogen-activated protein kinase 14
polypeptide(L) Q8CF89 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Ligand SB4 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE
Ligand TLA L(+)-TARTARIC ACID

4LOQ
Mechanism and consequence of the autoactivation of p38 alpha mitogen-activated protein kinase promoted by TAB1.

Entity type Code Description
polypeptide(L) P47811 Mitogen-activated protein kinase 14
polypeptide(L) Q8CF89 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Ligand SB4 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE