Tak1

Tgf-beta-activated kinase 1

Reviewed UniProt entries for Tak1 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q15750 TAB1_HUMAN TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) TAB1 MAP3K7IP1 Homo sapiens (Human) 504
Q8CF89 TAB1_MOUSE TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 1) (TGF-beta-activated kinase 1-binding protein 1) (TAK1-binding protein 1) Tab1 Map3k7ip1 Mus musculus (Mouse) 502

Small molecules tested in Tak1 binding assays:

1 datapoints for 1 distinct small molecules


Name CHEMBL162
Affinity IC50 = 0.035uM
Assay description Inhibition of TAB1
-- Homologous single protein target assigned: TAB1_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19397322
Doc title Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells.
PDB None

7 PDB entries for Tak1 and its protein partners


2J4O
Tak1-Binding Protein 1 is a Pseudophosphatase.

Entity type Code Description
polypeptide(L) Q15750 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 1

2POM
XIAP Induces NF-kappaB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization.

Entity type Code Description
polypeptide(L) Q15750 Mitogen-activated protein kinase kinase kinase 7-interacting protein 1

2POP
XIAP Induces NF-kappaB Activation via the BIR1/TAB1 Interaction and BIR1 Dimerization.

Entity type Code Description
polypeptide(L) Q15750 Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
polypeptide(L) Q15750 Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
polypeptide(L) P98170 Baculoviral IAP repeat-containing protein 4

2YDS
Synergy of Peptide and Sugar in O-Glcnacase Substrate Recognition.

Entity type Code Description
polypeptide(L) Q0TR53 O-GLCNACASE NAGJ
polypeptide(L) Q15750 TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
Ligand NAG SUGAR (N-ACETYL-D-GLUCOSAMINE)

2YIY
The Discovery and Synthesis of Selective Dfg-Out Tak-1 Inhibitors

Entity type Code Description
polypeptide(L) O43318 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7, TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
polypeptide(L) Q15750 MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7, TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
Ligand YIY (1E)-1-[5-TERT-BUTYL-2-(3-FLUOROPHENYL)-1H-PYRAZOL-3-YLIDENE]-3-(4-PYRIDIN-3-YLOXYPHENYL)UREA

4AY6
O-Glcnac Transferase Invokes Nucleotide Sugar Pyrophosphate Participation in Catalysis

Entity type Code Description
polypeptide(L) O15294 UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANS FERASE 110 KDA SUBUNIT
polypeptide(L) Q15750 TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1
Ligand 12V (2S,3R,4R,5S,6R)-3-(ACETYLAMINO)-4,5-DIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-THIOPYRAN-2-YL [(2R,3S,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE

4GS6
Mechanism and In Vitro Pharmacology of TAK1 Inhibition by (5Z)-7-Oxozeaenol.

Entity type Code Description
polypeptide(L) O43318 Tak1-Tab1 fusion protein
polypeptide(L) Q15750 Tak1-Tab1 fusion protein
Ligand 1FM (3S,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE