Transthyretin

Transthyretin

Reviewed UniProt entries for Transthyretin and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
O46375 TTHY_BOVIN Transthyretin (Prealbumin) TTR Bos taurus (Bovine) 147
P27731 TTHY_CHICK Transthyretin (Prealbumin) (TBPA) TTR Gallus gallus (Chicken) 150
O55245 TTHY_CROPO Transthyretin (crocTTR) (Prealbumin) TTR Crocodylus porosus (Saltwater crocodile) (Estuarine crocodile) 150
Q9MYN8 TTHY_ERIEU Transthyretin (Prealbumin) TTR Erinaceus europaeus (Western European hedgehog) 145
P42204 TTHY_MACEU Transthyretin (Prealbumin) TTR Macropus eugenii (Tammar wallaby) 149
Q8HXW1 TTHY_MACFA Transthyretin (Prealbumin) TTR QccE-10711 QccE-14396 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 147
Q29616 TTHY_MACGI Transthyretin (Prealbumin) TTR Macropus giganteus (Eastern gray kangaroo) 149
P49141 TTHY_MONDO Transthyretin (Prealbumin) TTR Monodelphis domestica (Gray short-tailed opossum) 149
P07309 TTHY_MOUSE Transthyretin (Prealbumin) Ttr Mus musculus (Mouse) 147
Q5U7I5 TTHY_PANTR Transthyretin (Prealbumin) TTR Pan troglodytes (Chimpanzee) 147
P49142 TTHY_PETBR Transthyretin (Prealbumin) TTR Petaurus breviceps (Australian sugar glider) 149
P50390 TTHY_PIG Transthyretin (Prealbumin) TTR Sus scrofa (Pig) 150
Q5NVS2 TTHY_PONAB Transthyretin (Prealbumin) TTR Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 147
P07489 TTHY_RABIT Transthyretin (Prealbumin) TTR Oryctolagus cuniculus (Rabbit) 127
P02767 TTHY_RAT Transthyretin (Prealbumin) (TBPA) Ttr Tt Rattus norvegicus (Rat) 147
P12303 TTHY_SHEEP Transthyretin (Prealbumin) TTR Ovis aries (Sheep) 147
P49143 TTHY_SMIMA Transthyretin (Prealbumin) TTR Sminthopsis macroura (Stripe-faced dunnart) 149
O46654 TTHY_SORAR Transthyretin (Prealbumin) TTR Sorex araneus (Eurasian common shrew) (European shrew) 147
P30623 TTHY_TRARU Transthyretin (Prealbumin) (TBPA) TTR Trachydosaurus rugosus (Shingleback lizard) (Tiliqua rugosus) 150
B7ZS96 TTHY_XENLA Transthyretin (xTTR) (Prealbumin) ttr Xenopus laevis (African clawed frog) 153
A4QNN7 TTHY_XENTR Transthyretin (Prealbumin) ttr Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 151
Q22288 TTR15_CAEEL Transthyretin-like protein 15 ttr-15 T07C4.5 Caenorhabditis elegans 130
P55955 TTR16_CAEEL Transthyretin-like protein 16 (Unknown spot 4 protein from 2D-page) ttr-16 Y5F2A.1 Caenorhabditis elegans 132
P34502 TTR1_CAEEL Transthyretin-like protein 1 ttr-1 K03H1.6 Caenorhabditis elegans 156
P34500 TTR2_CAEEL Transthyretin-like protein 2 ttr-2 K03H1.4 Caenorhabditis elegans 148
P34499 TTR3_CAEEL Transthyretin-like protein 3 ttr-3 K03H1.3 Caenorhabditis elegans 148
Q22285 TTR46_CAEEL Transthyretin-like protein 46 ttr-46 T07C12.7 Caenorhabditis elegans 179
Q03575 TTR5_CAEEL Transthyretin-like protein 5 ttr-5 C40H1.5 Caenorhabditis elegans 139
P02766 TTHY_HUMAN Transthyretin (ATTR) (Prealbumin) (TBPA) TTR PALB Homo sapiens (Human) 147

Small molecules tested in Transthyretin binding assays:

592 datapoints for 350 distinct small molecules


Name DFHBPCA
Affinity None
Assay description None
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm030347n
Doc title Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis
PDB 3D2T - (1FL)

Name DCHBPCA
Affinity None
Assay description None
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm030347n
Doc title Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis
PDB 2B77 - (3CA)

Name DFBPCA
Affinity None
Assay description None
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm030347n
Doc title Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis
PDB 2B9A - (FBC)

Name DFBP4CA
Affinity None
Assay description None
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm030347n
Doc title Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis
PDB 2F7I - (26C)

Name CHEMBL1034
Affinity Activity = 17%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB 1DVX - (DIF)

Name CHEMBL1034
Affinity Activity = 85%
Assay description Displacement of 4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzoate from recombinant TTR assessed as fluorescence at 37 degC after 3 hrs
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB 1DVX - (DIF)

Name CHEMBL1034
Affinity Activity = 99%
Assay description Displacement of S-phenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzothioate from human TTR assessed as fluorescence at 37 degC after 3 hrs
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB 1DVX - (DIF)

Name CHEMBL1213030
Affinity Active
Assay description Binding affinity to TTR in human plasma at 10.8 uM after 24 hrs RP-HPLC analysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213030
Affinity Active
Assay description Binding affinity to wild type TTR tetramer in human plasma assessed as covalent chemoselective amide bond formation with Lys15 residue of TTR subunit at 7.2 uM after 18 hrs by RP-HPLC analysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213030
Affinity Activity = 21%
Assay description Inhibition of wild type TTR amyloidogenesis assessed as fibril formation at 3.6 uM after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213030
Affinity Activity = 49%
Assay description Binding affinity to wild type TTR in human plasma assessed as covalent modification of TTR subunit after 18 hrs by RP-HPLC analysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213030
Affinity Dose-dependent effect
Assay description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213030
Affinity Time = 59min
Assay description Stabilization of wild-type TTR tetramer assessed as time needed for 95% TTR-compound conjugate formation by C18-RP-HPLC
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213030
Affinity IC50 = 2.26uM
Assay description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213030
Affinity Active
Assay description Binding affinity to wild type TTR assessed as induction of benzoylation at Lys15 residue of TTR subunit by LC-MS method
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213030
Affinity Activity = 4%
Assay description Inhibition of wild type TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213030
Affinity t1/2 = 5min
Assay description Stabilization of wild-type TTR tetramer assessed as rate of TTR-compound conjugate formation by C18-RP-HPLC
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213031
Affinity Active
Assay description Binding affinity to wild type TTR tetramer in human plasma assessed as covalent chemoselective amide bond formation with Lys15 residue of TTR subunit at 7.2 uM after 18 hrs by RP-HPLC analysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB 3HJ0 - (A93)

Name CHEMBL1213031
Affinity Activity = 16%
Assay description Inhibition of wild type TTR amyloidogenesis assessed as fibril formation at 3.6 uM after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB 3HJ0 - (A93)

Name CHEMBL1213031
Affinity Activity = 32%
Assay description Binding affinity to wild type TTR in human plasma assessed as covalent modification of TTR subunit after 18 hrs by RP-HPLC analysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB 3HJ0 - (A93)

Name CHEMBL1213031
Affinity Active
Assay description Binding affinity to wild type TTR assessed as induction of benzoylation at Lys15 residue of TTR subunit by LC-MS method
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB 3HJ0 - (A93)

Name CHEMBL1213031
Affinity Active
Assay description Stabilization of recombinant TTR assessed as inhibition of urea-induced TTR tetramer dissociation over 144 hrs by far-UV CD spectroscopy
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB 3HJ0 - (A93)

Name CHEMBL1213031
Affinity Time = 1314min
Assay description Stabilization of wild-type TTR tetramer assessed as time needed for 95% TTR-compound conjugate formation by C18-RP-HPLC
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB 3HJ0 - (A93)

Name CHEMBL1213031
Affinity Active
Assay description Binding affinity to TTR in human plasma at 10.8 uM after 24 hrs RP-HPLC analysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB 3HJ0 - (A93)

Name CHEMBL1213031
Affinity Dose-dependent effect
Assay description Inhibition of wild type TTR induced cytotoxicity in human IMR32 cells assessed as cell viability after 24 hrs by resazurin reduction assay
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB 3HJ0 - (A93)

Name CHEMBL1213031
Affinity Activity = 1%
Assay description Inhibition of wild type TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB 3HJ0 - (A93)

Name CHEMBL1213031
Affinity Dose-dependent effect
Assay description Stabilization of recombinant TTR assessed as inhibition of urea-induced TTR tetramer dissociation over 144 hrs by far-UV CD spectroscopy
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB 3HJ0 - (A93)

Name CHEMBL1213031
Affinity IC50 = 1.96uM
Assay description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB 3HJ0 - (A93)

Name CHEMBL1213031
Affinity t1/2 = 247min
Assay description Stabilization of wild-type TTR tetramer assessed as rate of TTR-compound conjugate formation by C18-RP-HPLC
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB 3HJ0 - (A93)

Name CHEMBL1213031
Affinity Dose-dependent effect
Assay description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB 3HJ0 - (A93)

Name CHEMBL1213032
Affinity Active
Assay description Binding affinity to wild-type TTR assessed as nonchemoselective conjugation of TTR after 18 hrs by C18-RP-HPLC
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213057
Affinity Active
Assay description Binding affinity to wild-type TTR assessed as nonchemoselective conjugation of TTR after 18 hrs by C18-RP-HPLC
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213058
Affinity Active
Assay description Binding affinity to wild-type TTR assessed as nonchemoselective conjugation of TTR after 18 hrs by C18-RP-HPLC
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213659
Affinity t1/2 = 143min
Assay description Stabilization of wild-type TTR tetramer assessed as rate of TTR-compound conjugate formation by C18-RP-HPLC
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213659
Affinity Activity = 36%
Assay description Binding affinity to wild type TTR in human plasma assessed as covalent modification of TTR subunit after 18 hrs by RP-HPLC analysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213659
Affinity IC50 = 2uM
Assay description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213659
Affinity Active
Assay description Binding affinity to wild type TTR tetramer in human plasma assessed as covalent chemoselective amide bond formation with Lys15 residue of TTR subunit at 7.2 uM after 18 hrs by RP-HPLC analysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213659
Affinity Time = 1272min
Assay description Stabilization of wild-type TTR tetramer assessed as time needed for 95% TTR-compound conjugate formation by C18-RP-HPLC
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213659
Affinity Activity = 12%
Assay description Inhibition of wild type TTR amyloidogenesis assessed as fibril formation at 3.6 uM after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213659
Affinity Active
Assay description Binding affinity to wild type TTR assessed as induction of benzoylation at Lys15 residue of TTR subunit by LC-MS method
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213659
Affinity Dose-dependent effect
Assay description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213659
Affinity Activity = 2%
Assay description Inhibition of wild type TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213659
Affinity Active
Assay description Binding affinity to TTR in human plasma at 10.8 uM after 24 hrs RP-HPLC analysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213660
Affinity Time = 81min
Assay description Stabilization of wild-type TTR tetramer assessed as time needed for 95% TTR-compound conjugate formation by C18-RP-HPLC
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213660
Affinity Active
Assay description Binding affinity to wild type TTR assessed as induction of benzoylation at Lys15 residue of TTR subunit by LC-MS method
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213660
Affinity Active
Assay description Binding affinity to TTR in human plasma at 10.8 uM after 24 hrs RP-HPLC analysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213660
Affinity Dose-dependent effect
Assay description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213660
Affinity Dose-dependent effect
Assay description Inhibition of wild type TTR induced cytotoxicity in human IMR32 cells assessed as cell viability after 24 hrs by resazurin reduction assay
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213660
Affinity Active
Assay description Binding affinity to wild type TTR tetramer in human plasma assessed as covalent chemoselective amide bond formation with Lys15 residue of TTR subunit at 7.2 uM after 18 hrs by RP-HPLC analysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213660
Affinity Activity = 48%
Assay description Binding affinity to wild type TTR in human plasma assessed as covalent modification of TTR subunit after 18 hrs by RP-HPLC analysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213660
Affinity Activity = 16%
Assay description Inhibition of wild type TTR amyloidogenesis assessed as fibril formation at 3.6 uM after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213660
Affinity Activity = 2%
Assay description Inhibition of wild type TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213660
Affinity t1/2 = 15min
Assay description Stabilization of wild-type TTR tetramer assessed as rate of TTR-compound conjugate formation by C18-RP-HPLC
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL1213660
Affinity IC50 = 2uM
Assay description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL121772
Affinity None observed
Assay description Ability to bind TTR selectively over all other proteins in human blood plasma (equiv bound); None observed
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/14711308
Doc title Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
PDB None

Name CHEMBL122167
Affinity None observed
Assay description Ability to bind TTR selectively over all other proteins in human blood plasma (equiv bound)
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/14711308
Doc title Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
PDB None

Name CHEMBL122977
Affinity None observed
Assay description Ability to bind TTR selectively over all other proteins in human blood plasma (equiv bound)
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/14711308
Doc title Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
PDB None

Name CHEMBL1312
Affinity Concentration = 0.000000044M
Assay description Concentration at which 50% total binding against prealbumin protein occurs
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3009810
Doc title Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
PDB None

Name CHEMBL139
Affinity Activity = 33%
Assay description Inhibition of wild type human TTR aggregation expressed in Escherichia coli assessed as fibril formation at 20 uM after 72 hrs relative by spectrofluorimetry
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19954984
Doc title Identification of a novel ligand binding motif in the transthyretin channel.
PDB 1DVX - (DIF)

Name CHEMBL14092
Affinity KPCB < 0.1M-1
Assay description Displacement of [125I]thyroxin from human plasma prealbumin.
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3097319
Doc title A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
PDB None

Name CHEMBL14092
Affinity Concentration >> 0.0000001M
Assay description Concentration at which 50% total binding against prealbumin protein occurs
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3009810
Doc title Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
PDB None

Name CHEMBL14092
Affinity Not Active
Assay description Relative binding affinity was determined for thyroxin binding prealbumin (TBPA) from rat liver with respect to thyroxine (T4) as KA(comp)/KA(T4) using competitive binding experiment; a = no binding
-- Homologous single protein target assigned: TTHY_RAT (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3100800
Doc title Polychlorinated biphenyls and related compound interactions with specific binding sites for thyroxine in rat liver nuclear extracts.
PDB None

Name CHEMBL14658
Affinity KPCB = 61.6M-1
Assay description Displacement of [125I]thyroxin from human plasma prealbumin.
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3097319
Doc title A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
PDB None

Name CHEMBL14658
Affinity KT4 = 5.03M-1
Assay description Thyroxine binding constant on human plasma prealbumin.
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3097319
Doc title A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
PDB None

Name CHEMBL14658
Affinity Concentration = 0.0000000032M
Assay description Concentration at which 50% total binding against prealbumin protein occurs
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3009810
Doc title Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
PDB None

Name CHEMBL150462
Affinity Ka(T4) = 0.3%
Assay description Ability to displace L-[125I]thyoxine from the high affinity prealbumin binding site was expressed as ratio of its apparent association constant to that of DL-thyroxine
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7108895
Doc title Computer graphics in drug design: molecular modeling of thyroid hormone-prealbumin interactions.
PDB None

Name CHEMBL151226
Affinity Ka(T4) = 1.6%
Assay description Ability to displace L-[125I]thyoxine from the high affinity prealbumin binding site was expressed as ratio of its apparent association constant to that of DL-thyroxine
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7108895
Doc title Computer graphics in drug design: molecular modeling of thyroid hormone-prealbumin interactions.
PDB None

Name CHEMBL1544
Affinity Concentration = 0.0000006M
Assay description Concentration at which 50% total binding against prealbumin protein occurs
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3009810
Doc title Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
PDB None

Name CHEMBL158778
Affinity Concentration = 0.000000003M
Assay description Concentration at which 50% total binding to prealbumin protein.
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3009810
Doc title Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
PDB None

Name CHEMBL160172
Affinity Concentration = 0.0000000048M
Assay description Concentration at which 50% total binding against prealbumin protein occurs
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3009810
Doc title Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
PDB None

Name CHEMBL160213
Affinity Concentration = 0.0000000024M
Assay description Concentration at which 50% total binding against prealbumin protein occurs
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3009810
Doc title Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
PDB None

Name CHEMBL160726
Affinity Concentration = 0.00000000087M
Assay description Concentration at which 50% total binding to prealbumin protein.
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3009810
Doc title Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
PDB None

Name CHEMBL1624
Affinity Activity = 95%
Assay description Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19651509
Doc title Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
PDB 3OZK - (T44)

Name CHEMBL1624
Affinity IC50 = 10.5uM
Assay description Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assay
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19651509
Doc title Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
PDB 3OZK - (T44)

Name CHEMBL1624
Affinity Concentration = 0.00000001M
Assay description Concentration at which 50% total binding against prealbumin protein occurs
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3009810
Doc title Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
PDB 3OZK - (T44)

Name CHEMBL1624
Affinity Not Active
Assay description Displacement of [125I]thyroxin from TTR
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19651509
Doc title Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
PDB 3OZK - (T44)

Name CHEMBL163825
Affinity Ka(T4) = 0.7%
Assay description Ability to displace L-[125I]thyoxine from the high affinity prealbumin binding site was expressed as ratio of its apparent association constant to that of L-thyroxine
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7108895
Doc title Computer graphics in drug design: molecular modeling of thyroid hormone-prealbumin interactions.
PDB None

Name CHEMBL165029
Affinity Ka(T4) = 6.3%
Assay description Ability to displace L-[125I]thyoxine from the high affinity prealbumin binding site was expressed as ratio of its apparent association constant to that of DL-thyroxine
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7108895
Doc title Computer graphics in drug design: molecular modeling of thyroid hormone-prealbumin interactions.
PDB None

Name CHEMBL165030
Affinity Ka(T4) = 1.6%
Assay description Ability to displace L-[125I]thyoxine from the high affinity prealbumin binding site was expressed as ratio of its apparent association constant to that of DL-thyroxine
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7108895
Doc title Computer graphics in drug design: molecular modeling of thyroid hormone-prealbumin interactions.
PDB None

Name CHEMBL1672720
Affinity Activity = 0%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672720
Affinity Activity = 0%
Assay description Displacement of S-phenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzothioate from human TTR assessed as fluorescence at 37 degC after 3 hrs
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672720
Affinity Activity = -6%
Assay description Displacement of 4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzoate from recombinant TTR assessed as fluorescence at 37 degC after 3 hrs
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672721
Affinity Activity = 2%
Assay description Displacement of S-phenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzothioate from human TTR assessed as fluorescence at 37 degC after 3 hrs
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672721
Affinity Activity = 2%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672721
Affinity Activity = -6%
Assay description Displacement of 4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzoate from recombinant TTR assessed as fluorescence at 37 degC after 3 hrs
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672722
Affinity Activity = -7%
Assay description Displacement of 4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzoate from recombinant TTR assessed as fluorescence at 37 degC after 3 hrs
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672722
Affinity Activity = 3%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672722
Affinity Activity = 2%
Assay description Displacement of S-phenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzothioate from human TTR assessed as fluorescence at 37 degC after 3 hrs
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672723
Affinity Activity = -6%
Assay description Displacement of 4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzoate from recombinant TTR assessed as fluorescence at 37 degC after 3 hrs
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672723
Affinity Activity = 1%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672723
Affinity Activity = 3%
Assay description Displacement of S-phenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzothioate from human TTR assessed as fluorescence at 37 degC after 3 hrs
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672724
Affinity Activity = 42%
Assay description Displacement of S-phenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzothioate from human TTR assessed as fluorescence at 37 degC after 3 hrs
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672724
Affinity Activity = 1%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672724
Affinity Activity = -3%
Assay description Displacement of 4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzoate from recombinant TTR assessed as fluorescence at 37 degC after 3 hrs
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672725
Affinity Activity = 3%
Assay description Displacement of 4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzoate from recombinant TTR assessed as fluorescence at 37 degC after 3 hrs
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672725
Affinity Activity = 1%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL1672725
Affinity Activity = 30%
Assay description Displacement of S-phenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzothioate from human TTR assessed as fluorescence at 37 degC after 3 hrs
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL167443
Affinity Ka(T4) = 28.7%
Assay description Ability to displace L-[125I]thyoxine from the high affinity prealbumin binding site was expressed as ratio of its apparent association constant to that of DL-thyroxine
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7108895
Doc title Computer graphics in drug design: molecular modeling of thyroid hormone-prealbumin interactions.
PDB None

Name CHEMBL175448
Affinity Formation = 62%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL175498
Affinity Formation = 87%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL175518
Affinity Formation = 86%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL175721
Affinity Formation = 94%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL175759
Affinity Formation = 34%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL175829
Affinity Formation = 50%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL175865
Affinity Formation = 0%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL175876
Affinity Formation = 61%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL175896
Affinity Formation = 0%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL175909
Affinity Activity = 91%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h) in absence of TTR, assay conditions, compound (7.2 uM), pH 4.4, 37C
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL175909
Affinity Formation = 1%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL175909
Affinity Activity = 83%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h), assay conditions compound (7.2 uM), WT-TTR (3.6 uM, pH 4.4, 37C)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL175910
Affinity Formation = 56%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL175919
Affinity Formation = 46%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176040
Affinity Formation = 90%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176051
Affinity Activity = 88%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h) in absence of TTR, assay conditions, compound (7.2 uM), pH 4.4, 37C
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176051
Affinity Formation = 0%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176051
Affinity Activity = 81%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h), assay conditions compound (7.2 uM), WT-TTR (3.6 uM, pH 4.4, 37C)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176091
Affinity Formation = 74%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176097
Affinity Formation = 94%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176100
Affinity Formation = 78%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176156
Affinity Activity = 20%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h) in absence of TTR, assay conditions, compound (7.2 uM), pH 4.4, 37C
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176156
Affinity Formation = 1%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176156
Affinity Activity = 88%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h), assay conditions compound (7.2 uM), WT-TTR (3.6 uM, pH 4.4, 37C)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176165
Affinity Formation = 8%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176205
Affinity Formation = 94%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176215
Affinity Activity = 84%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h), assay conditions compound (7.2 uM), WT-TTR (3.6 uM, pH 4.4, 37C)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176215
Affinity Activity = 79%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h) in absence of TTR, assay conditions, compound (7.2 uM), pH 4.4, 37C
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176215
Affinity Formation = 0%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176224
Affinity Formation = 18%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176253
Affinity Formation = 15%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176255
Affinity Formation = 3%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176277
Affinity Formation = 84%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176433
Affinity Activity = 81%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h), assay conditions compound (7.2 uM), WT-TTR (3.6 uM, pH 4.4, 37C)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176433
Affinity Activity = 85%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h) in absence of TTR, assay conditions, compound (7.2 uM), pH 4.4, 37C
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176433
Affinity Formation = 0%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176434
Affinity Formation = 56%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176552
Affinity Activity = 74%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h), assay conditions compound (7.2 uM), WT-TTR (3.6 uM, pH 4.4, 37C)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176552
Affinity Activity = 4%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h) in absence of TTR, assay conditions, compound (7.2 uM), pH 4.4, 37C
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176552
Affinity Formation = 1%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL176767
Affinity Formation = 9%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL179150
Affinity Formation = 59%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL179223
Affinity Formation = 87%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL179301
Affinity Formation = 75%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL179436
Affinity Formation = 50%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL179631
Affinity Formation = 1%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL180100
Affinity Formation = 0%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL180367
Affinity Formation = 0%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL180370
Affinity Formation = 32%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL181750
Affinity Inhibition = 7.2uM
Assay description Inhibitory concentration against transthyretin in human blood plasma was determined by TTR amyloid fibril formation assay (TTR 3.6 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15686915
Doc title Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL182714
Affinity Inhibition = 7.2uM
Assay description Inhibitory concentration against transthyretin in human blood plasma was determined by TTR amyloid fibril formation assay (TTR 3.6 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15686915
Doc title Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL190816
Affinity Formation = 77%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL190926
Affinity Activity = 24%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h) in absence of TTR, assay conditions, compound (7.2 uM), pH 4.4, 37C
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL190926
Affinity Activity = 79%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h), assay conditions compound (7.2 uM), WT-TTR (3.6 uM, pH 4.4, 37C)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL190926
Affinity Formation = 0%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL191034
Affinity Formation = 39%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL191193
Affinity Formation = 30%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL191765
Affinity Formation = 1%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL191765
Affinity Activity = 78%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h) in absence of TTR, assay conditions, compound (7.2 uM), pH 4.4, 37C
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL191765
Affinity Activity = 98%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h), assay conditions compound (7.2 uM), WT-TTR (3.6 uM, pH 4.4, 37C)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL191766
Affinity Formation = 83%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL191774
Affinity Formation = 9%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL192448
Affinity Formation = 88%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL193532
Affinity Formation = 12%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL193545
Affinity Formation = 21%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL193580
Affinity Formation = 32%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL193710
Affinity Formation = 33%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL193711
Affinity Formation = 15%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL193785
Affinity Formation = 75%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL193843
Affinity Formation = 91%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL193859
Affinity Formation = 98%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL193894
Affinity Formation = 79%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL194111
Affinity Formation = 4%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL194146
Affinity Formation = 3%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL194175
Affinity Formation = 95%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL194660
Affinity Formation = 4%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL194661
Affinity Activity = 80%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h) in absence of TTR, assay conditions, compound (7.2 uM), pH 4.4, 37C
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL194661
Affinity Activity = 83%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h), assay conditions compound (7.2 uM), WT-TTR (3.6 uM, pH 4.4, 37C)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL194661
Affinity Activity = 0%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h) in absence of TTR, assay conditions, compound (7.2 uM), pH 4.4, 37C
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL194661
Affinity Formation = 3%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL194661
Affinity Activity = 76%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h), assay conditions compound (7.2 uM), WT-TTR (3.6 uM, pH 7.2, 37C)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL195075
Affinity Formation = 96%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL195242
Affinity Formation = 83%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL195757
Affinity Formation = 92%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL2068685
Affinity Delta G = -10.7kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068685
Affinity Delta G = -8.7kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068686
Affinity Delta G = -7.6kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068687
Affinity Delta G = -8.2kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068688
Affinity Delta G = -7.9kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068689
Affinity Delta G = -6.6kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068690
Affinity Delta G = -8.4kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068691
Affinity Delta G = -8kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068692
Affinity Delta G = -9kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068693
Affinity Delta G = -5.2kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068694
Affinity Delta G = -11.9kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068695
Affinity Delta G = -11.1kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068696
Affinity Delta G = -9.2kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068696
Affinity Delta G = -7kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068697
Affinity Delta G = -9.7kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068698
Affinity Delta G = -11.3kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068699
Affinity Delta G = -9.7kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068700
Affinity Delta G = -9.2kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068701
Affinity Delta G = -7.7kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068702
Affinity Delta G = -7.8kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068703
Affinity Delta G = -7.7kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068704
Affinity Delta G = -7.1kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068705
Affinity Delta G = -11.4kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068706
Affinity Delta G = -7.4kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068707
Affinity Delta G = -10kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068708
Affinity Delta G = -7.6kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL2068709
Affinity Delta G = -7.8kCal M-1
Assay description Binding affinity against prealbumin
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7205888
Doc title Quantitative structure-activity relationships by distance geometry: thyroxine binding site.
PDB None

Name CHEMBL227491
Affinity IC50 > 50uM
Assay description Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assay
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19651509
Doc title Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
PDB None

Name CHEMBL227491
Affinity Activity = 31%
Assay description Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19651509
Doc title Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
PDB None

Name CHEMBL227491
Affinity Not Active
Assay description Displacement of [125I]thyroxin from TTR
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19651509
Doc title Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
PDB None

Name CHEMBL23588
Affinity IC50 = 2.9uM
Assay description Inhibition of human transthyretin fibril formation at pH 4.4 after 72 hrs
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17360344
Doc title Synthesis and evaluation of transthyretin amyloidosis inhibitors containing carborane pharmacophores.
PDB 1BM7 - (FLF)

Name CHEMBL23588
Affinity Activity = 97%
Assay description Displacement of S-phenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzothioate from human TTR assessed as fluorescence at 37 degC after 3 hrs
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB 1BM7 - (FLF)

Name CHEMBL23588
Affinity Activity = 2%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB 1BM7 - (FLF)

Name CHEMBL23588
Affinity Activity = 14%
Assay description Inhibition of human transthyretin assessed as amyloid fibril formation at pH 4.4 after 72 hrs relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17360344
Doc title Synthesis and evaluation of transthyretin amyloidosis inhibitors containing carborane pharmacophores.
PDB 1BM7 - (FLF)

Name CHEMBL23588
Affinity Activity = 44%
Assay description Displacement of 4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzoate from recombinant TTR assessed as fluorescence at 37 degC after 3 hrs
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB 1BM7 - (FLF)

Name CHEMBL240165
Affinity Kd = 42nM
Assay description Binding affinity to transthyretin at pH 4.4
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17948976
Doc title Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
PDB None

Name CHEMBL240804
Affinity Kd = 13.9nM
Assay description Binding affinity to transthyretin at pH 4.4
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17948976
Doc title Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
PDB 4ABU - (FT1)

Name CHEMBL240805
Affinity Kd = 5.7nM
Assay description Binding affinity to transthyretin at pH 4.4
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17948976
Doc title Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
PDB 4ABV - (FT2)

Name CHEMBL240806
Affinity Kd = 0.3nM
Assay description Binding affinity to transthyretin at pH 4.4
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17948976
Doc title Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
PDB None

Name CHEMBL240808
Affinity Kd = 27nM
Assay description Binding affinity to transthyretin at pH 4.4
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17948976
Doc title Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
PDB None

Name CHEMBL241025
Affinity Active
Assay description Binding affinity to transthyretin at pH 4.4
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17948976
Doc title Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
PDB None

Name CHEMBL241453
Affinity Kd = 88nM
Assay description Binding affinity to transthyretin at pH 4.4
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17948976
Doc title Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
PDB None

Name CHEMBL241454
Affinity Kd = 27nM
Assay description Binding affinity to transthyretin at pH 4.4
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17948976
Doc title Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
PDB None

Name CHEMBL251921
Affinity Activity = 0%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL251932
Affinity Activity = 1%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18811132
Doc title Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
PDB 2QGD - (MR5)

Name CHEMBL251932
Affinity Activity = 1%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB 2QGD - (MR5)

Name CHEMBL251956
Affinity Activity = 52%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL251957
Affinity Activity = 45%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL252155
Affinity Activity = 59%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL252357
Affinity Activity = 77%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL252358
Affinity Activity = 17%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18811132
Doc title Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
PDB None

Name CHEMBL252358
Affinity Activity = 20%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL253156
Affinity Activity = 0%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL253167
Affinity Activity = 38%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL253359
Affinity Activity = 1%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18811132
Doc title Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
PDB 2QGC - (MR4)

Name CHEMBL253359
Affinity Activity = 1%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB 2QGC - (MR4)

Name CHEMBL253578
Affinity Activity = 89%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL253579
Affinity Activity = 91%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL253580
Affinity Activity = 86%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL253812
Affinity Activity = 83%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL253813
Affinity Activity = 62%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL254013
Affinity Activity = 89%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL254017
Affinity Activity = 62%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL254143
Affinity Activity = 83%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL254216
Affinity Activity = 79%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL254217
Affinity Activity = 88%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL254234
Affinity Activity = 4%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL254235
Affinity Activity = 3%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL254425
Affinity Activity = 93%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL254823
Affinity Activity = 61%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL255069
Affinity Activity = 13%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB 2QGE - (MR6)

Name CHEMBL255069
Affinity Activity = 12%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18811132
Doc title Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
PDB 2QGE - (MR6)

Name CHEMBL285527
Affinity Kd = 4.3uM
Assay description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli by isothermal direct titrimetric assay
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19954984
Doc title Identification of a novel ligand binding motif in the transthyretin channel.
PDB 3CFN - (2AN)

Name CHEMBL285527
Affinity Kd = 1.8uM
Assay description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli by equilibrium dialysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19954984
Doc title Identification of a novel ligand binding motif in the transthyretin channel.
PDB 3CFN - (2AN)

Name CHEMBL285527
Affinity Kd = 1.1uM
Assay description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli assessed as dissociation constant for first ligand binding event by isothermal direct titrimetric assay
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19954984
Doc title Identification of a novel ligand binding motif in the transthyretin channel.
PDB 3CFN - (2AN)

Name CHEMBL285527
Affinity Activity = 44%
Assay description Inhibition of wild type human TTR aggregation expressed in Escherichia coli assessed as fibril formation at 20 uM after 72 hrs relative by spectrofluorimetry
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19954984
Doc title Identification of a novel ligand binding motif in the transthyretin channel.
PDB 3CFN - (2AN)

Name CHEMBL285527
Affinity Kd = 1.1uM
Assay description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli assessed as dissociation constant for first ligand binding event by equilibrium dialysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19954984
Doc title Identification of a novel ligand binding motif in the transthyretin channel.
PDB 3CFN - (2AN)

Name CHEMBL285527
Affinity Kd = 4.8uM
Assay description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli assessed as dissociation constant for second ligand binding event by equilibrium dialysis
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19954984
Doc title Identification of a novel ligand binding motif in the transthyretin channel.
PDB 3CFN - (2AN)

Name CHEMBL285527
Affinity Kd = 10uM
Assay description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli by direct fluorescence titration method
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19954984
Doc title Identification of a novel ligand binding motif in the transthyretin channel.
PDB 3CFN - (2AN)

Name CHEMBL285527
Affinity Active
Assay description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli at 10 uM by fluorescence anisotropy
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19954984
Doc title Identification of a novel ligand binding motif in the transthyretin channel.
PDB 3CFN - (2AN)

Name CHEMBL285527
Affinity Kd = 4.8uM
Assay description Binding affinity to wild type human TTR denominated hormone binding site expressed in Escherichia coli assessed as dissociation constant for second ligand binding event by isothermal direct titrimetric assay
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19954984
Doc title Identification of a novel ligand binding motif in the transthyretin channel.
PDB 3CFN - (2AN)

Name CHEMBL311000
Affinity KPCB = 53.9M-1
Assay description Displacement of [125I]thyroxin from human plasma prealbumin.
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3097319
Doc title A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
PDB None

Name CHEMBL311000
Affinity Concentration = 0.0000000035M
Assay description Concentration at which 50% total binding against prealbumin protein occurs
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3009810
Doc title Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
PDB None

Name CHEMBL311000
Affinity KT4 = 9.93M-1
Assay description Thyroxine binding constant on human plasma prealbumin.
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3097319
Doc title A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
PDB None

Name CHEMBL311530
Affinity KT4 = 8.6M-1
Assay description Thyroxine binding constant on human plasma prealbumin.
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3097319
Doc title A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
PDB None

Name CHEMBL311530
Affinity KPCB = 6.49M-1
Assay description Displacement of [125I]thyroxin from human plasma prealbumin.
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3097319
Doc title A theoretical study of the binding of polychlorinated biphenyls (PCBs), dibenzodioxins, and dibenzofuran to human plasma prealbumin.
PDB None

Name CHEMBL326294
Affinity Activity = 24%
Assay description Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity at 40 mM after 1.5 hrs by turbidimetric assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19651509
Doc title Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
PDB None

Name CHEMBL326294
Affinity Not Active
Assay description Displacement of [125I]thyroxin from TTR
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19651509
Doc title Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
PDB None

Name CHEMBL326294
Affinity IC50 > 50uM
Assay description Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assay
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19651509
Doc title Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
PDB None

Name CHEMBL332171
Affinity None observed
Assay description Ability to bind TTR selectively over all other proteins in human blood plasma (equiv bound); None observed
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/14711308
Doc title Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
PDB None

Name CHEMBL333715
Affinity None observed
Assay description Ability to bind TTR selectively over all other proteins in human blood plasma (equiv bound); None observed
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/14711308
Doc title Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
PDB None

Name CHEMBL352220
Affinity Concentration = 0.0000000025M
Assay description Concentration at which 50% total binding to prealbumin protein.
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3009810
Doc title Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
PDB None

Name CHEMBL360566
Affinity Formation = 87%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL362442
Affinity Formation = 97%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL362949
Affinity Formation = 1%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL362949
Affinity Activity = 89%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h) in absence of TTR, assay conditions, compound (7.2 uM), pH 4.4, 37C
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL362949
Affinity Activity = 100%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h), assay conditions compound (7.2 uM), WT-TTR (3.6 uM, pH 4.4, 37C)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL363133
Affinity Activity = 76%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h), assay conditions compound (7.2 uM), WT-TTR (3.6 uM, pH 4.4, 37C)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL363133
Affinity Formation = 0%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL363133
Affinity Activity = 8%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h) in absence of TTR, assay conditions, compound (7.2 uM), pH 4.4, 37C
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL363615
Affinity Formation = 4%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL365522
Affinity Formation = 83%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL366023
Affinity Formation = 72%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL366427
Affinity Formation = 6%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL366686
Affinity Formation = 27%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL366815
Affinity Formation = 9%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL367043
Affinity Formation = 91%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL367239
Affinity Formation = 77%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL367618
Affinity Formation = 3%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL368051
Affinity Formation = 6%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL368059
Affinity Unstable
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM); compound is unstable
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL368705
Affinity Formation = 63%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL368740
Affinity Formation = 63%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL368797
Affinity Formation = 90%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL369648
Affinity Formation = 13%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL369649
Affinity Formation = 24%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL369672
Affinity Formation = 83%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL370002
Affinity Formation = 83%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL370727
Affinity Formation = 81%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL371046
Affinity Formation = 9%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL371202
Affinity Formation = 65%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL371216
Affinity Formation = 55%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL371827
Affinity Formation = 68%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL373228
Affinity Formation = 93%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL378695
Affinity IC50 = 8.1uM
Assay description Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assay
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19651509
Doc title Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
PDB None

Name CHEMBL378695
Affinity Not Active
Assay description Displacement of [125I]thyroxin from TTR
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19651509
Doc title Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
PDB None

Name CHEMBL378695
Affinity Activity = 100%
Assay description Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19651509
Doc title Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors.
PDB None

Name CHEMBL383588
Affinity Formation = 57%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL383590
Affinity Formation = 71%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL393435
Affinity Activity = 86%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL394034
Affinity Kd = 120nM
Assay description Binding affinity to transthyretin at pH 4.4
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17948976
Doc title Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
PDB None

Name CHEMBL398653
Affinity Activity = 18%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL398654
Affinity Activity = 2%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL398927
Affinity Activity = 60%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL399092
Affinity Activity = 68%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL399093
Affinity Activity = 9%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL399165
Affinity Activity = 86%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL399166
Affinity Activity = 87%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL400867
Affinity Activity = 96%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL400914
Affinity Activity = 87%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL400915
Affinity Activity = 26%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL400943
Affinity Activity = 0%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL401072
Affinity Activity = 88%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL401363
Affinity Activity = 70%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL401846
Affinity Activity = 88%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL402051
Affinity Activity = 13%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL413564
Affinity Formation = 84%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL415088
Affinity Activity = 93%
Assay description Inhibition of human TTR amyloidogenesis assessed as fibril formation at 7.2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18095641
Doc title Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.
PDB None

Name CHEMBL42115
Affinity Concentration = 0.000000016M
Assay description Concentration at which 50% total binding against prealbumin protein occurs
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/3009810
Doc title Structurally specific binding of halogenated biphenyls to thyroxine transport protein.
PDB 3OZK - (T44)

Name CHEMBL432234
Affinity Kd1 = 9nM
Assay description The first dissociation constant for binding to WT TTR determined by isothermal titration calorimetry (25 C, pH 8.0)
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/14711308
Doc title Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
PDB 2B9A - (FBC)

Name CHEMBL432234
Affinity Kd2 = 1100nM
Assay description The second dissociation constant for binding to WT TTR determined by isothermal titration calorimetry (25 C, pH 8.0)
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/14711308
Doc title Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
PDB 2B9A - (FBC)

Name CHEMBL434681
Affinity Ka(T4) = 8.6%
Assay description Ability to displace L-[125I]thyoxine from the high affinity prealbumin binding site was expressed as ratio of its apparent association constant to that of DL-thyroxine
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/7108895
Doc title Computer graphics in drug design: molecular modeling of thyroid hormone-prealbumin interactions.
PDB None

Name CHEMBL434790
Affinity None observed
Assay description Ability to bind TTR selectively over all other proteins in human blood plasma (equiv bound)
-- Homologous single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/14711308
Doc title Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
PDB None

Name CHEMBL435532
Affinity Formation = 0%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL435532
Affinity Activity = 81%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h) in absence of TTR, assay conditions, compound (7.2 uM), pH 4.4, 37C
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL435532
Affinity Activity = 77%
Assay description Percentage compound remaining at the conclusion of the acid-mediated fibril formation assay (72 h), assay conditions compound (7.2 uM), WT-TTR (3.6 uM, pH 4.4, 37C)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL438498
Affinity Kd = 0.2nM
Assay description Binding affinity to transthyretin at pH 4.4
-- Direct single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/17948976
Doc title Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates.
PDB None

Name CHEMBL441845
Affinity Formation = 31%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL442167
Affinity Active
Assay description Inhibition of wild type TTR amyloidogenesis assessed as fibril formation at 1.8 to 2.7 uM after 120 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL442167
Affinity IC50 = 3.07uM
Assay description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL442167
Affinity Dose-dependent effect
Assay description Inhibition of wild type TTR induced cytotoxicity in human IMR32 cells assessed as cell viability after 24 hrs by resazurin reduction assay
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL442167
Affinity Active
Assay description Noncovalent binding affinity to TTR K15A mutant T4 site assessed as fibril formation at 7.2 uM after 72 hrs at pH 4.4 by RP-HPLC analysis
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL442167
Affinity Active
Assay description Noncovalent binding affinity to wild type TTR T4 site assessed as fibril formation at 7.2 uM after 72 hrs at pH 4.4 by RP-HPLC analysis
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL442167
Affinity Dose-dependent effect
Assay description Inhibition of wild type TTR amyloidogenesis assessed as inhibition of fibril formation after 72 hrs at pH 4.4 by spectrophotometry relative to untreated control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20081815
Doc title Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.
PDB None

Name CHEMBL443208
Affinity INH = 1%
Assay description Inhibition of wild type TTR aggregation expressed in Escherichia coli assessed as fibril formation at 7.2 uM after 72 hrs relative to untreated-control
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19191553
Doc title Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
PDB None

Name CHEMBL447480
Affinity Formation = 3%
Assay description Percentage of WT-TTR (3.6 uM) amyloid fibril formation at pH 4.4 upon incubation with the compound (7.2 uM)
-- Direct single protein target assigned: TTHY_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743199
Doc title Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
PDB None

Name CHEMBL448030
Affinity Activity = 35%
Assay description Displacement of 4-fluorophenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzoate from recombinant TTR assessed as fluorescence at 37 degC after 3 hrs
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL448030
Affinity Activity = 25%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL448030
Affinity INH = 25%
Assay description Inhibition of wild type TTR aggregation expressed in Escherichia coli assessed as fibril formation at 7.2 uM after 72 hrs relative to untreated-control
-- Homologous single protein target assigned: TTHY_HUMAN (Intermediate curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19191553
Doc title Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.
PDB None

Name CHEMBL448030
Affinity Activity = 24%
Assay description Displacement of S-phenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzothioate from human TTR assessed as fluorescence at 37 degC after 3 hrs
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL448148
Affinity Activity = 29%
Assay description Displacement of S-phenyl 3-(4-hydroxy-3,5-dimethylstyryl)benzothioate from human TTR assessed as fluorescence at 37 degC after 3 hrs
-- Direct single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21273081
Doc title A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.
PDB None

Name CHEMBL448148
Affinity Activity = 2%
Assay description Inhibition of wild type-TTR expressed in Escherichia coli assessed as amyloid fibril formation at pH 4.4 at 7. 2 uM after 72 hrs by acid-mediated aggregation assay relative to control
-- Homologous single protein target assigned: TTHY_HUMAN (Autocuration) --
DOI