Tubulin

Tubulin beta chain

Reviewed UniProt entries for Tubulin and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
P10878 TBB_TOXGO Tubulin beta chain (Beta-tubulin) Toxoplasma gondii 449
Q2HJ86 TBA1D_BOVIN Tubulin alpha-1D chain TUBA1D Bos taurus (Bovine) 452
Q8SRI6 TBA_ENCCU Tubulin alpha chain TUB1 ECU07_1190 Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) 441
A6NHL2 TBAL3_HUMAN Tubulin alpha chain-like 3 TUBAL3 Homo sapiens (Human) 446
Q3UX10 TBAL3_MOUSE Tubulin alpha chain-like 3 Tubal3 Mus musculus (Mouse) 446
Q38771 TBA_AVESA Tubulin alpha chain TUBA Avena sativa (Oat) 447
Q9SCC8 TBAN_GUITH Tubulin alpha chain; nucleomorph (Nucleomorph alpha-tubulin) tubA atubNM Guillardia theta (Cryptomonas phi) 448
Q752Y2 TBA_ASHGO Tubulin alpha chain TUB1 AFR441C Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) 448
P87066 TBA_CANAX Tubulin alpha chain TUB1 Candida albicans (Yeast) 448
P53372 TBA1_PNECA Tubulin alpha chain TUB1 Pneumocystis carinii 449
Q9NY65 TBA8_HUMAN Tubulin alpha-8 chain (Alpha-tubulin 8) (Tubulin alpha chain-like 2) TUBA8 TUBAL2 Homo sapiens (Human) 449
Q5I2J3 TBA_GIBZE Tubulin alpha chain (Alpha-tubulin) TUB1 FGSG_00639 Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum) 449
Q92335 TBA_SORMK Tubulin alpha chain TUBA SMAC_08161 Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell) 449
P10872 TBA_TETPY Tubulin alpha chain Tetrahymena pyriformis 449
P41351 TBA_TETTH Tubulin alpha chain (Alpha-tubulin) Tetrahymena thermophila 449
P08537 TBA_XENLA Tubulin alpha chain tuba tuba1 Xenopus laevis (African clawed frog) 449
Q28IX8 TBA_XENTR Tubulin alpha chain tuba tuba1 TNeu063j16.1 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 449
P18288 TBAT_ONCMY Tubulin alpha chain; testis-specific Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) 450
P52273 TBA_BOMMO Tubulin alpha chain Bombyx mori (Silk moth) 450
Q08114 TBA_EUPOC Tubulin alpha chain Euplotes octocarinatus 450
P28268 TBA_EUPVA Tubulin alpha chain Euplotes vannus (Marine ciliate) (Moneuplotes vannus) 450
P50719 TBA_HAECO Tubulin alpha chain Haemonchus contortus (Barber pole worm) 450
Q8WQ47 TBA_LEPDS Tubulin alpha chain (allergen Lep d ?) Lepidoglyphus destructor (Fodder mite) 450
O94128 TBA_MYCGR Tubulin alpha chain Mycosphaerella graminicola (Speckled leaf blotch fungus) (Septoria tritici) 450
Q91060 TBA_NOTVI Tubulin alpha chain Notophthalmus viridescens (Eastern newt) (Triturus viridescens) 450
P30436 TBA_ONCKE Tubulin alpha chain Oncorhynchus keta (Chum salmon) 450
P28287 TBA_OXYGR Tubulin alpha chain Oxytricha granulifera 450
P33629 TBA_PRUDU Tubulin alpha chain TUBA Prunus dulcis (Almond) (Prunus amygdalus) 450
Q9ZRJ4 TBA_CHLVU Tubulin alpha chain TUBA TUA1 Chlorella vulgaris (Green alga) 451
Q9FT36 TBA_DAUCA Tubulin alpha chain TBA Daucus carota (Carrot) 451
Q06331 TBA_ENTDO Tubulin alpha chain Enteroctopus dofleini (Giant octopus) (Octopus dofleini) 451
P33625 TBA_EUGGR Tubulin alpha chain TUBA Euglena gracilis 451
P36220 TBA_TORMA Tubulin alpha chain (Alpha T6) Torpedo marmorata (Marbled electric ray) 451
P04106 TBA_TRYBR Tubulin alpha chain Trypanosoma brucei rhodesiense 451
Q27352 TBA_TRYCR Tubulin alpha chain Trypanosoma cruzi 451
Q9ZRB7 TBA_WHEAT Tubulin alpha chain TUBA Triticum aestivum (Wheat) 451
Q71G51 TBA_NEOCA Tubulin alpha chain (Alpha-tubulin) TUBA Neospora caninum (Coccidian parasite) 453
P14642 TBA_PLAFK Tubulin alpha chain Plasmodium falciparum (isolate K1 / Thailand) 453
P12543 TBA_PLAYO Tubulin alpha chain PY01155 Plasmodium yoelii yoelii 453
P10873 TBA_TOXGO Tubulin alpha chain (Alpha-tubulin) Toxoplasma gondii 453
Q9C413 TBA_GLOLA Tubulin alpha chain (Alpha-tubulin) TUB1 Glomerella lagenarium (Anthracnose fungus) (Colletotrichum lagenarium) 454
P32255 TBA_DICDI Tubulin alpha chain (Alpha-tubulin) tubA DDB_G0287689 Dictyostelium discoideum (Slime mold) 457
Q27380 TBB_EIMTE Tubulin beta chain (Beta-tubulin) Eimeria tenella (Coccidian parasite) 449
Q8SS99 TBB_ENCCU Tubulin beta chain (Beta-tubulin) TUB2 ECU03_0820i Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite) 439
Q24829 TBB_ENCHE Tubulin beta chain (Beta-tubulin) TUB2 Encephalitozoon hellem (Microsporidian parasite) 439
Q9GSR5 TBB_ENCIN Tubulin beta chain (Beta-tubulin) TUB2 Encephalitozoon intestinalis (Microsporidian parasite) 439
Q9SEV2 TBBN_GUITH Tubulin beta chain; nucleomorph (Nucleomorph beta-tubulin) tubB btubNM Guillardia theta (Cryptomonas phi) 441
Q04709 TBB_BABBO Tubulin beta chain (Beta-tubulin) Babesia bovis 441
P33188 TBB1_PARTE Tubulin beta chain (Beta-tubulin) bPT2 GSPATT00021361001; bPT3 GSPATT00036831001 Paramecium tetraurelia 442
P12457 TBB_EUGGR Tubulin beta chain (Beta-tubulin) TUBB Euglena gracilis 442
P24637 TBB_PNECA Tubulin beta chain (Beta-tubulin) TUB-B Pneumocystis carinii 442
P11857 TBB_STYLE Tubulin beta chain (Beta-tubulin) TUBB1; TUBB2 Stylonychia lemnae 442
P04107 TBB_TRYBR Tubulin beta chain (Beta-tubulin) Trypanosoma brucei rhodesiense 442
P08562 TBB_TRYCR Tubulin beta chain (Beta-tubulin) Trypanosoma cruzi 442
P11482 TBB1_VOLCA Tubulin beta chain (Beta-tubulin) TUBB1; TUBB2 Volvox carteri (Green alga) 443
O04386 TBB_CHLIN Tubulin beta chain (Beta-tubulin) TUBB Chlamydomonas incerta 443
P22852 TBB_POLAG Tubulin beta chain (Beta-tubulin) TUBB1; TUBB2; TUBB3 Polytomella agilis (Quadriflagellate alga) 443
P10876 TBB_TETPY Tubulin beta chain (Beta-tubulin) BETA-TT1; BETA-TT2 Tetrahymena pyriformis 443
P41352 TBB_TETTH Tubulin beta chain (Beta-tubulin) BTU1; BTU2 Tetrahymena thermophila 443
Q9LKI8 TBB_THAWE Tubulin beta chain (Beta-tubulin) Thalassiosira weissflogii (Marine diatom) 443
P07437 TBB5_HUMAN Tubulin beta chain (Tubulin beta-5 chain) TUBB TUBB5 OK/SW-cl.56 Homo sapiens (Human) 444
P69895 TBB5_MACMU Tubulin beta chain (Tubulin beta-5 chain) TUBB TUBB5 Macaca mulatta (Rhesus macaque) 444
Q7JJU6 TBB5_PANTR Tubulin beta chain (Tubulin beta-5 chain) TUBB TUBB5 Pan troglodytes (Chimpanzee) 444
Q767L7 TBB5_PIG Tubulin beta chain (Tubulin beta-5 chain) TUBB TUBB5 Sus scrofa (Pig) 444
Q5R943 TBB5_PONAB Tubulin beta chain (Tubulin beta-5 chain) TUBB TUBB5 Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) 444
Q91575 TBB5_XENLA Tubulin beta chain (Tubulin beta-5 chain) tubb tubb5 Xenopus laevis (African clawed frog) 444
Q6GLE7 TBB5_XENTR Tubulin beta chain (Tubulin beta-5 chain) tubb tubb5 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 444
P20802 TBB_ACHKL Tubulin beta chain (Beta-tubulin) Achlya klebsiana 444
Q9N2N6 TBB_EUPFO Tubulin beta chain (Beta-tubulin) Euplotes focardii 444
Q08115 TBB_EUPOC Tubulin beta chain (Beta-tubulin) Euplotes octocarinatus 444
P41387 TBB_ONCGI Tubulin beta chain (Beta-tubulin) TBB Onchocerca gibsoni 444
O59837 TBB_PHYCI Tubulin beta chain (Beta-tubulin) Phytophthora cinnamomi (Cinnamon fungus) 444
O44388 TBB_TRITR Tubulin beta chain (Beta-tubulin) Trichuris trichiura (Whipworm) 444
Q8WZE0 TBB_USTVI Tubulin beta chain (Beta-tubulin) Ustilago violacea (Smut fungus) (Microbotryum violaceum) 444
P41742 TBB_AJECA Tubulin beta chain (Beta-tubulin) TUB2 Ajellomyces capsulatus (Darlings disease fungus) (Histoplasma capsulatum) 445
P79008 TBB_COPC7 Tubulin beta chain (Beta-tubulin) CC1G_04743 Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata) 445
P02554 TBB_PIG Tubulin beta chain (Beta-tubulin) Sus scrofa (Pig) 445
Q7KQL5 TBB_PLAF7 Tubulin beta chain (Beta-tubulin) PF10_0084 Plasmodium falciparum (isolate 3D7) 445
P14140 TBB_PLAFA Tubulin beta chain (Beta-tubulin) Plasmodium falciparum 445
P14643 TBB_PLAFK Tubulin beta chain (Beta-tubulin) Plasmodium falciparum (isolate K1 / Thailand) 445
Q91240 TBB_PSEAM Tubulin beta chain (Beta-tubulin) Pseudopleuronectes americanus (Winter flounder) (Pleuronectes americanus) 445
P30668 TBB_SCHCO Tubulin beta chain (Beta-tubulin) TUB-2 Schizophyllum commune (Split gill fungus) 445
P16040 TBB_ERYGR Tubulin beta chain (Beta-tubulin) TUB2 Erysiphe graminis subsp. hordei (Grass mildew) (Blumeria graminis subsp. hordei) 446
P20365 TBB_EUPCR Tubulin beta chain (Beta-tubulin) Euplotes crassus 446
P05304 TBB_GIAIN Tubulin beta chain (Beta-tubulin) Giardia intestinalis (Giardia lamblia) 446
P53374 TBB_GIBFU Tubulin beta chain (Beta-tubulin) TUB2 Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium moniliforme) 446
Q4HZS8 TBB_GIBZE Tubulin beta chain (Beta-tubulin) TUB2 FGSG_09530 Gibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum) 446
Q9UV72 TBB_PESMI Tubulin beta chain (Beta-tubulin) TUBB Pestalotiopsis microspora 446
Q92268 TBB_PLESA Tubulin beta chain (Beta-tubulin) Pleurotus sajor-caju (Oyster mushroom) 446
P41741 TBB_ACRCH Tubulin beta chain (Beta-tubulin) TUB2 Acremonium chrysogenum (Cephalosporium acremonium) 447
P53373 TBB_BOTFU Tubulin beta chain (Beta-tubulin) tubA benA btuB Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea) 447
Q3KVN1 TBB_CERBT Tubulin beta chain (Beta-tubulin) TUB1 Cercospora beticola (Sugarbeet leaf spot) 447
Q4R9N3 TBB_COCHE Tubulin beta chain (Beta-tubulin) TUB1 Cochliobolus heterostrophus (Drechslera maydis) 447
P35394 TBB_ENTDO Tubulin beta chain (Beta-tubulin) Enteroctopus dofleini (Giant octopus) (Octopus dofleini) 447
P93176 TBB_HORVU Tubulin beta chain (Beta-tubulin) TUBB Hordeum vulgare (Barley) 447
Q6QDC9 TBB_MYCGR Tubulin beta chain (Beta-tubulin) TUB1 Mycosphaerella graminicola (Speckled leaf blotch fungus) (Septoria tritici) 447
O42786 TBB_MYCPJ Tubulin beta chain (Beta-tubulin) TUB1 Mycosphaerella pini (Red band needle blight disease fungus) (Dothistroma pini) 447
P05220 TBB_NEUCR Tubulin beta chain (Beta-tubulin) tub-2 B2C22.060 NCU04054 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 447
P11833 TBB_PARLI Tubulin beta chain (Beta-tubulin) Paracentrotus lividus (Common sea urchin) 447
P53375 TBB_PENDI Tubulin beta chain (Beta-tubulin) TUB2 Penicillium digitatum (Green mold) 447
P41799 TBB_PHANO Tubulin beta chain (Beta-tubulin) tubB tubA SNOG_06790 SNOG_06791 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum) 447
P53376 TBB_RHYSE Tubulin beta chain (Beta-tubulin) Rhynchosporium secalis (Barley scald fungus) 447
Q5UBX3 TBB_TRIRU Tubulin beta chain (Beta-tubulin) Trichophyton rubrum (Athletes foot fungus) (Epidermophyton rubrum) 447
Q86ZP5 TBB_UNCNE Tubulin beta chain (Beta-tubulin) Uncinula necator (Grape powdery mildew) 447
Q96TU8 TBB_UROFA Tubulin beta chain (Beta-tubulin) TBB1 Uromyces fabae (Rust fungus) 447
P41388 TBB_VENIN Tubulin beta chain (Beta-tubulin) Venturia inaequalis (Apple scab fungus) 447
P22012 TBB_ASPFL Tubulin beta chain (Beta-tubulin) Aspergillus flavus 448
Q4WA70 TBB_ASPFU Tubulin beta chain (Beta-tubulin) AFUA_7G00250 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) 448
Q2U2U3 TBB_ASPOR Tubulin beta chain (Beta-tubulin) benA56 AO090038000317 Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) 448
Q00264 TBB_ASPPA Tubulin beta chain (Beta-tubulin) benR Aspergillus parasiticus 448
P17938 TBB_EPITY Tubulin beta chain (Beta-tubulin) TUBB TUB2 Epichloe typhina 448
Q9HFQ3 TBB_MELLI Tubulin beta chain (Beta-tubulin) TUB1 Melampsora lini (Rust fungus) 448
Q52NY7 TBB_METAN Tubulin beta chain (Beta-tubulin) Metarhizium anisopliae (Entomophthora anisopliae) 448
P33127 TBB_NEOCO Tubulin beta chain (Beta-tubulin) TUB2 Neotyphodium coenophialum (Tall fescue endophyte fungus) (Acremonium coenophialum) 448
P05219 TBB_SCHPO Tubulin beta chain (Beta-tubulin) nda3 alp12 SPBC26H8.07c Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) 448
Q4P235 TBB_USTMA Tubulin beta chain (Beta-tubulin) UM05828 Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus) 448
P10875 TBB_CANAX Tubulin beta chain (Beta-tubulin) TUB2 Candida albicans (Yeast) 449
Q39445 TBB_CICAR Tubulin beta chain (Beta-tubulin) TUBB Cicer arietinum (Chickpea) (Garbanzo) 449
P41385 TBB_BOMMO Tubulin beta chain (Beta-tubulin) Bombyx mori (Silk moth) 450
P34108 TBB_NAEGR Tubulin beta chain (Beta-tubulin) Naegleria gruberi (Amoeba) 451
P32256 TBB_DICDI Tubulin beta chain (Beta-tubulin) tubB DDB_G0269196 Dictyostelium discoideum (Slime mold) 455
P50259 TBB_PORPU Tubulin beta chain (Beta-tubulin) TUBB1 Porphyra purpurea 457
P02557 TBB_YEAST Tubulin beta chain (Beta-tubulin) TUB2 YFL037W Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Bakers yeast) 457
Q84TG9 TBB_PORYE Tubulin beta chain (Beta-tubulin) TUBB1 Porphyra yezoensis 458
Q9VRX3 TBBP_DROME Probable tubulin beta chain CG32396 (Beta-tubulin CG32396) CG32396 Drosophila melanogaster (Fruit fly) 462
P21148 TBB_LEIME Tubulin beta chain (Beta-tubulin) Leishmania mexicana 445

Small molecules tested in Tubulin binding assays:

82 datapoints for 69 distinct small molecules


Name CHEMBL103307
Affinity IC50 > 40uM
Assay description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16213720
Doc title Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
PDB None

Name CHEMBL105402
Affinity Inhibition = 18%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL105416
Affinity Inhibition = 10%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL107
Affinity IC50 = 1.26uM
Assay description In vitro inhibitory concentration required to displace [3H]colchicine from its binding site on tubulin
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12852768
Doc title Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
PDB None

Name CHEMBL107
Affinity IC50 = 10uM
Assay description In vitro tubulin polymerization-inhibitory activity.
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873473
Doc title Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.
PDB None

Name CHEMBL107
Affinity Inhibition = 78%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL112192
Affinity IC50 = 0.22uM
Assay description In vitro inhibitory concentration required to displace [3H]colchicine from its binding site on tubulin
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12852768
Doc title Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
PDB None

Name CHEMBL116173
Affinity IC50 = 0.37uM
Assay description In vitro inhibitory concentration required to displace [3H]colchicine from its binding site on Tubulin
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/12852768
Doc title Novel benzylidene-9(10H)-anthracenones as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
PDB None

Name CHEMBL11627
Affinity Inhibition = 6%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL123092
Affinity IC50 = 40uM
Assay description Ability to inhibit the binding of [3H]colchicine to porcine tubulin
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/14552774
Doc title The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents.
PDB None

Name CHEMBL126094
Affinity IC50 = 60uM
Assay description Ability to inhibit the binding of [3H]colchicine to porcine tubulin
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/14552774
Doc title The total synthesis of an aurone isolated from Uvaria hamiltonii: aurones and flavones as anticancer agents.
PDB None

Name CHEMBL150438
Affinity IC50 = 22.5uM
Assay description Effect on tubulin binding and the concentration required to cause 50% decrease in tubulin assembly at 350 nm.
-- Direct single protein target assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11140732
Doc title Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
PDB None

Name CHEMBL150438
Affinity IC50 = 226uM
Assay description Concentration required to cause 50% decrease in the binding of [3H]colchicine from purified porcine tubulin.
-- Direct single protein target assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11140732
Doc title Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
PDB None

Name CHEMBL150463
Affinity IC50 > 100uM
Assay description Effect on tubulin binding and the concentration required to cause 50% decrease in tubulin assembly at 350 nm.
-- Direct single protein target assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11140732
Doc title Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
PDB None

Name CHEMBL150463
Affinity IC50 = 298uM
Assay description Concentration required to cause 50% decrease in the binding of [3H]colchicine from purified porcine tubulin.
-- Direct single protein target assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11140732
Doc title Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
PDB None

Name CHEMBL150582
Affinity IC50 = 4uM
Assay description Concentration required to cause 50% decrease in the binding of [3H]colchicine from purified porcine tubulin.
-- Direct single protein target assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11140732
Doc title Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
PDB None

Name CHEMBL150582
Affinity IC50 = 0.6uM
Assay description Effect on tubulin binding and the concentration required to cause 50% decrease in tubulin assembly at 350 nm.
-- Direct single protein target assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11140732
Doc title Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
PDB None

Name CHEMBL159
Affinity Activity = 25%
Assay description Inhibition of beta tubulin nucleotide site assessed as inhibition of displacement of cold GDP by [alpha32P]GTP at 20 uM by rapid filtration technique
-- Homologous single protein target assigned: TBB5_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19072542
Doc title Synthesis and biological evaluation of vinca alkaloids and phomopsin hybrids.
PDB None

Name CHEMBL196754
Affinity IC50 = 18uM
Assay description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16213720
Doc title Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
PDB None

Name CHEMBL201511
Affinity Not Active
Assay description Inhibition of tubulin polymerization in porcine brain upto 10 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16480264
Doc title Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.
PDB None

Name CHEMBL201512
Affinity Not Active
Assay description Inhibition of tubulin polymerization in porcine brain upto 10 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16480264
Doc title Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.
PDB None

Name CHEMBL201949
Affinity Not Active
Assay description Inhibition of tubulin polymerization in porcine brain upto 10 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16480264
Doc title Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.
PDB None

Name CHEMBL202135
Affinity Not Active
Assay description Inhibition of tubulin polymerization in porcine brain upto 10 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16480264
Doc title Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.
PDB None

Name CHEMBL202215
Affinity Not Active
Assay description Inhibition of tubulin polymerization in porcine brain upto 10 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16480264
Doc title Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.
PDB None

Name CHEMBL212716
Affinity Inhibition = 10%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL213322
Affinity Inhibition = 9%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL213482
Affinity Inhibition = 0%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL213924
Affinity IC50 = 17uM
Assay description Inhibition of tubulin polymerization in porcine brain
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL213924
Affinity Inhibition = 73%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL215051
Affinity Inhibition = 11%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL2180486
Affinity Not Active
Assay description Effect on MAP-rich pig beta-tubulin polymerization at 40 ug/mL by microtiter plate-based light scattering assay
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23050700
Doc title A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.
PDB None

Name CHEMBL2207288
Affinity Not Active
Assay description Induction of pig MAP-rich beta-tubulin polymerization at 40 ug/ml measured for 60 mins by microtiter plate based light scattering assay
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23127490
Doc title 3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.
PDB None

Name CHEMBL2207300
Affinity Not Active
Assay description Induction of pig MAP-rich beta-tubulin polymerization at 40 ug/ml measured for 60 mins by microtiter plate based light scattering assay
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23127490
Doc title 3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.
PDB None

Name CHEMBL262001
Affinity IC50 = 4uM
Assay description In vitro tubulin polymerization-inhibitory activity.
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873473
Doc title Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.
PDB None

Name CHEMBL276705
Affinity Inhibition = 7%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL276711
Affinity IC50 > 40uM
Assay description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16213720
Doc title Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
PDB None

Name CHEMBL298557
Affinity Inhibition < 20%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL298564
Affinity Inhibition < 20%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL298774
Affinity Inhibition < 20%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL299414
Affinity Inhibition < 20%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL303103
Affinity IC50 > 50uM
Assay description In vitro tubulin polymerization-inhibitory activity.
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873473
Doc title Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.
PDB None

Name CHEMBL313952
Affinity IC50 = 6.9uM
Assay description Inhibition of tubulin polymerization in porcine brain
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL330174
Affinity Inhibition = 71%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL330174
Affinity IC50 = 16uM
Assay description Inhibition of tubulin polymerization in porcine brain
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL345556
Affinity IC50 = 6.6uM
Assay description Effect on tubulin binding and the concentration required to cause 50% decrease in tubulin assembly at 350 nm.
-- Direct single protein target assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11140732
Doc title Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
PDB None

Name CHEMBL345556
Affinity IC50 = 36uM
Assay description Concentration required to cause 50% decrease in the binding of [3H]colchicine from purified porcine tubulin.
-- Direct single protein target assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11140732
Doc title Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
PDB None

Name CHEMBL356370
Affinity IC50 = 16.3uM
Assay description Effect on tubulin binding and the concentration required to cause 50% decrease in tubulin assembly at 350 nm.
-- Direct single protein target assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11140732
Doc title Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
PDB None

Name CHEMBL356370
Affinity IC50 = 36uM
Assay description Concentration required to cause 50% decrease in the binding of [3H]colchicine from purified porcine tubulin.
-- Direct single protein target assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/11140732
Doc title Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
PDB None

Name CHEMBL372076
Affinity Not Active
Assay description Inhibition of tubulin polymerization in porcine brain upto 10 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16480264
Doc title Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.
PDB None

Name CHEMBL372120
Affinity IC50 = 4.5uM
Assay description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16213720
Doc title Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
PDB None

Name CHEMBL372944
Affinity Not Active
Assay description Inhibition of tubulin polymerization in porcine brain upto 10 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16480264
Doc title Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.
PDB None

Name CHEMBL377049
Affinity IC50 = 7.8uM
Assay description Inhibition of tubulin polymerization in porcine brain
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL377049
Affinity Not Active
Assay description Inhibition of tubulin depolymerization in porcine brain at 10 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL377049
Affinity Inhibition = 78%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL378162
Affinity IC50 > 40uM
Assay description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16213720
Doc title Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
PDB None

Name CHEMBL379199
Affinity Inhibition = 0%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL379989
Affinity Inhibition = 81%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL381099
Affinity Not Active
Assay description Inhibition of tubulin polymerization in porcine brain upto 10 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16480264
Doc title Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.
PDB None

Name CHEMBL381416
Affinity IC50 > 40uM
Assay description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16213720
Doc title Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
PDB None

Name CHEMBL382128
Affinity IC50 = 7.6uM
Assay description Inhibition of tubulin polymerization in porcine brain
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16480264
Doc title Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors.
PDB None

Name CHEMBL382323
Affinity IC50 > 40uM
Assay description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16213720
Doc title Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
PDB None

Name CHEMBL382519
Affinity IC50 = 9.1uM
Assay description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16213720
Doc title Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
PDB None

Name CHEMBL384602
Affinity Inhibition = 10%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL427407
Affinity Inhibition = 8%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL428647
Affinity Active
Assay description Induction of pig MAP-rich beta-tubulin polymerization at 25 ug/ml measured for 60 mins by microtiter plate based light scattering assay
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23127490
Doc title 3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.
PDB 2WBE - (TA1)

Name CHEMBL428647
Affinity Active
Assay description Stimulation of MAP-rich pig beta-tubulin polymerization at 25 ug/mL by microtiter plate-based light scattering assay
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23050700
Doc title A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.
PDB 2WBE - (TA1)

Name CHEMBL446991
Affinity Active
Assay description Inhibition of beta tubulin nucleotide site assessed as inhibition of displacement of cold GDP by [alpha32P]GTP at 20 uM by rapid filtration technique
-- Homologous single protein target assigned: TBB5_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/19072542
Doc title Synthesis and biological evaluation of vinca alkaloids and phomopsin hybrids.
PDB None

Name CHEMBL51746
Affinity Inhibition < 20%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL52182
Affinity Inhibition < 20%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL52597
Affinity Inhibition < 20%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL53033
Affinity Inhibition < 20%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL53153
Affinity Inhibition < 14%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL53263
Affinity Inhibition < 20%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL53698
Affinity Inhibition < 20%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL54551
Affinity Inhibition < 20%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL54952
Affinity Inhibition < 20%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL55225
Affinity Inhibition < 20%
Assay description Inhibition of porcine brain tubulin assembly at 40 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15027874
Doc title Synthesis and antitubulin activity of N1- and N4-substituted 3,5-dinitro sulfanilamides against African trypanosomes and Leishmania.
PDB None

Name CHEMBL61
Affinity IC50 = 1.56uM
Assay description Inhibition of porcine brain tubulin polymerization by GTP-induced assembly
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16213720
Doc title Conformationally restricted analogs of Combretastatin A-4 derived from SU5416.
PDB 1SA1 - (POD)

Name CHEMBL61572
Affinity IC50 = 4uM
Assay description In vitro tubulin polymerization-inhibitory activity; 4-6
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/9873473
Doc title Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells.
PDB None

Name CHEMBL89081
Affinity Inhibition = 3%
Assay description Inhibition of tubulin polymerization in porcine brain at 20 uM
-- Direct protein complex subunits assigned: TBB_PIG (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/16870433
Doc title Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
PDB None

Name CHEMBL9514
Affinity Active
Assay description Inhibition of pig MAP-rich beta-tubulin polymerization at 10 ug/ml measured for 60 mins by microtiter plate based light scattering assay
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23127490
Doc title 3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.
PDB None

Name CHEMBL9514
Affinity Active
Assay description Inhibition of MAP-rich pig beta-tubulin polymerization at 10 ug/mL by microtiter plate-based light scattering assay
-- Direct single protein target assigned: TBB_PIG (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23050700
Doc title A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.
PDB None

18 PDB entries for Tubulin and its protein partners


1FFX
The 4 A X-ray structure of a tubulin:stathmin-like domain complex.

Entity type Code Description
polypeptide(L) P02550 PROTEIN (TUBULIN)
polypeptide(L) P02554 PROTEIN (TUBULIN)
polypeptide(L) 1FFX PROTEIN (STATHMIN-LIKE DOMAIN OF RB3)
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE
Ligand GDP GUANOSINE-5'-DIPHOSPHATE

1IA0
Switch-based Mechanism of Kinesin Motors

Entity type Code Description
polypeptide(L) P02550 TUBULIN ALPHA CHAIN
polypeptide(L) P02554 TUBULIN BETA CHAIN
polypeptide(L) P33173 KINESIN-LIKE PROTEIN KIF1A
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand TXL TAXOTERE
Ligand ACP PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER

1JFF
Refined structure of alpha beta-tubulin at 3.5 A resolution.

Entity type Code Description
polypeptide(L) P02550 tubulin alpha chain
polypeptide(L) P02554 tubulin beta chain
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand TA1 TAXOL

1SA0
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.

Entity type Code Description
polypeptide(L) P02550 Tubulin alpha chain
polypeptide(L) P02554 Tubulin beta chain
polypeptide(L) P63043 Stathmin 4
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand CN2 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE

1SA1
Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.

Entity type Code Description
polypeptide(L) P02550 Tubulin alpha chain
polypeptide(L) P02554 Tubulin beta chain
polypeptide(L) P02554 Stathmin 4
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand POD 9-HYDROXY-5-(3,4,5-TRIMETHOXYPHENYL)-5,8,8A,9-TETRAHYDROFURO[3',4':6,7]NAPHTHO[2,3-D][1,3]DIOXOL-6(5AH)-ONE

1TUB
Structure of the alpha beta tubulin dimer by electron crystallography.

Entity type Code Description
polypeptide(L) P02550 TUBULIN
polypeptide(L) P02554 TUBULIN
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand TXL TAXOTERE

1TVK
The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography

Entity type Code Description
polypeptide(L) P02550 Tubulin alpha chain
polypeptide(L) P02554 Tubulin beta chain
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE
Ligand EP EPOTHILONE A

2HXF
High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations

Entity type Code Description
polypeptide(L) P02550 Tubulin alpha chain
polypeptide(L) P02554 Tubulin beta chain
polypeptide(L) P33173 Kinesin-like protein KIF1A
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand TA1 TAXOL
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

2HXH
High-resolution cryo-EM maps show the nucleotide binding pocket of KIF1A in open and closed conformations

Entity type Code Description
polypeptide(L) P02550 Tubulin alpha chain
polypeptide(L) P02554 Tubulin beta chain
polypeptide(L) P33173 Kinesin-like protein KIF1A
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand TA1 TAXOL
Ligand ADP ADENOSINE-5'-DIPHOSPHATE

2WBE
9-Angstrom Structure of a Microtubule-Bound Mitotic Motor.

Entity type Code Description
polypeptide(L) P02550 TUBULIN ALPHA-1D CHAIN
polypeptide(L) P02554 TUBULIN BETA-2B CHAIN
polypeptide(L) 2WBE BIPOLAR KINESIN KRP-130
polypeptide(L) P46863 BIPOLAR KINESIN KRP-130
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand TA1 TAXOL
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

2XRP
Template-Free 13-Protofilament Microtubule-Map Assembly Visualized at 8 A Resolution.

Entity type Code Description
polypeptide(L) Q6B856 TUBULIN BETA-2B CHAIN
polypeptide(L) Q2HJ86 TUBULIN ALPHA-1D CHAIN
polypeptide(L) O43602 NEURONAL MIGRATION PROTEIN DOUBLECORTIN
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE

3QNZ
Crystal structures of human IGA1 and IGG1 fab fragments sharing the same variable domains

Entity type Code Description
polypeptide(L) 3QNZ Fab fragment of IMMUNOGLOBULIN G1 LIGHT CHAIN
polypeptide(L) 3QNZ Fab fragment of IMMUNOGLOBULIN G1 HEAVY CHAIN
polypeptide(L) P07437 peptide from Tubulin beta chain

3QO0
Crystal structures of human IGA1 and IGG1 fab fragments sharing the same variable domains

Entity type Code Description
polypeptide(L) 3QO0 Fab fragment of IMMUNOGLOBULIN G1 LIGHT CHAIN
polypeptide(L) 3QO0 Fab fragment of IMMUNOGLOBULIN G1 HEAVY CHAIN
polypeptide(L) P07437 Peptide from Tubulin beta chain

4AQV
The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5.

Entity type Code Description
polypeptide(L) Q2HJ86 TUBULIN ALPHA-1D CHAIN
polypeptide(L) Q6B856 TUBULIN BETA-2B CHAIN
polypeptide(L) P52732 KINESIN-LIKE PROTEIN KIF11
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand TA1 TAXOL
Ligand ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER

4AQW
The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5.

Entity type Code Description
polypeptide(L) Q2HJ86 TUBULIN ALPHA-1D CHAIN
polypeptide(L) Q6B856 TUBULIN BETA-2B CHAIN
polypeptide(L) P52732 KINESIN-LIKE PROTEIN KIF11
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand TA1 TAXOL

4ATU
Molecular Basis for Specific Regulation of Neuronal Kinesin- 3 Motors by Doublecortin Family Proteins.

Entity type Code Description
polypeptide(L) Q6B856 TUBULIN BETA-2B CHAIN
polypeptide(L) Q2HJ86 TUBULIN ALPHA-1D CHAIN
polypeptide(L) O43602 NEURONAL MIGRATION PROTEIN DOUBLECORTIN
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE

4ATX
Molecular Basis for Specific Regulation of Neuronal Kinesin- 3 Motors by Doublecortin Family Proteins.

Entity type Code Description
polypeptide(L) Q6B856 TUBULIN BETA-2B CHAIN
polypeptide(L) Q2HJ86 TUBULIN ALPHA-1D CHAIN
polypeptide(L) Q2PQA9 KINESIN-1 HEAVY CHAIN
Ligand GDP GUANOSINE-5'-DIPHOSPHATE
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE

4FFB
A TOG:alpha/beta-tubulin Complex Structure Reveals Conformation-Based Mechanisms For a Microtubule Polymerase

Entity type Code Description
polypeptide(L) P09733 Tubulin alpha-1 chain
polypeptide(L) P02557 Tubulin beta chain
polypeptide(L) P46675 Protein STU2
Ligand GTP GUANOSINE-5'-TRIPHOSPHATE