UL42

Dna-binding protein ul42

Reviewed UniProt entries for UL42 and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
P10226 PAP_HHV11 DNA polymerase processivity factor (DNA-binding protein UL42) (Polymerase accessory protein) (PAP) UL42 Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) 488
P89463 PAP_HHV2H DNA polymerase processivity factor (DNA-binding protein UL42) (Polymerase accessory protein) (PAP) UL42 Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) 470
Q6UDI9 PAP_PSHV1 DNA polymerase processivity factor (DNA-binding protein UL42) (Polymerase accessory protein) (PAP) UL42 Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1) (Pachecos disease virus) 500

Small molecules tested in UL42 binding assays:

4 datapoints for 4 distinct small molecules


Name BP1
Affinity IC50 (FP) 35uM
Assay description Fluorescence polarization (UL42 and Pol peptide)
-- Direct single protein target assigned: PAP_HHV11 (Expert curation) --
DOI http://dx.doi.org/10.1016/j.chembiol.2004.01.018
Doc title Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication.
PDB None

Name BP3
Affinity IC50 (FP) 12uM
Assay description Fluorescence polarization (UL42 and Pol peptide)
-- Direct single protein target assigned: PAP_HHV11 (Expert curation) --
DOI http://dx.doi.org/10.1016/j.chembiol.2004.01.018
Doc title Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication.
PDB None

Name BP5
Affinity IC50 (FP) 15uM
Assay description Fluorescence polarization (UL42 and Pol peptide)
-- Direct single protein target assigned: PAP_HHV11 (Expert curation) --
DOI http://dx.doi.org/10.1016/j.chembiol.2004.01.018
Doc title Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication.
PDB None

Name BP9
Affinity IC50 (FP) 48uM
Assay description Fluorescence polarization (UL42 and Pol peptide)
-- Direct single protein target assigned: PAP_HHV11 (Expert curation) --
DOI http://dx.doi.org/10.1016/j.chembiol.2004.01.018
Doc title Identification of a small molecule that inhibits herpes simplex virus DNA Polymerase subunit interactions and viral replication.
PDB None

1 PDB entries for UL42 and its protein partners


1DML
The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase.

Entity type Code Description
polypeptide(L) P10226 DNA POLYMERASE PROCESSIVITY FACTOR
polypeptide(L) P07917 DNA POLYMERASE