XIAP

Baculoviral iap repeat-containing protein 4 (x-linked inhibitor of apoptosis protein)

Reviewed UniProt entries for XIAP and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q60989 XIAP_MOUSE Baculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3 ubiquitin-protein ligase XIAP) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (mIAP-3) (mIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) Xiap Aipa Api3 Birc4 Miha Mus musculus (Mouse) 496
Q9R0I6 XIAP_RAT Baculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3 ubiquitin-protein ligase XIAP) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (rIAP-3) (rIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) Xiap Api3 Birc4 Rattus norvegicus (Rat) 496
A5D8Q0 XIAP_XENLA Baculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3 ubiquitin-protein ligase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (xXIAP) xiap birc4 Xenopus laevis (African clawed frog) 488
Q5BKL8 XIAP_XENTR Baculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3 ubiquitin-protein ligase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) xiap birc4 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 492
Q9NR28 DBLOH_HUMAN Diablo homolog; mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) DIABLO SMAC Homo sapiens (Human) 239
Q9JIQ3 DBLOH_MOUSE Diablo homolog; mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac) Diablo Smac Mus musculus (Mouse) 237
Q5RBH2 DBLOH_PONAB Diablo homolog; mitochondrial DIABLO Pongo abelii (Sumatran orangutan) 239
A4GZV0 DBLOH_XENLA Diablo homolog; mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac protein) (XSmac) diablo smac Xenopus laevis (African clawed frog) 244
Q0IJ31 DBLOH_XENTR Diablo homolog; mitochondrial (Direct IAP-binding protein with low pI) (Second mitochondria-derived activator of caspase) (Smac protein) diablo smac Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) 244
P98170 XIAP_HUMAN Baculoviral IAP repeat-containing protein 4 (EC 6.3.2.-) (E3 ubiquitin-protein ligase XIAP) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) XIAP API3 BIRC4 IAP3 Homo sapiens (Human) 497

Small molecules tested in XIAP binding assays:

1034 datapoints for 549 distinct small molecules


Name Embelin
Affinity IC50 (FP) 4uM
Assay description Fluorencence Polarisation assay; Smac peptides fluorescent label
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm030420+
Doc title Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database.
PDB None

Name EmbelinDev_6a
Affinity Ki (FP) 10uM
Assay description Fluorencence Polarisation assay; Smac peptides fluorescent label
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmcl.2006.08.072
Doc title Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein.
PDB None

Name EmbelinDev_6d
Affinity Ki (FP) 700nM
Assay description Fluorencence Polarisation assay; Smac peptides fluorescent label
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmcl.2006.08.072
Doc title Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein.
PDB None

Name SmacLike_1
Affinity Kd (FP) 12nM
Assay description Fluorencence Polarisation assay; Smac peptides fluorescent label
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm040037k
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB 1TFQ - (998)

Name SmacLike_2
Affinity Kd (FP) 5nM
Assay description Fluorencence Polarisation assay; Smac peptides fluorescent label
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm040037k
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB 1TFT - (997)

Name JMC51_21
Affinity Ki (FP) 0.067 +- 0.018 uM
Assay description Fluorencence Polarisation assay; Smac peptides fluorescent label
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1021/jm8006849
Doc title Structure-based design, synthesis, evaluation, and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP).
PDB 2JK7 - (BI6)

Name Smac005
Affinity IC50 FP 270 +- 20 nM
Assay description Fluorencence Polarisation assay; Smac peptides fluorescent label
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1016/j.jmb.2008.09.064
Doc title Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
PDB 3CM7 - (X22)

Name Smac005
Affinity IC50 FP 270 +- 20 nM
Assay description Fluorencence Polarisation assay; Smac peptides fluorescent label
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1016/j.jmb.2008.09.064
Doc title Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
PDB 3CLX - (X22)

Name Smac010
Affinity IC50 FP 970 +- 120 nM
Assay description Fluorencence Polarisation assay; Smac peptides fluorescent label
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1016/j.jmb.2008.09.064
Doc title Targeting the X-linked inhibitor of apoptosis protein through 4-substituted azabicyclo[5.3.0]alkane smac mimetics. Structure, activity, and recognition principles.
PDB 3CM2 - (X23)

Name CHEMBL1095993
Affinity IC50 = 28nM
Assay description Binding affinity to XIAP linker BIR2-BIR3 domain site 2 by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443226
Doc title
PDB None

Name CHEMBL1095993
Affinity IC50 = 3.2uM
Assay description Binding affinity to XIAP linker BIR2 domain by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443226
Doc title
PDB None

Name CHEMBL1095993
Affinity IC50 = 0.43nM
Assay description Binding affinity to XIAP linker BIR2-BIR3 domain site 1 by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443226
Doc title
PDB None

Name CHEMBL1095994
Affinity IC50 = 1.3nM
Assay description Binding affinity to XIAP linker BIR2-BIR3 domain site 1 by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443226
Doc title
PDB None

Name CHEMBL1095994
Affinity IC50 = 40.5uM
Assay description Binding affinity to XIAP linker BIR2 domain by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443226
Doc title
PDB None

Name CHEMBL1095994
Affinity IC50 = 1106nM
Assay description Binding affinity to XIAP linker BIR2-BIR3 domain site 2 by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20443226
Doc title
PDB None

Name CHEMBL1230661
Affinity Kd = 5nM
Assay description Binding affinity to XIAP BIR3-domain (unknown origin)
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23886811
Doc title Solid phase synthesis of Smac/DIABLO-derived peptides using a Safety-Catch resin: identification of potent XIAP BIR3 antagonists.
PDB 1TFT - (997)

Name CHEMBL1230662
Affinity Kd = 0.01uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB 1TFQ - (998)

Name CHEMBL1241424
Affinity Ki = 108nM
Assay description Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20684551
Doc title Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
PDB None

Name CHEMBL1241424
Affinity IC50 = 361nM
Assay description Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20684551
Doc title Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
PDB None

Name CHEMBL1241425
Affinity Ki = 305.2nM
Assay description Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20684551
Doc title Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
PDB None

Name CHEMBL1241425
Affinity IC50 = 1017nM
Assay description Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20684551
Doc title Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
PDB None

Name CHEMBL1241426
Affinity Ki = 36nM
Assay description Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20684551
Doc title Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
PDB None

Name CHEMBL1241426
Affinity IC50 = 125nM
Assay description Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20684551
Doc title Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
PDB None

Name CHEMBL1242922
Affinity Ki = 330.6nM
Assay description Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20684551
Doc title Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
PDB None

Name CHEMBL1242922
Affinity IC50 = 1102nM
Assay description Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20684551
Doc title Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
PDB None

Name CHEMBL1243385
Affinity Ki = 320.3nM
Assay description Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20684551
Doc title Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
PDB None

Name CHEMBL1243385
Affinity IC50 = 1068nM
Assay description Displacement of fluorescent SM5F peptide from His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/20684551
Doc title Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.
PDB None

Name CHEMBL150
Affinity IC50 > 100uM
Assay description Displacement of fluorescent SM5F peptide from XIAP linker BIR3 domain after 3 hrs by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21087868
Doc title In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3.
PDB None

Name CHEMBL1616141
Affinity Ki = 1.74uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1616141
Affinity Ki > 39uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1616828
Affinity Ki = 0.66uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1616828
Affinity Ki = 8.06uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1617609
Affinity Ki = 4.41uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1617609
Affinity Ki = 0.8uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1617615
Affinity Ki = 0.64uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1617615
Affinity Ki = 40.15uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1617615
Affinity Not Active
Assay description Antagonist activity at XIAP in TRAIL-resistant human HeLa cells at 5 uM
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1617658
Affinity Ki = 1.4uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1617658
Affinity Ki = 4.07uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1617726
Affinity Ki = 1.91uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1617726
Affinity Ki = 12.71uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1617727
Affinity Ki = 2.33uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1617727
Affinity Ki = 0.65uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1617819
Affinity Ki = 41.32uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1617819
Affinity Ki = 1.83uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1617821
Affinity Ki > 39uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1617821
Affinity Ki = 1.94uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1618026
Affinity Ki = 26.15uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1618026
Affinity Ki = 20.07uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1618558
Affinity Ki = 3.65uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1618558
Affinity Ki = 21.15uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1618706
Affinity Ki = 1.29uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1618706
Affinity Ki = 1.5uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1618815
Affinity Ki = 9.82uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1618815
Affinity Ki = 1.7uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1619739
Affinity Ki = 1.29uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1619739
Affinity Ki = 0.54uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1619777
Affinity Ki > 39uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1619777
Affinity Ki > 56uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1619873
Affinity Ki > 39uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1619873
Affinity Ki = 2.38uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1620115
Affinity Ki > 39uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1620115
Affinity Ki = 5.46uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1620854
Affinity Ki = 5.62uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1620854
Affinity Ki = 9.7uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1620862
Affinity Ki = 1.67uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1620862
Affinity Ki = 0.35uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1620893
Affinity Ki = 3.12uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1620893
Affinity Ki = 0.7uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1621001
Affinity Ki = 4.94uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1621001
Affinity Ki = 13.78uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1621070
Affinity Ki = 34.18uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1621070
Affinity Ki = 3uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1621745
Affinity Ki = 3.36uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1621745
Affinity Ki = 0.59uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1621840
Affinity Ki = 37.06uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1621840
Affinity Ki = 6.07uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1621842
Affinity Ki = 0.055uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1621842
Affinity Ki = 0.06uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1621842
Affinity Ki = 1.37uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1621842
Affinity Ki = 1.37uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1621847
Affinity Ki = 2.55uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1621847
Affinity Ki = 16.21uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1622024
Affinity Ki = 0.12uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1622024
Affinity Ki = 2.01uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1622095
Affinity Ki = 1.88uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1622095
Affinity Ki = 21.48uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1622564
Affinity Ki = 0.99uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1622564
Affinity Ki = 0.42uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1622682
Affinity Ki = 7.2uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1622682
Affinity Ki = 56.13uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1622728
Affinity Ki = 4.75uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1622728
Affinity Ki = 6.1uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1623521
Affinity Ki = 1.4uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1623521
Affinity Ki = 4.97uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1623582
Affinity Ki = 0.74uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1623582
Affinity Ki = 5.5uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1623606
Affinity Ki = 13.14uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1623606
Affinity Ki = 39uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1624542
Affinity Ki = 3.78uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1624542
Affinity Ki > 39uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1624713
Affinity Ki = 0.44uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1624713
Affinity Ki = 1.51uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1624713
Affinity Ki = 1.51uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1624713
Affinity Ki = 0.44uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1625066
Affinity Ki = 1.08uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1625066
Affinity Ki = 1.08uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1625066
Affinity Ki = 0.39uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1625066
Affinity Ki = 0.39uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1625398
Affinity Ki > 56uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1625398
Affinity Ki > 39uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1625435
Affinity Ki = 3.04uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1625435
Affinity Ki = 65.62uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1625449
Affinity Ki = 10.93uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1625449
Affinity Ki = 8.18uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1625863
Affinity Ki > 39uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1625863
Affinity Ki = 4.54uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1626340
Affinity Ki = 2.29uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1626340
Affinity Ki = 51.79uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1627154
Affinity Ki = 1.18uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1627154
Affinity Ki = 8.79uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL1642586
Affinity IC50 > 10.4uM
Assay description Displacement of fluorescent SM5F peptide from XIAP linker BIR3 domain after 3 hrs by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21087868
Doc title In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3.
PDB None

Name CHEMBL1672168
Affinity IC50 = 280nM
Assay description Inhibition of XIAP by FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672169
Affinity Ki = 270nM
Assay description Inhibition of XIAP by FP assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672259
Affinity Activity = 100uM
Assay description Inhibition of XIAP at 100 uM
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672260
Affinity Kd = 31nM
Assay description Inhibition of XIAP by FP assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672261
Affinity INH = 16.7%
Assay description Inhibition of XIAP-Bir3 domain at 10 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672261
Affinity INH = 15.8%
Assay description Inhibition of XIAP-Bir3 domain at 10 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672261
Affinity INH = 83.2%
Assay description Inhibition of XIAP-Bir3 domain at 100 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672261
Affinity INH = 83.6%
Assay description Inhibition of XIAP-Bir3 domain at 100 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672261
Affinity INH = 97.1%
Assay description Inhibition of XIAP-Bir3 domain at 100 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672261
Affinity INH = 67.4%
Assay description Inhibition of XIAP-Bir3 domain at 10 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672262
Affinity Kd = 21.6uM
Assay description Inhibition of XIAP-Bir3 domain by calorimetric titration assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672262
Affinity Kd = 27.7uM
Assay description Inhibition of XIAP-Bir3 domain by NMR titration
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672262
Affinity INH = 96.9%
Assay description Inhibition of XIAP-Bir3 domain at 100 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672262
Affinity INH = 3.6%
Assay description Inhibition of XIAP-Bir3 domain at 100 nM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672262
Affinity INH = 77.2%
Assay description Inhibition of XIAP-Bir3 domain at 10 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672262
Affinity INH = 23.6%
Assay description Inhibition of XIAP-Bir3 domain at 1 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672263
Affinity INH = 82.5%
Assay description Inhibition of XIAP-Bir3 domain at 100 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672263
Affinity INH = 15.6%
Assay description Inhibition of XIAP-Bir3 domain at 10 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672264
Affinity INH = 11.1%
Assay description Inhibition of XIAP-Bir3 domain at 1 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672264
Affinity INH = 19.9%
Assay description Inhibition of XIAP-Bir3 domain at 10 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672264
Affinity INH = 23.4%
Assay description Inhibition of XIAP-Bir3 domain at 100 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672265
Affinity INH = 97.2%
Assay description Inhibition of XIAP-Bir3 domain at 100 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672265
Affinity INH = 58%
Assay description Inhibition of XIAP-Bir3 domain at 10 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672265
Affinity INH = 9.1%
Assay description Inhibition of XIAP-Bir3 domain at 100 nM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672265
Affinity INH = 12.3%
Assay description Inhibition of XIAP-Bir3 domain at 1 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672266
Affinity INH = 15%
Assay description Inhibition of XIAP-Bir3 domain at 10 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672266
Affinity INH = 10.8%
Assay description Inhibition of XIAP-Bir3 domain at 1 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1672266
Affinity INH = 20.7%
Assay description Inhibition of XIAP-Bir3 domain at 100 uM by TR-FRET assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL1773083
Affinity IC50 = 426nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1773083
Affinity Ki = 5nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1773083
Affinity Ki = 128nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1773083
Affinity IC50 = 16nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774031
Affinity Ki = 2nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774031
Affinity Ki = 39nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774031
Affinity IC50 = 134nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774031
Affinity IC50 = 6.4nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774154
Affinity Ki = 45nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774154
Affinity Dose-dependent effect
Assay description Antagonist activity at XIAP linker BIR2-BIR3 domain (unknown origin) using Ac-DEVD-AFC as substrate assessed as restoration of caspase 3 activity preincubated for 15 mins prior to substrate addition measured for 1 to 2 hrs by fluorescence assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23651223
Doc title
PDB None

Name CHEMBL1774154
Affinity IC50 = 153nM
Assay description Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL1774154
Affinity IC50 = 7.5nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774154
Affinity IC50 <= 1nM
Assay description Displacement of Smac-1F from human His-tagged XIAP linker BIR2-BIR3 linker (124 to 356 residues) after 3 hrs by fluorescent polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23062821
Doc title
PDB None

Name CHEMBL1774154
Affinity IC50 = 153nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774154
Affinity IC50 = 7.5nM
Assay description Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL1774154
Affinity IC50 = 41.2nM
Assay description Displacement of FITC-Smac from human His-tagged XIAP BIR3 domain (241 to 356 residues) after 3 hrs by fluorescent polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23062821
Doc title
PDB None

Name CHEMBL1774154
Affinity Dose-dependent effect
Assay description Antagonist activity at XIAP linker BIR2-BIR3 domain (unknown origin) using Z-LEHD as substrate assessed as restoration of caspase 9 activity preincubated for 15 mins prior to substrate addition measured after 1 hr by caspase-Glo 9 assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23651223
Doc title
PDB None

Name CHEMBL1774154
Affinity Ki = 45nM
Assay description Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL1774154
Affinity Ki = 2nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774154
Affinity Ki = 2nM
Assay description Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL1774155
Affinity Ki > 10000nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774155
Affinity Ki > 10000nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774155
Affinity IC50 > 50000nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774155
Affinity IC50 > 50000nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774156
Affinity IC50 = 10nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774156
Affinity Ki = 3nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774156
Affinity Ki = 56nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774156
Affinity IC50 = 190nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774157
Affinity IC50 = 6nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774157
Affinity IC50 = 187nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774157
Affinity Ki = 1.5nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774157
Affinity Ki = 55nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774158
Affinity Ki = 2nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774158
Affinity Ki = 52nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774158
Affinity IC50 = 7.9nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774158
Affinity IC50 = 177nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774159
Affinity Ki = 4nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774159
Affinity Ki = 185nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774159
Affinity IC50 = 613nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774159
Affinity IC50 = 17nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774160
Affinity Ki = 2nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774160
Affinity IC50 = 131nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774160
Affinity Ki = 38nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774160
Affinity IC50 = 6.6nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774161
Affinity Ki = 47nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774161
Affinity IC50 = 5.3nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774161
Affinity IC50 = 161nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774161
Affinity Ki = 1nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774162
Affinity Ki = 1nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774162
Affinity IC50 = 216nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774162
Affinity IC50 = 5.4nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774162
Affinity Ki = 64nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774163
Affinity IC50 = 212nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774163
Affinity Ki = 63nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774163
Affinity IC50 = 5.4nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774163
Affinity Ki = 1nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774164
Affinity Ki = 83nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774164
Affinity IC50 = 8.2nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774164
Affinity IC50 = 280nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774164
Affinity Ki = 3nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774165
Affinity Ki = 157nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774165
Affinity IC50 = 523nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774165
Affinity IC50 = 14nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774165
Affinity Ki = 4nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774166
Affinity IC50 = 618nM
Assay description Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774166
Affinity IC50 = 280nM
Assay description Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774166
Affinity Ki = 186nM
Assay description Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL1774166
Affinity Ki = 88nM
Assay description Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21462933
Doc title
PDB None

Name CHEMBL178103
Affinity Kd = 21uM
Assay description Dissociation constant against BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664855
Doc title Non-peptidic small molecule inhibitors of XIAP.
PDB None

Name CHEMBL179800
Affinity Kd = 7.1uM
Assay description Dissociation constant against BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664855
Doc title Non-peptidic small molecule inhibitors of XIAP.
PDB None

Name CHEMBL179951
Affinity Kd = 4.8uM
Assay description Dissociation constant against BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664855
Doc title Non-peptidic small molecule inhibitors of XIAP.
PDB None

Name CHEMBL1800078
Affinity Ki = 0.44uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1800078
Affinity Ki = 1.84uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1800335
Affinity Ki = 0.66uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1800335
Affinity Ki = 3.58uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1800336
Affinity Ki = 9.07uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1800336
Affinity Ki = 1.05uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1800337
Affinity Ki = 29.88uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL1800337
Affinity Ki > 56uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL180204
Affinity Ki = 0.028uM
Assay description Binding affinity towards BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct protein complex subunits assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664859
Doc title Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.
PDB None

Name CHEMBL180204
Affinity Ki = 0.25uM
Assay description Competitive inhibition of XIAP BIR3 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL180204
Affinity Ki = 1.36uM
Assay description Competitive inhibition of XIAP BIR2 domain by fluorescent polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21680182
Doc title Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP.
PDB None

Name CHEMBL180306
Affinity Ki = 13.4uM
Assay description Binding affinity towards BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct protein complex subunits assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664859
Doc title Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.
PDB None

Name CHEMBL180350
Affinity Kd > 100uM
Assay description Dissociation constant against BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664855
Doc title Non-peptidic small molecule inhibitors of XIAP.
PDB None

Name CHEMBL180555
Affinity Kd = 4.1uM
Assay description Dissociation constant against BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664855
Doc title Non-peptidic small molecule inhibitors of XIAP.
PDB None

Name CHEMBL1807163
Affinity Active
Assay description Inhibition of human recombinant GST tagged XIAP expressed in Escherichia coli assessed as restoration of XIAP-mediated suppression of caspase-3 activity after 1 hrs using fluorogenic tetrapeptide Ac-DEVD-AFC substrate by caspase de-repression assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21696964
Doc title Generation of Unnatural Natural Product library and identification of a small molecule inhibitor of XIAP.
PDB None

Name CHEMBL1807163
Affinity Active
Assay description Inhibition of human GST-tagged XIAP binding to active human caspase-3 at 3 uM after 1 hrs by GST pull-down assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21696964
Doc title Generation of Unnatural Natural Product library and identification of a small molecule inhibitor of XIAP.
PDB None

Name CHEMBL180741
Affinity Kd = 30uM
Assay description Dissociation constant against BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664855
Doc title Non-peptidic small molecule inhibitors of XIAP.
PDB None

Name CHEMBL180747
Affinity Kd = 25uM
Assay description Dissociation constant against BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664855
Doc title Non-peptidic small molecule inhibitors of XIAP.
PDB None

Name CHEMBL180851
Affinity Kd = 20uM
Assay description Dissociation constant against BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664855
Doc title Non-peptidic small molecule inhibitors of XIAP.
PDB None

Name CHEMBL181003
Affinity Ki = 0.18uM
Assay description Binding affinity towards BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct protein complex subunits assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664859
Doc title Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.
PDB None

Name CHEMBL181182
Affinity Ki = 68uM
Assay description Binding affinity towards BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct protein complex subunits assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664859
Doc title Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.
PDB None

Name CHEMBL181479
Affinity Ki = 0.024uM
Assay description Binding affinity towards BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct protein complex subunits assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664859
Doc title Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.
PDB None

Name CHEMBL181524
Affinity Kd = 15uM
Assay description Dissociation constant against BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664855
Doc title Non-peptidic small molecule inhibitors of XIAP.
PDB None

Name CHEMBL181711
Affinity Kd = 1.1uM
Assay description Dissociation constant against BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664855
Doc title Non-peptidic small molecule inhibitors of XIAP.
PDB None

Name CHEMBL181796
Affinity Kd = 5.6uM
Assay description Dissociation constant against BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664855
Doc title Non-peptidic small molecule inhibitors of XIAP.
PDB None

Name CHEMBL181872
Affinity Kd = 750nM
Assay description Inhibition of XIAP by FP assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL181872
Affinity Kd < 10uM
Assay description Inhibition of XIAP by NMR assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21241056
Doc title Screening multicomponent reactions for X-linked inhibitor of apoptosis-baculoviral inhibitor of apoptosis protein repeats domain binder.
PDB None

Name CHEMBL181872
Affinity Kd = 0.74uM
Assay description Dissociation constant against BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664855
Doc title Non-peptidic small molecule inhibitors of XIAP.
PDB None

Name CHEMBL182034
Affinity Ki = 0.22uM
Assay description Binding affinity towards BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct protein complex subunits assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664859
Doc title Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.
PDB None

Name CHEMBL182159
Affinity Ki = 1.2uM
Assay description Binding affinity towards BIR3 domain of X-linked IAP in fluorescence polarization anisotropy competition assay
-- Direct protein complex subunits assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15664859
Doc title Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.
PDB None

Name CHEMBL183992
Affinity Kd > 20uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL183992
Affinity Kd = 5uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL183992
Affinity Kd = 1.8uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL183992
Affinity Kd = 0.04uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL184046
Affinity Kd = 0.04uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL185928
Affinity Kd = 0.3uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL185940
Affinity Kd > 0.5uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL186265
Affinity Kd > 20uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL186319
Affinity Kd > 20uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL186717
Affinity Kd = 0.97uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL186755
Affinity Kd = 0.12uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL186819
Affinity Kd = 0.9uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL186839
Affinity Kd = 0.28uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL186911
Affinity Kd = 0.09uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL186911
Affinity Kd = 0.12uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL187005
Affinity Kd = 0.04uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL187099
Affinity Kd > 20uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL188350
Affinity Kd = 0.6uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL188508
Affinity Kd = 2.7uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL188510
Affinity Kd = 0.006uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL188726
Affinity Kd = 0.09uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL188934
Affinity Kd = 0.29uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL189071
Affinity Kd = 0.16uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL189074
Affinity Kd > 20uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL189145
Affinity Kd = 0.8uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL189145
Affinity Kd = 0.06uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL189145
Affinity Kd = 0.06uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL189145
Affinity Kd > 20uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL189145
Affinity Kd = 0.06uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL189145
Affinity Kd = 0.06uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL189202
Affinity Kd = 0.9uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL189768
Affinity Kd > 1uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB None

Name CHEMBL1938607
Affinity Not Active
Assay description Displacement of fluorescent H-Abu-Arg-Pro-Phe-Lys-NH-FAM-NH2 peptide from XIAP BIR3 domain by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21664815
Doc title
PDB None

Name CHEMBL1938608
Affinity Not Active
Assay description Displacement of fluorescent H-Abu-Arg-Pro-Phe-Lys-NH-FAM-NH2 peptide from XIAP BIR3 domain by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21664815
Doc title
PDB None

Name CHEMBL1938609
Affinity Not Active
Assay description Displacement of fluorescent H-Abu-Arg-Pro-Phe-Lys-NH-FAM-NH2 peptide from XIAP BIR3 domain by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21664815
Doc title
PDB None

Name CHEMBL1938610
Affinity Dose-dependent effect
Assay description Inhibition of XIAP in HEK293 cell lysate assessed as release of caspase-3 from BIR3 measuring formation of fluorescent AFC from DEVD-AFC by fluorimetry
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21664815
Doc title
PDB None

Name CHEMBL1938610
Affinity Dose-dependent effect
Assay description Inhibition of XIAP in HEK293 cell lysate assessed as release of caspase-9 from BIR3 measuring formation of fluorescent AFC from LEHD-AFC by fluorimetry
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21664815
Doc title
PDB None

Name CHEMBL1938610
Affinity IC50 = 1.52uM
Assay description Displacement of fluorescent H-Abu-Arg-Pro-Phe-Lys-NH-FAM-NH2 peptide from XIAP BIR3 domain by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21664815
Doc title
PDB None

Name CHEMBL1938611
Affinity Dose-dependent effect
Assay description Inhibition of XIAP in HEK293 cell lysate assessed as release of caspase-3 from BIR3 measuring formation of fluorescent AFC from DEVD-AFC by fluorimetry
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21664815
Doc title
PDB None

Name CHEMBL1938611
Affinity IC50 = 0.56uM
Assay description Displacement of fluorescent H-Abu-Arg-Pro-Phe-Lys-NH-FAM-NH2 peptide from XIAP BIR3 domain by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21664815
Doc title
PDB None

Name CHEMBL1938611
Affinity Dose-dependent effect
Assay description Inhibition of XIAP in HEK293 cell lysate assessed as release of caspase-9 from BIR3 measuring formation of fluorescent AFC from LEHD-AFC by fluorimetry
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21664815
Doc title
PDB None

Name CHEMBL1938613
Affinity IC50 = 0.65uM
Assay description Displacement of fluorescent H-Abu-Arg-Pro-Phe-Lys-NH-FAM-NH2 peptide from XIAP BIR3 domain by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21664815
Doc title DNA-instructed acyl transfer reactions for the synthesis of bioactive peptides.
PDB None

Name CHEMBL1950720
Affinity Kd = 0.9uM
Assay description Binding affinity to GST-tagged BIR3 domain of XIAP by isothermal titration calorimetry
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22264476
Doc title Discovery of aminopiperidine-based Smac mimetics as IAP antagonists.
PDB None

Name CHEMBL1950864
Affinity Kd = 0.9uM
Assay description Binding affinity to GST-tagged BIR3 domain of XIAP by isothermal titration calorimetry
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22264476
Doc title Discovery of aminopiperidine-based Smac mimetics as IAP antagonists.
PDB None

Name CHEMBL1957013
Affinity IC50 = 58nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957014
Affinity IC50 = 52nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957015
Affinity IC50 = 57nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957016
Affinity IC50 = 78nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957017
Affinity IC50 = 47nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957018
Affinity IC50 = 47nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957019
Affinity IC50 = 53nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957020
Affinity IC50 = 44nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957021
Affinity IC50 = 41nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957022
Affinity IC50 = 198nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957023
Affinity IC50 = 65nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957024
Affinity IC50 = 111nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957025
Affinity IC50 = 181nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957026
Affinity IC50 = 57nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957105
Affinity IC50 = 58nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957106
Affinity IC50 = 57nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL1957107
Affinity IC50 = 52nM
Assay description Displacement of AbuRPF-K(5-Fam)-NH2 from recombinant human His-tagged-XIAP BIR3 domain after 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22342627
Doc title Rational design, synthesis and characterization of potent, drug-like monomeric Smac mimetics as pro-apoptotic anticancer agents.
PDB None

Name CHEMBL2063862
Affinity Ki = 0.43uM
Assay description Displacement of 5-FAM-conjugated AVP-diPhe-FAM from XIAP BIR3 domain after 30 mins by fluorescence polarization-based competition assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22413863
Doc title Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
PDB None

Name CHEMBL2063863
Affinity Ki = 0.19uM
Assay description Displacement of 5-FAM-conjugated AVP-diPhe-FAM from XIAP BIR3 domain after 30 mins by fluorescence polarization-based competition assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22413863
Doc title Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
PDB None

Name CHEMBL2063864
Affinity Ki = 7.6uM
Assay description Displacement of 5-FAM-conjugated AVP-diPhe-FAM from XIAP BIR3 domain after 30 mins by fluorescence polarization-based competition assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22413863
Doc title Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
PDB None

Name CHEMBL2063865
Affinity Ki = 0.8uM
Assay description Displacement of 5-FAM-conjugated AVP-diPhe-FAM from XIAP BIR3 domain after 30 mins by fluorescence polarization-based competition assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22413863
Doc title Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
PDB None

Name CHEMBL2063866
Affinity Ki = 0.41uM
Assay description Displacement of 5-FAM-conjugated AVP-diPhe-FAM from XIAP BIR3 domain after 30 mins by fluorescence polarization-based competition assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22413863
Doc title Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
PDB None

Name CHEMBL2063867
Affinity Ki = 0.7uM
Assay description Displacement of 5-FAM-conjugated AVP-diPhe-FAM from XIAP BIR3 domain after 30 mins by fluorescence polarization-based competition assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22413863
Doc title Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
PDB None

Name CHEMBL2063868
Affinity Ki = 0.035uM
Assay description Displacement of 5-FAM-conjugated AVP-diPhe-FAM from XIAP BIR3 domain after 30 mins by fluorescence polarization-based competition assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22413863
Doc title Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
PDB None

Name CHEMBL2063869
Affinity Ki = 29.8uM
Assay description Competitive inhibition of XIAP-BIR2 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL2063869
Affinity Ki = 0.028uM
Assay description Displacement of 5-FAM-conjugated AVP-diPhe-FAM from XIAP BIR3 domain after 30 mins by fluorescence polarization-based competition assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22413863
Doc title Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
PDB None

Name CHEMBL2063869
Affinity Active
Assay description Inhibition of Flag-tagged XIAP BIR3 domain binding to cIAP1 expressed in human HEK293T cells at 1 to 50 uM after 2 hrs by immunoprecipitation
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22413863
Doc title Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
PDB None

Name CHEMBL2063869
Affinity Active
Assay description Inhibition of Flag-tagged XIAP BIR3 domain binding to cIAP2 expressed in human HEK293T cells at 1 to 50 uM after 2 hrs by immunoprecipitation
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22413863
Doc title Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
PDB None

Name CHEMBL2063869
Affinity Ki = 0.112uM
Assay description Displacement of 5-FAM-conjugated AVP-diPhe-FAM from XIAP BIR2 domain after 30 mins by fluorescence polarization-based competition assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22413863
Doc title Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
PDB None

Name CHEMBL2063869
Affinity Active
Assay description Inhibition of Flag-tagged XIAP BIR3 domain binding to ML-IAP expressed in human HEK293T cells at 1 to 50 uM after 2 hrs by immunoprecipitation
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22413863
Doc title Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
PDB None

Name CHEMBL2063869
Affinity Active
Assay description Inhibition of Flag-tagged XIAP BIR3 domain binding to caspase-9 expressed in human HEK293T cells at 1 to 100 uM after 2 hrs by immunoprecipitation
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22413863
Doc title Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).
PDB None

Name CHEMBL2063869
Affinity Ki = 0.26uM
Assay description Competitive inhibition of XIAP-BIR3 domain (unknown origin) by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23743278
Doc title Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP.
PDB None

Name CHEMBL2096803
Affinity Kd > 1uM
Assay description Binding affinity to the BIR3 Domain of XIAP
-- Direct single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB 1TFQ - (998)

Name CHEMBL2096803
Affinity Kd = 0.7uM
Assay description Binding affinity to the BIR3 domain of X-linked IAP
-- Homologous single protein target assigned: XIAP_HUMAN (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15317454
Doc title Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
PDB 1TFQ - (998)

Name CHEMBL2158051
Affinity Ki = 66.4nM
Assay description Competitive inhibition of human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21443232
Doc title A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.
PDB None

Name CHEMBL2158051
Affinity IC50 = 225nM
Assay description Competitive inhibition of human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21443232
Doc title A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.
PDB None

Name CHEMBL2158052
Affinity Ki = 67300nM
Assay description Competitive inhibition of human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21443232
Doc title A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.
PDB None

Name CHEMBL2158052
Affinity IC50 = 221000nM
Assay description Competitive inhibition of human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21443232
Doc title A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.
PDB None

Name CHEMBL2158053
Affinity Ki = 25.9nM
Assay description Competitive inhibition of human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21443232
Doc title A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.
PDB None

Name CHEMBL2158053
Affinity Active
Assay description Binding affinity to XIAP in human MDA-MB-231 cells after 30 mins in presence of SM-428 by biotin-streptavidin-pull-down assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21443232
Doc title A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.
PDB None

Name CHEMBL2158053
Affinity Dose-dependent effect
Assay description Binding affinity to XIAP in human MDA-MB-231 cells after 30 mins in presence of SM-406 by biotin-streptavidin-pull-down assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21443232
Doc title A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.
PDB None

Name CHEMBL2158053
Affinity Active
Assay description Binding affinity to cIAP1 in human MDA-MB-231 cells after 30 mins in presence of SM-428 by biotin-streptavidin-pull-down assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21443232
Doc title A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.
PDB None

Name CHEMBL2158053
Affinity Dose-dependent effect
Assay description Binding affinity to XIAP in human MDA-MB-231 cells after 30 mins by biotin-streptavidin-pull-down assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21443232
Doc title A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.
PDB None

Name CHEMBL2158054
Affinity Kd = 4.4nM
Assay description Binding affinity to His6-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) assessed as dissociation constant after 2 to 3 hrs by fluorescence polarization assay
-- Direct single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/21443232
Doc title A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.
PDB None

Name CHEMBL2158599
Affinity Ki = 39nM
Assay description Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158599
Affinity IC50 = 134nM
Assay description Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158599
Affinity IC50 = 6.4nM
Assay description Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158599
Affinity Ki = 2nM
Assay description Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158600
Affinity Ki = 63nM
Assay description Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158600
Affinity Ki = 3nM
Assay description Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158600
Affinity IC50 = 188nM
Assay description Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158600
Affinity IC50 = 13.7nM
Assay description Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158601
Affinity Ki = 2nM
Assay description Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158601
Affinity IC50 = 7.6nM
Assay description Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158601
Affinity Ki = 48nM
Assay description Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158601
Affinity IC50 = 145nM
Assay description Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158602
Affinity Ki = 54nM
Assay description Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158602
Affinity IC50 = 7.8nM
Assay description Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158602
Affinity Ki = 2nM
Assay description Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158602
Affinity IC50 = 161nM
Assay description Binding affinity to BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/22148838
Doc title
PDB None

Name CHEMBL2158603
Affinity Ki = 2nM
Assay description Binding affinity to BIR2-BIR3 domain of XIAP by fluorescence polarization assay
-- Homologous single protein target assigned: XIAP_HUMAN (Autocuration) --