ZipA

Cell division protein zipa

Reviewed UniProt entries for ZipA and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q1R8W0 ZIPA_ECOUT Cell division protein ZipA homolog zipA UTI89_C2744 Escherichia coli (strain UTI89 / UPEC) 332
A4WD24 ZIPA_ENT38 Cell division protein ZipA homolog zipA Ent638_2940 Enterobacter sp. (strain 638) 317
A3N1V3 ZIPA_ACTP2 Cell division protein ZipA homolog zipA APL_1303 Actinobacillus pleuropneumoniae serotype 5b (strain L20) 336
B3H276 ZIPA_ACTP7 Cell division protein ZipA homolog zipA APP7_1354 Actinobacillus pleuropneumoniae serotype 7 (strain AP76) 336
B0BQN7 ZIPA_ACTPJ Cell division protein ZipA homolog zipA APJL_1316 Actinobacillus pleuropneumoniae serotype 3 (strain JL03) 336
A6VR17 ZIPA_ACTSZ Cell division protein ZipA homolog zipA Asuc_2068 Actinobacillus succinogenes (strain ATCC 55618 / 130Z) 343
B6EJQ7 ZIPA_ALISL Cell division protein ZipA homolog zipA VSAL_I2354 Aliivibrio salmonicida (strain LFI1238) (Vibrio salmonicida (strain LFI1238)) 308
C1DN28 ZIPA_AZOVD Cell division protein ZipA homolog zipA Avin_30300 Azotobacter vinelandii (strain DJ / ATCC BAA-1303) 285
Q1LU19 ZIPA_BAUCH Cell division protein ZipA homolog zipA BCI_0067 Baumannia cicadellinicola subsp. Homalodisca coagulata 256
A8ADI1 ZIPA_CITK8 Cell division protein ZipA homolog zipA CKO_00381 Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) 341
Q47YH9 ZIPA_COLP3 Cell division protein ZipA homolog zipA CPS_3467 Colwellia psychrerythraea (strain 34H / ATCC BAA-681) (Vibrio psychroerythus) 380
A7MKW3 ZIPA_CROS8 Cell division protein ZipA homolog zipA ESA_00833 Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii) 319
A7ZPL3 ZIPA_ECO24 Cell division protein ZipA homolog zipA EcE24377A_2699 Escherichia coli O139:H28 (strain E24377A / ETEC) 328
B7UGB3 ZIPA_ECO27 Cell division protein ZipA homolog zipA E2348C_2598 Escherichia coli O127:H6 (strain E2348/69 / EPEC) 332
B7MHR6 ZIPA_ECO45 Cell division protein ZipA homolog zipA ECS88_2602 Escherichia coli O45:K1 (strain S88 / ExPEC) 332
B7LCF7 ZIPA_ECO55 Cell division protein ZipA homolog zipA EC55989_2702 Escherichia coli (strain 55989 / EAEC) 328
Q8X492 ZIPA_ECO57 Cell division protein ZipA homolog zipA Z3678 ECs3284 Escherichia coli O157:H7 328
B5YZV9 ZIPA_ECO5E Cell division protein ZipA homolog zipA ECH74115_3643 Escherichia coli O157:H7 (strain EC4115 / EHEC) 332
B7M6S2 ZIPA_ECO8A Cell division protein ZipA homolog zipA ECIAI1_2470 Escherichia coli O8 (strain IAI1) 328
C4ZVU3 ZIPA_ECOBW Cell division protein ZipA homolog zipA BWG_2174 Escherichia coli (strain K12 / MC4100 / BW2952) 328
B1XA83 ZIPA_ECODH Cell division protein ZipA homolog zipA ECDH10B_2577 Escherichia coli (strain K12 / DH10B) 328
A8A2Q8 ZIPA_ECOHS Cell division protein ZipA homolog zipA EcHS_A2547 Escherichia coli O9:H4 (strain HS) 328
A1ADS9 ZIPA_ECOK1 Cell division protein ZipA homolog zipA Ecok1_23250 APECO1_4134 Escherichia coli O1:K1 / APEC 332
Q0TF54 ZIPA_ECOL5 Cell division protein ZipA homolog zipA ECP_2436 Escherichia coli O6:K15:H31 (strain 536 / UPEC) 332
Q8FFC0 ZIPA_ECOL6 Cell division protein ZipA homolog zipA c2946 Escherichia coli O6 332
B1IX59 ZIPA_ECOLC Cell division protein ZipA homolog zipA EcolC_1266 Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) 328
B6I4Y9 ZIPA_ECOSE Cell division protein ZipA homolog zipA ECSE_2703 Escherichia coli (strain SE11) 328
B1LMK6 ZIPA_ECOSM Cell division protein ZipA homolog zipA EcSMS35_2567 Escherichia coli (strain SMS-3-5 / SECEC) 332
Q6D8S6 ZIPA_ERWCT Cell division protein ZipA homolog zipA ECA0896 Erwinia carotovora subsp. atroseptica (Pectobacterium atrosepticum) 332
B2VE39 ZIPA_ERWT9 Cell division protein ZipA homolog zipA ETA_11020 Erwinia tasmaniensis (strain DSM 17950 / Et1/99) 304
Q7VMX6 ZIPA_HAEDU Cell division protein ZipA homolog zipA HD_0831 Haemophilus ducreyi (strain 35000HP / ATCC 700724) 334
Q4QLI9 ZIPA_HAEI8 Cell division protein ZipA homolog zipA NTHI1266 Haemophilus influenzae (strain 86-028NP) 328
A5UD03 ZIPA_HAEIE Cell division protein ZipA homolog zipA CGSHiEE_06555 Haemophilus influenzae (strain PittEE) 328
A5UIM7 ZIPA_HAEIG Cell division protein ZipA homolog zipA CGSHiGG_09155 Haemophilus influenzae (strain PittGG) 328
P44113 ZIPA_HAEIN Cell division protein ZipA homolog zipA HI_1101 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 328
B8F313 ZIPA_HAEPS Cell division protein ZipA homolog zipA HAPS_0010 Haemophilus parasuis serovar 5 (strain SH0165) 272
Q0I2I2 ZIPA_HAES1 Cell division protein ZipA homolog zipA HS_0371 Haemophilus somnus (strain 129Pt) (Histophilus somni (strain 129Pt)) 335
B0US80 ZIPA_HAES2 Cell division protein ZipA homolog zipA HSM_0641 Haemophilus somnus (strain 2336) (Histophilus somni (strain 2336)) 335
C4K4K3 ZIPA_HAMD5 Cell division protein ZipA homolog zipA HDEF_0768 Hamiltonella defensa subsp. Acyrthosiphon pisum (strain 5AT) 277
B5XVT3 ZIPA_KLEP3 Cell division protein ZipA homolog zipA KPK_1380 Klebsiella pneumoniae (strain 342) 354
A6TC48 ZIPA_KLEP7 Cell division protein ZipA homolog zipA KPN78578_27080 KPN_02759 Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578) 353
Q65RN5 ZIPA_MANSM Cell division protein ZipA homolog zipA MS1768 Mannheimia succiniciproducens (strain MBEL55E) 359
A1TZT8 ZIPA_MARAV Cell division protein ZipA homolog zipA Maqu_1166 Marinobacter aquaeolei (strain ATCC 700491 / DSM 11845 / VT8) (Marinobacter hydrocarbonoclasticus (strain DSM 11845)) 338
Q9CKC8 ZIPA_PASMU Cell division protein ZipA homolog zipA PM1695 Pasteurella multocida (strain Pm70) 323
C6D9P6 ZIPA_PECCP Cell division protein ZipA homolog zipA PC1_0778 Pectobacterium carotovorum subsp. carotovorum (strain PC1) 336
Q7N6Y5 ZIPA_PHOLL Cell division protein ZipA homolog zipA plu1397 Photorhabdus luminescens subsp. laumondii (strain TT01) 303
Q6LTU6 ZIPA_PHOPR Cell division protein ZipA homolog zipA PBPRA0866 Photobacterium profundum (Photobacterium sp. (strain SS9)) 352
Q48KR3 ZIPA_PSE14 Cell division protein ZipA homolog zipA PSPPH_1778 Pseudomonas syringae pv. phaseolicola (strain 1448A / Race 6) 289
A6V7X4 ZIPA_PSEA7 Cell division protein ZipA homolog zipA PSPA7_3805 Pseudomonas aeruginosa (strain PA7) 290
B7UVJ4 ZIPA_PSEA8 Cell division protein ZipA homolog zipA PLES_38001 Pseudomonas aeruginosa (strain LESB58) 289
Q02K11 ZIPA_PSEAB Cell division protein ZipA homolog zipA PA14_44670 Pseudomonas aeruginosa (strain UCBPP-PA14) 289
Q9I3I5 ZIPA_PSEAE Cell division protein ZipA homolog zipA PA1528 Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) 289
Q1ICK1 ZIPA_PSEE4 Cell division protein ZipA homolog zipA PSEEN1768 Pseudomonas entomophila (strain L48) 294
Q4KFH2 ZIPA_PSEF5 Cell division protein ZipA homolog zipA PFL_1892 Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) 284
C3JYN4 ZIPA_PSEFS Cell division protein ZipA homolog zipA PFLU_4589 Pseudomonas fluorescens (strain SBW25) 287
A4XVY6 ZIPA_PSEMY Cell division protein ZipA homolog zipA Pmen_2747 Pseudomonas mendocina (strain ymp) 273
A5W0T9 ZIPA_PSEP1 Cell division protein ZipA homolog zipA Pput_1593 Pseudomonas putida (strain F1 / ATCC 700007) 297
Q3KFB3 ZIPA_PSEPF Cell division protein ZipA homolog zipA Pfl01_1800 Pseudomonas fluorescens (strain Pf0-1) 288
B0KPX4 ZIPA_PSEPG Cell division protein ZipA homolog zipA PputGB1_3839 Pseudomonas putida (strain GB-1) 296
Q88F24 ZIPA_PSEPK Cell division protein ZipA homolog zipA PP_4275 Pseudomonas putida (strain KT2440) 297
B1JC07 ZIPA_PSEPW Cell division protein ZipA homolog zipA PputW619_3601 Pseudomonas putida (strain W619) 294
Q87YY5 ZIPA_PSESM Cell division protein ZipA homolog zipA PSPTO_3657 Pseudomonas syringae pv. tomato (strain DC3000) 288
Q4ZVF7 ZIPA_PSEU2 Cell division protein ZipA homolog zipA Psyr_1818 Pseudomonas syringae pv. syringae (strain B728a) 287
A4VKM9 ZIPA_PSEU5 Cell division protein ZipA homolog zipA PST_1856 Pseudomonas stutzeri (strain A1501) 273
B5F0F6 ZIPA_SALA4 Cell division protein ZipA homolog zipA SeAg_B2572 Salmonella agona (strain SL483) 328
A9MIF9 ZIPA_SALAR Cell division protein ZipA homolog zipA SARI_00460 Salmonella arizonae (strain ATCC BAA-731 / CDC346-86 / RSK2980) 326
Q57LT0 ZIPA_SALCH Cell division protein ZipA homolog zipA SCH_2426 Salmonella choleraesuis 328
B5FQC0 ZIPA_SALDC Cell division protein ZipA homolog zipA SeD_A2793 Salmonella dublin (strain CT_02021853) 328
B5R3V5 ZIPA_SALEP Cell division protein ZipA homolog zipA SEN2409 Salmonella enteritidis PT4 (strain P125109) 328
B5RCQ0 ZIPA_SALG2 Cell division protein ZipA homolog zipA SG2460 Salmonella gallinarum (strain 287/91 / NCTC 13346) 328
B4TCF7 ZIPA_SALHS Cell division protein ZipA homolog zipA SeHA_C2687 Salmonella heidelberg (strain SL476) 328
B4SZU6 ZIPA_SALNS Cell division protein ZipA homolog zipA SNSL254_A2621 Salmonella newport (strain SL254) 328
Q5PND8 ZIPA_SALPA Cell division protein ZipA homolog zipA SPA0437 Salmonella paratyphi A 328
A9N361 ZIPA_SALPB Cell division protein ZipA homolog zipA SPAB_00528 Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7) 328
C0PZB3 ZIPA_SALPC Cell division protein ZipA homolog zipA SPC_1232 Salmonella paratyphi C (strain RKS4594) 328
B5BB71 ZIPA_SALPK Cell division protein ZipA homolog zipA SSPA0410 Salmonella paratyphi A (strain AKU_12601) 328
B4TQF9 ZIPA_SALSV Cell division protein ZipA homolog zipA SeSA_A2663 Salmonella schwarzengrund (strain CVM19633) 328
P0A2N7 ZIPA_SALTI Cell division protein ZipA homolog zipA STY2664 t0429 Salmonella typhi 328
P0A2N6 ZIPA_SALTY Cell division protein ZipA homolog zipA STM2428 Salmonella typhimurium 328
A8GHF3 ZIPA_SERP5 Cell division protein ZipA homolog zipA Spro_3445 Serratia proteamaculans (strain 568) 332
A1S5R6 ZIPA_SHEAM Cell division protein ZipA homolog zipA Sama_1515 Shewanella amazonensis (strain ATCC BAA-1098 / SB2B) 350
A6WPS6 ZIPA_SHEB8 Cell division protein ZipA homolog zipA Shew185_2680 Shewanella baltica (strain OS185) 356
A9L5Z2 ZIPA_SHEB9 Cell division protein ZipA homolog zipA Sbal195_2759 Shewanella baltica (strain OS195) 356
Q12L81 ZIPA_SHEDO Cell division protein ZipA homolog zipA Sden_2515 Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) 336
Q080K8 ZIPA_SHEFN Cell division protein ZipA homolog zipA Sfri_2462 Shewanella frigidimarina (strain NCIMB 400) 352
B0TKB3 ZIPA_SHEHH Cell division protein ZipA homolog zipA Shal_2576 Shewanella halifaxensis (strain HAW-EB4) 306
A3QFJ6 ZIPA_SHELP Cell division protein ZipA homolog zipA Shew_2378 Shewanella loihica (strain ATCC BAA-1088 / PV-4) 335
Q8ED69 ZIPA_SHEON Cell division protein ZipA homolog zipA SO_2897 Shewanella oneidensis (strain MR-1) 344
A8H375 ZIPA_SHEPA Cell division protein ZipA homolog zipA Spea_1688 Shewanella pealeana (strain ATCC 700345 / ANG-SQ1) 325
A4Y803 ZIPA_SHEPC Cell division protein ZipA homolog zipA Sputcn32_2365 Shewanella putrefaciens (strain CN-32 / ATCC BAA-453) 342
A0KVI3 ZIPA_SHESA Cell division protein ZipA homolog zipA Shewana3_1568 Shewanella sp. (strain ANA-3) 346
A8FU25 ZIPA_SHESH Cell division protein ZipA homolog zipA Ssed_1737 Shewanella sediminis (strain HAW-EB3) 341
Q0HK32 ZIPA_SHESM Cell division protein ZipA homolog zipA Shewmr4_1507 Shewanella sp. (strain MR-4) 346
Q0HWD3 ZIPA_SHESR Cell division protein ZipA homolog zipA Shewmr7_1574 Shewanella sp. (strain MR-7) 346
A1RII6 ZIPA_SHESW Cell division protein ZipA homolog zipA Sputw3181_1644 Shewanella sp. (strain W3-18-1) 342
B1KJT6 ZIPA_SHEWM Cell division protein ZipA homolog zipA Swoo_2848 Shewanella woodyi (strain ATCC 51908 / MS32) 311
B2TWZ6 ZIPA_SHIB3 Cell division protein ZipA homolog zipA SbBS512_E2768 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) 328
Q31Y67 ZIPA_SHIBS Cell division protein ZipA homolog zipA SBO_2436 Shigella boydii serotype 4 (strain Sb227) 328
Q32DE1 ZIPA_SHIDS Cell division protein ZipA homolog zipA SDY_2609 Shigella dysenteriae serotype 1 (strain Sd197) 332
Q83QN9 ZIPA_SHIFL Cell division protein ZipA homolog zipA SF2467 S2613 Shigella flexneri 327
Q3YZD0 ZIPA_SHISS Cell division protein ZipA homolog zipA SSON_2501 Shigella sonnei (strain Ss046) 328
Q2NSC1 ZIPA_SODGM Cell division protein ZipA homolog zipA SG1679 Sodalis glossinidius (strain morsitans) 329
C4LAQ5 ZIPA_TOLAT Cell division protein ZipA homolog zipA Tola_0630 Tolumonas auensis (strain DSM 9187 / TA4) 260
A5F2W2 ZIPA_VIBC3 Cell division protein ZipA homolog zipA VC0395_A0491 VC395_0985 Vibrio cholerae serotype O1 (strain ATCC 39541 / Ogawa 395 / O395) 291
Q9KTD2 ZIPA_VIBCH Cell division protein ZipA homolog zipA VC_0970 Vibrio cholerae 291
C3LTL8 ZIPA_VIBCM Cell division protein ZipA homolog zipA VCM66_0926 Vibrio cholerae serotype O1 (strain M66-2) 291
Q5E3L0 ZIPA_VIBF1 Cell division protein ZipA homolog zipA VF_1891 Vibrio fischeri (strain ATCC 700601 / ES114) 333
B5FGU8 ZIPA_VIBFM Cell division protein ZipA homolog zipA VFMJ11_2026 Vibrio fischeri (strain MJ11) 325
A7MT68 ZIPA_VIBHB Cell division protein ZipA homolog zipA VIBHAR_01311 Vibrio harveyi (strain ATCC BAA-1116 / BB120) 323
Q87RJ5 ZIPA_VIBPA Cell division protein ZipA homolog zipA VP0799 Vibrio parahaemolyticus 316
Q8DFK4 ZIPA_VIBVU Cell division protein ZipA homolog zipA VV1_0207 Vibrio vulnificus 311
Q7MMT6 ZIPA_VIBVY Cell division protein ZipA homolog zipA VV0981 Vibrio vulnificus (strain YJ016) 311
Q8PM10 ZIPA_XANAC Cell division protein ZipA homolog zipA XAC1624 Xanthomonas axonopodis pv. citri (strain 306) 243
Q3BV17 ZIPA_XANC5 Cell division protein ZipA homolog zipA XCV1665 Xanthomonas campestris pv. vesicatoria (strain 85-10) 243
Q4UTA8 ZIPA_XANC8 Cell division protein ZipA homolog zipA XC_2666 Xanthomonas campestris pv. campestris (strain 8004) 244
Q8PAB7 ZIPA_XANCP Cell division protein ZipA homolog zipA XCC1568 Xanthomonas campestris pv. campestris 244
Q9PAG1 ZIPA_XYLFA Cell division protein ZipA homolog zipA XF_2557 Xylella fastidiosa 243
Q87A87 ZIPA_XYLFT Cell division protein ZipA homolog zipA PD_1941 Xylella fastidiosa (strain Temecula1 / ATCC 700964) 243
A7FGC1 ZIPA_YERP3 Cell division protein ZipA homolog zipA YpsIP31758_1320 Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) 327
Q1C5X8 ZIPA_YERPA Cell division protein ZipA homolog zipA YPA_2179 Yersinia pestis bv. Antiqua (strain Antiqua) 328
B2K918 ZIPA_YERPB Cell division protein ZipA homolog zipA YPTS_2812 Yersinia pseudotuberculosis serotype IB (strain PB1/+) 328
P58492 ZIPA_YERPE Cell division protein ZipA homolog zipA YPO2990 y1491 YP_2615 Yersinia pestis 328
A9QZH1 ZIPA_YERPG Cell division protein ZipA homolog zipA YpAngola_A2745 Yersinia pestis bv. Antiqua (strain Angola) 328
Q1CJV8 ZIPA_YERPN Cell division protein ZipA homolog zipA YPN_1392 YP516_1536 Yersinia pestis bv. Antiqua (strain Nepal516) 328
A4TMG5 ZIPA_YERPP Cell division protein ZipA homolog zipA YPDSF_2098 Yersinia pestis (strain Pestoides F) 328
Q668M5 ZIPA_YERPS Cell division protein ZipA homolog zipA YPTB2712 Yersinia pseudotuberculosis 328
B1JFY9 ZIPA_YERPY Cell division protein ZipA homolog zipA YPK_1431 Yersinia pseudotuberculosis serotype O:3 (strain YPIII) 328
P77173 ZIPA_ECOLI Cell division protein ZipA zipA b2412 JW2404 Escherichia coli (strain K12) 328

Small molecules tested in ZipA binding assays:

24 datapoints for 23 distinct small molecules


Name BOMC12_1
Affinity IC50 (FP) 1mM
Assay description Flouro polarization assay
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2004.07.031
Doc title Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction.
PDB 1S1J - (IQZ)

Name BOMC12_2
Affinity IC50 (FP) 1uM
Assay description Flouro polarization assay
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2004.07.031
Doc title Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction.
PDB 1S1S - (WAC)

Name JMC48_1
Affinity Ki (FP) 12uM
Assay description Fluorescence polorization assay
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1021/jm040163o
Doc title A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction.
PDB 1Y2F - (WAI)

Name JMC48_3
Affinity Ki (FP) 83uM
Assay description Fluorescence polorization assay
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1021/jm040163o
Doc title A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction.
PDB 1Y2G - (CL3)

Name BOMC12_16a4
Affinity IC50 (FP) 296uM
Assay description Flouro polarization assay
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2004.07.031
Doc title Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction.
PDB None

Name BOMC12_6a7
Affinity IC50 (FP) 1.6mM
Assay description Flouro polarization assay
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2004.07.031
Doc title Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction.
PDB None

Name OBC1_14
Affinity IC50 (FP) 192uM
Assay description Flouro polarization assay
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1039/b312016c
Doc title Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.
PDB None

Name BOMC14_1
Affinity % Inh @ 50ug/ml 61%PI@50ug/ml
Assay description Inhibition at 50 ug/ml (%) by fluorescein-FtsZpeptide fluorescence polarization (FP) competition assay. It is interesting that the fluorescence polarization assay was not able to detect the weak binding to ZipA for many of the analogs for which the HSQC (NMR) experiment unambiguously showed specific binding to ZipA
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2006.07.050
Doc title Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
PDB None

Name BOMC14_2
Affinity % Inh @ 50ug/ml 23%PI@50ug/ml
Assay description Inhibition at 50 ug/ml (%) by fluorescein-FtsZpeptide fluorescence polarization (FP) competition assay. It is interesting that the fluorescence polarization assay was not able to detect the weak binding to ZipA for many of the analogs for which the HSQC (NMR) experiment unambiguously showed specific binding to ZipA
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2006.07.050
Doc title Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
PDB None

Name BOMC14_3
Affinity % Inh @ 50ug/ml 24%PI@50ug/ml
Assay description Inhibition at 50 ug/ml (%) by fluorescein-FtsZpeptide fluorescence polarization (FP) competition assay. It is interesting that the fluorescence polarization assay was not able to detect the weak binding to ZipA for many of the analogs for which the HSQC (NMR) experiment unambiguously showed specific binding to ZipA
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2006.07.050
Doc title Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
PDB None

Name BOMC14_5
Affinity % Inh @ 50ug/ml 7%PI@50ug/ml
Assay description Inhibition at 50 ug/ml (%) by fluorescein-FtsZpeptide fluorescence polarization (FP) competition assay. It is interesting that the fluorescence polarization assay was not able to detect the weak binding to ZipA for many of the analogs for which the HSQC (NMR) experiment unambiguously showed specific binding to ZipA
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2006.07.050
Doc title Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
PDB None

Name BOMC14_6
Affinity % Inh @ 50ug/ml 21%PI@50ug/ml
Assay description Inhibition at 50 ug/ml (%) by fluorescein-FtsZpeptide fluorescence polarization (FP) competition assay. It is interesting that the fluorescence polarization assay was not able to detect the weak binding to ZipA for many of the analogs for which the HSQC (NMR) experiment unambiguously showed specific binding to ZipA
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2006.07.050
Doc title Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
PDB None

Name BOMC14_7
Affinity % Inh @ 50ug/ml 35%PI@50ug/ml
Assay description Inhibition at 50 ug/ml (%) by fluorescein-FtsZpeptide fluorescence polarization (FP) competition assay. It is interesting that the fluorescence polarization assay was not able to detect the weak binding to ZipA for many of the analogs for which the HSQC (NMR) experiment unambiguously showed specific binding to ZipA
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2006.07.050
Doc title Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
PDB None

Name BOMC14_8
Affinity % Inh @ 50ug/ml 25%PI@50ug/ml
Assay description Inhibition at 50 ug/ml (%) by fluorescein-FtsZpeptide fluorescence polarization (FP) competition assay. It is interesting that the fluorescence polarization assay was not able to detect the weak binding to ZipA for many of the analogs for which the HSQC (NMR) experiment unambiguously showed specific binding to ZipA
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2006.07.050
Doc title Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
PDB None

Name OBC1_2
Affinity IC50 (FP) 2mM
Assay description Flouro polarization assay
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1039/b312016c
Doc title Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.
PDB None

Name OBC1_3
Affinity IC50 (FP) 2.7mM
Assay description Flouro polarization assay
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1039/b312016c
Doc title Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.
PDB None

Name BOMC14_9
Affinity % Inh @ 50ug/ml 38%PI@50ug/ml
Assay description Inhibition at 50 ug/ml (%) by fluorescein-FtsZpeptide fluorescence polarization (FP) competition assay. It is interesting that the fluorescence polarization assay was not able to detect the weak binding to ZipA for many of the analogs for which the HSQC (NMR) experiment unambiguously showed specific binding to ZipA
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2006.07.050
Doc title Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
PDB None

Name BOMC14_10
Affinity % Inh @ 50ug/ml n/a
Assay description Inhibition at 50 ug/ml (%) by fluorescein-FtsZpeptide fluorescence polarization (FP) competition assay. It is interesting that the fluorescence polarization assay was not able to detect the weak binding to ZipA for many of the analogs for which the HSQC (NMR) experiment unambiguously showed specific binding to ZipA
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2006.07.050
Doc title Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
PDB None

Name BOMC14_17
Affinity % Inh @ 50ug/ml 8%PI@50ug/ml
Assay description Inhibition at 50 ug/ml (%) by fluorescein-FtsZpeptide fluorescence polarization (FP) competition assay. It is interesting that the fluorescence polarization assay was not able to detect the weak binding to ZipA for many of the analogs for which the HSQC (NMR) experiment unambiguously showed specific binding to ZipA
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2006.07.050
Doc title Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
PDB None

Name BOMC14_20
Affinity % Inh @ 50ug/ml n/a
Assay description Inhibition at 50 ug/ml (%) by fluorescein-FtsZpeptide fluorescence polarization (FP) competition assay. It is interesting that the fluorescence polarization assay was not able to detect the weak binding to ZipA for many of the analogs for which the HSQC (NMR) experiment unambiguously showed specific binding to ZipA
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2006.07.050
Doc title Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
PDB None

Name BOMC14_21
Affinity % Inh @ 50ug/ml 35%PI@50ug/ml
Assay description Inhibition at 50 ug/ml (%) by fluorescein-FtsZpeptide fluorescence polarization (FP) competition assay. It is interesting that the fluorescence polarization assay was not able to detect the weak binding to ZipA for many of the analogs for which the HSQC (NMR) experiment unambiguously showed specific binding to ZipA
-- Direct single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://dx.doi.org/10.1016/j.bmc.2006.07.050
Doc title Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design.
PDB None

Name CHEMBL1161626
Affinity Kd = 12uM
Assay description Affinity for ZipA bacterial protein
-- Homologous single protein target assigned: ZIPA_ECOLI (Expert curation) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/15743191
Doc title A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction.
PDB 1Y2F - (WAI)

Name CHEMBL1161626
Affinity Ki = 12uM
Assay description Binding affinity to Escherichia coli ZipA assessed as inhibition of ZipA-FtsZ derived peptide interaction
-- Homologous single protein target assigned: ZIPA_ECOLI (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18075579
Doc title Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
PDB 1Y2F - (WAI)

Name CHEMBL369180
Affinity Kd = 83.1uM
Assay description Binding affinity to Escherichia coli ZipA
-- Homologous single protein target assigned: ZIPA_ECOLI (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/18075579
Doc title Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
PDB 1Y2G - (CL3)

8 PDB entries for ZipA and its protein partners


1F46
The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography.

Entity type Code Description
polypeptide(L) P77173 CELL DIVISION PROTEIN ZIPA

1F47
The bacterial cell-division protein ZipA and its interaction with an FtsZ fragment revealed by X-ray crystallography.

Entity type Code Description
polypeptide(L) P77173 CELL DIVISION PROTEIN ZIPA
polypeptide(L) P0A9A6 CELL DIVISION PROTEIN FTSZ

1F7W
Solution structure of ZipA, a crucial component of Escherichia coli cell division.

Entity type Code Description
polypeptide(L) P77173 CELL DIVISION PROTEIN ZIPA

1F7X
Solution structure of ZipA, a crucial component of Escherichia coli cell division.

Entity type Code Description
polypeptide(L) P77173 CELL DIVISION PROTEIN ZIPA

1S1J
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction

Entity type Code Description
polypeptide(L) P77173 Cell division protein zipA
Ligand IQZ (12BS)-1,2,3,4,12,12B-HEXAHYDROINDOLO[2,3-A]QUINOLIZIN-7(6H)-ONE

1S1S
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction

Entity type Code Description
polypeptide(L) P77173 Cell division protein zipA
Ligand WAC N-{3-[(12BS)-7-OXO-1,3,4,6,7,12B-HEXAHYDROINDOLO[2,3-A]QUINOLIZIN-12(2H)-YL]PROPYL}PROPANE-2-SULFONAMIDE

1Y2F
A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction

Entity type Code Description
polypeptide(L) P77173 Cell division protein zipA
Ligand WAI 4-{2-[4-(2-AMINOETHYL)PIPERAZIN-1-YL]PYRIDIN-4-YL}-N-(3-CHLORO-4-METHYLPHENYL)PYRIMIDIN-2-AMINE

1Y2G
A shape-based 3-D scaffold hopping method and its application to a bacterial protein-protein interaction

Entity type Code Description
polypeptide(L) P77173 Cell division protein zipA
Ligand CL3 N-METHYL-N-[3-(6-PHENYL[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-3-YL)PHENYL]ACETAMIDE