c-Myc

Myc proto-oncogene protein (c-myc)

Reviewed UniProt entries for c-Myc and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q2HJ27 MYC_BOVIN Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Bos taurus (Bovine) 439
P49032 MYC_CALJA Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Callithrix jacchus (White-tufted-ear marmoset) 438
Q28350 MYC_CANFA Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Canis familiaris (Dog) (Canis lupus familiaris) 439
P01109 MYC_CHICK Myc proto-oncogene protein (c-Myc) MYC Gallus gallus (Chicken) 416
P68271 MYC_FELCA Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Felis catus (Cat) (Felis silvestris catus) 439
Q9MZU0 MYC_GALVR Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Galeopterus variegatus (Malayan flying lemur) (Cynocephalus variegatus) 439
P49033 MYC_HYLLA Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Hylobates lar (Common gibbon) 439
B8XIA5 MYC_MACMU Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Macaca mulatta (Rhesus macaque) 439
P22555 MYC_MARMO Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Marmota monax (Woodchuck) 439
P01108 MYC_MOUSE Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) Myc Mus musculus (Mouse) 439
A1YG22 MYC_PANPA Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Pan paniscus (Pygmy chimpanzee) (Bonobo) 439
P23583 MYC_PANTR Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Pan troglodytes (Chimpanzee) 439
Q29031 MYC_PIG Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Sus scrofa (Pig) 439
A2T7L5 MYC_PONPY Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Pongo pygmaeus (Bornean orangutan) 439
Q9MZT8 MYC_PTEHP Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Pteropus hypomelanus (Island flying fox) (Variable flying fox) 440
P09416 MYC_RAT Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) Myc Rattus norvegicus (Rat) 439
Q28566 MYC_SHEEP Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Ovis aries (Sheep) 439
Q9MZT6 MYC_SYLFL Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Sylvilagus floridanus (Cottontail rabbit) 438
Q9MZT7 MYC_TADBR Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Tadarida brasiliensis (Brazilian free-tailed bat) 439
Q9MZT9 MYC_TUPGL Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Tupaia glis (Tree shrew) 439
P01106 MYC_HUMAN Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) MYC BHLHE39 Homo sapiens (Human) 439

Small molecules tested in c-Myc binding assays:

1 datapoints for 1 distinct small molecules


Name Mycro1
Affinity IC50(FP) 30uM
Assay description Fluorescence polorization assay
-- Direct single protein target assigned: MYC_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1016/j.chembiol.2006.05.011
Doc title Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules.
PDB None

5 PDB entries for c-Myc and its protein partners


1A93
Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper.

Entity type Code Description
polypeptide(L) P01106 MYC PROTO-ONCOGENE PROTEIN
polypeptide(L) P28574 MAX PROTEIN

1EE4
Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha.

Entity type Code Description
polypeptide(L) Q02821 KARYOPHERIN ALPHA
polypeptide(L) P01106 MYC PROTO-ONCOGENE PROTEIN

1MV0
A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants.

Entity type Code Description
polypeptide(L) P01106 Myc proto-oncogene protein
polypeptide(L) O00499 Myc box-dependent-interacting protein 1

1NKP
X-ray structures of Myc-Max and Mad-Max recognizing DNA: Molecular bases of regulation by proto-oncogenic transcription factors

Entity type Code Description
polydeoxyribonucleotide 1NKP 5'-D(*CP*GP*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*TP*C)-3'
polypeptide(L) P01106 Myc proto-oncogene protein
polypeptide(L) P61244 Max protein

2A93
Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper.

Entity type Code Description
polypeptide(L) P01106 C-MYC-MAX HETERODIMERIC LEUCINE ZIPPER
polypeptide(L) P28574 C-MYC-MAX HETERODIMERIC LEUCINE ZIPPER