c-Myc

Myc proto-oncogene protein (c-myc)

Reviewed UniProt entries for c-Myc and its protein partners


UniProt code UniProt Name Protein Name Gene Name Organism Length
Q2HJ27 MYC_BOVIN Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Bos taurus (Bovine) 439
P49032 MYC_CALJA Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Callithrix jacchus (White-tufted-ear marmoset) 438
Q28350 MYC_CANFA Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Canis familiaris (Dog) (Canis lupus familiaris) 439
P01109 MYC_CHICK Myc proto-oncogene protein (c-Myc) MYC Gallus gallus (Chicken) 416
P68271 MYC_FELCA Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Felis catus (Cat) (Felis silvestris catus) 439
Q9MZU0 MYC_GALVR Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Galeopterus variegatus (Malayan flying lemur) (Cynocephalus variegatus) 439
P49033 MYC_HYLLA Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Hylobates lar (Common gibbon) 439
B8XIA5 MYC_MACMU Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Macaca mulatta (Rhesus macaque) 439
P22555 MYC_MARMO Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Marmota monax (Woodchuck) 439
P01108 MYC_MOUSE Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) Myc Mus musculus (Mouse) 439
A1YG22 MYC_PANPA Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Pan paniscus (Pygmy chimpanzee) (Bonobo) 439
P23583 MYC_PANTR Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Pan troglodytes (Chimpanzee) 439
Q29031 MYC_PIG Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Sus scrofa (Pig) 439
A2T7L5 MYC_PONPY Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Pongo pygmaeus (Bornean orangutan) 439
Q9MZT8 MYC_PTEHP Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Pteropus hypomelanus (Island flying fox) (Variable flying fox) 440
P09416 MYC_RAT Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) Myc Rattus norvegicus (Rat) 439
Q28566 MYC_SHEEP Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Ovis aries (Sheep) 439
Q9MZT6 MYC_SYLFL Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Sylvilagus floridanus (Cottontail rabbit) 438
Q9MZT7 MYC_TADBR Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Tadarida brasiliensis (Brazilian free-tailed bat) 439
Q9MZT9 MYC_TUPGL Myc proto-oncogene protein (Proto-oncogene c-Myc) (Transcription factor p64) MYC Tupaia glis (Tree shrew) 439
P01106 MYC_HUMAN Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) MYC BHLHE39 Homo sapiens (Human) 439

Small molecules tested in c-Myc binding assays:

30 datapoints for 26 distinct small molecules


Name Mycro1
Affinity IC50(FP) 30uM
Assay description Fluorescence polorization assay
-- Direct single protein target assigned: MYC_HUMAN (Expert curation) --
DOI http://dx.doi.org/10.1016/j.chembiol.2006.05.011
Doc title Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules.
PDB None

Name CHEMBL1336889
Affinity Dose-dependent effect
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization by electrophoretic mobility shift assay
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL1336889
Affinity IC50 = 33uM
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization by electrophoretic mobility shift assay
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL1336889
Affinity INH = 93%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL1365380
Affinity INH = 0%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL1371773
Affinity INH = 2%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL1391773
Affinity INH = 8%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL1464017
Affinity INH = 0%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL1595909
Affinity INH = 13%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2205739
Affinity INH = 11%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2311551
Affinity INH = 2%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312740
Affinity INH = 10%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312741
Affinity INH = 11%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312742
Affinity INH = 39%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312743
Affinity INH = 0%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312744
Affinity INH = 36%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312745
Affinity INH = 0%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312746
Affinity INH = 20%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312747
Affinity INH = 28%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312748
Affinity INH = 0%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312749
Affinity INH = 0%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312750
Affinity INH = 2%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312751
Affinity INH = 25%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312752
Affinity INH = 0%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312753
Affinity INH = 17%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312754
Affinity INH = 33%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312755
Affinity INH = 0%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312756
Affinity INH = 38%
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization at 100 uM by electrophoretic mobility shift assay relative to control
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312756
Affinity Kd = 2.8uM
Assay description Binding affinity to human c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) expressed in Escherichia coli BL21 (DE3) by fluorescence polarization assay
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

Name CHEMBL2312756
Affinity IC50 = 146uM
Assay description Inhibition of recombinant His6-tagged c-Myc bHLH-ZIP domain (353 to 437 amino acid residues) (unknown origin) assessed as disruption of Myc-Max dimerization by electrophoretic mobility shift assay
-- Direct single protein target assigned: MYC_HUMAN (Autocuration) --
DOI http://www.ncbi.nlm.nih.gov/pubmed/23177256
Doc title Pharmacophore identification of c-Myc inhibitor 10074-G5.
PDB None

5 PDB entries for c-Myc and its protein partners


1A93
Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper.

Entity type Code Description
polypeptide(L) P01106 MYC PROTO-ONCOGENE PROTEIN
polypeptide(L) P28574 MAX PROTEIN

1EE4
Crystallographic analysis of the specific yet versatile recognition of distinct nuclear localization signals by karyopherin alpha.

Entity type Code Description
polypeptide(L) Q02821 KARYOPHERIN ALPHA
polypeptide(L) P01106 MYC PROTO-ONCOGENE PROTEIN

1MV0
A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants.

Entity type Code Description
polypeptide(L) P01106 Myc proto-oncogene protein
polypeptide(L) O00499 Myc box-dependent-interacting protein 1

1NKP
X-ray structures of Myc-Max and Mad-Max recognizing DNA: Molecular bases of regulation by proto-oncogenic transcription factors

Entity type Code Description
polydeoxyribonucleotide 1NKP 5'-D(*CP*GP*AP*GP*TP*AP*GP*CP*AP*CP*GP*TP*GP*CP*TP*AP*CP*TP*C)-3'
polypeptide(L) P01106 Myc proto-oncogene protein
polypeptide(L) P61244 Max protein

2A93
Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper.

Entity type Code Description
polypeptide(L) P01106 C-MYC-MAX HETERODIMERIC LEUCINE ZIPPER
polypeptide(L) P28574 C-MYC-MAX HETERODIMERIC LEUCINE ZIPPER